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  • Hindawi Limited  (61)
  • 2015-2019  (61)
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  • Hindawi Limited  (61)
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  • 2015-2019  (61)
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  • 1
    Online Resource
    Online Resource
    Interval-Valued Hesitant Fuzzy Multiattribute Group Decision Making Based on Improved Hamacher Aggregation Operators and Continuous Entropy
    Hindawi Limited ; 2017
    In:  Mathematical Problems in Engineering Vol. 2017 ( 2017), p. 1-20
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2017 ( 2017), p. 1-20
    Abstract: Under the interval-valued hesitant fuzzy information environment, we investigate a multiattribute group decision making (MAGDM) method with continuous entropy weights and improved Hamacher information aggregation operators. Firstly, we introduce the axiomatic definition of entropy for interval-valued hesitant fuzzy elements (IVHFEs) and construct a continuous entropy formula on the basis of the continuous ordered weighted averaging (COWA) operator. Then, based on the Hamacher t -norm and t -conorm, the adjusted operational laws for IVHFEs are defined. In order to aggregate interval-valued hesitant fuzzy information, some new improved interval-valued hesitant fuzzy Hamacher aggregation operators are investigated, including the improved interval-valued hesitant fuzzy Hamacher ordered weighted averaging (I-IVHFHOWA) operator and the improved interval-valued hesitant fuzzy Hamacher ordered weighted geometric (I-IVHFHOWG) operator, the desirable properties of which are discussed. In addition, the relationship among these proposed operators is analyzed in detail. Applying the continuous entropy and the proposed operators, an approach to MAGDM is developed. Finally, a numerical example for emergency operating center (EOC) selection is provided, and comparative analyses with existing methods are performed to demonstrate that the proposed approach is both valid and practical to deal with group decision making problems.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2017/2931482
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 2
    Online Resource
    Online Resource
    Blood Glucose Fluctuations in Type 2 Diabetes Patients Treated with Multiple Daily Injections
    Hindawi Limited ; 2016
    In:  Journal of Diabetes Research Vol. 2016 ( 2016), p. 1-8
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Abstract: To compare blood glucose fluctuations in type 2 diabetes mellitus (T2DM) patients were treated using three procedures: insulin intensive therapy which is continuous subcutaneous insulin infusion (CSII), MDI3 (three injections daily), and MDI4 (four injections daily). T2DM patients were hospitalized and were randomly assigned to CSII, aspart 30-based MDI3, and glargine based MDI4. Treatments were maintained for 2-3 weeks after the glycaemic target was reached. After completing the baseline assessment, 6-day continuous glucose monitoring (CGM) was performed before and after completion of insulin treatment. Treatment with CSII provided a greater improvement of blood glucose fluctuations than MDI (MDI3 or MDI4) therapy either in newly diagnosed or in long-standing T2DM patients. In long-standing diabetes patients, the MDI4 treatment group had significantly greater improvement of mean amplitude glycemic excursion (MAGE) than the MDI3 treatment group. However, in patients with newly diagnosed diabetes, there were no significant differences in the improvement of MAGE between MDI3 and MDI4 groups. Glargine based MDI4 therapy provided better glucose fluctuations than aspart 30-based MDI3 therapy, especially in long-standing T2DM patients, if CSII therapy was not available.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2016/1028945
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2711897-6
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  • 3
    Online Resource
    Online Resource
    Influence of Acarbose on Plasma Glucose Fluctuations in Insulin-Treated Patients with Type 2 Diabetes: A Pilot Study
    Hindawi Limited ; 2015
    In:  International Journal of Endocrinology Vol. 2015 ( 2015), p. 1-5
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2015 ( 2015), p. 1-5
    Abstract: Background and Aims. To evaluate the effect of adding acarbose on glycemic excursions measured by continuous glucose monitoring system (CGMS) in patients with type 2 diabetes mellitus (T2DM) already on insulin therapy. Materials and Methods. This was an opened and unblended study. 134 patients with T2DM were recruited. After initial rapidly corrected hyperglycaemia by continuous subcutaneous insulin infusion (CSII) for 7 d, a 4–6-day premixed insulin titration period subsequently followed. Patients were then randomized 1 : 1 to acarbose plus insulin group or insulin therapy group for 2 weeks. CGMS was used to measure glucose fluctuations for at least 3 days after therapy cessation. Results . Patients in acarbose plus insulin group achieved a significant improvement of MAGE compared to that of insulin therapy only group ( 5.56 ± 2.16 versus 7.50 ± 3.28  mmol/L, P = 0.0 44 ), accompanied by a significant decrease in the incremental AUC of plasma glucose concentration above 10.0 mmol/L (0.5 [ 0.03 , 0.9 ] versus 0.85 [ 0.23,1.4 ]  mmol/L per day, P = 0.037 ). Conclusions . Add-on acarbose to insulin therapy further improves glucose fluctuation in patients with T2DM. This study was registered with ClinicalTrials.gov registration number ChiCTR-TRC-11001218 .
