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  • Hindawi Limited  (16)
  • 2015-2019  (16)
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  • Hindawi Limited  (16)
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  • 2015-2019  (16)
Jahr
  • 1
    Online-Ressource
    Online-Ressource
    Maximally Localized States and Quantum Corrections of Black Hole Thermodynamics in the Framework of a New Generalized Uncertainty Principle
    Hindawi Limited ; 2015
    In:  Advances in High Energy Physics Vol. 2015 ( 2015), p. 1-15
    Details
    In: Advances in High Energy Physics, Hindawi Limited, Vol. 2015 ( 2015), p. 1-15
    Kurzfassung: As a generalized uncertainty principle (GUP) leads to the effects of the minimal length of the order of the Planck scale and UV/IR mixing, some significant physical concepts and quantities are modified or corrected correspondingly. On the one hand, we derive the maximally localized states—the physical states displaying the minimal length uncertainty associated with a new GUP proposed in our previous work. On the other hand, in the framework of this new GUP we calculate quantum corrections to the thermodynamic quantities of the Schwardzschild black hole, such as the Hawking temperature, the entropy, and the heat capacity, and give a remnant mass of the black hole at the end of the evaporation process. Moreover, we compare our results with that obtained in the frameworks of several other GUPs. In particular, we observe a significant difference between the situations with and without the consideration of the UV/IR mixing effect in the quantum corrections to the evaporation rate and the decay time. That is, the decay time can greatly be prolonged in the former case, which implies that the quantum correction from the UV/IR mixing effect may give rise to a radical rather than a tiny influence to the Hawking radiation.
    Materialart: Online-Ressource
    ISSN: 1687-7357 , 1687-7365
    URL: Article
    DOI: 10.1155/2015/627264
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2015
    ZDB Id: 2389407-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
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    Sparse Antenna Array Design for MIMO Radar Using Multiobjective Differential Evolution
    Hindawi Limited ; 2016
    In:  International Journal of Antennas and Propagation Vol. 2016 ( 2016), p. 1-12
    Details
    In: International Journal of Antennas and Propagation, Hindawi Limited, Vol. 2016 ( 2016), p. 1-12
    Kurzfassung: A two-stage design approach is proposed to address the sparse antenna array design for multiple-input multiple-output radar. In the first stage, the cyclic algorithm (CA) is used to establish a covariance matrix that satisfies the beam pattern approximation for a full array. In the second stage, a sparse antenna array with a beam pattern is designed to approximate the desired beam pattern. This paper focuses on the second stage. The optimization problem for the sparse antenna array design aimed at beam pattern synthesis is formulated, where the peak side lobe (PSL) is weakly constrained by the mean squared error. To solve this optimization problem, the differential evolution (DE) algorithm with multistrategy is introduced and PSL suppression is treated as an inequality constraint. However, in doing so, a new multiobjective optimization problem is created. To address this new problem, a multiobjective differential evolution algorithm based on Pareto technique is proposed. Numerical examples are provided to demonstrate the advantages of the proposed approach over state-of-the-art methods, including DE and genetic algorithm.
    Materialart: Online-Ressource
    ISSN: 1687-5869 , 1687-5877
    URL: Article
    DOI: 10.1155/2016/1747843
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2016
    ZDB Id: 2397585-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Chinese Herbal Decoction Based on Syndrome Differentiation as Maintenance Therapy in Patients with Extensive-Stage Small-Cell Lung Cancer: An Exploratory and Small Prospective Cohort Study
    Hindawi Limited ; 2015
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2015 ( 2015), p. 1-12
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-12
    Kurzfassung: Objective . To investigate the treatment effect and treatment length of Chinese herbal decoction (CHD) as maintenance therapy on patients with extensive-stage small-cell lung cancer (ES-SCLC) and to reflect the real syndrome differentiation (Bian Zheng) practices of traditional Chinese medicine (TCM). Patients and Methods . Different CHDs were prescribed for each patient based on syndrome differentiation. The length of CHD treatment was divided into two phases for analyzing progression-free survival (PFS) and postprogression survival (PPS). Results . Three hundred and fifty-seven CHDs were prescribed based on syndrome differentiation during the study period. Median PFS was significantly longer in patients who received CHD 〉 3 months than patients who received CHD ≤3 months in the first phase (8.7 months versus 4.5 months; hazard ratio (HR), 0.52; 95% confidence interval (CI), 0.41–0.99; P = 0.0009 ). Median PPS was significantly longer in patients who received CHD 〉 7 months than patients who received CHD ≤7 months in the second phase (11.7 months versus 5.1 months; HR, 2.32; 95% CI, 1.90–2.74; P = 0.002 ). Conclusion . CHD could improve PFS and PPS, which are closely related to treatment time and deepness of response of first-line therapy. In addition, CHD could improve body function and keep patients in a relatively stable state.
