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  • 1
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    Lagrangian ocean analysis : fundamentals and practices (2018)
    Elsevier
    Details
    Publication Date: 2022-05-26
    Description: © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Ocean Modelling 121 (2018): 49-75, doi:10.1016/j.ocemod.2017.11.008.
    Description: Lagrangian analysis is a powerful way to analyse the output of ocean circulation models and other ocean velocity data such as from altimetry. In the Lagrangian approach, large sets of virtual particles are integrated within the three-dimensional, time-evolving velocity fields. Over several decades, a variety of tools and methods for this purpose have emerged. Here, we review the state of the art in the field of Lagrangian analysis of ocean velocity data, starting from a fundamental kinematic framework and with a focus on large-scale open ocean applications. Beyond the use of explicit velocity fields, we consider the influence of unresolved physics and dynamics on particle trajectories. We comprehensively list and discuss the tools currently available for tracking virtual particles. We then showcase some of the innovative applications of trajectory data, and conclude with some open questions and an outlook. The overall goal of this review paper is to reconcile some of the different techniques and methods in Lagrangian ocean analysis, while recognising the rich diversity of codes that have and continue to emerge, and the challenges of the coming age of petascale computing.
    Description: EvS has received funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (grant agreement No 715386). This research for PJW was supported as part of the Energy Exascale Earth System Model (E3SM) project, funded by the U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research. Funding for HFD was provided by Grant No. DE-SC0012457 from the US Department of Energy. PB acknowledges support for this work from NERC grant NE/R011567/1. SFG is supported by NERC National Capability funding through the Extended Ellett Line Programme.
    Keywords: Ocean circulation ; Lagrangian analysis ; Connectivity ; Particle tracking ; Future modelling
    Repository Name: Woods Hole Open Access Server
    Type: Article
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    PAPER (OA)
  • 2
    Electronic Resource
    Electronic Resource
    A General Process for Preparation of Core-Shell Particles of Complete and Smooth Shells (2005)
    Oxford, UK : Blackwell Science Inc
    Journal of the American Ceramic Society 88 (2005), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Core-shell particles have attracted much research attention in recent years because of the great potential in protection, modification, and functionalization of the core particles with suitable shell materials to achieve specific physical, chemical, and biological performance. A general approach for preparation of core-shell particles possessing complete and smooth shells is presented. The shell layer was constructed by introducing nanoparticles of desired shell material, prepared with the reverse micelle process, onto the core particle surface via layer-by-layer electrostatic adsorption, hydrophilic and hydrophobic interactions, and subsequent sintering. The proposed process is illustrated by coating silica spheres with four different shell materials, including Ag, CdS, ZnS, and TiO2. The successful formation of complete and smooth shell was examined with a novel light scattering intensity decay method and also by direct observation of scanning electron microscope and transmission electron microscope images.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1551-2916.2005.00070.x
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation (2006)
    [s.l.] : Nature Publishing Group
    Nature 439 (2006), S. 594-598 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] How a cell chooses to proliferate or to differentiate is an important issue in stem cell and cancer biology. Drosophila neuroblasts undergo self-renewal with every cell division, producing another neuroblast and a differentiating daughter cell, but the mechanisms controlling the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04299
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Pathophysiologie des Plexus chorioideus (1931)
    Springer
    Journal of neurology 117-119 (1931), S. 570-584 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Werden Plexuszellen länger als wenige Minuten nach dem Tode in situ gelassen, so neigen sie zu einem vakuolären Zerfall mit Verlust des Bürstensaumes. 2. Werden Plexuszellen operativ in einer kombinierten Bulbokapnin-Äthernarkose gewonnen, so zeigen sie eine starke Schwellung, die schließlich auch auf den Kern übergreift, und eine Ansammlung von Fett. 3. Unsere Versuche bestätigen, daß die Weedsche Lösung in die Plexuszellen eindringt. 4. Ebenso bestätigen sie Askanazys Beobachtung, daß Eisen in die Plexuszellen eindringt, wenn Erytrocyten in den Liquor gelangen. Ob es sich bei diesen beiden Vorgängen um eine passive Infiltration oder um eine aktive Resorption handelt, wagen wir noch nicht zu entscheiden. 5. Es hat sich kein Anhaltspunkt dafür ergeben, daß Fette oder Lipoide vom Liquorraum aus in den Plexus dringen. 6. Es fand sich nach Einspritzung gewaschener Erytrocyten ebenso nach Einspritzung von Luft oder Trypanblau in den Liquor eine Reaktion der Plexusepithelien, die wahrscheinlich eine nicht spezifische Antwort dieser Zellen auf Entzündungsreize darstellt. Sie besteht in einer trüben Schwellung mit Vermehrung der Mitochondrien und des Golgi-Apparates und des intrazellulären Fettes. Bei den Versuchen mit Blutinjektion wurden die Veränderungen bis zu 12 Tagen nach der Injektion studiert. In dieser Zeit vermindert sich die Kernfärbbarkeit, während die übrige Zelle schon zur Norm zurückkehrt. Der operative Teil der Versuche wurde im Physiologischen Institut durchgeführt. Für die Erlaubnis hierzu sind wir Herrn Prof. R. Lim zu herzlichem Dank verpflichtet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01673871
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    Paper (German National Licenses)
    Fulltext
  • 5
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    Lagrangian ocean analysis: fundamentals and practices (2018)
    Elsevier
    In:  Ocean Modelling, 121 . pp. 49-75.
