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  • Georg Thieme Verlag KG  (3)
  • 2015-2019  (3)
  • Medicine  (3)
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  • Georg Thieme Verlag KG  (3)
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  • 2015-2019  (3)
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  • Medicine  (3)
RVK
  • 1
    Online Resource
    Online Resource
    Nonalcoholic steatohepatitis (NASH) – current treatment recommendations and future developments
    Georg Thieme Verlag KG ; 2019
    In:  Zeitschrift für Gastroenterologie Vol. 57, No. 04 ( 2019-04), p. 508-517
    Details
    In: Zeitschrift für Gastroenterologie, Georg Thieme Verlag KG, Vol. 57, No. 04 ( 2019-04), p. 508-517
    Abstract: Nonalcoholic fatty liver disease (NAFLD) includes nonalcoholic fatty liver (NAFL), nonalcoholic steato hepatitis (NASH) and NASH cirrhosis. NAFLD is the leading cause of liver diseases in the Western world (Central Europe, United States). The NAFLD incidence increases because of increasing type 2 diabetes and obesity. This article reviews the scientific findings of epidemiology, diagnostic, and therapeutic management of NAFLD. Lifestyle modifications (low-caloric Mediterranean diet and exercise training) to reduce weight are a major factor in the treatment of NAFLD. Pharmacological therapies may be useful in patients with NASH and fibrosis as well as nonresponders to lifestyle modifications. Currently, however, no pharmacological substances are approved for the indication NASH.
    Type of Medium: Online Resource
    ISSN: 0044-2771 , 1439-7803
    URL: Article
    DOI: 10.1055/a-0784-8827
    RVK:
    XA 10000
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Nicht-alkoholische Fettlebererkrankung (NAFLD)
    Georg Thieme Verlag KG ; 2015
    In:  DMW - Deutsche Medizinische Wochenschrift Vol. 140, No. 14 ( 2015-7-16), p. 1051-1055
    Details
    In: DMW - Deutsche Medizinische Wochenschrift, Georg Thieme Verlag KG, Vol. 140, No. 14 ( 2015-7-16), p. 1051-1055
    Type of Medium: Online Resource
    ISSN: 0012-0472 , 1439-4413
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1055/s-005-29622
    DOI: 10.1055/s-00000011
    DOI: 10.1055/s-0041-102787
    RVK:
    XA 39100
    RVK:
    XA 10000
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2015
    detail.hit.zdb_id: 2035474-5
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    Online Resource
  • 3
    Online Resource
    Online Resource
    A 2-step fast-track elastometry service for advanced workup of nonalcoholic fatty liver disease (NAFLD) patients – single-center real-world experience of outpatient clinical practice
    Georg Thieme Verlag KG ; 2019
    In:  Zeitschrift für Gastroenterologie Vol. 57, No. 10 ( 2019-10), p. 1209-1217
    Details
    In: Zeitschrift für Gastroenterologie, Georg Thieme Verlag KG, Vol. 57, No. 10 ( 2019-10), p. 1209-1217
    Abstract: Introduction and aims Nonalcoholic fatty liver disease (NAFLD) is increasing globally with an estimated prevalence of approximately 25 %. Nonalcoholic steatohepatitis as the progressive disease entity often leads to fibrosis and end-stage disease. The magnitude of NAFLD patients are not diagnosed and have no access to further clinical assessment. Diagnostic pathways for individual risk evaluation fitting with available resources are of utmost importance in real-world clinical practice. Methods Retrospective analysis of 1346 anonymized outpatient datasets at Würzburg University Hospital, Germany. Transient elastography (TE) with controlled attenuation parameter and laboratory-based risk scores (NFS, FIB-4) were the main diagnostic workup tools for risk stratification. Results After preselection based on questionnaire information NAFLD still accounts for one-fifth of patients in the liver outpatient service. More than 80 % of NAFLD patients receive their first-time diagnosis in our unit. Laboratory-based risk scores and TE are valuable tools for second-step risk assessment as shown in our clinical data analysis. Moreover, 65 % of NAFLD patients use inpatient services for at least 1 day. The policy to perform liver biopsy in high-risk patients above the recommended threshold of 9.6 kPa if any clinical doubt exists regarding the diagnosis of cirrhosis leads to a histological down staging in almost 80 %. Conclusion Questionnaire-based referral from primary care followed by broadly available fast-track TE and eventually liver biopsy for selected patients is the standard practice in our unit. This approach represents a feasible model to handle the large gap between availability and clinical need for TE facilities.
    Type of Medium: Online Resource
    ISSN: 0044-2771 , 1439-7803
    URL: Article
    DOI: 10.1055/a-0981-6484
    RVK:
    XA 10000
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
    Location Call Number Limitation Availability
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    Online Resource
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