Note: Cover Page -- Contents -- Contributors -- Chapter 1: Chromosome 22 Deletion Syndrome And Schizophrenia -- I. Introduction -- II. 22q11DS: Mechanism of the Deletion -- III. 22q11DS: Clinical Phenotype -- IV. 22q11DS: Psychosis -- V. 22q11DS: Neuropathology -- VI. 22q11DS: Positional Cloning Schizophrenia Susceptibility Loci -- VII. 22q11DS: Murine Models -- VIII. Catechol-O-Methyltransferase -- IX. Conclusions -- References -- Chapter 2: Characterization of Proteome of Human Cerebrospinal Fluid -- I. Introduction -- II. Materials and Methods -- A. Collection of Human CSF by Lumbar Puncture and Exclusion Criteria -- B. CSF Sample Preparation and Fractionation with SDS-PAGE -- C. In-Gel Digestion -- D. Protein Identification Using LC Followed by LCQ-MS -- E. Protein Identification Using Off-Line SCX Chromatography Followed by LTQ-FT MS -- F. Data Processing and Analysis -- III. Results -- A. Proteins Identified by muLC-LCQ-MS/MS -- B. Proteins Identified by nanoLC-LTQ-FT MS/MS Following Off-Line SCX Separation -- C. Reexamination of Previously Identified Proteins -- D. Discussion -- Acknowledgments -- References -- Chapter 3: Hormonal Pathways Regulating Intermale And Interfemale Aggression -- I. Introduction -- A. Common Regulatory Concepts in Males and Females -- II. Females -- A. DHEA as a Neurosteroid -- III. Males -- A. Regulation in the Adult -- B. Neural Steroid Receptors -- IV. Hormonal Modulation of Serotonin Function -- V. Conclusions -- Acknowledgments -- References -- Chapter 4: Neuronal GAP Junctions: Expression, Function, And Implications For Behavior -- I. A Brief History of Gap Junctions -- II. Gap Junction Structure -- III. Gap Junctions in the Brain -- IV. Electrical Coupling in the Brain -- V. Properties and Function of Electrical Synapses -- VI. Modulation of Electrical Synapses and Gap-Junctional Coupling. , VII. Use-Dependent Plasticity -- VIII. Local Factors: Voltage, pH, and Calcium -- IX. Neurotransmitter and Second Messenger Modulation -- X. Concluding Remarks -- References -- Chapter 5: Effects of Genes and Stress on the Neurobiology of Depression -- I. Introduction -- II. Stress and Depression -- III. Genetics and Depression -- IV. Serotonergic System -- V. Candidate Gene Studies of the Serotonergic System -- A. Serotonin Transporter -- B. Serotonin Receptors -- C. Other Serotonin Receptors -- D. Tryptophan Hydroxylase -- VI. Current Stress and the Serotonergic System -- A. Early Life Stress and the Serotonergic System -- VII. Gene Stress Interaction -- VIII. Hypothalamic-Pituitary-Adrenocortical (HPA) Axis -- A. Genetics and the HPA Axis -- B. Early Life Stress and the HPA Axis -- IX. Noradrenergic System -- A. Genetics and the Noradrenergic System -- B. Current Stress and the Noradrenergic System -- C. Early Life Stress and the Noradrenergic System -- X. Dopaminergic System in Depression -- A. Genetics and the Dopaminergic System -- B. Current Stress and the Dopaminergic System -- C. Early Life Stress and the Dopaminergic System -- XI. GABAergic System -- A. Genetics and the GABAergic System -- B. Early Life Stress and the GABAergic System -- XII. Brain Derived Neurotrophic Factor -- A. Genetics and BDNF -- B. Current Stress and BDNF -- C. Early Life Stress and BDNF -- XIII. Conclusions -- References -- Chapter 6: Quantitative Imaging with the Micro-pet Small-Animal Pet Tomograph -- I. Introduction -- II. Setup and Calibration -- A. Scanner Setup -- B. Calibration -- C. Quality Control -- D. External Radioactivity Measurements -- E. Animal Positioning -- III. Physical Corrections -- A. Randoms -- B. Deadtime -- C. Attenuation -- D. Scatter -- E. Normalization -- F. Natural Background Radioactivity of LSO -- IV. Image Reconstruction. , V. Data Analysis -- A. Anatomical Segmentation and Image Registration -- B. Partial Volume Correction -- VI. Conclusions -- References -- Chapter 7: Understanding Myelination Through Studying Its Evolution -- I. Introduction -- II. Evidence that Glial Cells First Interacted with Large Axons in a "Nonmyelin" Relationship -- III. Myelin-like Sheaths in Invertebrates -- A. Morphological Considerations -- B. Physiological Properties of Invertebrate Myelinated Fibers -- C. Biochemical Properties of Invertebrate Myelinated Fibers -- D. Concluding Remarks on Invertebrate Fiber Myelination -- IV. Vertebrate Myelinated Nervous System -- A. Morphological Features -- B. Biochemical and Molecular Features of Vertebrate Myelin Sheaths -- C. Differentiation of Myelinating CNS and PNS Glial Cells -- V. Use of Comparative Myelin Studies to Understand CNS Regeneration -- A. Myelin Inhibition, a Historical Perspective -- B. Characterization of Regeneration Inhibitors in Mammals -- C. Phylogeny of CNS Regeneration -- D. Comparative Genomics of the Myelin Inhibitory Machinery -- E. CNS Regeneration Despite Myelin Inhibitors-Does the Immune System Make the Difference? -- F. Conclusion: Collision of Biological Necessity and Clinical Needs -- VI. Future Studies of Myelin Evolution -- Acknowledgments -- References -- Index -- Contents of Recent Volumes.

