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  • 1
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    HDAC3-mediated silencing of miR-451 decreases chemosensitivity of patients with metastatic castration-resistant prostate cancer by targeting NEDD9
    SAGE Publications ; 2018
    In:  Therapeutic Advances in Medical Oncology Vol. 10 ( 2018-01-01), p. 175883591878313-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 10 ( 2018-01-01), p. 175883591878313-
    Abstract: Treatment of metastatic castration-resistant prostate cancer (mCRPC) with docetaxel often fails due to the emergence of chemoresistance. Thus, restoring chemosensitivity to docetaxel-based therapies remains a challenge in mCRPC treatment. Methods: microRNA (miR)-451 expression was measured in docetaxel-treated prostate cancer cells and tumor tissues by quantitative reverse-transcription polymerase chain reaction . Cell-counting kit 8 assay was performed to determine docetaxel chemoresistance. Neural-precursor-cell-expressed developmentally downregulated protein 9 (NEDD9) was identified as a novel target of miR-451 by dual-luciferase reporter system. Chromatin immunoprecipitation and co-immunoprecipitation assay were performed to confirm that histone deacetylase 3 (HDAC3)/Sp1 (a highly evolutionarily conserved transcription factor) interacted with the Sp1 binding sites in miR-451 promoter. Results: miR-451 was found to be silenced in docetaxel-treated prostate cancer cells and mCRPC tissues. Low miR-451 expression was closely associated with a high Gleason score, high Eastern Cooperative Oncology Group performance status score, visceral metastasis and poor prognosis. Low expression of miR-451 was significantly correlated with short progression-free survival (PFS) and overall survival (OS) according to Kaplan–Meier analysis, and miR-451 was determined to be an independent poor prognostic factor for PFS and OS in mCRPC patients by univariate and multivariate Cox regression analyses. NEDD9 was identified as a new and functional target of miR-451. Restoration of NEDD9 partially reversed the effects of miR-451 on enhancing chemosensitivity of prostate cancer cells. HDAC3 was confirmed to be involved in silencing of miR-451 expression in prostate cancer cells. Conclusions: The current data revealed a new HDAC3/Sp1/miR-451/NEDD9 signaling axis that regulates the chemosensitivity of prostate cancer cells and represents a novel therapeutic target for chemosensitizing mCRPC.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/1758835918783132
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2503443-1
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  • 2
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    Potential forcing mechanisms of Holocene lake-level changes at Nam Co, Tibetan Plateau: Inferred from the stable isotopic composition of shells of the gastropod Radix
    SAGE Publications ; 2017
    In:  The Holocene Vol. 27, No. 4 ( 2017-04), p. 594-604
    Details
    In: The Holocene, SAGE Publications, Vol. 27, No. 4 ( 2017-04), p. 594-604
    Abstract: The timing of lake-level fluctuations on the Tibetan Plateau and their relationship with climatic changes is still under debate, and the main reason for this is the lack of suitable archives for reconstructing the paleohydrology and paleoclimatology of the lakes. Here, we present the results of analyses of the shell geochemistry of Radix sp. from an exposed terrace of Nam Co lake on the south-central Tibetan Plateau. Optically stimulated luminescence (OSL) dating reveals that deep-water lacustrine sediments formed between ca. 4.4 and 2.2 ka, suggesting a high and stable lake level significantly above the present. The results of Sr/Ca, δ 13 C and δ 18 O analyses of the fossil shells of Radix sp. indicate that during the mid- to late-Holocene, lake-level variations in Nam Co were mainly controlled by variations in the Indian Summer Monsoon. A trend of decreasing evaporation also played an important role. Comparison with other results suggests a consistent pattern of mid- to late-Holocene lake-level changes across a large area of the Tibetan Plateau and adjacent regions to the south, which had a similar causal mechanism. Finally, our results indicate that fossil shells of the gastropod Radix sp. of the lakes on the Tibetan Plateau are a valuable archive for reconstructing the regional paleohydrology and paleoclimatology.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    URL: Article
    DOI: 10.1177/0959683616670247
    RVK:
    RA 1000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
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  • 3
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    Effectiveness of acupuncture for vascular cognitive impairment no dementia: a randomized controlled trial
    SAGE Publications ; 2019
    In:  Clinical Rehabilitation Vol. 33, No. 4 ( 2019-04), p. 642-652
    Details
    In: Clinical Rehabilitation, SAGE Publications, Vol. 33, No. 4 ( 2019-04), p. 642-652