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2015/601067
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2015
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Veronicastrum axillare Alleviates Ethanol-Induced Injury on Gastric Epithelial Cells via Downregulation of the NF-kB Signaling Pathway
    Hindawi Limited ; 2017
    In:  Gastroenterology Research and Practice Vol. 2017 ( 2017), p. 1-8
    Details
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
    Kurzfassung: We used human gastric epithelial cells (GES-1) line in an ethanol-induced cell damage model to study the protective effect of Veronicastrum axillare and its modulation to NF- κ B signal pathway. The goal was to probe the molecular mechanism of V. axillare decoction in the prevention of gastric ulcer and therefore provide guidance in the clinical application of V. axillare on treating injuries from chronic nephritis, pleural effusion, gastric ulcer, and other ailments. The effects of V. axillare -loaded serums on cell viability were detected by MTT assays. Enzyme-linked immunosorbent assay (ELISA) and Real-Time PCR methods were used to analyze the protein and mRNA expression of TNF- α , NF- κ B, I κ B α , and IKK β . The results showed that V. axillare -loaded serum partially reversed the damaging effects of ethanol and NF- κ B activator (phorbol-12-myristate-13-acetate: PMA) and increased cell viability. The protein and mRNA expressions of TNF- α , NF- κ B, I κ B α , and IKK β were significantly upregulated by ethanol and PMA while they were downregulated by V. axillare -loaded serum. In summary, V. axillare -loaded serum has significantly protective effect on GES-1 against ethanol-induced injury. The protective effect was likely linked to downregulation of TNF- α based NF- κ B signal pathway.
    Materialart: Online-Ressource
    ISSN: 1687-6121 , 1687-630X
    URL: Article
    DOI: 10.1155/2017/7395032
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2017
    ZDB Id: 2435460-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Electroacupuncture Treatment Alleviates the Remifentanil-Induced Hyperalgesia by Regulating the Activities of the Ventral Posterior Lateral Nucleus of the Thalamus Neurons in Rats
    Hindawi Limited ; 2018
    In:  Neural Plasticity Vol. 2018 ( 2018-11-11), p. 1-15
    Details
    In: Neural Plasticity, Hindawi Limited, Vol. 2018 ( 2018-11-11), p. 1-15
    Kurzfassung: Mechanisms underlying remifentanil- (RF-) induced hyperalgesia, a phenomenon that is generally named as opioid-induced hyperalgesia (OIH), still remain elusive. The ventral posterior lateral nucleus (VPL) of the thalamus, a key relay station for the transmission of nociceptive information to the cerebral cortex, is activated by RF infusion. Electroacupuncture (EA) is an effective method for the treatment of pain. This study aimed to explore the role of VPL in the development of OIH and the effect of EA treatment on OIH in rats. RF was administered to rats via the tail vein for OIH induction. Paw withdrawal threshold (PWT) in response to mechanical stimuli and paw withdrawal latency (PWL) to thermal stimulation were tested in rats for the assessment of mechanical allodynia and thermal hyperalgesia, respectively. Spontaneous neuronal activity and local field potential (LFP) in VPL were recorded in freely moving rats using the in vivo multichannel recording technique. EA at 2 Hz frequency (pulse width 0.6 ms, 1–3 mA) was applied to the bilateral acupoints “Zusanli” (ST.36) and “Sanyinjiao” (SP.6) in rats. The results showed that both the PWT and PWL were significantly decreased after RF infusion to rats. Meanwhile, both the spontaneous neuronal firing rate and the theta band oscillation in VPL LFP were increased on day 3 post-RF infusion, indicating that the VPL may promote the development of RF-induced hyperalgesia by regulating the pain-related cortical activity. Moreover, 2 Hz-EA reversed the RF-induced decrease both in PWT and PWL of rats and also abrogated the RF-induced augmentation of the spontaneous neuronal activity and the power spectral density (PSD) of the theta band oscillation in VPL LFP. These results suggested that 2 Hz-EA attenuates the remifentanil-induced hyperalgesia via reducing the excitability of VPL neurons and the low-frequency (theta band) oscillation in VPL LFP.
