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  • SAGE Publications  (18)
  • 2015-2019  (18)
  • 1
    Online Resource
    Online Resource
    Endoscopy-Assisted Total Mastectomy Followed by Immediate Pedicled Transverse Rectus Abdominis Musculocutaneous (TRAM) Flap Reconstruction : Preliminary Results of 48 Patients
    SAGE Publications ; 2015
    In:  Surgical Innovation Vol. 22, No. 4 ( 2015-08), p. 382-389
    Details
    In: Surgical Innovation, SAGE Publications, Vol. 22, No. 4 ( 2015-08), p. 382-389
    Abstract: Background. Endoscopy-assisted breast surgery performed through minimal axillary and/or periareolar incisions is a viable option for patients with breast cancer. In this study, we report the preliminary results of patients with breast cancer who underwent endoscopy-assisted total mastectomy (EATM) followed immediately by pedicled transverse abdominis musculocutaneous (TRAM) flap reconstruction. Methods. Patients in this study comprised women with breast cancer who received EATM and pedicled TRAM flap reconstruction. Clinicopathologic characteristics, type of surgery, complications, and rate of recurrence were recorded. The cosmetic outcomes were evaluated objectively by the surgeons and subjectively by the patients at 3-month postoperative follow-up. Results. A total of 48 patients underwent 49 EATM procedures followed by pedicled TRAM flap reconstruction. Of them, 79.6% underwent endoscopic-assisted nipple-sparing mastectomy and 20.4% received endoscopic-assisted skin-sparing mastectomy. The types of cancer among these patients included ductal carcinoma in situ in 34.7%, stage I cancer in 36.7%, stage II cancer in 24.5%, and stage IIIa cancer in 4.1% patients. Mean tumor size was 2.1 ± 1.4 cm. There were no cases of flap failure. Partial nipple areolar complex ischemia/necrosis occurred in 4 (10.3%) patients; however, all cases resolved after conservative treatment. In the aesthetic outcome evaluation, EATM + TRAM were associated with 89.8% good, 8.2% fair, and 2% unsatisfactory result. No local recurrence was observed during the follow-up period. Conclusion. EATM followed immediately by pedicled TRAM flap reconstruction is a safe procedure and results in good cosmetic outcome in women with early-stage breast cancer.
    Type of Medium: Online Resource
    ISSN: 1553-3506 , 1553-3514
    URL: Article
    DOI: 10.1177/1553350614546003
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2233576-6
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  • 2
    Online Resource
    Online Resource
    Effects of Upper Airway Surgery on Daytime Sleepiness in Nonobese Patients with Obstructive Sleep Apnea/Hypopnea Syndrome
    SAGE Publications ; 2018
    In:  Annals of Otology, Rhinology & Laryngology Vol. 127, No. 12 ( 2018-12), p. 912-918
    Details
    In: Annals of Otology, Rhinology & Laryngology, SAGE Publications, Vol. 127, No. 12 ( 2018-12), p. 912-918
    Abstract: The aim of this study was to evaluate the effects of upper airway surgery on daytime sleepiness in nonobese patients with obstructive sleep apnea/hypopnea syndrome (OSA). Methods: This retrospective study included 121 consecutive adult nonobese patients with OSA from a tertiary academic medical center. Patients with OSA who refused continuous positive airway pressure therapy, or in whom it was unsuccessful, and then underwent OSA surgery were enrolled. Evaluations of excessive daytime sleepiness using the Epworth Sleepiness Scale (ESS) and major parameters of objective full-night polysomnography were collected preoperatively and at least 3 months postoperatively. Statistical analysis was performed using the Wilcoxon signed rank test and Wilcoxon rank sum test. Results: When pre- and postoperative ESS and polysomnographic parameters were compared in all patients, ESS scores, apnea/hypopnea index, and snoring index showed statistically significant improvements ( P = .007, P 〈 .001, and P 〈 .001, respectively). When patients were classified into mild, moderate, and severe OSA groups, snoring index had statistically significant improvements in all 3 groups, and apnea/hypopnea index had statistically significant decreases in the moderate and severe OSA groups. Although reductions in ESS scores were found in all 3 groups, the most statistically significant improvement was noted only in the severe OSA group. Conclusions: OSA surgery can improve daytime sleepiness in nonobese patients with OSA, especially for patients with severe OSA. This study elucidates the effects of OSA surgery on daytime sleepiness by excluding the major confounding factor of obesity. This study adds to the literature on the effects of upper airway surgery for nonobese patients with OSA on daytime quality of life.