    Abstract: To evaluate the effectiveness of acupuncture in patients with vascular cognitive impairment no dementia (VCIND) in comparison with citicoline, an agent for cognitive disturbances associated with chronic cerebral disorders. Design: A randomized controlled multicenter trial. Setting: In three hospitals in Beijing, China. Subjects: A total of 216 patients with VCIND were recruited. Interventions: Patients with VCIND (mean age of 65.4 years) were randomized to receive acupuncture (two sessions per week) or oral citicoline (100 mg three times daily) over three months. Main measures: The primary outcome was the change from baseline to three months in cognitive symptom, measured by Alzheimer’s disease Assessment Scale, cognitive subscale (ADAS-cog). Secondary outcomes included changes from baseline to six months in ADAS-cog, executive function measured by the Clock Drawing Test (CDT), and functional disability measured by the Ability of Daily Living (ADL) scale at three and six months. Results: At three months, the acupuncture group had a greater decrease in mean ADAS-cog score (−2.33 ± 0.31) than the citicoline group (−1.38 ± 0.34) with a mean difference of −0.95 (95% CI, −1.84 to −0.07, P = 0.035). The mean change from baseline to six months in ADAS-cog also significantly favored acupuncture treatments (acupuncture change −2.61 vs citicoline −1.25, difference: −1.36 points; 95% CI, −2.20 to −0.51; P = 0.002). There was no difference between the two groups on CDT and ADL scores at either time point. Conclusion: Compared with citicoline, acupuncture has comparable and even superior efficacy with improved cognitive and daily living performance as a complementary and alternative medicine treatment for VCIND.
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    URL: Article
    DOI: 10.1177/0269215518819050
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2028323-4
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  • 4
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    The Efficacy of Near-Infrared Spectroscopy Monitoring in Carotid Endarterectomy: A Prospective, Single-Center, Observational Study
    SAGE Publications ; 2019
    In:  Cell Transplantation Vol. 28, No. 2 ( 2019-02), p. 170-175
    Details
    In: Cell Transplantation, SAGE Publications, Vol. 28, No. 2 ( 2019-02), p. 170-175
    Abstract: There has been no gold standard for intraoperative monitoring in carotid endarterectomy (CEA) till now. The purpose of the current study was to investigate the value of near-infrared spectroscopy (NIRS) monitoring in CEA and explore the thresholds for intraoperative cerebral hypoperfusion. Eighty-four consecutive patients who underwent CEA surgery in Xuan Wu Hospital of Capital Medical University from August 2015 to June 2016 were enrolled in this study. All patients were intraoperatively monitored by transcranial Doppler ultrasonography (TCD) and NIRS. Regional oxygen saturation (rSO 2 ) monitored by NIRS and blood flow velocity of the middle cerebral artery (V-MCA) monitored by TCD were continuously recorded. Correlation analysis was conducted for NIRS and TCD monitoring values. Intraoperative shunting was performed in five patients according to the TCD monitoring results and surgeon preference. During clamping of the carotid artery, the Pearson correlation index between rSO 2 and V-MCA was 0.581 (P 〈 0.001). A cut-off of 12.3% decrease of rSO 2 was identified as the optimal threshold for intraoperative hypoperfusion indicated by TCD monitoring, when the sensitivity and specificity were 64.3% and 90.0%, respectively, with a 0.570 Kappa value. Physical examination immediately after operation showed no ischemic injury occurred, and no death and stroke occurred during the postoperative hospitalization. Our study demonstrated that NIRS could serve as a favorable monitoring tool during CEA. A 12.3% decrease of rSO 2 could be adopted as a reliable threshold for intraoperative cerebral hypoperfusion.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    URL: Article
    DOI: 10.1177/0963689718817760
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2020466-8
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  • 5
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    A prospective study of psychological resilience and depression among left-behind children in China
    SAGE Publications ; 2017
    In:  Journal of Health Psychology Vol. 22, No. 5 ( 2017-04), p. 627-636
    Details
    In: Journal of Health Psychology, SAGE Publications, Vol. 22, No. 5 ( 2017-04), p. 627-636
    Type of Medium: Online Resource
    ISSN: 1359-1053 , 1461-7277
    URL: Article
    DOI: 10.1177/1359105315610811
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2021897-7
    SSG: 5,2
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  • 6
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    Mechanical reinforcement and shape memory effect of graphite nanoplatelet–reinforced epoxy composites
    SAGE Publications ; 2015
