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  • Springer  (70)
  • Blackwell Science Inc  (2)
  • 2015-2019
  • 2000-2004  (16)
  • 1985-1989  (43)
  • 1960-1964  (13)
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Keywords
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Primary aldosteronism by carcinoma of the adrenal cortex (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 428-432 
    Details
    ISSN: 1432-1440
    Keywords: Rare cause of primary aldosteronism ; Hypokalemic hypertension ; Diagnostic procedure ; Treatment of malignant adrenal disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 58-year-old white woman with hypertension and severe hypokalemia was found to have a carcinoma of the left adrenal gland. Plasma renin activity was constantly under the normal limit, while plasma aldosterone levels were pathologically elevated. Plasma cortisol (8:00 a.m.) and excretion rates of urinary free cortisol were within the normal range. After an adrenalectomy, relapsing excessive aldosterone secretion was successfully treated with opDDD (Lysodrene). Ten months after the diagnosis was established, the patient died from a bleeding liver metastasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715766
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  • 2
    Electronic Resource
    Electronic Resource
    Minoxidil and captopril in severe hypertension (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 327-332 
    Details
    ISSN: 1432-1440
    Keywords: Severe hypertension ; Minoxidil ; Captopril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antihypertensive efficacy of minoxidil and captopril was compared in 23 males with essential or renal parenchymatous hypertension refractory to conventional antihypertensive drug therapy. Following a pretreatment period the patients were randomly assigned to receive either minoxidil, 2.5 mg twice daily (n=12), or captopril, 25 mg twice daily (n=11). In patients with diastolic blood pressure 〉95 mmHg, doses of minoxidil and captopril were increased in 2-week intervals. Patients who maintained diastolic pressure 〉95 mmHg and/or those with intolerable side effects were switched over to the alternative substance. After a mean observation period of 12 weeks a significant decrease in systolic and diastolic blood pressure was observed (179/114 vs 148/92 mmHg in the minoxidil group; 176/111 vs 158/97 mmHg in the captopril group). The primary response rate was 75% in patients treated with minoxidil and 55% in those with captopril (not significant). After the change to the alternative substance two of the four non-responders on captopril and one of the two non-responders on minoxidil became responders. Side effects occurred significantly more often during minoxidil than captopril (p〈0.05). The high efficacy of minoxidil and captopril in the treatment of severe hypertension refractory to conventional drugs was confirmed. Minoxidil lowered blood pressure slightly more than captopril, but it had a higher incidence of side effects than captopril.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711952
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  • 3
    Electronic Resource
    Electronic Resource
    Captopril before and after spironolactone therapy in primary aldosteronism (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 361-363 
    Details
    ISSN: 1432-1440
    Keywords: Primary aldosteronism ; Captopril ; Spironolactone ; Renin-angiotensin ; Converting-enzyme ; Secondary hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In three patients with primary aldosteronism, the acute effect of a single dose of captopril on the elevated mean arterial blood pressure (MAP) was studied before and after 4 weeks of treatment with spironolactone. Before spironolactone therapy, captopril did not cause any drop in MAP. Four weeks later, after an oral daily dose of 400 mg spironolactone, MAP was still elevated in all three patients, though electrolyte abnormalities were fully corrected. Since plasma renin activity (PRA) was increased to values above the normal range, the acute effect of captopril on MAP was tested again. A single dose of 25 mg captopril then caused a fall in MAP to normal. These data reveal the conversion from a renin-independent to a renindependent kind of hypertension after spironolactone therapy in three patients with primary aldosteronism syndrome. This might be of pathogenetic and therapeutic interest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731655
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  • 4
    Electronic Resource
    Electronic Resource
    Atenolol versus pindolol: Side-effects in hypertension (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 89-91 
    Details
    ISSN: 1432-1041
    Keywords: atenolol ; pindolol ; sleep disturbance ; β-blockers ; dreaming ; fatigue ; hypertension ; lipophilicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary This randomized crossover out-patient study was designed to compare the antihypertensive effects of atenolol and pindolol. After a wash-out period of two weeks in pretreated cases, 107 patients with essential hypertension were given either atenolol 100 mg once-daily or pindolol 20 mg slow release (SR) once-daily. Both atenolol and pindolol lowered blood pressure over the 24 week period. The diastolic blood pressure reduction was significantly greater (p〈0.01) with atenolol than with pindolol. Before β-blocker therapy, many patients had already experienced side-effects such as fatigue, sleep disturbances and dreams. This probably relates to the high sensitivity of the analogue scale used to assess side-effects, and to the high incidence of such symptoms in untreated patients. As the study progressed there was a reduction in the frequency of fatigue (p〈0.03) and dreams (p〈0.05) in both groups, whereas sleep disturbances significantly increased under pindolol (p〈0.05) but decreased under atenolol (p〈0.05). The only important side-effect difference between the two β-blockers was the higher incidence of sleep disturbances with pindolol which may be due to the higher lipophilicity of this β-blocker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543717