    Type of Medium: Online Resource
    ISSN: 0003-4894 , 1943-572X
    URL: Article
    DOI: 10.1177/0003489418800089
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2033055-8
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  • 3
    Online Resource
    Online Resource
    Safety and efficacy of nilotinib in routine clinical practice in patients with chronic myeloid leukemia in chronic or accelerated phase with resistance or intolerance to imatinib: results from the NOVEL study
    SAGE Publications ; 2018
    In:  Therapeutic Advances in Hematology Vol. 9, No. 3 ( 2018-03), p. 65-78
    Details
    In: Therapeutic Advances in Hematology, SAGE Publications, Vol. 9, No. 3 ( 2018-03), p. 65-78
    Abstract: Nilotinib, a second-generation tyrosine kinase inhibitor (TKI), is approved for the treatment of patients with chronic myeloid leukemia (CML) in many countries, including Taiwan. Though a number of controlled clinical trials have demonstrated the safety and efficacy of nilotinib, studies assessing the safety and efficacy of nilotinib in routine clinical practice are limited. Methods: The current study was an open-label, single-arm study conducted across 12 centers in Taiwan in adult patients with CML in chronic or accelerated phase with confirmed Ph+ chromosome (or BCR-ABL) and resistant or intolerant to one or more previous TKIs. The primary objective was to collect the long-term safety data in patients treated with nilotinib 400 mg, twice daily for up to 2 years. Results: The study enrolled 85 patients with CML, including 76 in the chronic phase (CML-CP) and 9 in the accelerated phase (CML-AP). Overall, 1166 adverse events (AEs) were reported in 80 patients (94.1%), of which 70 AEs (6%) in 28 patients (32.9%) were serious and 336 AEs (28.8%) reported in 60 patients (70.6%) were drug-related. Common drug-related AEs were thrombocytopenia (21.2%), increased alanine aminotransferase (21.2%) and pruritus (17.7%). Of the 85 patients, 19 switched from imatinib due to intolerance – AEs were resolved in 16 of these 19 patients (84.2%). By 24 months, the cumulative rates of complete cytogenetic response (CCyR), major molecular response (MMR), MR4.0 ( BCR-ABL1 IS ⩽0.01%) and MR4.5 ( BCR-ABL1 IS ⩽0.0032%) were 75.3, 56.8, 16.2 and 7.4%, respectively. Patients with CML-CP at baseline had higher overall survival (OS) and progression-free survival (PFS) than those with CML-AP. Conclusion: This is the first study that demonstrated that nilotinib is effective and well-tolerated in patients resistant or intolerant to imatinib in the real-world setting in Taiwan, reflecting effective management of CML by physicians under routine clinical practice in Taiwan.
    Type of Medium: Online Resource
    ISSN: 2040-6207 , 2040-6215
    URL: Article
    DOI: 10.1177/2040620718756603
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2585183-4
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  • 4
    Online Resource
    Online Resource
    Mortality and vertebral fracture risk associated with long-term oral steroid use in patients with chronic obstructive pulmonary disease: A systemic review and meta-analysis
    SAGE Publications ; 2019
    In:  Chronic Respiratory Disease Vol. 16 ( 2019-01-01), p. 147997311983828-
    Details
    In: Chronic Respiratory Disease, SAGE Publications, Vol. 16 ( 2019-01-01), p. 147997311983828-
    Abstract: Short-term oral steroid use may improve lung function and respiratory symptoms in patients with stable chronic obstructive pulmonary disease (COPD). However, long-term oral steroid (LTOS) use is not recommended owing to its potential adverse effects. Our study aimed to investigate whether chronic use of oral steroids for more than 4 months would increase mortality and vertebral fracture risk in patients with stable COPD. A systemic search of the PubMed database was conducted, and meta-analysis was performed using Review Manager 5.3. Five studies with a total of 1795 patients showed there was an increased risk of mortality in patients using LTOS (relative risk, 1.63; 95% confidence interval (CI), 1.19–2.23; p 〈 0.0001; I 2 = 86%). In addition, four studies with a total of 17,764 patients showed there was an increased risk of vertebral fracture in patients using LTOS (odds ratio, 2.31; 95% CI, 1.52–3.50; p = 0.03; I 2 = 65%). Our meta-analysis showed LTOS was associated with increased mortality and vertebral fracture risk in patients with COPD, and this risk may be due to the adverse effects of LTOS and progression COPD.
