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  • 1
    Online Resource
    Online Resource
    S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis
    SAGE Publications ; 2016
    In:  Journal of International Medical Research Vol. 44, No. 1_suppl ( 2016-09), p. 33-37
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 44, No. 1_suppl ( 2016-09), p. 33-37
    Abstract: To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis. Methods Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and semiquantitative polymerase chain reaction. Results The study included biopsies from nine patients with psoriatic arthritis and nine control subjects. S100A8 and S100A9 were present at visibly higher levels in psoriatic plaques compared with normal skin samples. S100A8 and S100A9 RNA levels were significantly higher in the peripheral region of plaques compared with the central region. Conclusion Both S100A8 and S100A9 may represent good therapeutic targets in psoriasis and psoriatic arthritis.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060515598900
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2082422-1
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  • 2
    Online Resource
    Online Resource
    Synovial fluid from patients with rheumatoid arthritis modulates monocyte cell-surface phenotype
    SAGE Publications ; 2016
    In:  Journal of International Medical Research Vol. 44, No. 1_suppl ( 2016-09), p. 15-21
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 44, No. 1_suppl ( 2016-09), p. 15-21
    Abstract: To investigate the ability of synovial fluid from patients with rheumatoid arthritis (RA) or osteoarthritis (OA) to modulate cell-surface phenotype, function and viability of monocytes. Methods Monocytes from healthy donors were incubated with synovial fluid from patients with RA or OA. These were then cultured with autologous healthy CD4+ T-cells. Immunoglobulin-like transcript 4 (ILT4) and CD86 were evaluated on stimulated monocytes and CD4+ T-cells via fluorescence activated cell sorting. Results Monocytes incubated with synovial fluid from patients with RA (SF-RA; n = 12) had significantly lower ILT4 and higher CD86 levels than those incubated with synovial fluid from patients with OA (SF-OA; n = 12) or medium alone. In patients with RA, there was a significant negative correlation between ILT4 and disease activity score (DAS; r = −0.699), and a positive correlation between CD86 and DAS ( r = 0.626). T-cells costimulated with monocytes cultured with SF-RA produced significantly more interferon-γ and tumour necrosis factor-α than those costimulated with monocytes cultured with SF-OA or controls. Conclusions Soluble mediators in SF-RA could contribute to modulating inflammation and local effectiveness of the immune response.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060515593231
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2082422-1
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  • 3
    Online Resource
    Online Resource
    Expression of immunoglobulin-like transcript 4 as an inhibitory receptor in patients with psoriatic arthritis
    SAGE Publications ; 2016
    In:  Journal of International Medical Research Vol. 44, No. 1_suppl ( 2016-09), p. 22-27
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 44, No. 1_suppl ( 2016-09), p. 22-27
    Abstract: To investigate the presence of immunoglobulin-like transcript (ILT)4 and costimulatory proteins (CD40, CD80 and CD86), as well as tumour necrosis factor (TNF)-α production in antigen-presenting cells (APCs) from patients with psoriatic arthritis, before and after treatment with the antitumour necrosis factor-α therapy, adalimumab. Methods Peripheral blood monocytes from patients with psoriatic arthritis and healthy controls were cultured with CD40 ligand (CD40L) to stimulate differentiation to APCs. Cell-surface phenotype was analysed via fluorescence-activated cell sorting. Results CD40L-stimulation resulted in significantly more ILT4 + monocytes in cultures from control subjects ( n = 21) than those from patients ( n = 20). ILT4-positivity on CD40L-stimulated monocytes was negatively correlated with disease activity in patients. Adalimumab treatment resulted in significant increases from baseline in ILT4-positivity, and in decreases in CD40, CD80 and CD86-positivity in monocytes from patients. Conclusion The effect of adalimumab on monocyte surface phenotype may be due to modification of the inflammatory milieu associated with therapy-induced reduction of disease activity in psoriatic arthritis.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060515598899
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2082422-1
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  • 4
    Online Resource
    Online Resource
    Remission and low disease activity in a cohort of real-life patients with rheumatoid arthritis treated with first-line antitumour necrosis factor
    SAGE Publications ; 2016
    In:  Journal of International Medical Research Vol. 44, No. 1_suppl ( 2016-09), p. 90-94
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 44, No. 1_suppl ( 2016-09), p. 90-94
    Abstract: This retrospective study used various indices to evaluate remission and low disease activity in ‘real life’ patients with rheumatoid arthritis (RA), given antitumour necrosis factor (anti-TNF) as a first-line treatment; changes in concomitant steroid and conventional synthetic disease-modifying antirheumatic drug (csDMARD) treatment were also assessed. Methods Remission and low disease activity were analysed in patients with RA treated with anti-TNF using the 28-joint Disease Activity Score (DAS28), Simplified Disease Activity Index (SDAI) and Clinical Disease Activity Index (CDAI). Remission and low disease activity were recorded after 6 months, 1 year and 2 years, along with concomitant prednisone and csDMARD treatment. Results A total of 271 patients with RA were included in the study. After 6 months, remission rates were 18.0%, 20.3% and 23.0% as assessed by CDAI, SDAI and DAS28, respectively. After 1 year and 2 years, respectively, remission rates were 18.4% and 15.9% using CDAI, 21.8% and 17.3% using SDAI, and 22.1% and 17.3% using DAS28. Low disease activity was achieved in 30–40% of patients, depending on the indices used. There was a significant reduction in the number of patients on prednisone and csDMARDs during anti-TNF treatment. Conclusion Remission with first-line anti-TNF treatment is an achievable goal in clinical practice, allowing a reduction in concomitant csDMARD and prednisone treatment.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060515593262
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2082422-1
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  • 5
    Online Resource
    Online Resource
    Serological markers associated with disease activity in patients with rheumatoid arthritis treated with rituximab
    SAGE Publications ; 2016
    In:  Journal of International Medical Research Vol. 44, No. 1_suppl ( 2016-09), p. 53-57
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 44, No. 1_suppl ( 2016-09), p. 53-57
    Abstract: To evaluate prospectively serological markers at baseline and during treatment in patients with rheumatoid arthritis (RA) initiating rituximab treatment, following failure of antitumour necrosis factor (TNF)-α therapy. Methods Patients with RA and healthy control subjects were recruited. Plasma complement (C)3, C4, rheumatoid factor (RF), anticitrullinated protein antibody (ACPA), immunoglobulin (Ig)M, A and G, disease activity scores (DAS) and therapeutic response were recorded at baseline and at 6, 12 and 18 months. Results Patients ( n = 35) had significantly higher C3 and C4 levels than controls ( n = 30). At 12 months after initiation of rituximab, C3 and C4 levels were significantly lower in patients who responded to treatment, compared with nonresponders. There were direct correlations between C3 levels and DAS at 12 months in the study population as a whole, and between IgM levels and DAS in responding patients after 6, 12 and 18 months’ treatment. Conclusions C3 and IgM levels may represent potentially useful serological markers of disease activity during rituximab treatment in patients with RA.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060515593240
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2082422-1
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