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  • 1
    Publication Date: 2022-05-26
    Description: © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Ocean Modelling 121 (2018): 49-75, doi:10.1016/j.ocemod.2017.11.008.
    Description: Lagrangian analysis is a powerful way to analyse the output of ocean circulation models and other ocean velocity data such as from altimetry. In the Lagrangian approach, large sets of virtual particles are integrated within the three-dimensional, time-evolving velocity fields. Over several decades, a variety of tools and methods for this purpose have emerged. Here, we review the state of the art in the field of Lagrangian analysis of ocean velocity data, starting from a fundamental kinematic framework and with a focus on large-scale open ocean applications. Beyond the use of explicit velocity fields, we consider the influence of unresolved physics and dynamics on particle trajectories. We comprehensively list and discuss the tools currently available for tracking virtual particles. We then showcase some of the innovative applications of trajectory data, and conclude with some open questions and an outlook. The overall goal of this review paper is to reconcile some of the different techniques and methods in Lagrangian ocean analysis, while recognising the rich diversity of codes that have and continue to emerge, and the challenges of the coming age of petascale computing.
    Description: EvS has received funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (grant agreement No 715386). This research for PJW was supported as part of the Energy Exascale Earth System Model (E3SM) project, funded by the U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research. Funding for HFD was provided by Grant No. DE-SC0012457 from the US Department of Energy. PB acknowledges support for this work from NERC grant NE/R011567/1. SFG is supported by NERC National Capability funding through the Extended Ellett Line Programme.
    Keywords: Ocean circulation ; Lagrangian analysis ; Connectivity ; Particle tracking ; Future modelling
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Environmental science & technology 18 (1984), S. 362-364 
    ISSN: 1520-5851
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of natural products 45 (1982), S. 532-538 
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 26 (1978), S. 1253-1255 
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 117-119 (1931), S. 570-584 
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Werden Plexuszellen länger als wenige Minuten nach dem Tode in situ gelassen, so neigen sie zu einem vakuolären Zerfall mit Verlust des Bürstensaumes. 2. Werden Plexuszellen operativ in einer kombinierten Bulbokapnin-Äthernarkose gewonnen, so zeigen sie eine starke Schwellung, die schließlich auch auf den Kern übergreift, und eine Ansammlung von Fett. 3. Unsere Versuche bestätigen, daß die Weedsche Lösung in die Plexuszellen eindringt. 4. Ebenso bestätigen sie Askanazys Beobachtung, daß Eisen in die Plexuszellen eindringt, wenn Erytrocyten in den Liquor gelangen. Ob es sich bei diesen beiden Vorgängen um eine passive Infiltration oder um eine aktive Resorption handelt, wagen wir noch nicht zu entscheiden. 5. Es hat sich kein Anhaltspunkt dafür ergeben, daß Fette oder Lipoide vom Liquorraum aus in den Plexus dringen. 6. Es fand sich nach Einspritzung gewaschener Erytrocyten ebenso nach Einspritzung von Luft oder Trypanblau in den Liquor eine Reaktion der Plexusepithelien, die wahrscheinlich eine nicht spezifische Antwort dieser Zellen auf Entzündungsreize darstellt. Sie besteht in einer trüben Schwellung mit Vermehrung der Mitochondrien und des Golgi-Apparates und des intrazellulären Fettes. Bei den Versuchen mit Blutinjektion wurden die Veränderungen bis zu 12 Tagen nach der Injektion studiert. In dieser Zeit vermindert sich die Kernfärbbarkeit, während die übrige Zelle schon zur Norm zurückkehrt. Der operative Teil der Versuche wurde im Physiologischen Institut durchgeführt. Für die Erlaubnis hierzu sind wir Herrn Prof. R. Lim zu herzlichem Dank verpflichtet.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 1 (1984), S. 269-271 
    ISSN: 1573-904X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The in vitro antibacterial and anti-fungal activity of benz[g]isoquinoline-5,10-dione (1), benzo[g]quinoline-5, 10-dione (2), benzo[g]quinoline-5,6-dione (3), and anthraquinone (4) was determined using the agar well-diffusion assay. The minimum inhibitory concentrations (MIC's) of each of the active compounds (1–3) was determined using the two-fold serial dilution technique. Of the four compounds tested, benz[g]isoquinoline-5,10-dione exhibited the best overall activity against both bacteria and fungi. Particularly noteworthy was its significant antifungal activity which was comparable to the activity of the standard antifungal antibiotic amphotericin B.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2021-02-08
    Description: Highlights: • Lagrangian ocean analysis is a powerful way to analyse the output of ocean circulation models • We present a review of the Kinematic framework, available tools, and applications of Lagrangian ocean analysis • While there are unresolved questions, the framework is robust enough to be used widely in ocean modelling Abstract: Lagrangian analysis is a powerful way to analyse the output of ocean circulation models and other ocean velocity data such as from altimetry. In the Lagrangian approach, large sets of virtual particles are integrated within the three-dimensional, time-evolving velocity fields. Over several decades, a variety of tools and methods for this purpose have emerged. Here, we review the state of the art in the field of Lagrangian analysis of ocean velocity data, starting from a fundamental kinematic framework and with a focus on large-scale open ocean applications. Beyond the use of explicit velocity fields, we consider the influence of unresolved physics and dynamics on particle trajectories. We comprehensively list and discuss the tools currently available for tracking virtual particles. We then showcase some of the innovative applications of trajectory data, and conclude with some open questions and an outlook. The overall goal of this review paper is to reconcile some of the different techniques and methods in Lagrangian ocean analysis, while recognising the rich diversity of codes that have and continue to emerge, and the challenges of the coming age of petascale computing.