    Type of Medium: Online Resource
    ISSN: 1479-9731 , 1479-9731
    URL: Article
    DOI: 10.1177/1479973119838280
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2222367-8
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  • 5
    Online Resource
    Online Resource
    Anti-inflammatory and Cytotoxic Compounds from Solanum macaonense
    SAGE Publications ; 2015
    In:  Natural Product Communications Vol. 10, No. 2 ( 2015-02), p. 1934578X1501000-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 10, No. 2 ( 2015-02), p. 1934578X1501000-
    Abstract: One new cerebroside, macaocerebroside A (1), and 15 known compounds (2–16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2–5) were active against superoxide anion generation with IC 50 values of 3.3–4.8 μM; especially, 3 inhibited elastase release with an IC 50 value of 4.0 μM. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC 50 value of 4.0 μM. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC 50 values of 34.6, 41.3, and 31.8 μM, respectively.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1501000235
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 6
    Online Resource
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    The Association Between Drinking Habits and Family Relationships in 3 Villages of Indigenous Taiwanese
    SAGE Publications ; 2015
    In:  Asia Pacific Journal of Public Health Vol. 27, No. 2 ( 2015-03), p. NP2721-NP2731
    Details
    In: Asia Pacific Journal of Public Health, SAGE Publications, Vol. 27, No. 2 ( 2015-03), p. NP2721-NP2731
    Abstract: Although the vast majority of indigenous peoples in Taiwan consume alcohol, little is known about the relationship between alcoholic behavior and family relationships. A total of 471 residents from 3 villages in Alishan township in Taiwan were interviewed using a questionnaire that asked for demographic information and included the Family Function Scale and questions regarding the individual’s consumption of alcohol. It was found that 50% of the participants drink alcohol, and 71% of their family members consume alcohol; 47% of the respondents indicated excessive alcohol consumption (ie, were heavy drinkers). When individuals are knowledgeable about alcohol-related health issues, their families generally function better (odds ratio = 2.56; 95% confidence interval = 1.38-4.74; P 〈 .01). Those who were moderate and heavy drinkers were 2.5 and 3.0 times, respectively, more likely to have poor family relationships than those who were light drinkers. It is necessary to promote the reduction of alcohol consumption among indigenous peoples.
    Type of Medium: Online Resource
    ISSN: 1010-5395 , 1941-2479
    URL: Article
    DOI: 10.1177/1010539512452754
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2394975-2
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  • 7
    Online Resource
    Online Resource
    Development and analysis of a small-size electric field coupling wireless power system
    SAGE Publications ; 2015
    In:  Advances in Mechanical Engineering Vol. 7, No. 12 ( 2015-12-01), p. 168781401562032-
    Details
    In: Advances in Mechanical Engineering, SAGE Publications, Vol. 7, No. 12 ( 2015-12-01), p. 168781401562032-
    Abstract: This study intends to fabricate a small-size capacitive wireless transmission device. As to the design of electrode plates, the active electrode is designed in two ways, through row array and column array, and the area of an electrode plate is limited to below 20.25 cm 2 . Moreover, the passive electrode of row-array electrode plates is designed in three ways: general row array, window array, and rhombus array. As seen from the results of circuit simulation, the transmission efficiency of the capacitive wireless transmission device is as high as 0.7. In the actual circuit experiment, the electrode plate in the window-array design has the highest efficiency at 51%. In addition, the electrode plates in the window array and those in other arrays have higher stability and transmission efficiency. In the rotational angle dislocation experiment, the unit area current amount of the column-array electrode plates in the high coupling region is also smaller than that of the window-array electrode plates. However, the performance of column-array electrode plates reaches higher stability in the angle dislocation experiment, and its anti-angle dislocation is obviously higher than that of the electrode plates designed in the other three row arrays. Moreover, when the area of the column-array electrode plates is 22.25 cm 2 , the highest transmission distance is 22.5 mm.
