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  • ECO-Vector LLC  (3)
  • 2015-2019  (3)
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  • ECO-Vector LLC  (3)
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  • 2015-2019  (3)
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  • 1
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2015
    In:  Pediatrician (St. Petersburg) Vol. 6, No. 3 ( 2015-09-15), p. 104-111
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 6, No. 3 ( 2015-09-15), p. 104-111
    Abstract: The paper deals with redistribution of energetic and plastic resources in the organism during stress, acute phase response and diabetes mellitus. Assuming metabolic regulation is based upon balanced contradictory influences of diverse chemical signals (substrates, ions, autacoids, hormones, neurotransmitters, physiological autoantibodies) the peculiarities of insulin- and counter-insulin effects during acute and chronic adaptation under stress, acute phase response and diabetes mellitus have been discussed. The role of chronic stress and accompanying metabolic disorders has been accentuated as a basis for stress-associated diseases’ development. The role of outstanding Argentinean pathophysiologist Bernardo Alberto Houssay (1887-1971) is discussed. He had devoted himself to studies of pituitary bioregulators’ influence on insulin effects immediately after insulin discovery and had established in 1924 that pituitary removal is able to increase sensitivity to insulin in dogs, and developed “secondary diabetes mellitus” concept as a result of counter-insulin hormones’ excess (especially hormones of adenohypophysis and the adrenal glands (“steroid diabetes”). Bernardo Alberto Houssay was really the first to experimentally prove pituitary and adrenal bioregulators to oppose the insulin effects. Bernardo Alberto Houssay has been 46 times nominated for the Nobel prize for 17 years (1931 through 1947), and finally was awarded the Nobel prize in 1947 for achievements in Physiology and Medicine for disclosing the role of pituitary in carbohydrate metabolism (he was the first ever Nobel prize winner from Latin America). The paper discusses publications by B. A. Houssay, current development of his ideas, as well as historical and biographical information on his research and his scientific school of endocrinologists-pathophysiologists in the context of his epoch, on the background of history of Argentina [3 figs, bibliography: 34 refs].
    Type of Medium: Online Resource
    ISSN: 2587-6252 , 2079-7850
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2015
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  • 2
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2017
    In:  Bulletin of the Russian Military Medical Academy Vol. 19, No. 3 ( 2017-12-15), p. 3-14
    In: Bulletin of the Russian Military Medical Academy, ECO-Vector LLC, Vol. 19, No. 3 ( 2017-12-15), p. 3-14
    Abstract: The article written by the co-chairmen of the First St. Petersburg Congress on Autoimmunity "Bridge between East and West", held in St. Petersburg State University June 30-July 2, 2017 describes this event and gives an overview of the main lectures and discussions during the Congress. The latest data on the role of diet, adjuvants, vaccines, viruses and microbiome, on genetic factors, stress, smoking, lifestyle, drugs - in etiology, as well as the role of lymphocytes, macrophages, various autoantibodies, complement and cytokines - in the pathogenesis and diagnosis of autoimmune diseases were discussed. The congress discussed their comorbidity, ways of treatment and prevention, markers, methodology and contribution of serological tests in the diagnosis and classification of autoimmune diseases. Current data on physiological autoimmunity, as well as the early predictive role of autoantibodies were described. The participants performed philosophical discussions about immunological concepts, and organizational discussions of the standardization of diagnostics and the principles of working with large databases, as applied to this field. The programme included Clinical Pathophysiology все of various autoimmune rheumatologic, psycho-neurological, endocrine, cardiovascular, obstetric-gynecological and many other diseases. The authors conclude that the rapid formation of Autoimmunology as a new integral medical branch happens nowadays (9 figs, bibliography: 69 refs).
    Type of Medium: Online Resource
    ISSN: 2687-1424 , 1682-7392
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2017
    Location Call Number Limitation Availability
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  • 3
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2017
    In:  Pediatrician (St. Petersburg) Vol. 8, No. 4 ( 2017-08-15), p. 39-42
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 8, No. 4 ( 2017-08-15), p. 39-42
    Abstract: Today, autoimmune Hashimoto´s thyroiditis is the most common cause of hypothyroidism. Thyroid hormones are involved in almost all metabolic processes, their deficiency leads to disruption of metabolic processes in all organs and systems, which is the reason for the rich clinical picture and variety of symptoms of hypothyroidism. The deficiency of thyroid hormones also has a significant negative impact on a person's mental health, identifying a diverse clinical picture – from mild disorders to serious mental disorders. For hypothyroidism, such psycho-neurological changes as drowsiness, weakness, loss of interest in the surroundings, loss of memory and intelligence are also characteristic. Delirious and delirious-hallucinatory conditions are described, as well as anxious and depressive conditions. Hypothyroid psychoneurological disorders have recently become more common, and therefore their diagnosis and correction are becoming more urgent. Persons with hypothyroi dism often mistakenly go not to the endocrinologist, but to a psychiatrist and receive therapy, but psychotropic drugs and antidepressants in hypothyroidism don´t give the proper effect and even are contraindicated. Hypocalcemia is very often observed with Hashimoto´s thyroiditis, it can be explained by autoimmune parathyroiditis with a hypoparathyroid clinic, that is, with autoimmune thyroiditis, the function of parathyroid glands may be disrupted. The article presents the results of our own research. A group of patients with autoimmune thyroiditis and hypothyroidism was examined. Complaints, anamnesis and clinic of the disease, levels of TSH, thyroid hormones, total and ionized calcium, inorganic phosphorus, vitamin D3 were studied.
    Type of Medium: Online Resource
    ISSN: 2587-6252 , 2079-7850
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2017
    Location Call Number Limitation Availability
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