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  • 1
    Online Resource
    Online Resource
    Comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: A retrospective analysis: KCSG GU 17‐03
    Wiley ; 2019
    In:  Cancer Medicine Vol. 8, No. 12 ( 2019-09), p. 5431-5437
    Details
    In: Cancer Medicine, Wiley, Vol. 8, No. 12 ( 2019-09), p. 5431-5437
    Abstract: The regional lymph node‐positive bladder cancer was classified as stage IV in the AJCC 7th edition but was changed to stage IIIB in the 8th edition, revised in 2018. Among the various studies involving immune checkpoint inhibitors, groups that had only lymph node metastasis showed better outcomes than those with distant metastasis. Therefore, it is necessary to rethink the treatment strategy for lymph node‐positive bladder cancer. The aim of this study was to compare the treatment outcomes of chemotherapy, surgery, and combination therapy in patients with lymph node‐positive bladder cancer. From 1 January 2010 to 31 December 2015, patients with bladder cancer presenting local lymph node metastasis at the time of diagnosis were treated with a single treatment strategy, with either radical cystectomy or chemotherapy or with a combined strategy using both. Treatment outcomes were retrospectively analyzed on the basis of clinical indices and survival time. Out of 230 patients with bladder cancer, 44 (19.1%) were treated with palliative chemotherapy, 30 (13.0%) with neoadjuvant chemotherapy followed by cystectomy, 129 (56.1%) with cystectomy followed by adjuvant chemotherapy, and 27 (11.7%) with cystectomy alone. Median survival among all groups was 30.4 months. For each group, median overall survival was 19.3, 49.1, 42.6, and 11.2 months, respectively. This study represents an advancement in understanding the impact of clinical treatment patterns of lymph node‐positive bladder cancer through comparison of survival data of patients treated with different therapeutic strategies. Combined treatment resulted in better outcomes than did single treatments.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v8.12
    DOI: 10.1002/cam4.2446
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2659751-2
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  • 2
    Online Resource
    Online Resource
    miR‐204 downregulates EphB2 in aging mouse hippocampal neurons
    Wiley ; 2016
    In:  Aging Cell Vol. 15, No. 2 ( 2016-04), p. 380-388
    Details
    In: Aging Cell, Wiley, Vol. 15, No. 2 ( 2016-04), p. 380-388
    Abstract: Hippocampal synaptic function and plasticity deteriorate with age, often resulting in learning and memory deficits. As MicroRNAs (miRNAs) are important regulators of neuronal protein expression, we examined whether miRNAs may contribute to this age‐associated decline in hippocampal function. We first compared the small RNA transcriptome of hippocampal tissues from young and old mice. Among 269 hippocampal miRNAs, 80 were differentially expressed (≥ twofold) among the age groups. We focused on 36 miRNAs upregulated in the old mice compared with those in the young mice. The potential targets of these 36 miRNAs included 11 critical Eph/Ephrin synaptic signaling components. The expression levels of several genes in the Eph/Ephrin pathway, including EphB2, were significantly downregulated in the aged hippocampus. EphB2 is a known regulator of synaptic plasticity in hippocampal neurons, in part by regulating the surface expression of the NMDA receptor NR1 subunit. We found that EphB2 is a direct target of miR‐204 among miRNAs that were upregulated with age. The transfection of primary hippocampal neurons with a miR‐204 mimic suppressed both EphB2 mRNA and protein expression and reduced the surface expression of NR1. Transfection of miR‐204 also decreased the total expression of NR1. miR‐204 induces senescence‐like phenotype in fully matured neurons as evidenced by an increase in p16‐positive cells. We suggest that aging is accompanied by the upregulation of miR‐204 in the hippocampus, which downregulates EphB2 and results in reduced surface and total NR1 expression. This mechanism may contribute to age‐associated decline in hippocampal synaptic plasticity and the related cognitive functions.