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  • 5
    Electronic Resource
    Electronic Resource
    Long-Term Effectiveness of Operative Procedures for Stanford Type A Aortic Dissections (2004)
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 19 (2004), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Background: The object was to evaluate the long-term effectiveness of strategies for managing the aortic root and distal aorta in type A dissections. Methods: From 1990 to 1999, 50 patients (32 men (64.07%); 18 women, (36.0%); mean age 57.4 ± 11.1 years) underwent operation for ascending aortic dissection. Surgical strategies included aortic root replacement with a composite graft (21/50; 42.0%), valve replacement with supracoronary ascending aortic graft (3/50, 6%), and valve preservation or repair (26/50; 52.0%). Results: Overall hospital mortality rate was 18.0%. Follow-up was completed for 47 patients (94.0%) and ranged from 1 month to 10.5 years (mean 28.8 months). Actuarial survival for patients discharged from the hospital was 84% at 1 year, 75% at 5 years, and 66% at 10 years. There was no significant difference between the various procedures regarding mortality, neurological complications, long-term survival, and proximal reoperations. The ascending aorta alone was replaced in 8 of 50 patients (16%), ascending and hemiarch in 30 of 50 patients (60%), and arch and proximal descending aorta in 12 of 50 patients (24%). Hospital mortality (11.5%, 20.0%, and 16.7%, respectively; p 〉 0.05) and 5- and 10-year survival (p 〉 0.05) were not statistically dependent on the extension of the resection distally. Residual distal dissection was not associated with a decrease in late survival. With regard to emergency surgery (36/50) there was no significant difference in hospital mortality (p 〉 0.05) and 5-year survival (p 〉 0.05) between those who had undergone coronary angiography (19/36; 52.8%) on the day of surgery with those who had not (17/36; 47.2%). Conclusions: Preservation or repair of the aortic valve can be recommended in the majority of patients with type A dissection. Distal extension of the resection does not increase surgical risk. Residual distal dissection does not decrease late survival. Preoperative coronary angiography may not affect survival in patients undergoing emergency surgery. (J Card Surg 2004;19:240-245)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0886-0440.2004.04062.x
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  • 6
    Electronic Resource
    Electronic Resource
    The Edwards MIRA™ Heart Valve Prosthesis: (2004)
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 19 (2004), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Background: The Edwards MIRA™ mechanical heart valve is designed to optimize hemodynamics, reduce thrombogenicity, and avoid mechanical failure with a special hinge mechanism. The purpose of the study was to investigate the clinical performance and postoperative hemodynamic results of the first European patients receiving Edwards MIRA™ mechanical heart valves. Methods: From March 1998 to March 1999 a total of 54 Edwards MIRA™ valves model numbers 3600 (aortic, n = 44) and 9600 (mitral, n = 10) were implanted in 52 (36 male, 16 female; mean age 61 ± 10.1 years) consecutive patients undergoing mechanical valve replacement in a prospective study. Follow-up of the patients including physical examination, ECG, blood tests, and Doppler were performed prior to discharge, at 6 months, at 1 year, and at least 2 years postoperatively. Results: Through October 2001 a total of 172 follow-up examinations were completed (51 patients at discharge, 46 patients at 6 months, 43 patients at 12 months, 32 patients at 2 years or beyond). All patients were in NYHA class I and II at the 6-month and 2+-year follow-up. All the patients stated an improved quality of life. Hospital mortality was 1.9%. There were no complications related to anticoagulation. Mean international normalized ratio at 6 months was 3.2 (range 1.9 to 4.3); lactate dehydrogenase was slightly increased with 264 ± 103 U/L on average (normal value 80 to 240 U/L). No signs of valvular dysfunction or paravalvular leakage were observed. Mean pressure gradients were related to valve diameter: after mitral valve replacement (size 27, 29, 31 mm: 4.8, 3.2, 2.1 mmHg); after aortic valve replacement (size 19, 21, 23, 25 mm: 12.1, 13.1, 9.3, 8.2 mmHg). Conclusions: These preliminary data suggest good hemodynamic function and a low rate of valve-related complications of the Edwards-MIRA™ mechanical prosthesis. (J Card Surg 2004;19:226-231)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0886-0440.2004.04060.x
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  • 7
    Electronic Resource
    Electronic Resource
    Trypsin inhibitor activity of basidiomycetous mushrooms (2000)
    Springer
    European food research and technology 211 (2000), S. 346-348 
    Details
    ISSN: 1438-2385
