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  • 1
    In: Journal of Advanced Nursing, Wiley, Vol. 72, No. 7 ( 2016-07), p. 1689-1700
    Abstract: To describe an integrative review protocol to analyse and synthesize peer‐reviewed research evidence in relation to engagement of patients and their families in communication during transitions of care to, in and from acute care settings. Background Communication at transitions of care in acute care settings can be complex and challenging, with important information about patients not always clearly transferred between responsible healthcare providers. Involving patients and their families in communication during transitions of care may improve the transfer of clinical information and patient outcomes and prevent adverse events during hospitalization and following discharge. Recently, optimizing patient and family participation during care transitions has been acknowledged as central to the implementation of patient‐centred care. Design Integrative review with potential for meta‐analysis and application of framework synthesis. Review method The review will evaluate and synthesize qualitative and quantitative research evidence identified through a systematic search. Primary studies will be selected according to inclusion criteria. Data collection, quality appraisal and analysis of the evidence will be conducted by at least two authors. Nine electronic databases (including CINAHL and Medline) will be searched. The search will be restricted to 10 years up to December 2013. Data analysis will include content and thematic analysis. Discussion The review will seek to identify all types of patient engagement activities employed during transitions of care communication. The review will identify enablers for and barriers to engagement for patients, families and health professionals. Key strategies and tools for improving patient engagement, clinical communication and promoting patient‐centred care will be recommended based on findings.
    Type of Medium: Online Resource
    ISSN: 0309-2402 , 1365-2648
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2009963-0
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  • 2
    In: Scandinavian Journal of Caring Sciences, Wiley, Vol. 30, No. 3 ( 2016-09), p. 565-573
    Abstract: Existing practice strategies for actively involving patients in care during hospitalisation are poorly understood. The aim of this study was to explore how healthcare professionals engaged patients in communication associated with care transitions. Method An instrumental, collective case study approach was used to generate empirical data about patient transitions in care. A purposive sample of key stakeholders representing (i) patients and their families; (ii) hospital discharge planning team members; and (iii) healthcare professionals was recruited in five Australian health services. Individual and group semi‐structured interviews were conducted to elicit detailed explanations of patient engagement in transition planning. Interviews lasted between 30 and 60 minutes and were digitally recorded and transcribed verbatim. Data collection and analysis were conducted simultaneously and continued until saturation was achieved. Thematic analysis was undertaken. Results Five themes emerged as follows: (i) organisational commitment to patient engagement; (ii) the influence of hierarchical culture and professional norms on patient engagement; (iii) condoning individual healthcare professionals' orientations and actions; (iv) understanding and negotiating patient preferences; and (v) enacting information sharing and communication strategies. Most themes illustrated how patient engagement was enabled; however, barriers also existed. Conclusion Our findings show that strong organisational and professional commitment to patient‐centred care throughout the organisation was a consistent feature of health services that actively engaged patients in clinical communication. Understanding patients' needs and preferences and having both formal and informal strategies to engage patients in clinical communication were important in how this involvement occurred.
    Type of Medium: Online Resource
    ISSN: 0283-9318 , 1471-6712
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2031090-0
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  • 3
    In: Limnology and Oceanography, Wiley, Vol. 61, No. S1 ( 2016-11)
    Abstract: The Chesapeake Bay is a eutrophic estuary that undergoes seasonal bottom water hypoxia. Methane (CH 4 ) gas bubbles are found within the upper sediment layers, but whether this greenhouse gas escapes to the water column or the atmosphere is not well known. Here, we hypothesize that when bottom waters become anoxic, CH 4 is released from the sediments, builds up under the pycnocline, and escapes to the atmosphere at the end of hypoxia. Osmotically powered pumps (OsmoSamplers) were used for the first time to test this hypothesis. They were deployed from April to October 2013 and continuously collected bottom water into small diameter, copper tubing. Upon recovery, the tubing was cut into 4 d increments, and the enclosed water extracted and measured for CH 4 concentrations. Results showed that in April, CH 4 concentrations were low (∼1 μ M) when bottom waters were fully oxygenated and increased as anoxic conditions set in. By mid‐July, CH 4 concentrations peaked and reached as high as 40 μ M, most likely coming from the sediments. By early August, concentrations decreased until they returned to background levels when normal oxygen conditions returned in late September. While most of the built‐up CH 4 was gone by the end of anoxia, CH 4 concentrations measured in discrete surface water samples in June and September suggest that there was still a significant flux of CH 4 to the atmosphere. Taken together, our time‐series data shows that the CH 4 flux from the Chesapeake Bay is temporally variable, potentially significant, and dependent on physical processes (e.g., storms) occurring in the Bay.