Note: front cover -- copyright -- table of contents -- contributors -- MAPPING NEURORECEPTORS AT WORK: ON THE DEFINITION AND INTERPRETATION OF BINDING POTENTIALS AFTER 20 YEARS OF PROGRESS -- I. Twenty Years of Progress -- II. Remaining Issues -- III. Solutions -- References 1 -- MITOCHONDRIAL DYSFUNCTION IN BIPOLAR DISORDER: FROM MAGNETIC RESONANCE SPECTROSCOPIC FINDINGS TO THEIR MOLECULAR MECHANISMS -- I. Introduction 2 -- II. Phosphorus-31 Magnetic Resonance Spectroscopy -- III. Near-Infrared Spectroscopy -- IV. Molecular Genetic Findings -- V. Roles of Mitochondrial Calcium Regulation -- VI. Conclusions -- References 2 -- LARGE-SCALE MICROARRAY STUDIES OF GENE EXPRESSION IN MULTIPLE REGIONS OF THE BRAIN IN SCHIZOPHRENIA AND ALZHEIMER'S DISEASE -- I. Introduction 3 -- II. Gene Expression Profiling Using Microarrays: Technologies Overview -- III. Postmortem Brains and Gene Expression Studies -- IV. Comparison of Gene Expression Profiles among Normal Brain Regions -- V. Gene Expression Profiles of Brain Regions in Alzheimer's Disease -- VI. Gene Expression Profiling in Schizophrenia -- VII. Future Perspectives -- References 3 -- REGULATION OF SEROTONIN 2C RECEPTOR PRE-mRNA EDITING BY SEROTONIN -- I. Introduction 4 -- II. Modification of RNA Sequences by RNA Editing via Hydrolytic Deaminations of Adenosines -- III. Enzymes Responsible for A-to-I Editing and Their Substrate Requirements -- IV. A-to-I Editing of the 5- HT2C Receptor Pre- mRNA -- V. Modulation of 5- HT2C Receptor Function by RNA Editing -- VI. 5- HT2C Pre- mRNA Editing Responses to Sustained Changes of Postsynaptic 5-HT2C Receptor Activation -- VII. 5- HT2C Pre- mRNA Editing in the Human Prefrontal Cortex and Alterations in Editing-Site Preferences in Brains of Subjects with Major Depression -- VIII. Conclusions and Future Directions -- References 4. , THE DOPAMINE HYPOTHESIS OF DRUG ADDICTION: HYPODOPAMINERGIC STATE -- I. Drug Addiction as a Brain Disease -- II. The Mesolimbic Dopamine System -- III. Behavioral Animal Models -- IV. Biochemical Studies -- V. Primate Studies -- VI. Conclusions -- Acknowledgments 5 -- References 5 -- HUMAN AND ANIMAL SPONGIFORM ENCEPHALOPATHIES ARE AUTOIMMUNE DISEASES: A NOVEL THEORY AND ITS SUPPORTING EVIDENCE -- I. Introduction 6 -- II. A New Theory on the Mechanism of Pathogenesis of Spongiform Encephalopathies (SEs) -- III. Supporting Evidence -- IV. Early Diagnosis, Treatment, and Prevention of Various SE Diseases -- V. Conclusions -- Acknowledgments 6 -- References 6 -- ADENOSINE AND BRAIN FUNCTION -- I. Introduction 7 -- II. Regulation of Brain Adenosine Levels in the Central Nervous System -- III. Adenosine Receptors -- IV. Functions of Adenosine Receptors -- V. Adenosine-Dopamine Interactions in Brain -- VI. Phenotypes of Knockout Mice -- VII. Adenosine Receptors and Protection against Ischemic and Excitotoxic Brain Injuries -- VIII. Adenosine A2A Receptors and Neurodegenerative Disorders -- IX. Adenosine Receptors and Psychiatric Disorders -- X. Adenosine and the Regulation of Sleep- Wake Cycles -- XI. Adenosine and Epilepsy -- XII. Adenosine and Pain -- Acknowledgments 7 -- References 7 -- Index -- Contents of Recent Volumes.

