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  • 1
    Publication Date: 2015-02-12
    Description: We analyze observations of subionospherically propagating very low frequency (VLF) radio waves to determine outer radiation belt Energetic Electron Precipitation (EEP) flux magnitudes. The radio wave receiver in Sodankylä, Finland (SGO) observes signals from the transmitter with call sign NAA (Cutler, Maine). The receiver is part of the Antarctic-Arctic Radiation-belt Dynamic Deposition VLF Atmospheric Research Konsortia (AARDDVARK). We use a near-continuous dataset spanning November 2004 until December 2013 to determine the long time period EEP variations. We determine quiet day curves (QDC) over the entire period and use these to identify propagation disturbances caused by EEP. LWPC radio wave propagation modeling is used to estimate the precipitating electron flux magnitudes from the observed amplitude disturbances, allowing for solar cycle changes in the ambient D-region and dynamic variations in the EEP energy spectra. Our method performs well during the summer months when the day-lit ionosphere is the most stable, but fails during the winter. From the summer observations we have obtained 693 days worth of hourly EEP flux magnitudes over the 2004-2013 period. These AARDDVARK-based fluxes agree well with independent satellite precipitation measurements during high intensity events. However, our method of EEP detection is 10-50 times more sensitive to low flux levels than the satellite measurements. Our EEP variations also show good agreement with the variation in lowerband chorus wave powers, providing some confidence that chorus is the primary driver for the outer-belt precipitation we are monitoring.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
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  • 2
    Publication Date: 2015-02-25
    Description: Immune enhancement is desirable in situations where decreased immunity results in increased morbidity. We investigated whether blocking the surface inhibitory receptor PD-1 and/or p38 MAP kinase could enhance the proliferation of the effector memory CD8 + T-cell subset that re-expresses CD45RA (EMRA) and exhibits characteristics of senescence, which include decreased proliferation and telomerase activity but increased expression of the DNA damage response-related protein γH2AX. Blocking of both PD-1 and p38 MAPK signalling in these cells enhanced proliferation and the increase was additive when both pathways were inhibited simultaneously in both young and old human subjects. In contrast, telomerase activity in EMRA CD8 + T cells was only enhanced by blocking the p38 but not the PD-1 signalling pathway, further indicating that non-overlapping signalling pathways were involved. Although blocking p38 MAPK inhibits TNF-α secretion in the EMRA population, this decrease was counteracted by the simultaneous inhibition of PD-1 signalling in these cells. Therefore, end-stage characteristics of EMRA CD8 + T cells are stringently controlled by distinct and reversible cell signalling events. In addition, the inhibition of PD-1 and p38 signalling pathways together may enable the enhancement of proliferation of EMRA CD8 + T cells without compromising their capacity for cytokine secretion. This article is protected by copyright. All rights reserved
    Print ISSN: 0014-2980
    Electronic ISSN: 1521-4141
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 3
    Publication Date: 2015-01-14
    Description: We demonstrate the application of a high-resolution X-ray Computed Tomography (CT) method to quantify water distribution in soil pores under successive reductive drying. We focus on the wet end of the water release characteristic (WRC) (0 to -75 kPa) to investigate changes in soil water distribution in contrasting soil textures (sand and clay) and structures (sieved and field structured), to determine the impact of soil structure on hydraulic behaviour. The 3D structure of each soil was obtained from the CT images (at a 10 µ m resolution). Stokes equations for flow were solved computationally for each measured structure to estimate hydraulic conductivity. The simulated values obtained compared extremely well with the measured saturated hydraulic conductivity values. By considering different sample sizes we were able to identify that the smallest possible representative sample size which is required to determine a globally valid hydraulic conductivity. This article is protected by copyright. All rights reserved.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
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  • 4
    Publication Date: 2015-04-26