    Type of Medium: Online Resource
    ISSN: 0024-3590 , 1939-5590
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2033191-5
    detail.hit.zdb_id: 412737-7
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    SSG: 14
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  • 4
    In: The FASEB Journal, Wiley, Vol. 29, No. S1 ( 2015-04)
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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  • 5
    In: Cancer, Wiley, Vol. 123, No. 24 ( 2017-12-15), p. 4800-4807
    Abstract: Although the scientific benefits of obtaining a new biopsy and requiring specific results for trial enrollment are clear, studies with such a design lead to a lengthening of the screening period, which, in some cases, is associated with clinical decline before enrollment. Implications for the interpretation of data from studies of this design should be explored. See also pages 4764‐6.
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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    detail.hit.zdb_id: 2599218-1
    detail.hit.zdb_id: 2594979-2
    detail.hit.zdb_id: 1429-1
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2016
    In:  Ecological Applications Vol. 26, No. 4 ( 2016-06), p. 996-1002
    In: Ecological Applications, Wiley, Vol. 26, No. 4 ( 2016-06), p. 996-1002
    Abstract: Climate change, historical fire suppression, and a rise in human movements in urban‐forest boundaries have resulted in an increased use of long‐term fire retardant ( LTFR ). While LTFR is an effective fire‐fighting tool, it contains high concentrations of nitrogen and phosphorus, and little is known about how this nutrient pulse affects terrestrial ecosystems. We used field surveys and greenhouse experiments to quantify effects of LTFR on plant productivity, community composition, and plant interactions with the ubiquitous root symbiont arbuscular mycorrhizal fungi ( AMF ). In the field, LTFR applications were associated with persistent shifts in plant communities toward exotic annuals with little or no dependency of AMF . Plants exposed to LTFR were less colonized by AMF , both in field surveys and in the greenhouse, and this was most likely due to the substantial and persistent increase in soil available phosphorus. All plants grew bigger with LTFR in the greenhouse, but the invasive annual cheatgrass ( Bromus tectorum ) benefitted most. While LTFR can control fires, it may cause long‐term changes in soil nutrient availabilities, disrupt plant interactions with beneficial soil microbes, and exasperate invasion by some exotic plants.
    Type of Medium: Online Resource
    ISSN: 1051-0761 , 1939-5582
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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    SSG: 12
    SSG: 23
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  • 7
    In: Ecological Applications, Wiley, Vol. 26, No. 5 ( 2016-07), p. 1421-1436
    Abstract: Exurban residential land (one housing unit per 0.2–16.2 ha) is growing in importance as a human‐dominated land use. Carbon storage in the soils and vegetation of exurban land is poorly known, as are the effects on C storage of choices made by developers and residents. We studied C storage in exurban yards in southeastern Michigan , USA , across a range of parcel sizes and different types of neighborhoods. We divided each residential parcel into ecological zones ( EZ ) characterized by vegetation, soil, and human behavior such as mowing, irrigation, and raking. We found a heterogeneous mixture of trees and shrubs, turfgrasses, mulched gardens, old‐field vegetation, and impervious surfaces. The most extensive zone type was turfgrass with sparse woody vegetation (mean 26% of parcel area), followed by dense woody vegetation (mean 21% of parcel area). Areas of turfgrass with sparse woody vegetation had trees in larger size classes ( 〉 50 cm dbh) than did areas of dense woody vegetation. Using aerial photointerpretation, we scaled up C storage to neighborhoods. Varying C storage by neighborhood type resulted from differences in impervious area (8–26% of parcel area) and area of dense woody vegetation (11–28%). Averaged and multiplied across areas in differing neighborhood types, exurban residential land contained 5240 ± 865 g C/m 2 in vegetation, highly sensitive to large trees, and 13 800 ± 1290 g C/m 2 in soils (based on a combined sampling and modeling approach). These contents are greater than for agricultural land in the region, but lower than for mature forest stands. Compared with mature forests, exurban land contained more shrubs and less downed woody debris and it had similar tree size‐class distributions up to 40 cm dbh but far fewer trees in larger size classes. If the trees continue to grow, exurban residential land could sequester additional C for decades. Patterns and processes of C storage in exurban residential land were driven by land management practices that affect soil and vegetation, reflecting the choices of designers, developers, and residents. This study provides an example of human‐mediated C storage in a coupled human–natural system.