    Keywords: Key wordsCraterellus ; Gomphidius ; Higher fungi ; Hydnum ; Hygrophorus, Laccaria ; Trypsin inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Laccaria and Hygrophorus species, Craterellus cornucopioides, Gomphidius glutinosus, Macrolepiota rhacodes and Hydnum repandum. The inhibiting activities found were higher than those of cereals but lower than those of some fabaceous plants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002170000180
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  • 8
    Electronic Resource
    Electronic Resource
    Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin (1987)
    Springer
    Journal of neural transmission 70 (1987), S. 383-398 
    Details
    ISSN: 1435-1463
    Keywords: diazepam ; N-desmethyldiazepam ; endogenous benzodiazepine receptor ligand
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Benzodiazepine-binding inhibitory (BBI) activity was detected in aqueous extracts of brain and peripheral tissues of rats. The BBI activity in brain and in adrenals was, at least partially, due to the presence of N-des-methyldiazepam and diazepam as shown by HPLC, UV-spectroscopy and mass spectrometry. In addition, BBI activity was found in standardized rat food, as well as in a variety of cereals and in other nutritive plant products. In wheat grains diazepam and N-desmethyldiazepam could be identified by HPLC and analysis by gas chromatography combined with mass spectrometry. The estimated amounts of the two benzodiazepines present in rat brain and adrenals and in wheat grains were in the low ppb range. Since laboratory contamination was rigorously excluded we conclude that diazepam and N-desmethyldiazepam are naturally occurring compounds. These findings may explain their occurrence in the brain and adrenals of animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01253613
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  • 9
    Electronic Resource
    Electronic Resource
    In vivo effects of anticonvulsant drugs on nerve terminal (synaptosomal) GABA levels in 11 brain regions of the rat (1985)
    Springer
    Journal of neural transmission 63 (1985), S. 157-167 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thein vivo effects of two GABA-elevating drugs with anticonvulsant properties, namely valproic acid (VPA) and aminooxyacetic acid (AOAA), on nerve terminal GABA levels in discrete rat brain regions were studied by means of a newly developed synaptosomal model. The profile of synaptosomal GABA increases obtained with AOAA was quite different from that seen with VPA. Thus, AOAA (30 mg/kg i.p., 2 hours) caused significant increases in olfactory bulb, cortex, hippocampus, thalamus and cerebellum, whereas VPA (200 mg/kg i.p., 0.5 hour) significantly increased GABA also in hypothalamus, substantia nigra and superior and inferior colliculus. In contrast to the regional selectivity of both drugs with respect to synaptosomal GABA levels, AOAA in most regions was more potent than VPA in increasing whole tissue GABA levels determined prior to subcellular fractionation. The data thus demonstrate that comparison of GABA levels in synaptosomal fractions rather than homogenates from discrete brain areas provides a more sensitive index of the action of GABA-elevating drugs administeredin vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01252615
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  • 10
    Electronic Resource
    Electronic Resource
    Vergleichende Untersuchung des Mineralstoffgehaltes der GattungenAgaricus (Champignon) undPleurotus (Austernseitling) (1989)
    Springer
    European food research and technology 189 (1989), S. 346-350 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Description / Table of Contents: Zusammenfassung Die vergleichende Untersuchung der chemischen Zusammensetzung von Champignon-(Agaricus) und Austernseitling- (Pleurotus) Arten bzw. von ihren gezüchteten Sorten erfolgte hinsichtlich 23 mineralischer Elemente. Aufgrund des Vergleiches der erzielten Ergebnisse konnte festgestellt werden: DieAgaricus-Arten erwiesen sich mit Ausnahme des gezüchteten Champignons als bedeutende Arsenakkumulatoren, worüber das Schrifttum kaum etwas berichtet, während dies bei denPleurotus-Arten kaum vorkommt. Eine bedeutende Bioakkumulation zeigte die GattungAgaricus hinsichtlich des Cadmiums, mit Ausnahme der ArtenA. xanthoderma undA. bisporus. Eine beachtenswerte Kupferakkumulationsfähigkeit konnte beiAgaricus-Arten (25–260 mg/kg) gegenüber dem Mittelwert von 12,6 mg/kg beiPleurotus festgestellt werden. Die Champignons sind durch einen höheren Kalium- und Phosphorgehalt gekennzeichnet, was aus ernährungsphysiologischer Sicht vorteilhaft ist.
    Notes: Summary Twenty-three mineral elements were investigated for their presence in someAgaricus andPleurotus species and their cultivated sorts. On the basis of the results, the following conclusions can be made. TheAgaricus species have remarkable accumulations of arsenic that are seldom reported in the literature (except forA. bisporus); this phenomenon could not be demonstrated in thePleurotus species. A remarkable accumulation of cadmium was found in theAgaricus species (except forA. bisporus andA. xanthoderma). A accumulation of copper was measured in theAgaricus fruit bodies (25–260 mg/kg), while the average copper level in thePleurotus species was 12.6 mg/kg. Only theAgaricus species can be characterized by an increased potassium and phosphorus content and this is advantageous from the point of view of nutritional-physiology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01683212
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