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2015/903524
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2502951-4
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  • 4
    Online Resource
    Online Resource
    Comparison of Efficacy and Safety of Lispro and Aspart Evaluated by Continuous Glucose Monitoring System in Patients with Newly Diagnosed Type 2 Diabetes
    Hindawi Limited ; 2018
    In:  International Journal of Endocrinology Vol. 2018 ( 2018), p. 1-7
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2018 ( 2018), p. 1-7
    Abstract: Objective . To compare the effect of the rapid-acting insulin analogues (RAIAs) aspart (NovoRapid) and lispro (Prandilin) on glycemic variations by continuous glucose monitoring system (CGMS) in patients within newly diagnosed type 2 diabetes mellitus (T2DM) receiving continuous subcutaneous insulin infusion (CSII) and metformin intensive therapy. Methods . This is a single-blind randomized controlled trial. A total of 110 patients with newly diagnosed T2DM and with hemoglobin A1c (HbA1c%) above 9% was hospitalized and randomly divided into two groups: group Asp (NovoRapid group) and group Lis (Prandilin group). They all received CSII and metformin therapy. Treatments were maintained for 2-3 weeks after the glycaemic target was reached. C-peptide and insulin and fructosamine were determined. CGMS was continuously applied for 4 days after reaching the glycemic target. Results . There were no significant differences in daily dosages of insulin, fasting plasma C-P and 2 h postprandial C-P and insulin, and fructosamine at the baseline and endpoint between the groups Asp and Lis. No significant differences were seen in the 24 h mean amplitude of glycemic excursions (MAGE), 24 h mean blood glucose (MBG), the standard deviation of the MBG (SDBG), fasting blood glucose, number of glycemic excursion (NGE), and the incidence of hypoglycemia between the two groups. Similarly, no significant differences were found in areas under the curve (AUC) of glucose above 10.0 mmol/L or the decremental area over the curve (AOC) of glucose below 3.9 mmol/L between the two groups. Conclusions . Lispro and aspart had the similar ability to control the glycemic variations in patients with newly diagnosed T2DM. This study was registered with ClinicalTrials.gov, number ChiCTR-IPR-17010338 .
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2018/2087960
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2502951-4
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  • 5
    Online Resource
    Online Resource
    Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men
    Hindawi Limited ; 2017
    In:  Journal of Diabetes Research Vol. 2017 ( 2017), p. 1-8
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
    Abstract: Objectives. We performed continuous glucose monitoring (CGM) to define the features of patients with newly diagnosed type 2 diabetes (T2D) before and after Continuous Subcutaneous Insulin Infusion (CSII) therapy. Methods. This was a retrospective analysis. Newly diagnosed T2D patients (106) were admitted from eight centers in China. They were divided into a younger patient group ( 〈 60 years) and an older patient group (≥60 years). Each group was further divided into male and female patients. CSII therapy was maintained for 3 weeks after the glycemic target was reached. CGM was performed 2 times before and after completion of insulin treatment. Results. CGM data showed the expected significant improvement of mean amplitude glycemic excursion (MAGE) with CSII therapy. The older patients had lower hourly glucose concentrations from 0200 to 0700 o’clock compared to the younger patients at baseline. Surprisingly, in the older patient group, the male patients had a potential risk of hypoglycemia after CSII therapy, especially during periods from 2300 to 2400 and 0400 to 0600. Conclusions. Our data suggested that older male patients with newly diagnosed T2D may have lower nocturnal glucose concentrations. This may potentially increase the risk of nocturnal hypoglycemia during CSII therapy. This study was registered with Chinese Clinical Trial Registry, number CliCTR-TRC-11001218 .
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2017/2740372
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2711897-6
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  • 6
    Online Resource
    Online Resource
    Influence of Dapagliflozin on Glycemic Variations in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
    Hindawi Limited ; 2016
    In:  Journal of Diabetes Research Vol. 2016 ( 2016), p. 1-6
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-6
    Abstract: Objectives . To observe changes in blood glycemic variations and oxidative stress level before and after dapagliflozin treatment in patients with newly diagnosed T2DM. Methods . This was a randomized, double-blind, placebo-controlled, phase 3 trial. A total of 28 patients with newly diagnosed T2DM with H b A 1 c levels of 7.5–10.5% were randomly selected to receive dapagliflozin or placebo treatment for 24 weeks. After baseline data were collected, we analyzed glycemic variations and plasma 8-iso PGF 2 α level at baseline and at the endpoint. Primary outcome was the changes of mean amplitude glycemic excursion (MAGE) within groups. Results . After 24-week dapagliflozin therapy, our data showed the significant improvement of MAGE with dapagliflozin therapy ( P = 0.010 ). Compared with control group, patients in dapagliflozin group exhibited reduction in 24-hour MBG ( P = 0.026 ) and lower mean plasma glucose concentrations, especially during periods from 2400 to 0200 and 1300 to 1800 ( P 〈 0.05 , resp.). In addition, plasma 8-iso PGF 2 α level was notably decreased in the treatment group compared to the control group ( P = 0.034 ). Conclusions. In conclusion, this study shows the ability of dapagliflozin to improve glycemic variations and associate with reduction of oxidative stress in patients with T2DM, which may benefit the cardiovascular system.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2016/5347262
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2711897-6
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  • 7
    Online Resource
    Online Resource
    New role of LRP5, associated with nonsyndromic autosomal-recessive hereditary hearing loss : XIA et al.
