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  • SAGE Publications  (144)
  • 2015-2019  (144)
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  • SAGE Publications  (144)
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  • 2015-2019  (144)
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  • 1
    Online Resource
    Online Resource
    Influence of de qi on the immediate analgesic effect of SP6 acupuncture in patients with primary dysmenorrhoea and cold and dampness stagnation : A multicentre randomised controlled trial
    SAGE Publications ; 2017
    In:  Acupuncture in Medicine Vol. 35, No. 5 ( 2017-10), p. 332-338
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 35, No. 5 ( 2017-10), p. 332-338
    Abstract: The aim of this multicentre randomised controlled trial was to investigate the contribution of de qi to the immediate analgesic effect of acupuncture in patients with primary dysmenorrhoea and the specific traditional Chinese medicine diagnosis cold and dampness stagnation. Method Eighty-eight patients with primary dysmenorrhoea and cold and dampness stagnation were randomly assigned to de qi (n=43) or no de qi (n=45) groups and underwent 30 min of SP6 acupuncture. The de qi group received deep needling at SP6 with manipulation using thick needles; the no de qi group received shallow needling with no manipulation using thin needles. In both groups the pain scores and actual de qi sensation were evaluated using a visual analogue scale for pain (VAS-P) and the acupuncture de qi clinical assessment scale (ADCAS), respectively. Results Both groups showed reductions in VAS-P, with no signficant differences between groups. ADCAS scores showed 43/43 and 25/45 patients in de qi and no de qi groups, respectively, actually experienced de qi sensation. Independent of original group allocation, VAS-P reductions associated with actual de qi (n=68) were greater than those without (28.4±18.19 mm vs 14.6±12.28 mm, p=0.008). Conclusions This study showed no significant difference in VAS-P scores in patients with primary dysmenorrhoea and cold and dampness stagnation immediately after SP6 acupuncture designed to induce or avoid de qi sensation. Both treatments significantly reduced VAS-P relative to baseline. Irrespective of group allocation, patients experiencing actual de qi sensation demonstrated larger reductions in pain score relative to those without, suggesting greater analgesic effects. Trial registration number Chinese Clinical Trial Registry (ChiCTR-TRC-13003086); Results.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1136/acupmed-2016-011228
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2126127-1
    detail.hit.zdb_id: 1360533-1
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  • 2
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    Electroacupuncture exerts an anti-migraine effect via modulation of the 5-HT7 receptor in the conscious rat
    SAGE Publications ; 2019
    In:  Acupuncture in Medicine Vol. 37, No. 1 ( 2019-02), p. 47-54
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 37, No. 1 ( 2019-02), p. 47-54
    Abstract: Acupuncture has been recommended as an alternative therapy for migraine. Emerging evidence suggests that the 5-HT 7 receptor (5-HT 7 R) plays a significant facilitatory role in descending modulation in migraine pathophysiology, and that activation of 5-HT 7 R in the descending pathway is involved in migraine central sensitisation. Objective: To investigate the ability of electroacupuncture (EA) to ameliorate central sensitisation via modulation of 5-HT 7 R in the descending pain pathways using a rat model of migraine induced by repetitive dural electrical stimulation (DES). Design: 64 male Sprague-Dawley rats were randomly divided into four groups: Normal group; DES group (receiving dural electrical stimulation only); DES+GB20 group (DES model group treated with EA at GB20); and DES+Sham group (DES model group treated with EA at a non-traditional (sham) acupuncture point). The presence of cutaneous allodynia was determined by measuring facial and hind-paw withdrawal latencies to electronic von-Frey. The expression of 5-HT 7 R in the descending pathways (periaqueductal grey, raphe magnus nucleus, and trigeminal nucleus caudalis) was assessed using immunofluorescence and Western blotting. Results: Facial and hind-paw withdrawal thresholds were significantly increased in the DES+GB20 group compared with the untreated DES group. The expression of 5-HT 7 R was significantly decreased in the DES+GB20 group compared with the DES group (one-way analysis of variance (ANOVA), P 〈 0.05). No significant differences in behaviour or expression were found between the rats in the DES+Sham group and the untreated DES group (one-way ANOVA, P 〉 0.05). Conclusion: EA at GB20 may ameliorate central sensitisation in migraine by inhibiting the activation of 5-HT 7 receptors in the descending pain pathway in a rat model of migraine.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1136/acupmed-2017-011410