    Details
    Publication Date: 2021-02-08
    Description: Highlights: • Lagrangian ocean analysis is a powerful way to analyse the output of ocean circulation models • We present a review of the Kinematic framework, available tools, and applications of Lagrangian ocean analysis • While there are unresolved questions, the framework is robust enough to be used widely in ocean modelling Abstract: Lagrangian analysis is a powerful way to analyse the output of ocean circulation models and other ocean velocity data such as from altimetry. In the Lagrangian approach, large sets of virtual particles are integrated within the three-dimensional, time-evolving velocity fields. Over several decades, a variety of tools and methods for this purpose have emerged. Here, we review the state of the art in the field of Lagrangian analysis of ocean velocity data, starting from a fundamental kinematic framework and with a focus on large-scale open ocean applications. Beyond the use of explicit velocity fields, we consider the influence of unresolved physics and dynamics on particle trajectories. We comprehensively list and discuss the tools currently available for tracking virtual particles. We then showcase some of the innovative applications of trajectory data, and conclude with some open questions and an outlook. The overall goal of this review paper is to reconcile some of the different techniques and methods in Lagrangian ocean analysis, while recognising the rich diversity of codes that have and continue to emerge, and the challenges of the coming age of petascale computing.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1016/j.ocemod.2017.11.008
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 6
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    Sustainability, Vol. 10, Pages 3259: An Application of Sustainable Development in Indigenous People’s Revival: The History of an Indigenous Tribe’s Struggle in Taiwan (2018)
    MDPI Publishing
    Details
    Publication Date: 2018-09-13
    Description: Sustainability, Vol. 10, Pages 3259: An Application of Sustainable Development in Indigenous People’s Revival: The History of an Indigenous Tribe’s Struggle in Taiwan Sustainability doi: 10.3390/su10093259 Authors: Cheng-Yu Yu Community development is seen as a crucial factor to realize sustainable development and vice versa, and for indigenous peoples in particular due to their associations with nature and natural resources. However, historical exploitation of indigenous peoples has resulted in their underachievement worldwide. The popularization of the concept of sustainable development followed a series of international treaties and conventions that shed light on indigenous peoples’ revival. Drawing upon Michel Foucault’s notion of the power-knowledge relationship, this article uses a case study of an indigenous tribe, the Smangus in Taiwan, to demonstrate how a politically, socially and economically disadvantaged community incorporates their traditional norms and customs into the notion of sustainable development and reinterprets it to adapt the community’s conditions. By re-uniting the community and establishing a cooperative organization, the community has revived cohesion in their community. The community’s conduct is investigated through the United Nations’ Sustainable Development Goals 2015–2030, and the article illustrates how it fulfils three Targets and the extent to which they are fulfilled. To conclude, Smangus’ case remind us of the importance of achieving sustainable development goals on micro- and local levels, and the value of empowering local communities to pursue their own sustainable development goals according to their circumstances. This article ends with suggestions for future research, and suggests that more studies using such a bottom-up approach to sustainable development would help to accumulate knowledge and experiences to establish a pattern of success to help other disadvantaged communities, draw focus to the need to bridge the policy gaps between the United Nations and local communities, and recall attention to the role of micro- and local communities to achieve sustainable development goals.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 7
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    [ASAP] Copper(II)-Catalyzed Four-Component Oxysulfonylation/Diazenylation: Synthesis of a-Arylhydrazo-ß-keto Sulfones (2018)
    American Chemical Society (ACS)
    Details
    Publication Date: 2018-09-15
    Description: The Journal of Organic Chemistry DOI: 10.1021/acs.joc.8b01843
    Print ISSN: 0022-3263
    Electronic ISSN: 1520-6904
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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  • 8