Note: Front Cover -- Neuroimmune Signaling in Drug Actions and Addictions -- Copyright -- Contents -- Contributors -- Chapter One: Neuroimmune Mechanisms of Alcohol and Drug Addiction -- 1. Introduction -- 2. Neuroimmune Modulation of Synaptic Function -- 3. Neuroinflammation -- 4. Neuroimmune Molecules in Neurodevelopment -- 5. Neuroimmune Factors Modulate Neuroendocrine Function -- 6. Neuroimmune Mechanism and Addiction -- 7. Summary -- References -- Chapter Two: Neuroimmune Pathways in Alcohol Consumption: Evidence from Behavioral and Genetic Studies in Rodents and Humans -- 1. Introduction -- 2. Immune Regulation of Ethanol Consumption and Ethanol Regulation of Immune Signaling -- 3. Peroxisome Proliferator-Activated Receptors: Anti-Inflammatory Action and Role in Alcohol Consumption -- 4. Alcohol Consumption and Neuroimmune-Related Gene Expression -- 5. Alcohol Consumption and Neuroimmune-Related microRNAs -- 6. Conclusions -- Acknowledgments -- References -- Chapter Three: Fetal Alcohol Spectrum Disorders and Neuroimmune Changes -- 1. Overview of Fetal Alcohol Spectrum Disorders -- 2. Normal Brain Development -- 3. FASD Neuropathology in Humans -- 4. FASD Neuropathology in Animal Models -- 5. Behavioral Consequences in Humans with FASD -- 6. Behavioral Consequences in Rodent Models of FASD -- 7. Overview: Alcohol Effects on Immune Response in the Brain -- 8. Microglia -- 8.1. Overview -- 8.2. Role in the CNS development -- 8.3. Function in the healthy CNS -- 8.4. Immune response -- 9. Potential Long-Term Consequences of Immune Activation in the Developing CNS -- 10. Link Between Ethanol and Immune Responses -- 10.1. Human studies -- 10.2. Animal studies -- 10.3. Signaling pathways -- 11. Therapies -- 11.1. Early diagnosis of FASD -- 11.2. Development of novel anti-inflammatory therapies for FASD -- 11.2.1. Pioglitazone -- 11.2.2. Minocycline. , 11.2.3. Naltrexone -- 12. Conclusions -- Acknowledgments -- References -- Chapter Four: Role of Microglia in Regulation of Ethanol Neurotoxic Action -- 1. Introduction -- 2. Microglial Cell Functions in the CNS -- 2.1. Microglial response to pathogens and tissue damage -- 2.2. Microglia, inflammation, and cell death -- 2.3. Microglial modulation of neuronal activity and development -- 3. Microglial Mechanisms of the Neurotoxic Effects of Alcohol -- 3.1. Alcohol-induced microglial activation, inflammation, and neurotoxicity -- 3.2. Alcohol-induced microglial production of ROS and neurotoxicity -- 4. Protective Effects of Microglia -- 5. Alcohol-Related Disease, Neurotoxicity, and Microglia -- 5.1. Adult alcohol-use disorders -- 5.2. Fetal alcohol spectrum disorders -- 5.3. Microglia priming hypothesis -- 6. Summary and Future Directions -- Acknowledgments -- References -- Chapter Five: Functions of the Chemokine Receptor CXCR4 in the Central Nervous System and Its Regulation by μ-Opioid Rece... -- 1. Chemokine System Overview -- 2. Opioid System Overview -- 3. CXCR4 and Opioids Actions in the Central Nervous System -- 3.1. Physiological and pathological roles of CXCR4 -- 3.2. Effects of opioids on neuronal and non-neuronal cells -- 4. CXCR4 Interactions with Opioids -- 4.1. Heterologous desensitization -- 4.2. Transcriptional regulation/changes in expression -- 4.3. Receptor dimerization -- 4.4. Novel regulatory mechanisms: Ferritin heavy chain -- 5. Chemokine and Opioid Interactions in HAND -- 6. Gaps and Future Challenges -- Acknowledgments -- References -- Chapter Six: Discovery of a Novel Site of Opioid Action at the Innate Immune Pattern-Recognition Receptor TLR4 and its Ro... -- 1. Introduction -- 2. Innate Immunity of the Central Nervous System -- 3. Parallels Between an Immune Response to