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  • 1
    Electronic Resource
    Electronic Resource
    Präoperative Kurzzeitstrahlentherapie in der chirurgischen Therapie des Rectumcarcinoms Langzeitergebnisse einer prospektiv-randomisierten Studie (1998)
    Springer
    Der Chirurg 69 (1998), S. 759-765 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Colorectal carcinoma ; Operative procedure ; Preoperative radiotherapy ; Randomized trial ; Local recurrence. ; Schlüsselwörter: Colorectales Carcinom ; Operationsverfahren ; präoperative Strahlentherapie ; randomisierte Studie ; locoregionäres Rezidiv.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Zur Klärung der Frage, ob die präoperative Kurzzeitstrahlentherapie die lokale Tumorkontrolle und das Überleben von Patienten mit primär operablem Rectumcarcinom verbessern kann, wurde im Zeitraum von 1988 bis 1993 eine prospektiv randomisierte Studie durchgeführt. 93 Patienten mit histologisch gesichertem Rectumcarcinom wurden entweder primär operiert (n = 46) oder mit 5 × 3,3 Gy vorbestrahlt und unmittelbar danach operiert (n = 47). Bei entsprechender Indikation (T4, UICC-Stadium III, R1/R2-Resektion) erfolgte eine postoperative Strahlentherapie. Bezüglich des Operationsverfahrens (abdominoperineale Rectumamputation vs. anteriore Rectumresektion) ergab sich kein signifikanter Unterschied des 5-Jahres-Überlebens (p = 0,393). Bei R0-Resektionen (n = 77) fand sich bei vorbestrahlten Patienten im statistischen Trend eine bessere lokale Tumorkontrolle (p = 0,08). Die 5-Jahres-Überlebensrate wurde durch die Kurzzeitvorbestrahlung signifikant verbessert (p = 0,027). Die niedrig dosierte Vorbestrahlung ist keine unabhängige Variable bzgl. des Überlebens (p = 0,078) oder der lokalen Tumorkontrolle (p = 0,07). Entsprechend den Ergebnissen anderer Autoren ließ sich in der vorgestellten Arbeit die lokale Tumorkontrolle beim Rectumcarcinom durch die Kurzzeitvorbestrahlung verbessern, das 5-Jahres-Überleben ist in der vorbestrahlten Gruppe sogar statistisch signifikant verlängert.
    Notes: Summary. To ascertain whether preoperative short-term radiotherapy can improve local tumor control and the long-term survival of patients with operable rectal cancer, a prospective randomised trial was performed from 1988 to 1993. Ninety-three patients with rectal cancer were either directly treated with surgery (n = 46) or underwent preoperative radiotherapy with 5 × 3.3 Gy irradiation and operation within 48 h (n = 47). If indicated (T4, UICC stage III) patients also received postoperative irradiation. Comparison of the methods of operation (abdominoperineal amputation versus anterior resection) revealed no significant difference in 5-year survival rate (P = 0.393). Local control of R0-resected tumors was improved after preoperative irradiation (P = 0.08). The 5-year survival rate was significantly higher after preoperative short-term radiotherapy (P = 0.027). Preoperative radiotherapy is not an independent factor according to overall survival (P = 0.078) and local recurrence (P = 0.07). In agreement with the results of other authors the present study indicates improved local tumor control of rectal cancer after preoperative radiation therapy. The 5-year survival rate was significantly better after preoperative radiotherapy than after surgery alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050487
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  • 2
    Electronic Resource
    Electronic Resource
    Morphometry of the aging female rat urethra (1996)
    Springer
    International urogynecology journal 7 (1996), S. 30-36 
    Details
    ISSN: 1433-3023
    Keywords: Aging ; Incontinence ; Rat ; Smooth ; Sphincter ; Striated ; Urethra
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Muscles in the limbs change with age, but the aging process of urethral muscles is unknown. Therefore, we compared smooth and striated muscle content in the female rat urethra in young (12 month) and old (32 month) animals, using immunochemical techniques. All the striated skeletal fibers at both ages contain slow myosin. Urethral diameter does not change with age (young, 1.44±0.08 mm; old, 1.46±0.10 mm,n=5), nor does the external sphincter width (young, 0.088±0.016 mm; old, 0.080±0.017 mm,n=5). Neither smooth nor skeletal muscle volume in the urethra is changed with age (skeletal: young, 20.72±2.94%; old, 19.95±2.35%. Smooth: young, 22.26±2.98%; old, 26.75±2.35%,n=5). The external striated sphincter is separate and distinct from the pubococcygeal region of the levator ani muscle, but is closely apposed to another layer of longitudinally oriented fibers into the vaginal musculature. The morphometric analysis shows no difference in urethral architecture in aging female rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01895103
