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  • SAGE Publications  (39)
  • 2015-2019  (39)
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  • SAGE Publications  (39)
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  • 2015-2019  (39)
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  • 1
    Online Resource
    Online Resource
    Metabolomic profile of arterial stiffness in aged adults
    SAGE Publications ; 2018
    In:  Diabetes and Vascular Disease Research Vol. 15, No. 1 ( 2018-01), p. 74-80
    Details
    In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 15, No. 1 ( 2018-01), p. 74-80
    Type of Medium: Online Resource
    ISSN: 1479-1641 , 1752-8984
    URL: Article
    DOI: 10.1177/1479164117733627
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2250797-8
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  • 2
    Online Resource
    Online Resource
    Enhanced sound insulation and mechanical properties based on inorganic fillers/thermoplastic elastomer composites
    SAGE Publications ; 2019
    In:  Journal of Thermoplastic Composite Materials Vol. 32, No. 7 ( 2019-07), p. 936-950
    Details
    In: Journal of Thermoplastic Composite Materials, SAGE Publications, Vol. 32, No. 7 ( 2019-07), p. 936-950
    Type of Medium: Online Resource
    ISSN: 0892-7057 , 1530-7980
    URL: Article
    DOI: 10.1177/0892705718766382
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2098671-3
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  • 3
    Online Resource
    Online Resource
    Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system
    SAGE Publications ; 2018
    In:  Journal of Psychopharmacology Vol. 32, No. 4 ( 2018-04), p. 469-481
    Details
    In: Journal of Psychopharmacology, SAGE Publications, Vol. 32, No. 4 ( 2018-04), p. 469-481
    Abstract: Major depressive disorder has become one of the most serious neuropsychiatric disorders worldwide. However, currently available antidepressants used in clinical practice are ineffective for a substantial proportion of patients and always have side effects. Besides being a lipid-regulating agent, gemfibrozil is an agonist of peroxisome proliferator-activated receptor-α (PPAR-α). We investigated the antidepressant effects of gemfibrozil on C57BL/6J mice using the forced swim test (FST) and tail suspension test (TST), as well as the chronic unpredictable mild stress (CUMS) model of depression. The changes in brain-derived neurotrophic factor (BDNF) signaling cascade in the brain after CUMS and gemfibrozil treatment were further assessed. Pharmacological inhibitors and lentivirus-expressed short hairpin RNA (shRNA) were also used to clarify the antidepressant mechanisms of gemfibrozil. Gemfibrozil exhibited significant antidepressant actions in the FST and TST without affecting the locomotor activity of mice. Chronic gemfibrozil administration fully reversed CUMS-induced depressive-like behaviors in the FST, TST and sucrose preference test. Gemfibrozil treatment also restored CUMS-induced inhibition of the hippocampal BDNF signaling pathway. Blocking PPAR-α and BDNF but not the serotonergic system abolished the antidepressant effects of gemfibrozil on mice. Gemfibrozil produced antidepressant effects in mice by promoting the hippocampal BDNF system.
    Type of Medium: Online Resource
    ISSN: 0269-8811 , 1461-7285
    URL: Article
    DOI: 10.1177/0269881118762072
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2028926-1
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  • 4
    Online Resource
    Online Resource
    Symptom Frequencies and Intensities in Hospitalized Patients With Advanced Cancer Having Depressive Disorder
    SAGE Publications ; 2017
    In:  American Journal of Hospice and Palliative Medicine® Vol. 34, No. 5 ( 2017-06), p. 456-460
    Details
    In: American Journal of Hospice and Palliative Medicine®, SAGE Publications, Vol. 34, No. 5 ( 2017-06), p. 456-460
    Abstract: To explore the frequencies and intensities of depressive symptoms associated with hospitalized patients with advanced cancer. Methods: A total of 196 hospitalized patients with advanced cancer were surveyed with the Edmonton Symptom Assessment System and Self-Rating Depression Scale (SDS). The χ 2 test and Wilcoxon rank-sum test were used to compare the frequency and intensity of symptoms between patients with and without depressive disorders. Spearman rank correlation was used to test the correlation between depression and symptoms. Results: Of the 196 enrolled patients, 115 (59%) were males. The median age of the patients was 58 (19-80) years. Seventy-six (39%) patients were diagnosed with depression (SDS ≥ 53). Patients with depressive disorders exhibited pain, drowsiness, and nausea along with a higher frequency and intensity of poor self-perception, appetite loss, anxiety, dyspnea, and fatigue. Depressive symptoms were positively correlated with the symptoms. Conclusion: Depressive disorders are very common and severe in hospitalized patients with advanced cancer. Identifying the frequencies and intensities of the symptoms enables early intervention to improve patients’ quality of life.