    Type of Medium: Online Resource
    ISSN: 1687-8140 , 1687-8140
    URL: Article
    DOI: 10.1177/1687814015620327
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2501620-9
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  • 8
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    Online Resource
    A rapid tool for emission outlet concentration simulation of scrubber and make-up air unit at different inlet concentrations
    SAGE Publications ; 2017
    In:  Building Services Engineering Research and Technology Vol. 38, No. 4 ( 2017-07), p. 461-474
    Details
    In: Building Services Engineering Research and Technology, SAGE Publications, Vol. 38, No. 4 ( 2017-07), p. 461-474
    Abstract: Currently in the cleanroom-related industries, both the air quality of indoors intake and outdoors emission should be controlled at a certain level. Wet scrubbers and air washers are the main facilities to clean up air for the process required. However, previous studies have found that these devices typically have lower removal efficiency for low inlet concentration contaminations; little information is available to explain the efficiency deterioration and only on the empirical basis. A theoretical model is proposed, which applies Fick’s second law to derive a rapid efficiency simulating formula. This model is different from the empirical equations of former studies, and is able to describe the relationship between the inlet concentration and removal efficiency of the air washing facilities. Moreover, the calculation time of the nonlinear recurrence equation is effectively lessened by the Euler equation and proven to be practical and concise for the rapid efficiency determination. Confirmation of the simulation formula was conducted by using the experimental data from the previous studies of the wet scrubber and in situ historical record of a make-up air unit. In this article, we describe how an outlet concentration and removal efficiency can be predicted using a generic simulating formula, leading to better design with less effort. The proposed model and equation minimize the design complexity and help to optimize the sizing and operational control of the air washing facilities. This not only decreases the construction and operating costs, but also lead to better energy usage. Practical application: Engineers can use the output of this paper to optimize air washer facility designs instead of intuitively extending the rinsing duration or enlarging the scale of the equipment. The model can be applied to both residential and industrial air washers to predict the efficiency and evaluate the performance. It also allows the quantitative analysis and risk assessment of an abrupt air washer breakdown in the clean manufacturing industries.
    Type of Medium: Online Resource
    ISSN: 0143-6244 , 1477-0849
    URL: Article
    DOI: 10.1177/0143624417701984
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2053866-2
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  • 9
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    Design of Employee Training in Taiwanese Nonprofits
    SAGE Publications ; 2015
    In:  Nonprofit and Voluntary Sector Quarterly Vol. 44, No. 1 ( 2015-02), p. 25-46
    Details
    In: Nonprofit and Voluntary Sector Quarterly, SAGE Publications, Vol. 44, No. 1 ( 2015-02), p. 25-46
    Abstract: Workforce learning has become a fundamental need for organizations that face a quick-changing world growing more complicated by the day. In this study, we focused on an examination into the factors that affect the design of employee training in nonprofits, including a discussion into the training practices of nonprofits as a result of those factors. Smaller nonprofits in Taiwan were studied; larger nonprofits, such as the Red Cross and World Vision, were not included in the present study. Through interviews with and surveys of 20 participating nonprofits in Taiwan, we found that the widely used linear training design framework, including assessment, design, development, implementation, and evaluation, might not be appropriate for many nonprofits due to organizational factors such as human resources, financial environments, and managerial systems. Due to the influence of these factors, the practice of training in nonprofits has moved beyond structured design, and diverse on-the-job approaches are now being applied.
    Type of Medium: Online Resource
    ISSN: 0899-7640 , 1552-7395
    URL: Article
    DOI: 10.1177/0899764013502878
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2029449-9
    SSG: 3,4
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  • 10
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    Conventional Western Treatment Associated With Chinese Herbal Medicine Ameliorates the Incidence of Head and Neck Cancer Among Patients With Esophageal Cancer
    SAGE Publications ; 2019
    In:  Integrative Cancer Therapies Vol. 18 ( 2019-01), p. 153473541983435-
    Details
    In: Integrative Cancer Therapies, SAGE Publications, Vol. 18 ( 2019-01), p. 153473541983435-
    Abstract: Background: Because of advances in medical treatment, the survival of cancer patients is prolonged. In line with the prolonged survival time of cancer the incidence of second primary cancer has increased. There is currently no effective way to prevent the occurrence of secondary primary cancer (SPC). Objectives: The aim of this study is to evaluate whether Chinese Herbal Medicine (CHM) is correlated with reduced occurrence of second primary cancer (SPC) of head and neck (H & N) in patients with esophageal cancer (EC). Method: We identified 15,546 patients who were diagnosed with esophageal cancer between Jan 1, 2000, and Dec 31, 2010. The patients with H & N cancer before receiving CHM were excluded. After the selection and matching process, both CHM and non-CHM cohorts each contained 850 individuals. We compared the cumulative incidence of SPC of H & N with or without CHM treatment in patients with EC by the Kaplan-Meier method. NodeXL is used to run a network analysis of CHM to examine the association between herbs and formulas. Results: Compared with non-CHM users, CHM-users showed a reduced incidence rate of SPC of H & N among the patients with EC. Reduced cumulative incidence of SPC of H & N among patients with EC was noted in the CHM cohort compared to the non-CHM cohort. The most commonly used single herbs and formulas were associated with reducing SPC occurrence. Conclusion: We propose that CHM as an adjuvant therapy may prevent the occurrence of SPC of H & N in patients with EC.
    Type of Medium: Online Resource
    ISSN: 1534-7354 , 1552-695X
    URL: Article
    DOI: 10.1177/1534735419834353
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2101248-9
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