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  • Hindawi Limited  (6)
  • 2015-2019  (6)
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  • Hindawi Limited  (6)
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  • 2015-2019  (6)
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  • 1
    Online Resource
    Online Resource
    AURKA rs8173 G〉C Polymorphism Decreases Wilms Tumor Risk in Chinese Children
    Hindawi Limited ; 2019
    In:  Journal of Oncology Vol. 2019 ( 2019-09-15), p. 1-7
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2019 ( 2019-09-15), p. 1-7
    Abstract: Wilms tumor is the most common type of renal malignancy in children. Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) in the AURKA gene could predispose to several human malignancies. We recruited 145 cases and 531 cancer-free controls to investigate whether AURKA gene variants modify Wilms tumor susceptibility. Three AURKA SNPs (rs1047972 C 〉 T, rs2273535 T 〉 A, and rs8173 G 〉 C) were genotyped by the Taqman methodology. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of association between AURKA SNPs and Wilms tumor risk. We found that only the rs8173 G 〉 C polymorphism was significantly associated with Wilms tumor risk (GC vs. GG: adjusted OR (AOR) = 0.50, 95% CI = 0.35–0.73, P = 0.0002 ; GC/CC vs. GG: AOR = 0.60, 95% CI = 0.42–0.88, P = 0.008 ). Stratification analysis revealed that rs8173 GC/CC genotypes were associated with Wilms tumor risk among children aged 〉 18 months (AOR = 0.56, 95% CI = 0.34–0.93, P = 0.024 ), male children (AOR = 0.54, 95% CI = 0.33–0.90, P = 0.017 ), and children with clinical stage III + IV diseases (AOR = 0.56, 95% CI = 0.35–0.90, P = 0.017 ). Haplotype analysis indicated that the CAG haplotype was significantly associated with increased Wilms tumor risk. In conclusion, our findings indicated that the AURKA rs8173 G 〉 C polymorphism was associated with decreased Wilms tumor risk in Chinese children.
    Type of Medium: Online Resource
    ISSN: 1687-8450 , 1687-8469
    URL: Article
    DOI: 10.1155/2019/9074908
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2461349-6
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  • 2
    Online Resource
    Online Resource
    miR-34b/c rs4938723 T〉C Decreases Neuroblastoma Risk: A Replication Study in the Hunan Children
    Hindawi Limited ; 2019
    In:  Disease Markers Vol. 2019 ( 2019-09-10), p. 1-6
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2019 ( 2019-09-10), p. 1-6
    Abstract: Neuroblastoma is the most common seen solid neural tumor in children less than age one. As mutation in the miR-34b/c gene is observed in several types of human malignancies, there likely to be similar events that contribute to the pathogenesis of neuroblastoma. We hypothesize that polymorphism in the miR-34b/c gene might predispose to neuroblastoma. Here, we conducted this replication study by genotyping rs4938723 T 〉 C from miR-34b/c in Hunan children (162 subjects with neuroblastoma and 270 control subjects) and examined its effect on the risk of neuroblastoma. We determined such association using logistic regression, adjusted for age and gender. Relative to those with TT genotype, subjects with C allele had reduced neuroblastoma risk (TC vs. TT: adjusted OR = 0.46 , 95 % CI = 0.30 ‐ 0.71 ; additive model: adjusted OR = 0.64 , 95 % CI = 0.47 ‐ 0.88 ; TC/CC vs. TT: adjusted OR = 0.49 , 95 % CI = 0.33 ‐ 0.73 ). Stratified analysis revealed that rs4938723 TC/CC carriers were less likely to develop neuroblastoma for patients in the subgroups of age ≤ 18   months , age 〉 18   months , females, males, tumors in retroperitoneal, tumors in other sites, and clinical stages II, III, IV, and III+IV. Our findings verified miR-34b/c rs4938723 C variant allele as a protective factor for the risk of neuroblastoma. Further investigation of how miR-34b/c rs4938723 T 〉 C might modify neuroblastoma risk is warranted.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2019/6514608
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2033253-1
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  • 3
    Online Resource
    Online Resource
    Nuclear diagnosis of the fuel areal density for direct-drive deuterium fuel implosion at the Shenguang-II Upgrade laser facility
    Hindawi Limited ; 2018
    In:  Laser and Particle Beams Vol. 36, No. 4 ( 2018-12), p. 494-501
    Details
    In: Laser and Particle Beams, Hindawi Limited, Vol. 36, No. 4 ( 2018-12), p. 494-501
    Abstract: In inertial confinement fusion experiments that involve short-laser pulses such as fast ignition (FI), diagnosis of neutrons is usually very challenging because high-intensity γ rays generated by short-laser pulses would mask the much weaker neutron signal. In this paper, fast-response scintillators with low afterglow and gated microchannel plate photomultiplier tubes are combined to build neutron time-of-flight (nTOF) spectrometers for such experiments. Direct-drive implosion experiments of deuterium-gas-filled capsules were performed at the Shenguang-II Upgrade (SG-II-UP) laser facility to study the compressed fuel areal density (〈ρ R 〉) and evaluate the performance of such nTOF diagnostics. Two newly developed quenched liquid scintillator detectors and a gated ultrafast plastic scintillator detector were used to measure the secondary DT neutrons and primary DD neutrons, respectively. The secondary neutron signals were clearly discriminated from the γ rays from (n, γ) reactions, and the compressed fuel areal density obtained with the yield-ratio method agrees well with the simulations. Additionally, a small scintillator decay tail and a clear DD neutron signal were observed in an integrated FI experiment as a result of the low afterglow of the oxygen-quenched liquid scintillator.