    Type of Medium: Online Resource
    ISSN: 1049-9091 , 1938-2715
    URL: Article
    DOI: 10.1177/1049909116655292
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2236674-X
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  • 5
    Online Resource
    Online Resource
    Effect of Low-Intensity Pulsed Ultrasound After Autologous Adipose-Derived Stromal Cell Transplantation for Bone-Tendon Healing in a Rabbit Model
    SAGE Publications ; 2019
    In:  The American Journal of Sports Medicine Vol. 47, No. 4 ( 2019-03), p. 942-953
    Details
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 47, No. 4 ( 2019-03), p. 942-953
    Abstract: Low-intensity pulsed ultrasound (LIPUS), as a safe biophysiotherapy, can enhance bone-tendon (B-T) healing in vivo and induce osteogenic or chondrogenic differentiation of mesenchymal stromal cells in vitro. This study aimed to determine whether LIPUS can improve the efficacy of transplanted mesenchymal stromal cells on B-T healing. Hypothesis: LIPUS can induce lineage-specific differentiation of transplanted adipose-derived stromal cells (ASCs) at the B-T healing site, thus resulting in superior healing quality when compared with LIPUS or ASCs alone. Study Design: Controlled laboratory study. Methods: A total of 112 mature rabbits with partial patellectomy in the hindlimb were randomly assigned into mock sonication without ASCs (control), ultrasonication without ASCs (LIPUS), mock sonication with ASCs (ASCs), and ultrasonication with ASCs (LIPUS + ASCs). The treatment time of the mock sonication or ultrasonication was 20 minutes per day. Autologous ASCs were transplanted to the healing site by fibrin glue during the operation, and LIPUS was delivered daily starting at postoperative day 3 until euthanasia. The patella–patellar tendon junctions were postoperatively harvested at 8 and 16 weeks for radiological, histological, and mechanical evaluations. Additionally, 9 animals were used for ASC tracking with mCherry protein. Results: Radiologically, there was more new bone formation and remodeling in the LIPUS + ASCs group as compared with the other groups. Synchrotron radiation micro–computed tomography showed that the LIPUS + ASCs group significantly increased bone volume fraction, trabecular thickness, and trabecular number at the healing site as compared with the other groups at postoperative 8 weeks ( P 〈 .05 for all). Histologically, immunohistochemical staining confirmed that the transplanted mCherry-ASCs can differentiate into osteoblasts and fibrochondrocytic-like cells. Meanwhile, as compared with the other groups, the LIPUS + ASCs group showed more formation and maturity of the fibrocartilage layer and new bone at postoperative weeks 8 and 16 ( P 〈 .05 for all). Biomechanically, the LIPUS + ASCs group showed significantly higher failure load and stiffness versus the other groups at postoperative weeks 8 and 16 ( P 〈 .05 for all). Conclusion: Autologous ASC transplantation stimulated with LIPUS can result in superior B-T healing quality when compared with LIPUS or ASCs alone. Clinical Relevance: This study demonstrates the effectiveness of using ASC transplantation stimulated with LIPUS for B-T healing and provides a foundation for future clinical studies.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    URL: Article
    DOI: 10.1177/0363546518820324
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 6
    Online Resource
    Online Resource
    Aeroelastic tailoring of composite sandwich panel with lamination parameters
    SAGE Publications ; 2016
    In:  Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering Vol. 230, No. 1 ( 2016-01), p. 105-117
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part G: Journal of Aerospace Engineering, SAGE Publications, Vol. 230, No. 1 ( 2016-01), p. 105-117
    Abstract: For sandwich panel with a thick core, stiffness matrix of composite sandwich panel can be formulated as function of membrane lamination parameters of the composite facesheet. In this paper, the flutter speed of a cantilevered sandwich panel is studied using lamination parameters of composite facesheet, with influence of transverse shear on sandwich panel considered. The results show that the flutter mode switch is not only related to the bending stiffness change, and also the transverse shear effect can result in switch of flutter mode. A minimum weight design of composite sandwich panel is conducted by using master-slave parallel real-coded genetic algorithm, with lamination parameters of facesheet and transverse shear modulus of foam core as design variables. The constraints considered include the flutter and divergence velocity constraints, the bound constraints of thicknesses of the facesheet and foam core. The feasible region constraints of membrane lamination parameters are also considered.