Lipopolysaccharide and Opioids. , 4. How Immune Mediators Can Alter Behavior -- 5. Stress and the Central Nervous System´s Innate Immune System -- 6. Addiction -- 6.1. Opponent theory and allostasis -- 7. Integrating Addiction Neuroscience with Immunology -- 7.1. Binge and intoxication -- 7.2. Withdrawal and negative affect -- 7.2.1. Within system adaptations-A desensitized reward pathway -- 7.2.2. Between system adaptations-Recruitment of antireward pathway -- 7.3. Preoccupation and craving -- 8. Conclusion -- References -- Chapter Seven: Neuroimmune Basis of Methamphetamine Toxicity -- 1. Introduction -- 2. Part 1 -- 2.1. Microglia and astrocytes -- 2.1.1. Microglia -- 2.1.2. Astrocytes -- 2.2. Inflammatory signaling -- 2.3. Molecular/cellular: receptors and transporters -- 2.3.1. Neurotransmitter modulation of methamphetamine´s inflammatory effects -- 3. Part 2 -- 3.1. Animal models -- 4. Part 3 -- 4.1. Blood-brain barrier and clinical considerations -- 4.1.1. Blood-brain barrier -- 4.1.2. Methamphetamine exposure and BBB integrity -- 4.1.3. Clinical picture: immune signaling in addictive and related behaviors -- 4.1.4. Chronic infection with human immunodeficiency virus and/or hepatitis C virus -- 5. Part 4 -- 5.1. Vaccine development -- 5.2. Neuroimmune-based and other anti-inflammatory treatment strategies -- 5.3. Future directions -- Acknowledgments -- References -- Chapter Eight: Marijuana Use and Brain Immune Mechanisms -- 1. Introduction -- 2. Phytocannabinoids and Immune Function -- 3. Immune Modulation and Cannabinoid Receptors -- 4. Marijuana and Neuroimmunity -- 5. Effect of Phytocannabinoids on Microglia -- 6. Marijuana and Astrocytes -- 7. Marijuana and Infectious Agents That Target the CNS -- 8. Summary and Future Prospectives -- References -- Chapter Nine: Interactions of HIV and Drugs of Abuse: The Importance of Glia, Neural Progenitors, and Host Genetic Factors. , 1. Introduction -- 1.1. Opiates and HIV-Preclinical and clinical findings -- 1.2. Psychostimulants and HIV -- 1.3. The central role of glia -- 2. Microglia -- 2.1. Microglia as innate immune effectors -- 2.2. Microglia and HIV -- 2.2.1. Opioid and HIV actions in microglia -- 2.2.2. Psychostimulant and HIV actions in microglia -- 2.2.2.1. Methamphetamine and HIV -- 3. Astroglia -- 3.1. Critical functions in neuronal support and gliotransmission -- 3.2. Innate immune effectors -- 3.3. Astroglia and HIV -- 3.4. Effects of opiates and HIV in astroglia -- 3.5. Effects of psychostimulants and HIV in astroglia -- 4. Genetic Factors That Modulate HIV-1 Infectivity and Neuropathogenesis -- 4.1. Introduction -- 4.1.1. Mitochondrial genetics -- 4.2. Gene variation in opiate drug abuse and HIV interactions -- 5. Neural/Glial Progenitors and HIV -- 5.1. Opiate and opiate-HIV interactions on progenitors and cell populations -- 5.2. Psychostimulant-HIV interactions on progenitors and cell populations -- 6. Conclusions -- Acknowledgments -- References -- Chapter Ten: Neuroimmune Basis of Alcoholic Brain Damage -- 1. Introduction -- 2. Alcohol-Induced Neurodegeneration and Alcoholism -- 3. Loss of Neurogenesis Could Contribute to Alcoholic Neurodegeneration -- 4. Monocytes and Innate Immune Genes -- 5. Alcohol, Neuroimmune Signaling, and Neurodegeneration -- 6. Ethanol Induction of HMGB1-TLR Signaling in Brain -- 7. NADPH Oxidase and Neurodegeneration -- 8. Neuroimmune Signaling, Hyperexcitability, and Neuronal Death -- 9. Adolescence: A Major Period of Risk for Alcohol Dependence -- 10. Neuroimmune Gene Expression in Postmortem Human Alcoholic Brain -- 11. Summary -- References -- Chapter Eleven: Converging Actions of Alcohol on Liver and Brain Immune Signaling -- 1. Introduction. , 