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  • 1
    In: Journal of Clinical Medicine, MDPI AG, Vol. 8, No. 7 ( 2019-07-19), p. 1060-
    Abstract: The theranostic concept represents a paradigmatic example of personalized treatment. It is based on the use of radiolabeled compounds which can be applied for both diagnostic molecular imaging and subsequent treatment, using different radionuclides for labelling. Clinically relevant examples include somatostatin receptor (SSTR)-targeted imaging and therapy for the treatment of neuroendocrine tumors (NET), as well as prostate-specific membrane antigen (PSMA)-targeted imaging and therapy for the treatment of prostate cancer (PC). As such, both classes of radiotracers can be used to triage patients for theranostic endoradiotherapy using positron emission tomography (PET). While interpreting PSMA- or SSTR-targeted PET/computed tomography scans, the reader has to navigate certain pitfalls, including (I.) varying normal biodistribution between different PSMA- and SSTR-targeting PET radiotracers, (II.) varying radiotracer uptake in numerous kinds of both benign and malignant lesions, and (III.) resulting false-positive and false-negative findings. Thus, two novel reporting and data system (RADS) classifications for PSMA- and SSTR-targeted PET imaging (PSMA- and SSTR-RADS) have been recently introduced under the umbrella term molecular imaging reporting and data systems (MI-RADS). Notably, PSMA- and SSTR-RADS are structured in a reciprocal fashion, i.e., if the reader is familiar with one system, the other system can readily be applied. Learning objectives of the present case-based review are as follows: (I.) the theranostic concept for the treatment of NET and PC will be briefly introduced, (II.) the most common pitfalls on PSMA- and SSTR-targeted PET/CT will be identified, (III.) the novel framework system for theranostic radiotracers (MI-RADS) will be explained, applied to complex clinical cases and recent studies in the field will be highlighted. Finally, current treatment strategies based on MI-RADS will be proposed, which will demonstrate how such a generalizable framework system truly paves the way for clinically meaningful molecular imaging-guided treatment of either PC or NET. Thus, beyond an introduction of MI-RADS, the present review aims to provide an update of recently published studies which have further validated the concept of structured reporting systems in the field of theranostics.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2662592-1
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  • 2
    In: Coatings, MDPI AG, Vol. 9, No. 5 ( 2019-05-10), p. 313-
    Abstract: Magnetic properties of the sustainable Fe–Sn alloys are already known. However, there is lack of information in the field of Fe–Sn electrodeposition. In the present study, a novel Fe(III)–Sn(II) electrolyte with tartaric acid as a single complexing agent is introduced. The influence of the pH and the current density on the structural properties of the Fe–Sn deposit was studied. The stability of the electrolytes as a main attribute of sustainability was tested. The ferromagnetic phases Fe5Sn3 and Fe3Sn were electrodeposited for the first time, and it was found that the mechanism of the Fe–Sn deposition changes from normal to anomalous at a pH value 3.0 and a current density of approximately 30 mA/cm2. A possible reason for the anomalous deposition of Fe–Sn is the formation of Fe-hydroxides on the cathode surface. Two electrolyte stability windows exist: The first stability window is around a pH value of 1.8 where bimetallic Fe–Sn tartrate complexes were formed, and second one is around a pH value of 3.5 where most of the Sn ions were present in the form of [Sn(tart)2]2− and Fe in the form of [Fe(tart)] + complexes.
    Type of Medium: Online Resource
    ISSN: 2079-6412
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2662314-6
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  • 3
    In: Tomography, MDPI AG, Vol. 4, No. 4 ( 2018-12-01), p. 159-163
    Abstract: Even as medical data sets become more publicly accessible, most are restricted to specific medical conditions. Thus, data collection for machine learning approaches remains challenging, and synthetic data augmentation, such as generative adversarial networks (GAN), may overcome this hurdle. In the present quality control study, deep convolutional GAN (DCGAN)–based human brain magnetic resonance (MR) images were validated by blinded radiologists. In total, 96 T1-weighted brain images from 30 healthy individuals and 33 patients with cerebrovascular accident were included. A training data set was generated from the T1-weighted images and DCGAN was applied to generate additional artificial brain images. The likelihood that images were DCGAN-created versus acquired was evaluated by 5 radiologists (2 neuroradiologists [NRs], vs 3 non-neuroradiologists [NNRs] ) in a binary fashion to identify real vs created images. Images were selected randomly from the data set (variation of created images, 40%–60%). None of the investigated images was rated as unknown. Of the created images, the NRs rated 45% and 71% as real magnetic resonance imaging images (NNRs, 24%, 40%, and 44%). In contradistinction, 44% and 70% of the real images were rated as generated images by NRs (NNRs, 10%, 17%, and 27%). The accuracy for the NRs was 0.55 and 0.30 (NNRs, 0.83, 0.72, and 0.64). DCGAN-created brain MR images are similar enough to acquired MR images so as to be indistinguishable in some cases. Such an artificial intelligence algorithm may contribute to synthetic data augmentation for “data-hungry” technologies, such as supervised machine learning approaches, in various clinical applications.
    Type of Medium: Online Resource
    ISSN: 2379-139X
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2857000-5
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