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    Energies, Vol. 11, Pages 1743: A Dual-Voltage-Vector Model-Free Predictive Current Controller for Synchronous Reluctance Motor Drive Systems (2018)
    MDPI Publishing
    In: Energies
    Details
    Publication Date: 2018-07-04
    Description: Energies, Vol. 11, Pages 1743: A Dual-Voltage-Vector Model-Free Predictive Current Controller for Synchronous Reluctance Motor Drive Systems Energies doi: 10.3390/en11071743 Authors: Cheng-Kai Lin Jen-te Yu Hao-Qun Huang Jyun-Ting Wang Hsing-Cheng Yu Yen-Shin Lai For current control in power conversion and motor drive systems, there exist three classic methods in the literature and they are the hysteresis current control (HCC), the sine pulse-width modulation (SPWM), and the space vector pulse width modulation (SVPWM). HCC is easy to implement, but has relatively large current harmonic distortion as the disadvantage. On the other hand, the SPWM and SVPWM use modulation technique, commonly together with at least one proportional-integral (PI) regulator to reduce load current ripples, and hence demanding more computation time. This paper aims to improve the performance of a recently proposed new current control method—the single-voltage-vector model predictive current control (SVV-MPCC), for synchronous reluctance motor (SynRMs) drives. To that end, a dual-voltage-vector model-free predictive current control (DVV-MFPCC) for SynRMs is proposed. Unlike the SVV-MPCC that applies only a single voltage vector per sampling period, the proposed DVV-MFPCC is capable of providing two successive segmentary current predictions in the next sampling period through all possible combinations from any two candidate switching states increasing the number of applicable switching modes from seven to nineteen and reducing the prediction error effectively. Moreover, the new control does not utilize any parameters of the SynRM nor its mathematical model. The performance is effectively enhanced compared to that of SVV-MPCC. The working principle of the DVV-MFPCC will be detailed in this paper. Finally, the SVV-MPCC, the single-voltage-vector model-free predictive current control (SVV-MFPCC), the dual-voltage-vector model predictive current control (DVV-MPCC), and the DVV-MFPCC are realized to control the stator currents of SynRM through a 32-bit microcontroller TMS320F28377S. Experimental results are provided to validate the new method and verify that the DVV-MFPCC performs better than do the SVV-MPCC, the SVV-MFPCC, and the DVV-MPCC.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 9
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    Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase [Molecular Biophysics] (2018)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2018-02-08
    Description: Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a highly sought-after therapeutic target for the management of cardiovascular diseases. New compounds that stimulate sGC show clinical promise, but where these stimulator compounds bind and how they function remains unknown. Here, using a photolyzable diazirine derivative of a novel stimulator compound, IWP-051, and MS analysis, we localized drug binding to the β1 heme domain of sGC proteins from the hawkmoth Manduca sexta and from human. Covalent attachments to the stimulator were also identified in bacterial homologs of the sGC heme domain, referred to as H-NOX domains, including those from Nostoc sp. PCC 7120, Shewanella oneidensis, Shewanella woodyi, and Clostridium botulinum, indicating that the binding site is highly conserved. The identification of photoaffinity-labeled peptides was aided by a signature MS fragmentation pattern of general applicability for unequivocal identification of covalently attached compounds. Using NMR, we also examined stimulator binding to sGC from M. sexta and bacterial H-NOX homologs. These data indicated that stimulators bind to a conserved cleft between two subdomains in the sGC heme domain. L12W/T48W substitutions within the binding pocket resulted in a 9-fold decrease in drug response, suggesting that the bulkier tryptophan residues directly block stimulator binding. The localization of stimulator binding to the sGC heme domain reported here resolves the longstanding question of where stimulators bind and provides a path forward for drug discovery.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 10
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    Regioselective and Switchable meso-Aminations and Couplings of 5,15-Diarylchlorins (2017)
    American Chemical Society (ACS)
    Details
    Publication Date: 2017-07-07
    Description: Organic Letters DOI: 10.1021/acs.orglett.7b01739
    Print ISSN: 1523-7060
    Electronic ISSN: 1523-7052
    Topics: Chemistry and Pharmacology
    Published by American Chemical Society (ACS)
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