2. Pathology and Cellular Characteristics of Neuroinflammation After Alcohol Exposure -- 2.1. Microglia and astrocytes -- 2.2. Neurons -- 2.3. Cytokines and chemokines -- 3. Molecular Mechanisms of Alcohol-Induced Neuroinflammation -- 3.1. Pattern recognition receptors sense danger signals in the brain (TLRs and NLRs) -- 3.2. Exogenous and endogenous danger signals are induced by alcohol use -- 3.3. Micro-RNAs -- 3.4. Oxidative stress -- 4. Crosstalk Between Organs -- 4.1. Gut-liver-brain axis -- 5. Therapeutic Targets -- 5.1. General consideration -- 5.2. TNFα system -- 5.3. IL-1β system -- 5.4. miR-155 -- 5.5. HMGB1 -- 5.6. TLR4 pathway -- 6. Conclusions -- References -- Chapter Twelve: Opportunities for the Development of Neuroimmune Therapies in Addiction -- 1. Introduction -- 1.1. Neuroinflammation and alcohol dependence -- 1.2. Neuroinflammation and MA dependence -- 1.3. Neuroinflammation and HIV -- 2. Neuroimmune Treatments -- 2.1. Ibudilast -- 2.2. Minocycline and doxycycline -- 2.3. Topiramate -- 2.4. Indomethacin -- 2.5. Rolipram -- 2.6. Anakinra (IL-1Ra) -- 2.7. PPAR agonists -- 2.8. Naltrexone/naloxone -- 2.9. Summary and conclusions -- References -- Chapter Thirteen: NeuroHIV and Use of Addictive Substances -- 1. Brain-Immune Interactions: Induction of Neuroinflammation by Systemic Infections -- 2. Medical Uses and Adverse Effects of Addictive Substances -- 3. HIV-1 Infection and HIV-Associated Neuropathology -- 4. HIV-1 Infection, NeuroHIV, and the Use of Addictive Substances -- 4.1. Addiction and neuroHIV -- 4.2. Endogenous opioid system -- 4.3. HIV-1 and the dopaminergic system -- 4.4. Morphine and neuroHIV -- 4.5. Alcohol and HIV-1 -- 4.6. Nicotine and HIV-1 -- 4.7. Interactive effects of alcohol and nicotine in neuroHIV -- 4.8. Cocaine and HIV-1 -- 4.9. Methamphetamine and HIV-1 -- 4.10. Marijuana and HIV-1 -- 4.11. Summary. , 5. Conclusion.

Note: Organometallic Chemistry -- Contents -- Chapter 1 Group I. The Alkali and Coinage Metals -- 1 Lithium -- Structural and Bonding Studies -- Polylithio-compounds -- Halogenocarbon Derivatives -- Some Organic Reactions -- 2 Sodium and Potassium -- 3 Copper, Silver, and Gold -- Copper and Silver π-Complexes -- σ-Bonded Organo-copper and -silver Compounds -- Gold -- Chapter 2 Group II. The Alkaline Earths and Zinc and its Congeners -- 1 Beryllium -- 2 Magnesium -- Preparation and Composition -- Reactions -- Inversions and Rearrangements -- Halogenocarbon Derivatives -- 3 Calcium, Strontium, and Barium -- 4 Zinc and Cadmium -- 5 Mercury -- Preparative Reactions -- Mercuration and Demercuration Reactions -- Other Reactions -- Carbene Precursors -- Chapter 3 Group III. Boron, Aluminium, Gallium, Indium, and Thallium -- 1 Introduction -- 2 Boron -- General -- Preparations -- Radical Reactions -- Mechanisms and Kinetics -- Preparative Reactions involving Radicals -- Non-radical Mechanisms and Kinetics -- Nucleophilic Displacements at Tetrahedral Boron Centres -- Displacement of the Alkyl Groups attached to Boranes -- Olefin Elimination and Addition -- Reactions of R3B -- Organic Reactions of R3B -- Hydrido-organoboranes -- Compounds containing Boron-Nitrogen Bonds -- Borinic and Boronic Acids and their Derivatives -- Synthesis -- Reactions -- Compounds containing Boron-Chalcogen Bonds -- Compounds containing Boron-Halogen Bonds -- 3 Aluminium -- Preparations and Reactions -- Structures, Bonding, and Exchange Reactions -- Organic Applications -- Mechanisms and Kinetics -- Various Reactions -- Transition-metal-Organoaluminium Systems -- 4 Gallium -- 5 Indium -- 6 Thallium -- Trialkylthalliums-R3T1 -- Dialkylthallium and Diarylthallium Compounds-R2T1X -- Monoalkylthallium and Monoarylthallium