GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: Forschungsbericht ; Meer ; Radar ; Wellenausbreitung
    Type of Medium: Book
    Series Statement: FWG-Report ...
    Language: German
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Book
    Book
    Eckernförde : Wehrtechnische Dienststelle für Schiffe und Marinewaffen, Maritime Technologie und Forschung
    Keywords: Forschungsbericht ; Meereskunde ; Kommunikationstechnik ; Lasertechnologie ; Wellenausbreitung
    Type of Medium: Book
    Pages: 45 Seiten , Illustrationen, Diagramme
    ISBN: 9783938717059 , 393871705X
    Series Statement: Report / WTD 71, Bundeswehr Technical Center for Ships and Naval Weapons, Maritime Technology and Research 65
    DDC: 620
    Language: English
    Note: Literaturverzeichnis: Seite 43-45
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 13 (1996), S. 1815-1820 
    ISSN: 1573-904X
    Keywords: elastase inhibitor ; monocyclic β-lactam ; NMR ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The objective was to evaluate the degradation profile of the elastase inhibitor DMP 777 and lay the foundation for formulation development. Methods. The pKa was determined by potentiometric titration in mixed-aqueous solvents. The degradation kinetics were studied as a function of pH, buffer concentration, ionic strength, methanol concentration and temperature using a stability-indicating HPLC assay. The degradation products were identified by LC-MS, NMR, and by comparison with authentic samples. Results. The pKa for the protonated piperazine nitrogen was estimated to be 7.04. The pH-rate profile is described by specific acid-, water-, and specific base-catalyzed pathways. The pH of maximum stability is in the range of 4 to 4.5 where water is the principal catalyst in the reaction. Buffer catalysis, primary salt effects and medium effects were observed. The proposed mechanism for acid catalyzed degradation is the rarely observed AAL1 which involves alkyl-nitrogen heterolysis. The driving force for the reaction appears to lie in the stability of the benzylic carbocation. The proposed mechanism for base catalyzed degradation is BAC2 which involves β-lactam ring opening. The β-lactam ring of DMP 777, a monolactam, appears to be as reactive as that in benzylpenicillin in the k OH controlled region where a similar mechanism of hydrolysis should be operative. A contributing factor to this increased reactivity may lie in the reduced basicity of the β-lactam nitrogen making it a good leaving group. Conclusions. The degradation profile indicates that development of a solution dosage form of DMP 777 with adequate shelf-life stability at room temperature is feasible.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2017-09-07
    Description: IJGI, Vol. 6, Pages 281: Mapping Parallels between Outdoor Urban Environments and Indoor Manufacturing Environments ISPRS International Journal of Geo-Information doi: 10.3390/ijgi6090281 Authors: Stefan Schabus Johannes Scholz Thomas Lampoltshammer The concepts of “Smart Cities” and “Smart Manufacturing” are different data-driven domains, although both rely on intelligent information technology and data analysis. With the application of linked data and affordance-based approaches, both domains converge, paving the way for new and innovative viewpoints regarding the comparison of urban tasks with indoor manufacturing tasks. The present study builds on the work, who state that cities are scaled versions of each other, by extending this thesis towards indoor manufacturing environments. Based on their structure and complexity, these environments are considered to form ecosystems of their own, comparable to “small cities”. This conceptual idea is demonstrated by examining the process of human problem-solving in transportation situations from both perspectives (i.e., city-level and manufacturing-level). In particular, the authors model tasks of human operators that are used to support transportation processes in indoor manufacturing environments based on affordances and spatial-temporal data. This paper introduces the fundamentals of the transformation process of outdoor tasks and process planning activities to indoor environments, particularly to semiconductor manufacturing environments. The idea is to examine the mapping of outdoor tasks and applications to indoor environments, and vice-versa, based on an example focusing on the autonomous transportation of production assets in a manufacturing environment. The approach is based on a spatial graph database, populated with an indoor navigation ontology and instances of indoor and outdoor objects. The results indicate that human problem-solving strategies can be applied to indoor manufacturing environments to support decision-making in autonomous transportation tasks.
    Electronic ISSN: 2220-9964
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2016-11-16
    Description: Neovascular age-related macular degeneration (nvAMD) can cause severe vision loss among the elderly. Genetic risk factors for AMD include several variants related to the immune system and lipid metabolism. Obesity is a well-known predisposing factor for nvAMD but how this metabolic disorder modulates angiogenesis in the posterior eye segment was largely unknown. In this issue of EMBO Molecular Medicine , Andriessen et al ( ) show that high-fat diet-induced obesity causes dysbiosis in the gut that drives retinal inflammation and pathological angiogenesis in a mouse model of laser-induced choroidal neovascularization (CNV). Obesity predisposes the elderly to neovascular age-related macular degeneration. Andriessen et al ( ) show now in a mouse model of choroidal neovascularization that high-fat diet-induced obesity causes gut microbiota dysbiosis that drives retinal inflammation and pathological angiogenesis.
    Print ISSN: 1757-4676
    Electronic ISSN: 1757-4684
    Topics: Medicine
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...