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  • 3
    Electronic Resource
    Electronic Resource
    Hyperfine structure of the resonance lines of53Cr and lifetimes of some excited states of the Cr I spectrum (1995)
    Springer
    The European physical journal 34 (1995), S. 87-90 
    Details
    ISSN: 1434-6079
    Keywords: 32.70.Fw ; 35.10.Fk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The hyperfine structure of the53Cr resonance linesa 7 S 3 ↔z 7 P 2,3,4 has been investigated by means of laser saturation spectroscopy. By comparison of the experimental signal curves with theoretically computed spectra the hitherto unknown sign of the magnetic hyperfine coupling constant in thea 7 S 3 ground state of53Cr could be determined unambigiously to be negative. Further the signs of the hfs coupling constants in thez 7 P states — so far only evaluated by theoretical reasoning — could be confirmed. Additionally the lifetimes of the statesz 7 P,z 5 P,f 7 D,z 5 F,e 7 D 5 andy 5 P 3 in the Cr I spectrum have been determined from the fluorescence decay after pulsed laser excitation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01439381
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  • 4
    Electronic Resource
    Electronic Resource
    COMBINATION OF ADAPTIVITY AND MESH SMOOTHING FOR THE FINITE ELEMENT ANALYSIS OF SHELLS WITH INTERSECTIONS (1997)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 2459-2474 
    Details
    ISSN: 0029-5981
    Keywords: adaptivity ; error computation ; shell structures ; linear finite element analysis ; mesh smoothing ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A compatible hierarchical adaptive scheme is proposed which allows to control both density and geometrical properties of meshes with four-node linear finite shell elements. The algorithm produces a sequence of meshes with two aims, nearly equal distribution of the local error in each element and a mesh with regular elements, thus internal element angles near 90° and length ratios of adjacent element sides near unity. This goal is achieved in an efficient manner imposing a combination of a local smoothing algorithm with the adaptive mesh generation.New created nodes are positioned on the real shell surface and shell boundaries which may be given e.g. by CAD data. Also the shell directors are determined from the normals on the real geometry. Shell intersections are detected automatically as common curves of two adjacent shell parts. As a shell continuum cannot be assumed for these intersections and thus simple standard adaptive schemes fail, shell intersections have to be treated in a way similar to shell boundaries. For some numerical examples the developed algorithms are demonstrated and the resulting meshes are shown. © 1997 by John Wiley & Sons, Ltd.
    Additional Material: 25 Ill.
    Type of Medium: Electronic Resource
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  • 5
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    Oxygen Isotopes in Marine Diatoms (Opal-A) (1996)
    In:  [Poster] In: Goldschmidt Conference 1996, 31.03.-04.04.1996, Heidelberg, Germany .
    Details
    Publication Date: 2019-02-05
    Type: Conference or Workshop Item , NonPeerReviewed
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  • 6
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    Acquisition of seismic refraction data within NFP20 (Switzerland) (1997)
    Birkhäuser
    In:  In: Deep Structure of the Swiss Alps: Results of NRP20. , ed. by Pfiffner, O. A. Birkhäuser, Basel, pp. 25-30.
    Details
    Publication Date: 2016-01-20
    Type: Book chapter , NonPeerReviewed
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  • 7
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    Methodological considerations of 3-D crustal structure modeling by 2-D seismic methods (1997)
    Birkhäuser
    In:  In: Deep Structure of the Swiss Alps. Results of NRP 20. , ed. by Pfiffner, O. A. Birkhäuser, Basel, pp. 31-38.
    Details
    Publication Date: 2016-04-11
    Description: Derivation and application to Central Alps of 3-D seismic crustal structure modeling by use of a large number of criss-crossing controlled-source seismology profiles.