    Type of Medium: Online Resource
    ISSN: 0263-0346 , 1469-803X
    URL: Article
    DOI: 10.1017/S026303461800054X
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2021816-3
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  • 4
    Online Resource
    Online Resource
    APEX1 Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study
    Hindawi Limited ; 2019
    In:  Oxidative Medicine and Cellular Longevity Vol. 2019 ( 2019-06-25), p. 1-8
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2019 ( 2019-06-25), p. 1-8
    Abstract: Neuroblastoma is a life-threatening extracranial solid tumor, preferentially occurring in children. However, its etiology remains unclear. APEX1 is a critical gene in the base excision repair (BER) system responsible for maintaining genome stability. Given the potential effects of APEX1 polymorphisms on the ability of the DNA damage repair, many studies have investigated the association between these variants and susceptibility to several types of cancer but not neuroblastoma. Here, we conducted a three-center case-control study to evaluate the association between APEX1 polymorphisms (rs1130409 T 〉 G, rs1760944 T 〉 G, and rs3136817 T 〉 C) and neuroblastoma risk in Chinese children, consisting of 469 cases and 998 controls. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated to evaluate the associations. No significant association with neuroblastoma risk was found for the studied APEX1 polymorphisms in the single locus or combination analysis. Interestingly, stratified analysis showed that rs1130409 GG genotype significantly reduced the risk of tumor in males. Furthermore, we found that carriers with 1-3 protective genotypes had a lower neuroblastoma risk in the children older than18 months and male, when compared to those without protective genotypes. In summary, our data indicate that APEX1 gene polymorphisms may have a weak effect on neuroblastoma susceptibility. These findings should be further validated by well-designed studies with larger sample size.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2019/5736175
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2455981-7
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  • 5
    Online Resource
    Online Resource
    Study and Application of Roof Cutting Pressure Releasing Technology in Retracement Channel Roof of Halagou 12201 Working Face
    Hindawi Limited ; 2018
    In:  Mathematical Problems in Engineering Vol. 2018 ( 2018-11-12), p. 1-15
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2018 ( 2018-11-12), p. 1-15
    Abstract: The retracement channel roof cutting (RCRC) technology can change the overburden structure actively by cutting off the roof of channel along the direction of working face tendency and make use of the gangue collapsing from roof cutting range to fill the goaf and weaken the mining pressure during the retracement process of working face. In order to solve the problems of high stress in surrounding rock and serious deformation of retracement channel in Halagou coal mine, it is the first time that the pressure releasing test is carried out on the 12201 working face by the method of the directional presplitting roof cutting in retracement channel. First, according to statics theory and energy theory, the stress state of hydraulic support and roof deformation mechanism of retracement channel are analyzed. Then the roof cutting design of retracement channel is determined according to the geological conditions of 12201 working face, and the cutting effect is analyzed by numerical simulation. Finally, the field test is carried out on the 12201 working face to verify the effect of pressure releasing by roof cutting. The result shows that, with the roof cutting design including the roof cutting height being 8m and roof cutting angle being 45°, the roof subsidence of the 12201 working face retracement channel in Halagou mine is reduced to 132.5mm, and the hydraulic support resistance is maintained at 1361KN. And there is no hydraulic support crushed; the deformation of the retracement channel is also small; namely, the effect of roof cutting for pressure releasing is obvious.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2018/6568983
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 6
    Online Resource
    Online Resource
    Development of Drug Loaded Nanoparticles Binding to Hydroxyapatite Based on a Bisphosphonate Modified Nonionic Surfactant
    Hindawi Limited ; 2015
    In:  Journal of Nanomaterials Vol. 2015 ( 2015), p. 1-12
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2015 ( 2015), p. 1-12
    Abstract: This study aimed at development of drug loaded nanoparticles which could bind to hydroxyapatite (HA) to construct drug or growth factor releasing bone graft substitutes. To this end, the terminal hydroxyl group of a nonionic surfactant Brij 78 (polyoxyethylene (20) stearyl ether) was first modified with pamidronate (Pa). Using Pa-Brij 78 as both a surfactant and an affinity ligand to HA, three different Pa surface functionalized nanoparticles were prepared, named as solid lipid nanoparticles (Pa-SNPs), nanoemulsions (Pa-NEMs), and PLGA nanoparticles (Pa-PNPs). A model drug curcumin was successfully encapsulated in the three nanoparticles. The sizes of Pa-NEM and Pa-PNP were around 150 nm and the size of Pa-SNP was around 90 nm with polydispersity indexes (PDIs) less than 0.20. Drug encapsulation efficiencies of the three nanoparticles were all greater than 85%. Furthermore, the order of binding affinity of the nanoparticles to HA was Pa-PNP 〉 Pa-NEM = Pa-SNP . After lyophilization, the sizes of the three nanoparticles were increased about 0.5–2.0-fold but their binding affinities to HA were almost the same as the fresh prepared nanoparticles. In conclusion, a Pa-modified Brij 78 was synthesized and used for fabrication of a series of drug loaded nanoparticles to construct drug-eluting HA-based bone graft substitutes.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2015/393968
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2229480-6
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