In:
Acta Radiologica, SAGE Publications, Vol. 57, No. 3 ( 2016-03), p. 271-278
Abstract:
Many imaging methods have been defined for quantification of hepatic steatosis in non-alcoholic fatty liver disease (NAFLD). However, studies comparing the efficiency of magnetic resonance imaging-proton density fat fraction (MRI-PDFF), magnetic resonance spectroscopy (MRS), and liver histology for quantification of liver fat content are limited. Purpose To compare the efficiency of MRI-PDFF and MRS in the quantification of liver fat content in individuals with NAFLD. Material and Methods A total of 19 NAFLD patients underwent MRI-PDFF, MRS, and liver biopsy for quantification of liver fat content. The MR examinations were performed on a 1.5 HDx MRI system. The MRI protocol included T1-independent volumetric multi-echo gradient-echo imaging with T2* correction and spectral fat modeling and MRS with STEAM technique. Results A close correlation was observed between liver MRI-PDFF- and histology- determined steatosis (r = 0.743, P 〈 0.001) and between liver MRS- and histology-determined steatosis (r = 0.712, P 〈 0.001), with no superiority between them (ƶ = 0.19, P = 0.849). For quantification of hepatic steatosis, a high correlation was observed between the two MRI methods (r = 0.986, P 〈 0.001). MRI-PDFF and MRS accurately differentiated moderate/severe steatosis from mild/no hepatic steatosis ( P = 0.007 and 0.013, respectively), with no superiority between them (AUC MRI-PDFF = 0.881 ± 0.0856 versus AUC MRS = 0.857 ± 0.0924, P = 0.461). Conclusion Both MRI-PDFF and MRS can be used for accurate quantification of hepatic steatosis.
Type of Medium:
Online Resource
ISSN:
0284-1851
,
1600-0455
DOI:
10.1177/0284185115580488
Language:
English
Publisher:
SAGE Publications
Publication Date:
2016
detail.hit.zdb_id:
2024579-8
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