    Type of Medium: Online Resource
    ISSN: 1474-9718 , 1474-9726
    URL: Issue
    URL: Article
    DOI: 10.1111/acel.2016.15.issue-2
    DOI: 10.1111/acel.12444
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2099130-7
    SSG: 12
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  • 3
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    Online Resource
    Prognostic value of preoperative N ‐terminal pro‐brain natriuretic peptide in non‐cardiac surgery of elderly patients with normal left ventricular systolic function
    Wiley ; 2016
    In:  Geriatrics & Gerontology International Vol. 16, No. 10 ( 2016-10), p. 1109-1116
    Details
    In: Geriatrics & Gerontology International, Wiley, Vol. 16, No. 10 ( 2016-10), p. 1109-1116
    Abstract: We investigated the prognostic value of preoperative N ‐terminal pro‐brain natriuretic peptide ( NT ‐pro BNP ) in non‐cardiac surgery in elderly patients who showed normal left ventricular function on preoperative echocardiography. Methods We analyzed 1459 patients aged older than 70 years who had consulted a cardiologist for the evaluation of cardiovascular risk for non‐cardiac surgery. Of the 721 patients who simultaneously underwent echocardiography and NT ‐pro BNP assessments, 506 who showed normal left ventricular systolic function were included. The predictive power of NT ‐pro BNP for the risk of major adverse cardiac and cerebrovascular events ( MACCE ) was evaluated. Results MACCE occurred in 40 (7.9%) of the 506 patients, and the median value of NT ‐pro BNP was higher in patients with complications than in those without ( MACCE group: 1700.5 pg/mL vs non MACCE group: 206.35 pg/mL; P   〈  0.001). The area under the receiver operating characteristic curve was 0.804 ( P   〈  0.001), with an optimal cut‐off of 425.3 pg/mL. Multivariate analysis showed that increased NT ‐pro BNP ( 〉 425.3 pg/mL; odds ratio 6.381; P   〈  0.001) was the only independent risk factor for the prediction of MACCE . Conclusions In elderly patients who showed normal left ventricular systolic function on echocardiography, measurement of preoperative NT ‐pro BNP concentration might be a useful test for predicting the occurrence of MACCE after non‐cardiac surgery. Geriatr Gerontol Int 2016; 16: 1109–1116.
    Type of Medium: Online Resource
    ISSN: 1444-1586 , 1447-0594
    URL: Issue
    URL: Article
    DOI: 10.1111/ggi.2016.16.issue-10
    DOI: 10.1111/ggi.12597
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2078308-5
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  • 4
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    Online Resource
    A Colloidal‐Quantum‐Dot‐Based Self‐Charging System via the Near‐Infrared Band
    Wiley ; 2018
    In:  Advanced Materials Vol. 30, No. 25 ( 2018-06)
    Details
    In: Advanced Materials, Wiley, Vol. 30, No. 25 ( 2018-06)
    Abstract: A novel self‐charging platform is proposed using colloidal‐quantum‐dot (CQD) photovoltaics (PVs) via the near‐infrared (NIR) band for low‐power electronics. Low‐bandgap CQDs can convert invisible NIR light sources to electrical energy more efficiently than wider spectra because of reduced thermalization loss. This energy‐conversion strategy via NIR photons ensures an enhanced photostability of the CQD devices. Furthermore, the NIR wireless charging system can be concealed using various colored and NIR‐transparent fabric or films, providing aesthetic freedom. Finally, an NIR‐driven wireless charging system is demonstrated for a wearable healthcare bracelet by integrating a CQD PVs receiver with a flexible lithium‐ion battery and entirely embedding them into a flexible strap, enabling permanent self‐charging without detachment.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v30.25
    DOI: 10.1002/adma.201707224
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1474949-X
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  • 5
    Online Resource
    Online Resource
    Synthesis, Optical Properties, and Multiplexed Raman Bio‐Imaging of Surface Roughness‐Controlled Nanobridged Nanogap Particles
    Wiley ; 2016
    In:  Small Vol. 12, No. 34 ( 2016-09), p. 4726-4734
    Details
    In: Small, Wiley, Vol. 12, No. 34 ( 2016-09), p. 4726-4734
    Abstract: Plasmonic nanostructures are widely studied and used because of their useful size, shape, composition and assembled structure‐based plasmonic properties. It is, however, highly challenging to precisely design, reproducibly synthesize and reliably utilize plasmonic nanostructures with enhanced optical properties. Here, we devise a facile synthetic method to generate Au surface roughness‐controlled nanobridged nanogap particles (Au‐RNNPs) with ultrasmall (≈1 nm) interior gap and tunable surface roughness in a highly controllable manner. Importantly, we found that particle surface roughness can be associated with and enhance the electromagnetic field inside the interior gap, and stronger nanogap‐enhanced Raman scattering (NERS) signals can