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2126127-1
    detail.hit.zdb_id: 1360533-1
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  • 3
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    Online Resource
    Application of the Polynomial-Based Least Squares and Total Least Squares Models for the Attenuated Total Reflection Fourier Transform Infrared Spectra of Binary Mixtures of Hydroxyl Compounds
    SAGE Publications ; 2016
    In:  Applied Spectroscopy Vol. 70, No. 3 ( 2016-03), p. 505-519
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 70, No. 3 ( 2016-03), p. 505-519
    Abstract: An analysis of binary mixtures of hydroxyl compound by Attenuated Total Reflection Fourier transform infrared spectroscopy (ATR FT-IR) and classical least squares (CLS) yield large model error due to the presence of unmodeled components such as H-bonded components. To accommodate these spectral variations, polynomial-based least squares (LSP) and polynomial-based total least squares (TLSP) are proposed to capture the nonlinear absorbance-concentration relationship. LSP is based on assuming that only absorbance noise exists; while TLSP takes both absorbance noise and concentration noise into consideration. In addition, based on different solving strategy, two optimization algorithms (limited-memory Broyden–Fletcher–Goldfarb–Shanno (LBFGS) algorithm and Levenberg–Marquardt (LM) algorithm) are combined with TLSP and then two different TLSP versions (termed as TLSP-LBFGS and TLSP-LM) are formed. The optimum order of each nonlinear model is determined by cross-validation. Comparison and analyses of the four models are made from two aspects: absorbance prediction and concentration prediction. The results for water-ethanol solution and ethanol-ethyl lactate solution show that LSP, TLSP-LBFGS, and TLSP-LM can, for both absorbance prediction and concentration prediction, obtain smaller root mean square error of prediction than CLS. Additionally, they can also greatly enhance the accuracy of estimated pure component spectra. However, from the view of concentration prediction, the Wilcoxon signed rank test shows that there is no statistically significant difference between each nonlinear model and CLS.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1177/0003702815626680
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1474251-2
    detail.hit.zdb_id: 204667-2
    SSG: 11
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  • 4
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    Heparin is Not Inferior to Bivalirudin in Percutaneous Coronary Intervention—Focusing on the Effect of Glycoprotein IIb/IIIa Inhibitor Use : A Meta-Analysis
    SAGE Publications ; 2015
    In:  Angiology Vol. 66, No. 9 ( 2015-10), p. 845-855
    Details
    In: Angiology, SAGE Publications, Vol. 66, No. 9 ( 2015-10), p. 845-855
    Abstract: Our aim was to compare the efficacy and safety of bivalirudin (Biv) versus heparin (Hep) with or without similar usage rate of glycoprotein IIb/IIIa inhibitors (GPIs) during percutaneous coronary intervention (PCI). The PubMed and EMbase were searched. Randomized trials comparing Biv versus Hep were eligible for inclusion. With imbalanced GPI use, Biv had significantly lower major bleeding (pooled risk ratio [RR], 0.67; 95% confidence interval [CI] , 0.54-0.83) without difference in mortality (pooled RR, 0.95; 95% CI, 0.80-1.14). With comparable GPI use, no significant difference was observed in major bleeding (pooled RR, 0.95; 95% CI, 0.82-1.10) and mortality (pooled RR, 1.13; 95% CI, 0.85-1.50). With no GPI use, Biv was associated with numerically higher mortality (pooled RR, 1.17; 95% CI, 0.83-1.65) without significant difference in major bleeding (pooled RR, 0.81; 95% CI, 0.64-1.02). In conclusion, when comparing different anticoagulants during PCI, the effect of GPIs should not be underestimated. Heparin as such was found noninferior to Biv.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    URL: Article
    DOI: 10.1177/0003319715568972
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2065911-8
    detail.hit.zdb_id: 80040-5
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  • 5
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    Into-Tunnel Repair Versus Onto-Surface Repair for Rotator Cuff Tears in a Rabbit Model
    SAGE Publications ; 2018
    In:  The American Journal of Sports Medicine Vol. 46, No. 7 ( 2018-06), p. 1711-1719
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 46, No. 7 ( 2018-06), p. 1711-1719