    Type of Medium: Online Resource
    ISSN: 1051-0761 , 1939-5582
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2010123-5
    SSG: 12
    SSG: 23
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  • 8
    In: The FEBS Journal, Wiley, Vol. 284, No. 6 ( 2017-03), p. 985-1002
    Abstract: The fungal pathogen Aspergillus fumigatus has been implicated in a drastic increase in life‐threatening infections over the past decade. However, compared to other microbial pathogens, little is known about the essential molecular processes of this organism. One such fundamental process is DNA replication. The protein responsible for ensuring processive DNA replication is PCNA (proliferating cell nuclear antigen, also known as the sliding clamp), which clamps the replicative polymerase to DNA . Here we present the first crystal structure of a sliding clamp from a pathogenic fungus ( A. fumigatus ), at 2.6Å. Surprisingly, the structure bears more similarity to the human sliding clamp than other available fungal sliding clamps. Reflecting this, fluorescence polarization experiments demonstrated that Afum PCNA interacts with the PCNA ‐interacting protein ( PIP ‐box) motif of human p21 with an affinity ( K d ) of 3.1 μ m . Molecular dynamics simulations were carried out to better understand how Afum PCNA interacts with human p21. These simulations revealed that the PIP ‐box bound to Afu PCNA forms a secondary structure similar to that observed in the human complex, with a central 3 10 helix contacting the hydrophobic surface pocket of Afum PCNA as well as a β‐strand that forms an antiparallel sheet with the Afum PCNA surface. Differences in the 3 10 helix interaction with PCNA , attributed to residue Thr131 of Afum PCNA , and a less stable β‐strand formation, attributed to residues Gln123 and His125 of Afum PCNA , are likely causes of the over 10‐fold lower affinity of the p21 PIP ‐box for Afum PCNA as compared to hPCNA . Database The atomic coordinates and structure factors for the Aspergillus fumigatus sliding clamp can be found in the RCSB Protein Data Bank ( http://www.rcsb.org ) under the accession code 5TUP .
    Type of Medium: Online Resource
    ISSN: 1742-464X , 1742-4658
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2172518-4
    SSG: 12
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  • 9
    In: Architectural Design, Wiley, Vol. 85, No. 5 ( 2015-09), p. 60-65
    Abstract: Process‐based biomimetics focuses on the transfer of biological principles to architectural construction. To realise the ICD/ITKE Research Pavilion 2014 ‐15, presented here by Moritz Doerstelmann, Jan Knippers, Valentin Koslowski, Achim Menges, Marshall Prado, Gundula Schieber and Lauren Vasey of the Institute for Computational Design (ICD) and Institute of Building Structures and Structural Design (ITKE) research team at the University of Stuttgart, sensor‐driven robotic fabrication was combined with advanced design computation and simulation. This enabled the construction of an architectural fibre structure on a pneumatic mould, drawing on the complex design of the web of a water spider.
    Type of Medium: Online Resource
    ISSN: 0003-8504 , 1554-2769
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2015
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    detail.hit.zdb_id: 161750-3
    SSG: 9,10
    SSG: 6,23
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