be generated from particles by increasing particle surface roughness. The finite‐element method‐based calculation results support and are matched well with the experimental results and suggest one needs to consider particle shape, nanogap and nanobridges simultaneously to understand and control the optical properties of this type of nanostructures. Finally, the potential of multiplexed Raman detection and imaging with RNNPs and the high‐speed, high‐resolution Raman bio‐imaging of Au‐RNNPs inside cells with a wide‐field Raman imaging setup with liquid crystal tunable filter are demonstrated. Our results provide strategies and principles in designing and synthesizing plasmonically enhanced nanostructures and show potential for detecting and imaging Raman nanoprobes in a highly specific, sensitive and multiplexed manner.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v12.34
    DOI: 10.1002/smll.201600289
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2168935-0
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  • 6
    Online Resource
    Online Resource
    Porcine spermatogonial stem cells self‐renew effectively in a three dimensional culture microenvironment
    Wiley ; 2017
    In:  Cell Biology International Vol. 41, No. 12 ( 2017-12), p. 1316-1324
    Details
    In: Cell Biology International, Wiley, Vol. 41, No. 12 ( 2017-12), p. 1316-1324
    Abstract: Generally, self‐renewal of spermatogonial stem cells (SSCs) is maintained in vivo in a three‐dimensional (3D) microenvironment consisting of the seminiferous tubule basement membrane, indicating the importance of the 3D microenvironment for in vitro culture of SSCs. Here, we report a 3D culture microenvironment that effectively maintains porcine SSC self‐renewal during culture. Porcine SSCs were cultured in an agarose‐based 3D hydrogel and in 2D culture plates either with or without feeder cells. Subsequently, the effects of 3D culture on the maintenance of undifferentiated SSCs were identified by analyzing cell colony formation and morphology, AP activity, and transcriptional and translational regulation of self‐renewal‐related genes and the effects on proliferation by analyzing cell viability and single cell‐derived colony number. The 3D culture microenvironment constructed using a 0.2% (w/v) agarose‐based 3D hydrogel showed the strongest maintenance of porcine SSC self‐renewal and induced significant improvements in proliferation compared with 2D culture microenvironments. These results demonstrate that self‐renewal of porcine SSCs can be maintained more effectively in a 3D than in a 2D culture microenvironment. Moreover, this will play a significant role in developing novel culture systems for SSCs derived from diverse species in the future, which will contribute to SSC‐related research.
    Type of Medium: Online Resource
    ISSN: 1065-6995 , 1095-8355
    URL: Issue
    URL: Article
    DOI: 10.1002/cbin.v41.12
    DOI: 10.1002/cbin.10844
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1462519-2
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Why Is Left Atrial Appendage Morphology Related to Strokes? An Analysis of the Flow Velocity and Orifice Size of the Left Atrial Appendage
    Wiley ; 2015
    In:  Journal of Cardiovascular Electrophysiology Vol. 26, No. 9 ( 2015-09), p. 922-927
    Details
    In: Journal of Cardiovascular Electrophysiology, Wiley, Vol. 26, No. 9 ( 2015-09), p. 922-927
    Abstract: A specific morphology of left atrial appendage (LAA) has been reported to be related to stroke in nonvalvular atrial fibrillation (AF) patients. However, the mechanism is not completely understood. This study evaluated whether a specific LAA morphology was related to stroke, and whether it was related to the change of flow velocity and size of LAA in AF patients. Methods The morphology, size, and flow velocity of LAA were evaluated in AF patients with ischemic strokes (stroke, n = 160) and age‐matched AF patients without ischemic strokes (control, n = 200). Results Compared with control, the stroke group had a larger LA dimension (4.5 ± 0.7 vs. 4.2 ± 0.6 cm, P 〈 0.001), larger LAA orifice area (5.3 ± 2.1 vs. 4.1 ± 1.7 cm 2 , P 〈 0.001), and slower LAA flow velocity (37 ± 19 vs. 51 ± 20 cm/s, P 〈 0.001). The stroke group had the chicken wing type less frequently than the control (34% vs. 50%, P = 0.003). After an adjustment for multiple potential confounding factors, the chicken wing type LAA had a decreased stroke risk (odds ratio 0.34, 95% confidence interval 0.14–0.84, P = 0.020). Patients with a chicken wing LAA had a smaller LAA orifice area (4.4 ± 1.6 vs. 4.9 ± 2.2 cm 2 , P = 0.013) and higher LAA velocity (55 ± 19 vs. 41 ± 20 cm/s, P 〈 0.001) than those with non‐chicken wing LAA. Conclusion A chicken wing type of LAA was related to the less incidence of stroke. Our results suggest that the relationship between a specific LAA morphology and stroke might be partially explained by the change of the size and flow velocity of LAA.