Compounds-RT1X2 -- Organic Reactions. , Thallium(i) Cyclopentadienides -- Chapter 4 Group III. The Carboranes -- Chapter 5 Group IV. The Silicon Group -- 1 Introduction -- 2 Formation of the Carbon-Metal Bond Synthesis -- Reactions of M-C Compounds -- 3 Cleavage of the Carbon-Metal Bond -- 4 Mechanistic Studies of Carbon-Metal Bond Cleavage -- Rearrangement Reactions involving the Silicon-Carbon Bond -- 5 Thermochemical, Spectroscopic, and Structural Studies -- 6 Cyclopentadienyl Derivatives of the Group IV Elements -- 7 Addition Reactions -- 8 Alkali-metal Derivatives R3MM' -- 9 Catenation -- 10 Carbenes and their Silicon Group Congeners -- 11 Mercury Derivatives -- 12 Free Radicals -- 13 Hydrides of Silicon and Germanium -- 14 Organotin Hydrides -- 15 Boron Derivatives -- 16 Nitrogen Derivatives -- Diazo-compounds -- Azides -- Addition Reactions -- Silazanes -- Aminosilanes -- 17 Phosphine, Arsine, and Stibine Derivatives -- 18 Silicon-Oxygen Compounds -- Alkoxysilanes and Siloxanes -- Rearrangements involving Compounds containing the Si-O Bond -- Silyl Esters -- Organosilicon Peroxides -- 19 Germanium-Oxygen Compounds -- 20 Tin-Oxygen Compounds -- 21 Sulphur Derivatives -- 22 Lead-Oxygen and Lead-Halogen Compounds -- 23 Halogen Exchange Reactions -- 24 Complexes of Silicon, Germanium, Tin, and Lead -- 25 Structural Determinations -- 26 Bonding in Group IV Organometallic Compounds -- Chapter 6 Metal Carbonyls -- 1 Introduction -- 2 Spectroscopic Studies -- 3 Preparation of Carbonyl Compounds -- 4 Hydrido(carbonyl)metal Complexes -- 5 Halogeno- and Azido-(carbonyl)metal Complexes -- Chapter 7 Organometallic Compounds containing Metal-Metal Bonds -- 1 Introduction -- 2 Compounds containing Transition Metal-Transition Metal Bonds -- Compounds containing Isolated Bonds and Bond Sequences -- Transition Metal Clusters. , 3 Compounds containing Bonds between Transition Metals and the Elements of Groups IB-VB -- Group IB -- Group IIB -- Group IIIB -- Boron -- Aluminium -- Indium and Thallium -- Group IV -- General Preparative Work -- The Nature of the Metal-Metal Bond -- Titanium Group -- Chromium Group -- Manganese Group -- Iron Group -- Cobalt Group -- Nickel Group -- Group V -- 4 Compounds containing Group IIB-Group IV Element Bonds -- Chapter 8 Substitution Reactions of Metal and Organo-metal Carbonyls with Group V and VI Donor Ligands -- 1 Introduction -- 2 General Papers on Metal Carbonyl Complexes -- 3 Group V -- 4 Group VI -- Complexes of Cr°, Mo° and W° -- Halogenocarbonyl Complexes of and IIMo WII -- Cyclopentadienyl Carbonyl Complexes of MoII and WII -- 5 Group VII -- Complexes of Mn° and Re0 -- Cyclopentadienyl Carbonyl Complexes of MnI -- Other Complexes of MnI and ReI -- 6 Group VIII: Fe, Ru, and Os -- Complexes of the Cluster Carbonyls -- Mononuclear Complexes of Fe° and Ru° -- Complexes containing the M2(CO)6 Unit (M = Fe or Ru) -- Cyclopentadienyl Carbonyl Complexes of FeII -- Other Complexes of FeII, RuII, and OsII -- 7 Group VIII: Co, Rh, and Ir -- Complexes of Co0, Rh°, and Ir° -- Complexes of Co1, Rh1, and Ir1 -- 8 Group VIII: Ni, Pd, and Pt -- 9 Copper -- Chapter 9 Carbene, Nitrene, and Related Complexes -- 1 Synthesis of Carbene Complexes -- 2 Structure and Bonding in Carbene Complexes -- 3 Reactions of Carbene Complexes -- 4 Nitrene Complexes -- Chapter 10 Complexes containing Metal-Carbon σ-Bonds -- 1 σ-Bonded Complexes -- Group IV -- Group V -- Group VI -- Group VII -- Group VIII -- Group I -- 2 Compounds Derived from Carbonylmetal Anions -- 3 Insertion Reactions -- Carbon Monoxide (and Decarbonylation Reactions) -- Sulphur Dioxide -- Olefins and Acetylenes -- Tetracyanoethylene -- Isocyanides -- 4 ortho-Metallation and