    Type: Book chapter , NonPeerReviewed
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  • 8
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    Preclinical Methods in Radiobiology (2016)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2016-07-02
    Description: There is an urgent need to improve reproducibility and translatability of preclinical data to fully exploit opportunities for molecular therapeutics involving radiation and radiochemotherapy. For i n vitro research, the clonogenic assay remains the current state-of-the-art of preclinical assays, whereas newer moderate and high-throughput assays offer the potential for rapid initial screening. Studies of radiation response modification by molecularly targeted agents can be improved using more physiologic 3D culture models. Elucidating effects on the cancer stem cells (CSC, and CSC-like) and developing biomarkers for defining targets and measuring responses are also important. In vivo studies are necessary to confirm in vitro findings, further define mechanism of action, and address immunomodulation and treatment-induced modification of the microenvironment. Newer in vivo models include genetically engineered and patient-derived xenograft mouse models and spontaneously occurring cancers in domesticated animals. Selection of appropriate endpoints is important for in vivo studies; for example, regrowth delay measures bulk tumor killing, whereas local tumor control assesses effects on CSCs. The reliability of individual assays requires standardization of procedures and cross-laboratory validation. Radiation modifiers must be tested as part of clinical standard of care, which includes radiochemotherapy for most tumors. Radiation models are compatible with but also differ from those used for drug screening. Furthermore, the mechanism of a drug as a chemotherapeutic agent may be different from its interaction with radiation and/or radiochemotherapy. This provides an opportunity to expand the use of molecular-targeted agents. Clin Cancer Res; 22(13); 3138–47. ©2016 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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  • 9
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    Hypoxia and Cancer Stem Cells in HPV-Negative HNSCC (2016)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2016-06-02
    Description: Purpose: To investigate the impact of hypoxia-induced gene expression and cancer stem cell (CSC) marker expression on outcome of postoperative cisplatin-based radiochemotherapy (PORT-C) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Experimental Design: Expression of the CSC markers CD44, MET , and SLC3A2 , and hypoxia gene signatures were analyzed in the resected primary tumors using RT-PCR and nanoString technology in a multicenter retrospective cohort of 195 patients. CD44 protein expression was further analyzed in tissue microarrays. Primary endpoint was locoregional tumor control. Results: Univariate analysis showed that hypoxia-induced gene expression was significantly associated with a high risk of locoregional recurrence using the 15-gene signature ( P = 0.010) or the 26-gene signature ( P = 0.002). In multivariate analyses, in patients with HPV16 DNA–negative but not with HPV16 DNA–positive tumors the effect of hypoxia-induced genes on locoregional control was apparent (15-gene signature: HR 4.54, P = 0.006; 26-gene signature: HR 10.27, P = 0.024). Furthermore, MET, SLC3A2, CD44 , and CD44 protein showed an association with locoregional tumor control in multivariate analyses ( MET : HR 3.71, P = 0.016; SLC3A2 : HR 8.54, P = 0.037; CD44 : HR 3.36, P = 0.054; CD44 protein n/a because of no event in the CD44-negative group) in the HPV16 DNA–negative subgroup. Conclusions: We have shown for the first time that high hypoxia-induced gene expression and high CSC marker expression levels correlate with tumor recurrence after PORT-C in patients with HPV16 DNA–negative HNSCC. After validation in a currently ongoing prospective trial, these parameters may help to further stratify patients for individualized treatment de-escalation or intensification strategies. Clin Cancer Res; 22(11); 2639–49. ©2016 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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  • 10
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    Surgical staging and prognosis in serous borderline ovarian tumours (BOT): A subanalysis of the AGO ROBOT study (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-02-19
    Description: Surgical staging and prognosis in serous borderline ovarian tumours (BOT): A subanalysis of the AGO ROBOT study British Journal of Cancer 112, 660 (17 February 2015). doi:10.1038/bjc.2014.648 Authors: F Trillsch, S Mahner, E Vettorazzi, L Woelber, A Reuss, K Baumann, M-D Keyver-Paik, U Canzler, K Wollschlaeger, D Forner, J Pfisterer, W Schroeder, K Muenstedt, B Richter, C Fotopoulou, B Schmalfeldt, A Burges, N Ewald-Riegler, N de Gregorio, F Hilpert, T Fehm, W Meier, P Hillemanns, L Hanker, A Hasenburg, H-G Strauss, M Hellriegel, P Wimberger, S Kommoss, F Kommoss, S Hauptmann & A du Bois
    Keywords: borderline ovarian tumourprognostic factorsstaging proceduresomentectomyperitoneal biopsiescytology
    Print ISSN: 0007-0920
    Electronic ISSN: 1532-1827
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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