    Description: On 31 May 2013 several rising-tone electromagnetic ion-cyclotron (EMIC) waves with intervals of pulsations of diminishing periods (IPDP) were observed in the magnetic local time afternoon and evening sectors during the onset of a moderate/large geomagnetic storm. The waves were sequentially observed in Finland, Antarctica, and western Canada. Co-incident electron precipitation by a network of ground-based Antarctic Arctic Radiation-belt Dynamic Deposition VLF Atmospheric Research Konsortia (AARDDVARK) and riometer instruments, as well as the Polar-orbiting Operational Environmental Satellite (POES) electron telescopes, was also observed. At the same time POES detected 30-80 keV proton precipitation drifting westwards at locations that were consistent with the ground-based observations, indicating substorm injection. Through detailed modelling of the combination of ground and satellite observations the characteristics of the EMIC-induced electron precipitation were identified as: latitudinal width of 2-3° or ΔL =1  R e , longitudinal width ~50° or 3 hours MLT, lower cut off energy 280 keV, typical flux 1×10 4  el. cm -2 sr -1 s -1 〉300 keV. The lower cutoff energy of the most clearly defined EMIC rising tone in this study confirms the identification of a class of EMIC-induced precipitation events with unexpectedly low energy cutoffs of 〈400 keV.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
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  • 5
    Publication Date: 2015-03-14
    Description: Very low frequency (VLF) transmissions propagating between the conducting Earth's surface and lower edge of the ionosphere have been used for decades to study the effect of space weather events on the upper atmosphere. The VLF response to these events can only be quantified by comparison of the observed signal to the estimated quiet-time or undisturbed signal levels, known as the quiet day curve (QDC). A common QDC calculation approach for periods of investigation of up to several weeks is to use observations made on quiet days close to the days of interest. This approach is invalid when conditions are not quiet around the days of interest. Longer term QDCs have also been created from specifically identified quiet days within the period and knowledge of propagation characteristics. This approach is time consuming, and can be subjective. We present three algorithmic techniques, which are based on either 1) a mean of previous days’ observations, 2) Principal Component Analysis, or 3) the Fast Fourier Transform (FFT), to calculate the QDC for a long-period VLF dataset without identification of specific quiet days as a basis. We demonstrate the effectiveness of the techniques at identifying the true QDCs of synthetic datasets created to mimic patterns seen in actual VLF data including responses to space weather events. We find the most successful technique is to use a smoothing method, developed within the study, on the dataset and then use the developed FFT algorithm. This technique is then applied to multi-year datasets of actual VLF observations.
    Print ISSN: 0048-6604
    Electronic ISSN: 1944-799X
    Topics: Geosciences , Physics
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  • 6
    Publication Date: 2015-10-22
    Description: Electromagnetic Ion Cyclotron (EMIC) waves are thought to be important drivers of energetic electron losses from the outer radiation belt through precipitation into the atmosphere. While the theoretical possibility of pitch angle scattering-driven losses from these waves has been recognized for more than 4 decades, there have been limited experimental precipitation observations to support this concept. We have combined satellite-based observations of the characteristics of EMIC waves, with satellite and ground-based observations of the EMIC-induced electron precipitation. In a detailed case study, supplemented by an additional 4 examples, we are able to constrain for the first time the location, size, and energy range of EMIC-induced electron precipitation inferred from coincident precipitation data and relate them to the EMIC wave frequency, wave power, and ion-band of the wave as measured in-situ by the Van Allen Probes. These observations will better constrain modeling into the importance of EMIC wave-particle interactions.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
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  • 7
    Publication Date: 2016-06-07
    Description: In response to the comment raised by Zhang et al (2016) we explore the differences in average velocity computed using slip and no-slip boundary conditions at the air water interface. We consider a porous medium in which the air phase acts to impede the movement of water rather than to lubricate it, a case closer to the observed distribution of water in our CT images. We find that, whilst the slip boundary condition may be a more accurate approximation, in cases where the air phase is seen to impede water movement the differences between the two approaches are negligible. This article is protected by copyright. All rights reserved.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