    Abstract: Clinically, onto-surface repair is commonly used for rotator cuff tears. The retear rate after rotator cuff repair (RCR) is relatively high, with failure occurring mostly at the tendon-bone connection site. For anterior cruciate ligament (ACL) reconstruction, into-tunnel reconstruction is commonly employed. The retear rate after ACL reconstruction is relatively low, with retears seldom occurring at the tendon-bone interface. No study on into-tunnel RCR has been conducted. Hypothesis: Into-tunnel RCR could promote fibrocartilage regeneration at the tendon-bone interface and has biomechanical advantage over onto-surface repair in a rabbit rotator cuff tear model. Study Design: Controlled laboratory study. Methods: Thirty-six New Zealand White rabbits were used in this study. The supraspinatus tendons were cut from the footprint to create a rotator cuff tear on both shoulders. On one side, the supraspinatus was cut longitudinally into 2 halves, sutured, and pulled into 2 tunnels through the greater tuberosity (into-tunnel repair). On the other side, the tendon was reattached to the surface of the footprint with transosseous sutures (onto-surface repair). Twelve animals were sacrificed, of which 6 were used for a histological examination and the other 6 for biomechanical testing, at 4, 8, and 12 weeks, respectively. Results: The tendon-bone interface in the into-tunnel group showed a different healing pattern from that in the onto-surface group. In the former, most of the tendon tissue in the tunnel was replaced with newly generated fibrocartilage; the rest of the tendon fibers appeared in large bundles with direct connection to the bone. In the latter, fibrocartilage regeneration was seldom found at the tendon-bone interface; the tendon near the bone surface appeared as small fibrils. The biomechanical evaluation revealed a higher ultimate load ( P 〈 .001) and stiffness ( P 〈 .001) at the tendon-bone junction in the into-tunnel group than those in the onto-surface group at 12 weeks. Conclusion: In a rabbit rotator cuff tear model, into-tunnel RCR could result in a different tendon-bone healing pattern, with obvious fibrocartilage regeneration at the interface and higher tendon-bone healing strength than that in onto-surface repair. Clinical Relevance: New RCR patterns may be developed to improve the tendon-bone healing pattern and obtain better tendon-bone healing strength.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546518764685
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
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    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 6
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    Daunomycin-loaded superparamagnetic iron oxide nanoparticles: Preparation, magnetic targeting, cell cytotoxicity, and protein delivery research
    SAGE Publications ; 2016
    In:  Journal of Biomaterials Applications Vol. 31, No. 2 ( 2016-08), p. 261-272
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 31, No. 2 ( 2016-08), p. 261-272
    Abstract: The clinical use of daunomycin is restricted by dose-dependent toxicity and low specificity against cancer cells. In the present study, modified superparamagnetic iron oxide nanoparticles were employed to load daunomycin and the drug-loaded nanospheres exhibited satisfactory size and smart pH-responsive release. The cellular uptake efficiency, targeted cell accumulation, and cell cytotoxicity experimental results proved that the superparamagnetic iron oxide nanoparticle-loading process brings high drug targeting without decreasing the cytotoxicity of daunomycin. Moreover, a new concern for the evaluation of nanophase drug delivery's effects was considered, with monitoring the interactions between human serum albumin and the drug-loaded nanospheres. Results from the multispectroscopic techniques and molecular modeling calculation elucidate that the drug delivery has detectable deleterious effects on the frame conformation of protein, which may affect its physiological function.
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328216654425
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2072559-0
    detail.hit.zdb_id: 639283-0
    SSG: 12
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  • 7
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    Preparation, Characterisation, Crystal Structure and Antibacterial Activity of two Bis-Schiff Bases Containing a Piperazine Ring
    SAGE Publications ; 2018
    In:  Journal of Chemical Research Vol. 42, No. 10 ( 2018-10), p. 512-514
    Details
    In: Journal of Chemical Research, SAGE Publications, Vol. 42, No. 10 ( 2018-10), p. 512-514
    Abstract: Two new bis-Schiff bases containing a piperazine ring, N,N‘-bis(4-chlorobenzylidene)- and N,N‘-bis(4-cyanobenzylidene)-1,4-bis(3-aminopropyl)piperazine, were prepared by the reaction of N,N‘-bis(3-aminopropyl)piperazine with 4-chloro- and 4-cyanobenzaldehyde, respectively. The dichloro compound was fully identified by X-ray crystallography and it exhibited good antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis.
