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  • 1
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    Online Resource
    Childhood asthma is associated with polymorphic markers of PROC on 2q14 in addition to 17q21 locus
    Wiley ; 2015
    In:  Pediatric Allergy and Immunology Vol. 26, No. 2 ( 2015-03), p. 173-180
    Details
    In: Pediatric Allergy and Immunology, Wiley, Vol. 26, No. 2 ( 2015-03), p. 173-180
    Abstract: Childhood asthma is caused by both genetic and environmental factors. The first genomewide association study ( GWAS ) for asthma revealed putative candidates on nine chromosomal regions in Caucasians, with 17q21 locus being the most widely replicated one. However, there was no replication study for the other loci. This study investigated genetic associations between childhood asthma and autosomal single nucleotide polymorphisms ( SNP s) on eight loci reported in the first GWAS among Hong Kong Chinese. Methods 510 asthmatic children and 510 non‐allergic controls were recruited. 110 tagging SNP s selected based on r 2  ≥ 0.80 and minor allele frequency ≥0.05 for Han Chinese among all SNP s located 50‐kb upstream and downstream of significant autosomal SNP s were genotyped by TaqMan allelic discrimination assays. Transcription factor binding of SNP s was determined by electrophoretic mobility shift assay ( EMSA ). Results Asthma was significantly associated with SNP s on 17q21 and 2q14 loci. Twelve SNP s on 17q21 were associated with asthma, with rs6503527 being the most significant SNP . Five SNP s of protein C gene ( PROC ) on 2q14 were associated with asthma, with rs6755028 being the most significant SNP . Plasma protein C concentrations were higher in asthmatic patients than controls, and five PROC SNP s were associated with plasma protein C concentrations. EMSA showed specific differential binding of rs878461 to nuclear extracts from bronchial epithelial and hepatocarcinoma cell lines. Conclusions Our findings identify PROC on 2q14 as a novel candidate for childhood asthma and replicate the genetic association for 17q21 locus. Rs878461 of PROC may increase asthma susceptibility by altering transcription factor binding.
    Type of Medium: Online Resource
    ISSN: 0905-6157 , 1399-3038
    URL: Issue
    URL: Article
    DOI: 10.1111/pai.2015.26.issue-2
    DOI: 10.1111/pai.12336
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2008584-9
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  • 2
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    Cross‐sectional survey of biosimilar insulin utilization in Asia: The Joint Asia Diabetes Evaluation Program
    Wiley ; 2018
    In:  Journal of Diabetes Investigation Vol. 9, No. 6 ( 2018-11), p. 1312-1322
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    In: Journal of Diabetes Investigation, Wiley, Vol. 9, No. 6 ( 2018-11), p. 1312-1322
    Abstract: Biosimilar insulin can reduce treatment costs, although the extent of its use is largely unknown. We examined biosimilar insulin use and its associations with the quality of glycemic control using the Joint Asia Diabetes Evaluation register. Materials and Methods We carried out a cross‐sectional analysis in 81,531 patients with type 1 and type 2 diabetes enrolled into the Joint Asia Diabetes Evaluation Program from 2007 to 2014. All insulin related terms are extracted from the Joint Asia Diabetes Evaluation portal, and compared clinical profiles between biosimilar and originator insulin users. Multivariate analysis was performed to assess the association of biosimilar insulin compared with originator insulin with dosage, glycated hemoglobin and hypoglycemia events. Results Amongst 81,531 patients, 20.5% ( n = 16,738) were insulin‐treated. In four countries with high use of biosimilar insulin, 4.7% ( n = 719) of insulin users ( n = 10,197) were treated with biosimilar insulin (India n = 507, 70.3%; the Philippines n = 90, 12.5%; China n = 62, 8.6%; Vietnam n = 60, 8.3%). Biosimilar insulin users were younger and had higher body mass index, glycated hemoglobin, insulin dosage and more frequent hypoglycemia than originator insulin users. These associations were non‐significant after adjustment for confounders. Only age, college education, diabetes education, lipid control, physical activity and history of cardiovascular complications were independently associated with these quality measures. Conclusions Biosimilar insulin use is not uncommon in Asia. Data exclusion due to incomplete capturing of brand names suggests possibly higher use. The multiple determinants of the quality of glycemic control call for establishment of prospective cohorts and diabetes registers to monitor the safety and efficacy of different brands of biosimilar insulin and their impacts on clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 2040-1116 , 2040-1124