    In:  Journal of Intelligent Material Systems and Structures Vol. 26, No. 12 ( 2015-08), p. 1491-1497
    Details
    In: Journal of Intelligent Material Systems and Structures, SAGE Publications, Vol. 26, No. 12 ( 2015-08), p. 1491-1497
    Abstract: The homogeneous dispersion of fine graphite nanoplatelets throughout the epoxy matrix with different mass fraction is prepared. Influence of graphite nanoplatelets of varied mass fraction in the mechanical reinforcement and shape memory effect of graphite nanoplatelets/epoxy composite is investigated. The morphology and crystal structure of graphite nanoplatelets are confirmed with the scanning electron microscope and X-ray diffraction, respectively. The shape memory effects and thermo-mechanical properties of graphite nanoplatelets/epoxy composite are studied using dynamic mechanical analysis. It is found that the storage elastic modulus increases with the mass fraction increase in graphite nanoplatelets in the graphite nanoplatelets/epoxy composite, which is the indication of greater recovery stress of graphite nanoplatelets/epoxy composite compared to that of the primitive epoxy material without graphite nanoplatelets. We had showed that the graphite nanoplatelets/epoxy composite is superior to primitive epoxy in shape memory effect and recovery speed.
    Type of Medium: Online Resource
    ISSN: 1045-389X , 1530-8138
    URL: Article
    DOI: 10.1177/1045389X14544142
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2088313-4
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  • 7
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    The Neuroprotective Effect of Amitriptyline on Radiation-Induced Impairment of Hippocampal Neurogenesis
    SAGE Publications ; 2019
    In:  Dose-Response Vol. 17, No. 4 ( 2019-10-01), p. 155932581989591-
    Details
    In: Dose-Response, SAGE Publications, Vol. 17, No. 4 ( 2019-10-01), p. 155932581989591-
    Abstract: The radioprotective effect of amitriptyline, an inhibitor of acid sphingomyelinase (ASMase), on radiation-induced impairment of hippocampal neurogenesis, loss of interneuron, and animal weight changes was investigated in BALB/c mice by immunostaining of biomarkers for cell division (Ki67), immature neurons (doublecortin or DCX), and interneurons (parvalbumin or PV) in the dentate gyrus (DG) of hippocampus. The results indicated that preirradiation (with 10 mg/kg, 2 times per day, for 7 consecutive days) or postirradiation (with 10 mg/kg, 2 times per day, for 14 consecutive days) treatment (pretreatment or posttreatment) with intraperitoneal injection of amitriptyline prevented the loss of newly generated neurons, proliferating cells, and interneurons in the subgranular zone of the DG. At the molecular level, pretreatment or posttreatment inhibited the expression of sphingomyelin phosphodiesterase 1 ( SMPD1) gene which codes for ASMase. The pretreatment for 7 days also prevented radiation-induced weight loss from 2 to 3 weeks, but not within 1 week after irradiation. On the other hand, the posttreatment with amitriptyline for 14 days could improve animal weight gain from 4 to 6 weeks after irradiation. The present study suggests that amitriptyline may be a promising candidate radio-neuroprotective drug to improve radiation-induced impairment of hippocampal neurogenesis and relevant neurological and neuropsychological disorders.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    URL: Article
    DOI: 10.1177/1559325819895912
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440820-7
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  • 8
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    Diagnostic Accuracy of Noncontrast CT in Detecting Acute Appendicitis: A Meta-analysis of Prospective Studies
    SAGE Publications ; 2015
    In:  The American Surgeon Vol. 81, No. 6 ( 2015-06), p. 626-629
    Details
    In: The American Surgeon, SAGE Publications, Vol. 81, No. 6 ( 2015-06), p. 626-629
    Abstract: The aim of the study is to evaluate the diagnostic accuracy of noncontrast CT in detecting acute appendicitis. Prospective studies in which noncontrast CT was performed to evaluate acute appendicitis were found on PubMed, EMBASE, and Cochrane Library. Pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were assessed. The summary receiver-operating characteristic curve was conducted and the area under the curve was calculated. Seven original studies investigating a total of 845 patients were included in this meta-analysis. The pooled sensitivity and specificity were 0.90 (95% CI: 0.86–0.92) and 0.94 (95% CI: 0.92–0.97), respectively. The pooled positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio was 12.90 (95% CI: 4.80–34.67), 0.09 (95% CI: 0.04–0.20), and 162.76 (95% CI: 31.05–853.26), respectively. The summary receiver-operating characteristic curve was symmetrical and the area under the curve was 0.97 (95% CI: 0.95–0.99). In conclusion, noncontrast CT has high diagnostic accuracy in detecting acute appendicitis, which is adequate for clinical decision making.