    Materialart: Online-Ressource
    ISSN: 2090-5904 , 1687-5443
    URL: Article
    DOI: 10.1155/2018/6109723
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2018
    ZDB Id: 2236872-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    The Leukocyte VCS Parameters Compared with Procalcitonin, Interleukin-6, and Soluble Hemoglobin Scavenger Receptor sCD163 for Prediction of Sepsis in Patients with Cirrhosis
    Hindawi Limited ; 2019
    In:  Disease Markers Vol. 2019 ( 2019-12-12), p. 1-10
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2019 ( 2019-12-12), p. 1-10
    Kurzfassung: Background . Patients with liver cirrhosis have a high risk of sepsis and a poor prognosis. Recently, a new standard for sepsis (Sepsis-3) has been proposed in the general population. The Coulter Lh 750 hematology analyzer can evaluate mean volume, conductivity, scatter, and distribution width of leukocyte. We tried to use Sepsis-3 criteria to study the diagnostic value of volume, conductivity, and scattering (VCS) parameters in sepsis and infection in patients with liver cirrhosis compared with traditional infection markers (PCT, IL-6, sCDl63). Methods . A blinded, cohort study was conducted in three different ED populations within three affiliated hospitals. A total of 249 patients with liver cirrhosis were enrolled in the study. According to the “Sepsis-3” consensus criteria, clinical history, and laboratory examination, the subjects were divided into sepsis ( n = 54 ), patients with infections ( n = 95 ), and patients without systemic infections ( n = 100 ). The blood samples of the patients were collected at the time of ED admission and were evaluated for the detection of sepsis. Results . The differences of MNV, MNS, MMV, MMS, MLV, NDW, and MDW in the three groups were statistically significant. In the diagnosis of sepsis in patients with liver cirrhosis, the sensitivity of combined detection of MMV and MDW was 88.89%; the specificity was 74%. This sensitivity was significantly better than the 83.3% achieved using 0.97 mg/L as the cutoff for sCD163. In the diagnosis of infection in cirrhosis, the sensitivity of combination of MNV and MMS was increased to 86.32%; the specificity was 92%. The sensitivity was the same as that achieved by using 0.31 ng/mL as the cutoff value of PCT, but the specificity increased. Conclusion . The leukocyte VCS parameter could be potential parameters for indicating sepsis and infection in patients with liver cirrhosis. The combined detection of MMV and MDW seemed to be helpful for the diagnosis of sepsis in these patients, and the combination of MNV and MMS could better indicate infection for them.
