In:
ChemistrySelect, Wiley, Vol. 3, No. 10 ( 2018-03-14), p. 2894-2903
Abstract:
The modern biomedical nanotechnology necessitates functionalized nanoparticles for targeted action on diseased cells with excellent physico chemical properties. The present study revealed the potential of fabricating juglone silver nano framework for selective cancer cell death by altering the redox states in the cancer cell and selectively inhibiting its growth and proliferation. Conjugation of Juglone with silver nanoparticle reduced the toxicity against normal cells and specifically only inhibited the proliferation of cancer cells. The mechanism of the selective cytotoxic and apoptotic effect on cancer cell was due to down‐regulation of NADPH oxidase 4, Hypoxia‐inducible factor 1α and subdued Pyruvate kinase M2 by arresting Wnt/β catenin signaling through ROS dependent caspase‐3 pathway. Collectively, our findings epitomized that functionalization of nanoparticle gives up a new perspective for adding‐in and tuning the therapeutic values by altering the redox states in cancer cells. Implications of this study opens up a new horizon in modern biomedicine for tuning therapeutic entities to meet the needs of practical applications in complex biological systems.
Type of Medium:
Online Resource
ISSN:
2365-6549
,
2365-6549
DOI:
10.1002/slct.201800152
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2844262-3
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