    Type of Medium: Online Resource
    ISSN: 0003-1348 , 1555-9823
    URL: Article
    DOI: 10.1177/000313481508100629
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
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  • 9
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    Inhibition of EZH2 expression is associated with the proliferation, apoptosis, and migration of SW620 colorectal cancer cells in vitro
    SAGE Publications ; 2015
    In:  Experimental Biology and Medicine Vol. 240, No. 4 ( 2015-04), p. 458-466
    Details
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 240, No. 4 ( 2015-04), p. 458-466
    Abstract: Epigenetic changes have been recently recognized as important in human cancers. Enhancer of zeste homologue 2 gene (EZH2) has been shown the overexpression in various human cancers, consistent with a straightforward role of EZH2 as an oncogene, but its function in carcinogenesis is partly contradictory. The role of EZH2 in development of human colorectal cancer (CRC) has not yet been clarified. In the present study, we observed up-regulation of EZH2 expression in tumor tissues from CRC patients. The expression of EZH2 in CRC cell lines is consistent with the trend in cancer tissues using reverse transcription polymerase chain reaction (RT-PCR). We showed that TNM stage and lymph node metastasis in CRC patients are significantly correlated with EZH2 expression levels. EZH2 level of transcription and protein is inhibited by small interfering RNA (siRNA). More importantly, EZH2-siRNA inhibits the proliferation and migration of SW620 cells while promoting their apoptosis, and inducing G0/G1 cell cycle arrest of SW620 cells. Collectively, our results suggest that upregulated EZH2 expression may contribute to the progression of the patients with CRC. A comprehensive study of epigenetic mechanisms and the relevance of EZH2 in CRC is important for fully understanding this disease and as a basis for developing new treatment options in patients with CRC.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    URL: Article
    DOI: 10.1177/1535370214542215
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 10
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    Functional Outcomes of Burn Patients with or without Rehabilitation in Mainland China
    SAGE Publications ; 2015
    In:  Hong Kong Journal of Occupational Therapy Vol. 26, No. 1 ( 2015-12), p. 15-23
    Details
    In: Hong Kong Journal of Occupational Therapy, SAGE Publications, Vol. 26, No. 1 ( 2015-12), p. 15-23
    Abstract: To evaluate the functional outcomes of moderate to severe burn patients with and without rehabilitation in terms of self-care performance and quality of life (QOL). Methods Fifty-five patients with total burn surface area of 30% or more were divided into two groups: rehabilitation and conventional care groups. The rehabilitation group underwent comprehensive rehabilitation interventions (e.g., occupational therapy, physiotherapy, and patient and family education) in addition to standard clinical interventions received by the conventional care group. The outcomes included self-care performance (Modified Barthel Index [MBI]), QOL (World Health Organization Quality of Life-BREF), pain and itchiness (Visual Analogue Scale [VAS] ), quality of sleep, and mental health (Self-Rating Depression Scale [SDS] and Self-Rating Anxiety Scale) measured before and 3 months after the intervention. Results After the intervention, significant improvements were found in MBI, all dimensions of QOL, pain, and SDS in the rehabilitation group (all p 〈 .05). In the conventional care group, significant improvements were found only in MBI (p 〈 .001), the physical health dimension of QOL (p 〈 .01), and pain (p 〈 .001). Group comparisons showed that the rehabilitation group achieved significantly better outcomes after the intervention in MBI (p 〈 .001), VAS score of itching (p = .009), and the physical health (p = .002), psychological health (p = .021), and social relationships dimensions of QOL (p 〈 .001). Conclusion Patients with moderate to severe burn injuries can benefit from rehabilitation interventions in terms of physical health, mental health, performance of daily living, and QOL.
    Type of Medium: Online Resource
    ISSN: 1569-1861 , 1876-4398
    URL: Article
    DOI: 10.1016/j.hkjot.2015.08.003
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2202253-3
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