Publication Date:
2017-07-06
Description:
Recurrent and functional regulatory mutations in breast cancer Nature 547, 7661 (2017). doi:10.1038/nature22992 Authors: Esther Rheinbay, Prasanna Parasuraman, Jonna Grimsby, Grace Tiao, Jesse M. Engreitz, Jaegil Kim, Michael S. Lawrence, Amaro Taylor-Weiner, Sergio Rodriguez-Cuevas, Mara Rosenberg, Julian Hess, Chip Stewart, Yosef E. Maruvka, Petar Stojanov, Maria L. Cortes, Sara Seepo, Carrie Cibulskis, Adam Tracy, Trevor J. Pugh, Jesse Lee, Zongli Zheng, Leif W. Ellisen, A. John Iafrate, Jesse S. Boehm, Stacey B. Gabriel, Matthew Meyerson, Todd R. Golub, Jose Baselga, Alfredo Hidalgo-Miranda, Toshi Shioda, Andre Bernards, Eric S. Lander & Gad Getz Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By contrast, much less is known about cancer-causing mutations in non-coding regions. Here we perform deep sequencing in 360 primary
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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