In:
mBio, American Society for Microbiology, Vol. 6, No. 3 ( 2015-07)
Kurzfassung:
Clostridium difficile is a leading cause of antibiotic-associated diarrhea and an important hospital pathogen. TcdA and TcdB are thought to be the primary virulence factors responsible for disease symptoms of C. difficile infections (CDI). However, the individual contributions of these toxins to disease remain contentious. Using three different animal models of infection, we show for the first time that TcdB alone causes severe damage to the gut, as well as systemic organ damage, suggesting that this toxin might be responsible for MODS, a serious but poorly understood complication of CDI. These findings provide important new insights into the host response to C. difficile during infection and should guide the rational development of urgently required nonantibiotic therapeutics for the treatment of CDI.
Materialart:
Online-Ressource
ISSN:
2161-2129
,
2150-7511
DOI:
10.1128/mBio.00551-15
Sprache:
Englisch
Verlag:
American Society for Microbiology
Publikationsdatum:
2015
ZDB Id:
2557172-2
Permalink