    Type of Medium: Online Resource
    ISSN: 1747-5198 , 2047-6507
    URL: Article
    DOI: 10.3184/174751918X15383854898654
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 3010810-X
    detail.hit.zdb_id: 2142358-1
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  • 8
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    Prepubertal exposure to T-2 toxin advances pubertal onset and development in female rats via promoting the onset of hypothalamic–pituitary–gonadal axis function
    SAGE Publications ; 2016
    In:  Human & Experimental Toxicology Vol. 35, No. 12 ( 2016-12), p. 1276-1285
    Details
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 35, No. 12 ( 2016-12), p. 1276-1285
    Abstract: T-2 toxin, a naturally produced Type A trichothecene mycotoxin, has been shown to damage the reproductive and developmental functions in livestocks. However, whether T-2 toxin can disturb the pubertal onset and development following prepubertal exposure remains unclear. To clarify this point, infantile female Sprague–Dawley rats were given a daily intragastric administration of vehicle or T-2 toxin at a dose of 375 μg/kg body weight for 5 consecutive days from postnatal day (PND) 15–19 (PND15–PND19). The days of vaginal opening, first diestrus, and first estrus in regular estrous cycle were advanced following T-2 toxin treatment, indicating prepubertal exposure to T-2 toxin induced the advancement of puberty onset. The relative weights of uterus and ovaries and the incidence of corpora lutea were all increased in T-2 toxin-treated rats; serum hormone levels of luteinizing hormone and estradiol and the messenger RNA expressions of gonadotropin-releasing hormone (GnRH) and GnRH receptor also displayed marked increases following exposure to T-2 toxin, all of which were well consistent with the manifestations of the advanced puberty onset. In conclusion, the present study reveals that prepubertal exposure to a high level of T-2 toxin promotes puberty onset in infantile female rats by advancing the initiation of hypothalamic–pituitary–gonadal axis function in female rats.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    URL: Article
    DOI: 10.1177/0960327116629529
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 1027454-6
    detail.hit.zdb_id: 1483723-7
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  • 9
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    Vibration analysis and control of a screw compressor outlet piping system
    SAGE Publications ; 2019
    In:  Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering Vol. 233, No. 2 ( 2019-04), p. 403-411
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, SAGE Publications, Vol. 233, No. 2 ( 2019-04), p. 403-411
    Abstract: The severe vibration of a screw compressor outlet piping system caused the premature failures of some thermowells and the unplanned shut down of the compressor system. The root causes of the vibration problem were investigated by numerical simulations. An acoustic model was established to predict the pressure pulsation of the gas inside the pipelines, and two finite element models were built to study the vibration characteristics of the overall piping system and of the thermowells. The numerical results indicated that the vibration problem may be attributed to the excessive pressure nonuniformity of the gas inside the pipelines, low overall stiffness of the piping system and the first-order structural resonance occurred on the thermowells. A pulsation attenuator was added and the pipelines were rearranged to reduce the pressure pulsation, some pipe supports were added to improve the overall stiffness of the piping system, and the thermowells were reinforced to avoid the first-order structural resonance. After the modifications, the field measurement data showed that the vibration of the piping system decreased significantly, and the modified piping system has been operating normally for nearly two years.
    Type of Medium: Online Resource
    ISSN: 0954-4089 , 2041-3009
    URL: Article
    DOI: 10.1177/0954408918763561
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2024897-0
    detail.hit.zdb_id: 1015040-7
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  • 10
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    A parallel algorithm for network traffic anomaly detection based on Isolation Forest
    SAGE Publications ; 2018
    In:  International Journal of Distributed Sensor Networks Vol. 14, No. 11 ( 2018-11), p. 155014771881447-
    Details
    In: International Journal of Distributed Sensor Networks, SAGE Publications, Vol. 14, No. 11 ( 2018-11), p. 155014771881447-
    Abstract: With the rapid development of large-scale complex networks and proliferation of various social network applications, the amount of network traffic data generated is increasing tremendously, and efficient anomaly detection on those massive network traffic data is crucial to many network applications, such as malware detection, load balancing, network intrusion detection. Although there are many methods around for network traffic anomaly detection, they are all designed for single machine, failing to deal with the case that the network traffic data are so large that it is prohibitive for a single computer to store and process the data. To solve these problems, we propose a parallel algorithm based on Isolation Forest and Spark for network traffic anomaly detection. We combine the advantages of Isolation Forest algorithm in network traffic anomaly detection and big data processing capability of Spark technology. Meanwhile, we apply the idea of parallelization to the process of modeling and evaluation. In the calculation process, by assigning tasks to multiple compute nodes, Isolation Forest and Spark can efficiently perform anomaly detection and evaluation process. By this way, we can also solve the problem of computation bottleneck on single machine. Extensive experiments on real world datasets show that our Isolation Forest and Spark is efficient and scales well for anomaly detection on large network traffic data.
    Type of Medium: Online Resource
    ISSN: 1550-1477 , 1550-1477
    URL: Article
    DOI: 10.1177/1550147718814471
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2192922-1
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