    Type: Article , PeerReviewed
    Format: text
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  • 8
    Publication Date: 2015-07-14
    Description: Patients suffering from eye floaters often resort to consulting more than one ophthalmologist. The purpose of this study, using the Health Belief Model (HBM), was to identify the factors that influence doctor-shopping behavior among patients with eye floaters. In this cross-sectional survey, 175 outpatients who presented floaters symptoms were enrolled. Data from 143 patients (77 first time visitors and 66 doctor-shoppers) who completed the questionnaire were analyzed. Descriptive and logistic regression analyses were performed. We found that women and non-myopia patients were significantly related with frequent attendance and doctor switching. Though the HBM has performed well in a number of health behaviors studies, but most of the conceptual constructors of HBM did not show significant differences between the first time visitors and true doctor-shoppers in this study. Motivation was the only significant category affecting doctor-shopping behavior of patients with eye floaters.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI Publishing
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  • 9
    Publication Date: 2015-07-02
    Description: Organic Letters DOI: 10.1021/acs.orglett.5b01674
    Print ISSN: 1523-7060
    Electronic ISSN: 1523-7052
    Topics: Chemistry and Pharmacology
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  • 10
    Publication Date: 2015-06-18
    Description: Manganese-enhanced MRI studies have proven to be useful in monitoring physiological activities associated with calcium ions (Ca 2+ ) due to the paramagnetic property of the manganese ion (Mn 2+ ), which makes it an excellent probe of Ca 2+ . In this study, we developed a method in which a Mn 2+ -enhanced T 1 -map MRI could enable the monitoring of Ca 2+ influx during the early stages of intestinal ischemia–reperfusion (I/R) injury. The Mn 2+ infusion protocol was optimized by obtaining dose-dependent and time-course wash-out curves using a Mn 2+ -enhanced T 1 -map MRI of rabbit abdomens following an intravenous infusion of 50 mmol/l MnCl 2 (5–10 nmol/g body weight (BW)). In the rabbit model of intestinal I/R injury, T 1 values were derived from the T 1 maps in the intestinal wall region and revealed a relationship between the dose of the infused MnCl 2 and the intestinal wall relaxation time. Significant Mn 2+ clearance was also observed over time in control animals after the infusion of Mn 2+ at a dose of 10 nmol/g BW. This technique was also shown to be sensitive enough to monitor variations in calcium ion homeostasis in vivo after small intestinal I/R injury. The T 1 values of the intestinal I/R group were significantly lower ( P  〈 0.05) than that of the control group at 5, 10, and 15 min after Mn 2+ infusion. Our data suggest that MnCl 2 has the potential to be an MRI contrast agent that can be effectively used to monitor changes in intracellular Ca 2+ homeostasis during the early stages of intestinal I/R injury. Copyright © 2015 John Wiley & Sons, Ltd. Manganese (Mn 2+ ) acts as an excellent probe of calcium ion (Ca 2+ ) influx for monitoring Ca 2+ -associated physiological activities in a Mn 2+ -enhanced MRI (MEMRI) study. In this study, we prospectively demonstrated that Mn 2+ -enhanced T 1 -map MRI has the sensitivity to monitor variations in Ca 2+ homeostasis in vivo directly related to Ca 2+ overload in the early stage of intestinal ischemia–reperfusion injury. MEMRI provides additional information in intestinal ischemia–reperfusion injury models used to monitor disease development.
    Print ISSN: 0952-3480
    Electronic ISSN: 1099-1492
    Topics: Medicine
    Published by Wiley-Blackwell
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