    Materialart: Online-Ressource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2019/1369798
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2033253-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    The Protective Effect of Salidroside on Hypoxia-Induced Corpus Cavernosum Smooth Muscle Cell Phenotypic Transformation
    Hindawi Limited ; 2017
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2017 ( 2017), p. 1-11
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
    Kurzfassung: Salidroside, a major active ingredient isolated from Rhodiola rosea , has a long application in Chinese medical history. It has widely demonstrated effects on fatigue, psychological stress, and depression and exhibits potential antihypoxia activity. Emerging evidence shows that hypoxia is an important independent risk factor for erectile dysfunction (ED). The aim of this study was to clarify the effect of salidroside on hypoxia-induced phenotypic transformation of corpus cavernosum smooth muscle cells (CCSMCs). Our results showed that salidroside decreased the hypoxia-induced expression of collagen and content of vimentin, a corpus cavernosum smooth muscle synthetic protein, in vitro. Simultaneously, salidroside increased expression of the CCSMC contractile proteins, α -smooth muscle actin ( α -SMA) and desmin. In vivo, similarly, the expressions of collagen and hypoxia-inducible factor-1 α were increased in bilateral cavernous neurectomy (BCN) rats while they were decreased in the salidroside group. Among the phenotypic proteins, α -SMA and desmin increased and vimentin decreased after treating BCN rats with salidroside compared with the BCN alone group. Overall, our results demonstrate that salidroside has the ability to oppose hypoxia and can inhibit the CCSMC phenotypic transformation induced by hypoxia. Salidroside may provide a new treatment method for ED.
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2017/3530281
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2017
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Transcatheter Aortic Valve Replacement in Patients with Aortic Stenosis Having Coronary Cusp Fusion versus Mixed Cusp Fusion Nonraphe Bicuspid Aortic Valve
    Hindawi Limited ; 2019
    In:  Journal of Interventional Cardiology Vol. 2019 ( 2019-11-03), p. 1-7
    Details
    In: Journal of Interventional Cardiology, Hindawi Limited, Vol. 2019 ( 2019-11-03), p. 1-7
    Kurzfassung: Objectives . We aimed to assess the procedural and clinical results of transcatheter aortic valve replacement (TAVR) for nonraphe bicuspid aortic stenosis (AS) with coronary vs mixed cusp fusion. Background . It remains unclear whether cusp fusion morphology affects TAVR outcomes in patients with nonraphe bicuspid AS. Methods . This retrospective study enrolled consecutive patients with severe symptomatic AS and type-0 bicuspid aortic valve, who underwent TAVR at our institution between 2012 and 2017. TAVR outcomes were defined based on the Valve Academic Research Consortium-2 recommendations. Results . Compared to patients with mixed cusp fusion (44/71), those with coronary cusp fusion (27/71) had a larger ellipticity index for the aortic annulus (21.9% ± 9.0% vs 15.6% ± 9.3%, p = 0.007 ) and increased left ventricular outflow tract obstruction (31.1% ± 9.4% vs 26.9% ± 7.5%, p = 0.04 ) but comparable rates of second valve implantation (15.9% vs 14.8%), mild paravalvular leakage (PVL, 38.5% vs 30.2%), permanent pacemaker implantation (PPM, 25.9% vs 15.9%), and 30-day mortality (7.4% vs 6.8%). Use of a first-generation transcatheter heart valve was associated with higher risk for mild PVL (odds ratio (OR) = 4.37; 95% confidence interval (95% CI) = 1.14–16.75; p = 0.03 ) but not PPM (OR = 0.77; 95% CI = 0.22–2.62; p = 0.67 ), whereas a larger oversizing ratio tended to be associated with a higher PPM rate (OR = 1.49; 95% CI = 0.46–4.86; p = 0.51 ) but lower incidence of mild PVL (OR = 0.51; 95% CI = 0.19–1.35; p = 0.17 ). Conclusions . In AS patients with type-0 bicuspid valves, cusp fusion morphology does not affect the procedural or clinical results of TAVR. Use of second-generation transcatheter heart valves may provide more favorable results in such patients. This trial is registered with NCT01683474 .