Related Reactions. , Nitrogen Donors -- Phosphorus Donors -- Carbon Donors -- Sulphur Ligands -- 5 Formation of M-C σ-Bonds from Olefin or Diene Complexes -- 6 Cobaloximes, Cobalamins, and Related Compounds -- 7 Organic Derivatives of Schiff-base Complexes -- Chapter 11 Hydrocarbon-Metal π-Complexes -- 1 Bonding in Mono-olefin and Acetylene Complexes -- 2 Mono-olefin Complexes -- 3 Mono-olefin Chelate Complexes -- 4 Acetylene Complexes -- 5 Acyclic Conjugated Diolefin Complexes -- 6 Cyclic Conjugated Diolefin Complexes -- Cyclobutadiene Complexes -- Cyclopentadiene Complexes -- Complexes of Six- and Seven-membered Rings -- Complexes of Eight-membered Rings -- 7 Complexes of Chelating Unconjugated Diolefins -- 8 Cationic Metal-Olefin and -Acetylene Complexes -- 9 Complexes Derived from Allenes and from Trimethyl-enemethane -- 10 Complexes of Polycyclic Hydrocarbons -- Chapter 12 π-Allylic Complexes -- 1 General Developments -- 2 Tantalum -- 3 Iron, Ruthenium, and Osmium -- 4 Cobalt, Rhodium, and Iridium -- 5 Nickel, Palladium, and Platinum -- Chapter 13 π-Cyclopentadlenyl, Arene, and Related Compounds -- 1 Introduction -- 2 π-Cyclopentadienyl Complexes -- Features of General Interest -- Group IV -- Preparation of Complexes -- Other Studies -- Group V -- Group VI -- Preparation of Complexes -- Other Studies -- Group VII -- Group VIII: Fe, Ru, and Os -- Preparation of Complexes -- Other Studies -- Group VIII: Co, Rh, and Ir -- Group VIII: Ni, Pd, and Pt -- Preparation of Complexes -- Other Studies -- Other Metals -- 3 π-Arene Complexes -- Group VI -- Preparation of Complexes -- Other Studies -- Group VII -- Group VIII: Fe, Ru, and Os -- Group VIII: Co, Rh, and Ir -- Group VIII: Ni -- Uranium -- 4 Carborane Complexes -- The [B9C211]2- Ligand and Related Systems -- Other Carborane Ligands -- Theory of Bonding in Carborane Complexes -- 5 Complexes with Other Related Ligands. , Tris(pyrazolyl)borate Complexes -- Borabenzene Complexes -- Borazole Complexes -- Pyrrole and Pyrrolyl Complexes -- Thiophen Complexes -- Chapter 14 Substitution Reactions of Hydrocarbon-Metal π-Complexes -- 1 Introduction -- 2 Results of General Interest -- 3 Individual Systems -- OC6H6)Cr(CO)3 (Benchrotrene) -- [(Tropylium)Cr(CO)3]+ and Related Complexes -- (π-C5H5)Mn(CO)3 (Cymantrene) -- (π-C4H4)Fe(CO)3 -- (π-Diene)Fe(CO)3 Complexes -- [(π-C5H5)Fe(π-C6H6)]+ Complexes -- (π-CsHs)2Co and Derived (π-C5H5)Co(π-diene) Complexes -- Cobalt-Carbon Cluster Compounds -- 4 Chemistry of the Iron-group Metallocenes (Ferrocene, Ruthenocene, and Osmocene) -- General -- General Chemistry -- Proton N.M.R. Studies -- Stereochemistry of Ferrocenes -- Biferrocenyls and Bridged Ferrocenes (Ferro-cenophanes) -- Polymeric Ferrocene Derivatives -- Ferrocene Derivatives containing Heteroatoms -- Boron -- Silicon and Germanium -- Phosphorus and Arsenic -- Sulphur -- Transition Metals -- Ferricinium Salts -- Chapter 15 Oxidative-addition and Related Reactions -- 1 Niobium and Tantalum -- 2 Chromium, Molybdenum, and Tungsten -- 3 Iron, Ruthenium, and Osmium -- 4 Cobalt, Rhodium, and Iridium -- 5 Nickel, Palladium, and Platinum -- Chapter 16 Homogeneous Catalysis -- 1 General -- 2 Hydrogenation -- 3 Isomerization -- 4 Skeletal Rearrangements -- 5 Rearrangement of Strained Cycloalkanes -- 6 Hydroformylation and Related Reactions -- 7 Dimerization and Oligomerization -- 8 Oxidation -- 9 Synthesis -- Reduction of Dinitrogen -- Chapter 17 X-Ray and Electron Diffraction Studies of Organometallic Compounds -- 1 Introduction -- Coverage -- Symbols, Abbreviations, and Conventions -- 2 Main Table Listing Compounds and Structural Data -- 3 Cross-reference Lists -- Metal Listings -- Ligand Listings -- Author Index.