    URL: Issue
    URL: Article
    DOI: 10.1111/jdi.2018.9.issue-6
    DOI: 10.1111/jdi.12843
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2542077-X
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  • 3
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    Pregnancy outcomes of Chinese women with gestational diabetes mellitus defined by the IADPSG's but not by the 1999 WHO's criteria
    Wiley ; 2015
    In:  Clinical Endocrinology Vol. 83, No. 5 ( 2015-11), p. 684-693
    Details
    In: Clinical Endocrinology, Wiley, Vol. 83, No. 5 ( 2015-11), p. 684-693
    Abstract: To compare pregnancy outcomes of women with gestational diabetes mellitus (GDM) newly defined by the International Association of Diabetes and Pregnancy Study Group (IADPSG)'s criteria vs GDM cases missed by a shift from the 1999 World Health Organization (WHO)'s criteria to the IADPSG's. Methods From 2010 to 2012, we recruited 17 808 women who registered within 12 weeks of gestation in Tianjin, China. All women underwent a 50‐g 1‐h glucose challenge test (GCT) at 24–28 weeks of gestation and further underwent a 75‐g 2‐h oral glucose tolerance test (OGTT) if the GCT result was ≥7·8 mmol/l. Women were divided into four groups, i.e., GDM defined by both criteria, GDM defined by the IADPSG's only, GDM defined by the 1999 WHO's only and non‐GDM by either of them. Large for gestational age (LGA), macrosomia, pregnancy‐induced hypertension (PIH) and preterm birth were compared among the four groups. Logistic regression was used to control for confounders. Results The use of IADPSG's and the 1999 WHO's criteria detected that 7·7% ( n  = 1378) and 6·8% ( n  = 1206) of women had GDM, respectively, with 429 GDM newly identified and 257 women missed by a shift from the 1999 WHO's to the IADPSG's. The IADPSG's newly defined GDM had significantly increased risks of LGA (adjusted OR: 2·23, 95%CI: 1·36–3·64) and macrosomia (2·65, 95%CI: 1·50–4·66) than the 1999 WHO's only defined GDM cases. Conclusions A shift of the 1999 WHO's criteria to the IADPSG's diagnosed more GDM cases who had worse pregnancy outcomes than those cases missed.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2015.83.issue-5
    DOI: 10.1111/cen.12801
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2004597-9
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  • 4
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    Safety of atorvastatin in Asian patients within clinical trials
    Wiley ; 2016
    In:  Cardiovascular Therapeutics Vol. 34, No. 6 ( 2016-12), p. 431-440
    Details
    In: Cardiovascular Therapeutics, Wiley, Vol. 34, No. 6 ( 2016-12), p. 431-440
    Abstract: Data on statin safety in Asian patients are limited compared with evidence from Western populations. Aim This study assessed atorvastatin safety among Asian patients enrolled in 58 randomized clinical trials. Methods Data from 52 short‐term trials (median exposure 4–72 weeks) and six long‐term cardiovascular outcomes trials (median exposure 3.1–4.9 years) conducted across the atorvastatin 10–80‐mg dose range were analyzed retrospectively to assess the incidence of safety endpoints. Results A total of 77 952 patients were identified (49 974 received atorvastatin), among whom 3191 were Asian (2519 received atorvastatin). In the short‐term trials, the incidence of all‐causality adverse events ( AE s) and serious AE s ( SAE s) in Asian patients treated with atorvastatin was similar to or lower than that observed with other statins or placebo, and discontinuations due to treatment‐related AE s/ SAE s were infrequent (2.0% across all doses). These observations were confirmed in the long‐term trials. Treatment‐related SAE s were rare (n = 4) among Asian patients receiving atorvastatin. No cases of rhabdomyolysis were observed in atorvastatin‐treated Asian patients, and the incidence of myalgia was 1.8% in the short‐term studies and 6.7% in the long‐term trials. Elevations ( 〉 3× the upper limit of normal) in liver transaminases were observed in ~2% of Asian patients receiving atorvastatin; renal AE s occurred in 〈 2%. Conclusion The incidence of AE s/ SAE s with atorvastatin 10–40‐mg in patients of Asian origin was low and comparable to placebo. Further evaluation of atorvastatin 80‐mg is required owing to the limited number of Asian patients (n = 281; 11.2%) who received this dose.
    Type of Medium: Online Resource
    ISSN: 1755-5914 , 1755-5922
    URL: Issue
    URL: Article
    DOI: 10.1111/cdr.2016.34.issue-6
    DOI: 10.1111/1755-5922.12214
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2417088-4
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