    Type of Medium: Online Resource
    ISSN: 1045-3873 , 1540-8167
    URL: Issue
    URL: Article
    DOI: 10.1111/jce.2015.26.issue-9
    DOI: 10.1111/jce.12710
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2037519-0
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  • 8
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    Online Resource
    Attenuated FOLFIRINOX in the salvage treatment of gemcitabine‐refractory advanced pancreatic cancer: a phase II study
    Wiley ; 2018
    In:  Cancer Communications Vol. 38, No. 1 ( 2018-12), p. 1-8
    Details
    In: Cancer Communications, Wiley, Vol. 38, No. 1 ( 2018-12), p. 1-8
    Abstract: Combination therapy with oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) chemotherapy drastically improves survival of advanced pancreatic cancer patients. However, the efficacy of FOLFIRINOX as a second‐line treatment after gemcitabine failure has not been tested prospectively. We investigated the feasibility and safety of attenuated FOLFIRINOX in patients with gemcitabine‐refractory advanced pancreatic cancer. Methods A multicenter phase II prospective open‐label, single‐arm study was conducted at 14 hospitals. Patients with histologically proven invasive ductal pancreatic adenocarcinoma, a measurable or evaluable lesion, Eastern Cooperative Oncology Group performance status 0 or 1, adequate organ function, and aged 19 years or older were eligible. Attenuated FOLFIRINOX consisted of oxaliplatin 65 mg/m 2 , irinotecan 135 mg/m 2 , and leucovorin 400 mg/m 2 injected intravenously on day 1 and 5‐fluorouracil 2000 mg/m 2 continuously infused intravenously over 46 h on days 1–2, repeated every 2 weeks. The primary endpoint was progression‐free survival from the initiation of FOLFIRINOX. Secondary endpoints were the objective response rate, disease control rate, overall survival, safety, and tolerability. We estimated overall survival and progression‐free survival using the Kaplan–Meier methods. Results We enrolled 39 patients from 14 institutions. The objective response rate was 10.3%, while the disease control rate was 64.1%. The 6‐month and 1‐year overall survival rates were 59.0% and 15.4%, respectively. Median progression‐free survival and overall survival were 3.8 months (95% confidence interval [CI] 1.5–6.0 months) and 8.5 months (95% CI 5.6–11.4 months), respectively. Grade 3 or 4 adverse events were neutropenia (41.0%), nausea (10.3%), anorexia (10.3%), anemia (7.7%), mucositis (7.7%), pneumonia/pleural effusion (5.1%), and fatigue (5.1%). One treatment‐related death attributable to septic shock occurred. Conclusion Attenuated FOLFIRINOX may be promising as a second‐line therapy for gemcitabine‐refractory pancreatic cancer.