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  • 8
    Publication Date: 2015-06-21
    Description: We find that during a large geomagnetic storm in October 2011 the trapped fluxes of 〉30, 〉100, and 〉300 keV outer radiation belt electrons were enhanced at L=3-4 during the storm main phase. A gradual decay of the trapped fluxes was observed over the following 5–7 days, even though no significant precipitation fluxes could be observed in the Polar Orbiting Environmental Satellite (POES) electron precipitation detectors. We use the Antarctic-Arctic Radiation-belt (Dynamic) Deposition - VLF Atmospheric Research Konsortium (AARDDVARK) receiver network to investigate the characteristics of the electron precipitation throughout the storm period. Weak electron precipitation was observed on the dayside for 5–7 days, consistent with being driven by plasmaspheric hiss. Using a previously published plasmaspheric hiss-induced electron energy e-folding spectrum of E 0 =365 keV, the observed radiowave perturbation levels at L=3-4 were found to be caused by 〉30 keV electron precipitation with flux ~100 el. cm −2 s −1 sr −1 . The low levels of precipitation explain the lack of response of the POES telescopes to the flux, because of the effect of the POES lower sensitivity limit and ability to measure weak diffusion-driven precipitation. The detection of dayside, inner plasmasphere electron precipitation during the recovery phase of the storm is consistent with plasmaspheric hiss wave-particle interactions, and shows that the waves can be a significant influence on the evolution of the outer radiation belt trapped flux that resides inside the plasmapause.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
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  • 9
    Publication Date: 2016-06-12
    Description: Alcohol induced hepatic steatosis is a significant risk factor for progressive liver disease. Cyclic adenosine monophosphate (cAMP) signalling has been shown to significantly regulate lipid metabolism; however, the role of altered cAMP homeostasis in alcohol mediated hepatic steatosis has never been studied. Our previous work demonstrated that increased expression of hepatic phosphodiesterase 4 (Pde4), which specifically hydrolyses and decreases cAMP levels, plays a pathogenic role in the development of liver inflammation/injury. The aim of this study was to examine the role of PDE4 in alcohol-induced hepatic steatosis. C57BL/6 wild type and Pde4b knockout ( Pde4b −/− ) mice were pair-fed control or ethanol liquid diets. One group of wild type mice received rolipram, a PDE4 specific inhibitor, during alcohol feeding. We demonstrate for the first time that an early increase in PDE4 enzyme expression and a resultant decrease in hepatic cAMP levels are associated with the significant reduction in carnitine palmitoyltransferase 1A (Cpt1a) expression. Notably, alcohol fed (AF) Pde4b −/− mice and AF wild type mice treated with Rolipram had significantly lower hepatic free fatty acid content compared to AF wild type mice. Importantly, PDE4 inhibition in alcohol fed mice prevented the decrease in hepatic Cpt1a expression via the Pparα/Sirt1/Pgc1α pathway. These results demonstrate that the alcohol- induced increase in hepatic Pde4, specifically Pde4b expression, and compromised cAMP signalling predisposes the liver to impaired fatty acid oxidation and the development of steatosis. Moreover, these data also suggest that hepatic PDE4 may be a clinically relevant therapeutic target for the treatment of alcohol induced hepatic steatosis.
    Print ISSN: 0022-3417
    Electronic ISSN: 1096-9896
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 10
    Publication Date: 2016-05-08
    Description: We report ion velocity distribution functions (VDFs) observed by Magnetospheric Multiscale mission (MMS), and present evidence for demagnetized ion speiser motion during magnetopause reconnection. The demagnetization is observed in the vicinity of the X-line, as well as near the current sheet mid-plane about tens of ion skin depths (d i ) away from the X-line. Close to the X-line before the outflow is built up, the VDFs are elongated, and the elongated part of VDFs rotates from the out-of-plane current direction towards the outflow directions downstream from the X-line. Further downstream, demagnetized ions exhibit a characteristic half-ring structure in the VDFs, as a result of the mixture of ions that have experienced different amounts of cyclotron turning around the magnetic field normal to the current sheet. Signatures of acceleration by electric fields are more pronounced in the VDFs near the X line than downstream.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
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