    Materialart: Online-Ressource
    ISSN: 0896-4327 , 1540-8183
    URL: Article
    DOI: 10.1155/2019/7348964
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2103585-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Identification of Key Candidate Proteins and Pathways Associated with Temozolomide Resistance in Glioblastoma Based on Subcellular Proteomics and Bioinformatical Analysis
    Hindawi Limited ; 2018
    In:  BioMed Research International Vol. 2018 ( 2018), p. 1-12
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2018 ( 2018), p. 1-12
    Kurzfassung: TMZ resistance remains one of the main reasons why treatment of glioblastoma (GBM) fails. In order to investigate the underlying proteins and pathways associated with TMZ resistance, we conducted a cytoplasmic proteome research of U87 cells treated with TMZ for 1 week, followed by differentially expressed proteins (DEPs) screening, KEGG pathway analysis, protein–protein interaction (PPI) network construction, and validation of key candidate proteins in TCGA dataset. A total of 161 DEPs including 65 upregulated proteins and 96 downregulated proteins were identified. Upregulated DEPs were mainly related to regulation in actin cytoskeleton, focal adhesion, and phagosome and PI3K-AKT signaling pathways which were consistent with our previous studies. Further, the most significant module consisted of 28 downregulated proteins that were filtered from the PPI network, and 9 proteins (DHX9, HNRNPR, RPL3, HNRNPA3, SF1, DDX5, EIF5B, BTF3, and RPL8) among them were identified as the key candidate proteins, which were significantly associated with prognosis of GBM patients and mainly involved in ribosome and spliceosome pathway. Taking the above into consideration, we firstly identified candidate proteins and pathways associated with TMZ resistance in GBM using proteomics and bioinformatic analysis, and these proteins could be potential biomarkers for prevention or prediction of TMZ resistance in the future.
    Materialart: Online-Ressource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2018/5238760
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2018
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    Radiosynthesis and Preliminary Biological Evaluation of 18 F-Fluoropropionyl-Chlorotoxin as a Potential PET Tracer for Glioma Imaging
    Hindawi Limited ; 2018
    In:  Contrast Media & Molecular Imaging Vol. 2018 ( 2018-12-20), p. 1-9
    Details
    In: Contrast Media & Molecular Imaging, Hindawi Limited, Vol. 2018 ( 2018-12-20), p. 1-9
    Kurzfassung: Purposes . Chlorotoxin can specifically bind to matrix metalloproteinase 2 (MMP-2), which are overexpressed in the glioma. In this work, radiosynthesis of [ 18 F]-fluoropropionyl-chlorotoxin ([ 18 F]-FP-chlorotoxin) as a novel PET tracer was investigated, and biodistribution in vivo and PET imaging were performed in the C6 glioma model. Procedures . [ 18 F]-FP-chlorotoxin was prepared from the reaction of chlorotoxin with [ 18 F]-NFB (4-nitrophenyl 2-[ 18 F]-fluoropropionate), which was synthesized from multistep reactions. Biodistribution was determined in 20 normal Kunming mice. Small-animal PET imaging with [ 18 F]-FP-chlorotoxin was performed on the same rats bearing orthotopic C6 glioma at different time points (60 min, 90 min, and 120 min) after injection and compared with 2-deoxy-2-[ 18 F] fluoro-D-glucose ([ 18 F]-FDG). Results . [ 18 F]-FP-Chlorotoxin was successfully synthesized in the radiochemical yield of 41% and the radiochemical purity of more than 98%. Among all the organs, the brain had the lowest and stable uptake of [ 18 F]-FP-chlorotoxin, while the kidney showed the highest uptake. Compared with [ 18 F]-FDG, a low uptake of [ 18 F]-FP-chlorotoxin was detected in normal brain parenchyma and a high accumulation of [ 18 F]-FP-chlorotoxin was found in the gliomas tissue. The glioma to normal brain uptake ratio of [ 18 F]-FP-chlorotoxin was higher than that of [ 18 F]-FDG. Furthermore, the uptake of [ 18 F]-FP-chlorotoxin at 90 min after injection was better than that at 60 min after injection. Conclusions . Compared with [ 18 F]-FDG, [ 18 F]-FP-chlorotoxin has a low and stable uptake in normal brain parenchyma. [ 18 F]-FP-Chlorotoxin seems to be a potential PET tracer with a good performance in diagnosis of the glioma.
    Materialart: Online-Ressource
    ISSN: 1555-4309 , 1555-4317
    URL: Article
    DOI: 10.1155/2018/8439162
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2018
    ZDB Id: 2222967-X
    Standort Signatur Einschränkungen Verfügbarkeit
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