    Type of Medium: Online Resource
    ISSN: 2523-3548 , 2523-3548
    URL: Article
    DOI: 10.1186/s40880-018-0304-1
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2922913-3
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  • 9
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    Online Resource
    Recurrent fusion transcripts detected by whole‐transcriptome sequencing of 120 primary breast cancer samples
    Wiley ; 2015
    In:  Genes, Chromosomes and Cancer Vol. 54, No. 11 ( 2015-11), p. 681-691
    Details
    In: Genes, Chromosomes and Cancer, Wiley, Vol. 54, No. 11 ( 2015-11), p. 681-691
    Abstract: Relatively few recurrent gene fusion events have been associated with breast cancer to date. In an effort to uncover novel fusion transcripts, we performed whole‐transcriptome sequencing of 120 fresh‐frozen primary breast cancer samples and five adjacent normal breast tissues using the Illumina HiSeq2000 platform. Three different fusion‐detecting tools (deFuse, Chimerascan, and TopHatFusion) were used, and the results were compared. These tools detected 3,831, 6,630 and 516 fusion transcripts (FTs) overall. We primarily focused on the results obtained using the deFuse software. More FTs were identified from HER2 subtype breast cancer samples than from the luminal or triple‐negative subtypes ( P   〈  0.05). Seventy fusion candidates were selected for validation, and 32 (45.7%) were confirmed by RT‐PCR and Sanger sequencing. Of the validated fusions, six were recurrent (found in 2 or more samples), three were in‐frame ( PRDX1‐AKR1A1, TACSTD2‐OMA1 , and C2CD2‐TFF1 ) and three were off‐frame ( CEACAM7‐CEACAM6, CYP4X1‐CYP4Z2P , and EEF1DP3‐FRY ). Notably, the novel read‐through fusion, EEF1DP3‐FRY , was identified and validated in 6.7% (8/120) of the breast cancer samples. This off‐frame fusion results in early truncation of the FRY gene, which plays a key role in the structural integrity during mitosis. Three previously reported fusions, PPP1R1B‐STARD3, MFGE8‐HAPL , and ETV6‐NTRK3 , were detected in 8.3, 3.3, and 0.8% of the 120 samples, respectively, by both deFuse and Chimerascan. The recently reported MAGI3‐AKT3 fusion was not detected in our analysis. Although future work will be needed to examine the biological significance of our new findings, we identified a number of novel fusions and confirmed some previously reported fusions. © 2015 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1045-2257 , 1098-2264
    URL: Issue
    URL: Article
    DOI: 10.1002/gcc.v54.11
    DOI: 10.1002/gcc.22279
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1018988-9
    detail.hit.zdb_id: 1492641-6
    SSG: 12
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  • 10
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    Patterns of care for orbital marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue in Korea throughout 2016: Results from a multicenter cross‐sectional cohort study (KROG 16–19)
    Wiley ; 2019
    In:  Asia-Pacific Journal of Clinical Oncology Vol. 15, No. 6 ( 2019-12), p. 358-363
    Details
    In: Asia-Pacific Journal of Clinical Oncology, Wiley, Vol. 15, No. 6 ( 2019-12), p. 358-363
    Abstract: Primary orbital mucosa‐associated lymphoid tissue (MALT) lymphomas are generally sensitive to radiotherapy (RT), but a “wait and see” strategy has also been used in asymptomatic patients. Recently, orbital MALT lymphoma has been reported to be associated with Chlamydia psittaci infection. This study aimed to assess the current patterns of care in clinical practice for orbital MALT lymphoma in South Korea. Methods We performed a multicenter, cross‐sectional cohort study of patterns of care for orbital MALT lymphoma in South Korea throughout 2016. All patients were pathologically confirmed to have orbital MALT lymphoma. Results Overall, eight institutions with 90 patients participated. The survey showed that the most frequent upfront treatment for orbital MALT lymphoma was RT (80/90, 90%). Other treatment modalities were given to a limited number of orbital MALT lymphoma patients as follows: watch and wait, 6/90 (7%); antibiotics, 3/90 (3%) and chemotherapy, 1/90 (1%). Generally, RT was administered to the entire involved site such as the entire conjunctiva/eyelid or entire orbit (96%), with a median total dose of 25.2 Gy. Lens shielding was performed for most patients with conjunctival and eyelid tumors (93%). Conclusions RT was the conventional treatment modality for orbital MALT lymphoma. Currently, RT is performed for the entire involved subsites at a lower dose than that previously used, and lens shielding was applied to minimize the orbital complication.
    Type of Medium: Online Resource
    ISSN: 1743-7555 , 1743-7563
    URL: Issue
    URL: Article
    DOI: 10.1111/ajco.v15.6
    DOI: 10.1111/ajco.13221
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2187409-8
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