    Type of Medium: Online Resource
    ISSN: 0954-4100 , 2041-3025
    URL: Article
    DOI: 10.1177/0954410015587724
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2032759-6
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  • 7
    Online Resource
    Online Resource
    Safety and effectiveness of multi-antenna microwave ablation-oriented combined therapy for large hepatocellular carcinoma
    SAGE Publications ; 2019
    In:  Therapeutic Advances in Gastroenterology Vol. 12 ( 2019-01), p. 175628481986296-
    Details
    In: Therapeutic Advances in Gastroenterology, SAGE Publications, Vol. 12 ( 2019-01), p. 175628481986296-
    Abstract: In patients with a large, unresectable hepatocellular carcinoma (HCC), the primary recommendation is for transarterial chemoembolization (TACE) but used alone TACE is not typically curative. Combinations of TACE followed in a delayed fashion by single-applicator thermal ablation have also been suboptimal. As an alternative, we investigated the combination of TACE followed within 1–3 days by multi-antenna microwave ablation (MWA) in patients with a large HCC, to determine the feasibility, safety, local control, and short-term survival rates of this approach. Methods: We retrospectively studied 43 patients with a large HCC (mean diameter, 8.8 cm; SD, 2.8 cm) treated between July 2015 and July 2018, who underwent TACE followed within 3 days by multi-antenna simultaneous MWA. We measured the liver and renal function before and after treatment, recorded complications, used three-dimensional software and imaging to calculate tumor necrosis rates at 1 month after therapy, and calculated overall survival (OS) and progression-free survival (PFS) using the Kaplan–Meier method. Results: Mean follow up was 12.2 (range, 3.5–35.6) months. All patients completed the treatment protocol. At 1 month after combined therapy, tumor necrosis was complete in 16 (37.2%), nearly complete in 19 (44.2%), and partial in 8 (18.6%) patients. The 1- and 2-year OS rates were 64.0% and 46.8%, respectively, with a median OS of 23.0 months; and the 1- and 2-year PFS rates were 19.9% and 4.4%, respectively, with a median PFS of 4.2 months. A transient change in liver function occurred 3 days after MWA but resolved within 1 month. Only two patients had major complications, which were treatable and resolved. Conclusion: Multi-antenna MWA-oriented combined therapy is feasible and well tolerated, and it results in satisfactory initial local control and short-term survival in some but not all patients with a large HCC.
    Type of Medium: Online Resource
    ISSN: 1756-2848 , 1756-2848
    URL: Article
    DOI: 10.1177/1756284819862966
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440710-0
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  • 8
    Online Resource
    Online Resource
    Nerve injury elevates functional Cav3.2 channels in superficial spinal dorsal horn
    SAGE Publications ; 2019
    In:  Molecular Pain Vol. 15 ( 2019-01), p. 174480691983656-
    Details
    In: Molecular Pain, SAGE Publications, Vol. 15 ( 2019-01), p. 174480691983656-
    Type of Medium: Online Resource
    ISSN: 1744-8069 , 1744-8069
    URL: Article
    DOI: 10.1177/1744806919836569
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2174252-2
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  • 9
    Online Resource
    Online Resource
    Fault Detection Based on Near-Infrared Spectra for the Oil Desalting Process
    SAGE Publications ; 2018
    In:  Applied Spectroscopy Vol. 72, No. 8 ( 2018-08), p. 1199-1204
    Details
    In: Applied Spectroscopy, SAGE Publications, Vol. 72, No. 8 ( 2018-08), p. 1199-1204
    Abstract: The fault detection problem of the oil desalting process is investigated in this paper. Different from the traditional fault detection approaches based on measurable process variables, near-infrared (NIR) spectroscopy is applied to acquire the process fault information from the molecular vibrational signal. With the molecular spectra data, principal component analysis was explored to calculate the Hotelling T 2 and squared prediction error, which act as fault indicators. Compared with the traditional fault detection approach based on measurable process variables, NIR spectra-based fault detection illustrates more sensitivity to early failure because of the fact that the changes in the molecular level can be identified earlier than the physical appearances on the process. The application results show that the detection time of the proposed method is earlier than the traditional method by about 200 min.
    Type of Medium: Online Resource
    ISSN: 0003-7028 , 1943-3530
    URL: Article
    DOI: 10.1177/0003702818776022
    RVK:
    VA 2367
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 1474251-2
    SSG: 11
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  • 10
    Online Resource
    Online Resource
    Preparation and characterization of micro or nano cellulose fibers via electroless Ni-P composite coatings
    SAGE Publications ; 2016
    In:  Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanomaterials, Nanoengineering and Nanosystems Vol. 230, No. 4 ( 2016-12), p. 213-221
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanomaterials, Nanoengineering and Nanosystems, SAGE Publications, Vol. 230, No. 4 ( 2016-12), p. 213-221
    Abstract: Ni-P composite coatings were prepared on cellulose fiber surface via a simple electroless Ni-P approach. The metal-coated extent, dispersion extent of micro or nano cellulose fibers and crystalline structure of Ni-P composite coatings were investigated. The homogeneous hollow composite coatings and metal-coated extent of micro or nano cellulose fibers were improved with the increase in ultrasonic power, and the ideal composite coatings were obtained as ultrasonic up to 960 W. The metallization for cellulose fibers enhanced the dispersion extent of micro or nano cellulose fibers. A uniform coating, consisting of the hollow coating on cellulose fibers surface, could be obtained. At the same time, metallization did not damage the original structure and surface functional groups of cellulose fibers. The concentration of cellulose fibers and ultrasonic power had a direct influence on the metal-coated extent of cellulose fiber surface. The metal-coated extent, dispersion extent of micro or nano cellulose fibers and crystalline structure of Ni-P composite coatings exhibited excellent properties as the concentration of cellulose fibers and ultrasonic power were 2 g/L and 960 W, respectively.
    Type of Medium: Online Resource
    ISSN: 2397-7914 , 2397-7922
    URL: Article
    DOI: 10.1177/1740349915590006
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2961164-7
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