    Hindawi Limited ; 2017
    In:  Human Mutation Vol. 38, No. 10 ( 2017-10), p. 1421-1431
    Details
    In: Human Mutation, Hindawi Limited, Vol. 38, No. 10 ( 2017-10), p. 1421-1431
    Type of Medium: Online Resource
    ISSN: 1059-7794
    URL: Issue
    URL: Article
    DOI: 10.1002/humu.2017.38.issue-10
    DOI: 10.1002/humu.23285
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia
    Hindawi Limited ; 2018
    In:  Oxidative Medicine and Cellular Longevity Vol. 2018 ( 2018-12-18), p. 1-11
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2018 ( 2018-12-18), p. 1-11
    Abstract: Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood. Autophagy plays an important role in neuronal apoptosis induced by ischemia. However, whether autophagy is involved in neuron apoptosis induced by cardiac arrest has been less studied. This study found that TRPML1 participates in cerebral ischemic reperfusion injury. Primary neurons were isolated and treated with mucolipin synthetic agonist 1 (ML-SA1), as well as infected with the recombinant lentivirus TRPML1 overexpression vector in vitro . ML-SA1 was delivered intracerebroventricularly in transient global ischemia model. Protein expression levels were determined by western blot. Neurological deficit score and the infarct volume were analyzed for the detection of neuronal damage. We found that TRPML1 was significantly downregulated in vivo and in vitro ischemic reperfusion model. We also observed that TRPML1 overexpression or treatment with the ML-SA1 attenuated neuronal death in primary neurons and ameliorated neurological dysfunction in vivo. Our findings suggested that autophagy and apoptosis were activated after transient global ischemia. Administration of ML-SA1 before transient global ischemia ameliorated neurological dysfunction possibly through the promotion of autophagy and the inhibition of apoptosis.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2018/4612727
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2455981-7
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  • 9
    Online Resource
    Online Resource
    Ox-LDL Induces Dysfunction of Endothelial Progenitor Cells via Activation of NF- κ B
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: Dyslipidemia increases the risks for atherosclerosis in part by impairing endothelial integrity. Endothelial progenitor cells (EPCs) are thought to contribute to endothelial recovery after arterial injury. Oxidized low-density lipoprotein (ox-LDL) can induce EPC dysfunction, but the underlying mechanism is not well understood. Human EPCs were cultured in endothelial growth medium supplemented with VEGF (10 ng/mL) and bFGF (10 ng/mL). The cells were treated with ox-LDL (50  µ g/mL). EPC proliferation was assayed by using CCK8 kits. Expression and translocation of nuclear factor-kabba B (NF- κ B) were evaluated. The level of reactive oxygen species (ROS) in cells was measured using H2DCF-DA as a fluorescence probe. The activity of NADPH oxidase activity was determined by colorimetric assay. Ox-LDL significantly decreased the proliferation, migration, and adhesion capacity of EPCs, while significantly increased ROS production and NADPH oxidase expression. Ox-LDL induced NF- κ B P65 mRNA expression and translocation in EPCs. Thus ox-LDL can induce EPC dysfunction at least by increasing expression and translocation of NF- κ B P65 and NADPH oxidase activity, which represents a new mechanism of lipidemia-induced vascular injury.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/175291
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 10
    Online Resource
    Online Resource
    Real-time hybrid simulation of multi-story structures installed with tuned liquid damper : RTHS of Multi-story Structures Installed with TLD
    Hindawi Limited ; 2016
    In:  Structural Control and Health Monitoring Vol. 23, No. 7 ( 2016-07), p. 1015-1031
    Details
    In: Structural Control and Health Monitoring, Hindawi Limited, Vol. 23, No. 7 ( 2016-07), p. 1015-1031
    Type of Medium: Online Resource
    ISSN: 1545-2255
    URL: Issue
    URL: Article
    DOI: 10.1002/stc.v23.7
    DOI: 10.1002/stc.1822
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2146618-X
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