Note: Front Cover -- Cytogenetics of Cells in Culture -- Copyright Page -- Table of Contents -- CHARLES MARC POMERAT -- LIST OF CONTRIBUTORS -- PREFACE -- Chapter 1. CYTOGENETIC ALTERATIONS IN MIXED CULTURES OF MAMMALIAN SOMATIC CELLS IN VITRO -- INTRODUCTION -- CONCLUSIONS AND SUMMARY -- REFERENCES -- Chapter 2. HYBRIDIZATION OF SOMATIC CELLS JN VITRO -- INTRODUCTION -- HYBRIDS OBTAINED UP TO DATE -- SELECTION AND VIABILITY OF HYBRIDS -- CHROMOSOME SEGREGATION^ -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3. SELECTION PRESSURE IN MAMMALIAN CELL POPULATIONS -- INTRODUCTION -- THE CONTRIBUTION OF ERROR -- NORMAL SOMATIC TISSUES -- IRRADIATED SOMATIC TISSUES -- DISCUSSION -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4. PHASE CINEMATOGRAPHY STUDIES ON THE EFFECTS OF RADIATION AND OF SOME CHEMICALS ON CELLS AND CHROMOSOMES -- INTRODUCTION -- CYTOLOGICAL RESPONSES OF VARIOUS CELLULAR ORGANELLES TO CERTAIN CHEMICALS -- BEHAVIOR OF CHROMOSOMES IN GRASSHOPPER SPERMATOCYTES FOLLOWING β-IRRADIATION -- BEHAVIOR OF THE TELOPHASE CHROMOSOME GROUP IN SILKWORM SPERMATOCYTES FOLLOWING ULTRAVIOLET MICROBEAM IRRADIATION -- GENERAL SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 5. CELLULAR INTERPRETATION OF ASPECTS OF THE ACUTE MAMMALIAN RADIATION SYNDROME -- INTRODUCTION -- DIFFICULTIES IN INTERPRETATION OF THE RADIATION SYNDROME -- SURVIVAL CURVES FOR MAMMALIAN CELLS IN VITRO -- INTERPRETATION OF THE ACUTE WHOLE-BODY RADIATION SYNDROME ON THE BASIS OF CELL REPRODUCTIVE KILLING -- FURTHER EXPERIMENTAL EVIDENCE FOR THIS FORMULATION -- IDENTIFICATION OF THE SITE WITHIN THE CELL RESPONSIBLE FOR THE LETHAL ACTION -- SUMMARY -- REFERENCES -- Chapter 6. RETENTION OF EUPLOIDY AND MUTAGENICITY OF HETEROCHROMATIN IN CULTURE -- INTRODUCTION -- SEX HETEROCHROMATIN -- RETENTION OF EUPLOIDY IN VITRO -- EUPLOID SPONTANEOUS NEOPLASIA -- INDUCED MALIGNANCIES. , IN VIVO TRANSPLANTATION OF POLYOMA-TRANSFORMED EUPLOID CELL LINES -- SPONTANEOUS TUMOR 89 -- SPECIFICITY OF BUDR FOR SECONDARY CONSTRICTIONS -- TELOMERIC ASSOCIATION -- LESION OF SECONDARY CONSTRICTIONS OF X-CHROMOSOMES OF POLYOMA-TRANSFORMED CELLS -- CHARACTERISTICS OF AN ADENOVIRUS -- SUMMARY -- ADDENDUM -- REFERENCES -- Chapter 7. THE NATURE, ORIGIN, AND GENETIC IMPLICATIONS OF STRUCTURAL ABNORMALITIES OF THE SEX CHROMOSOMES IN MAN -- INTRODUCTION -- ABNORMALITIES OF THE Y-CHROMOSOME -- SUMMARY -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 8. CHROMOSOME STUDIES IN THE GENERAL POPULATION -- INTRODUCTION -- COMPOSITION OF THE STUDY POPULATION -- METHOD -- RESULTS: GERIATRIC POPULATION -- GENERAL POPULATION -- DISCUSSION -- SUMMARY -- REFERENCES -- Chapter 9. ALTÉRATIONS CHROMOSOMIQUES DANS DES CELLULES CULTIVÉES EN PRÉSENCE D'EXTRAITS TISSULAIRES HÉTÉROSPÉCIFIQUES1 -- INTRODUCTION -- MATERIEL ET TECHNIQUES -- RESULTATS -- DISCUSSION -- RESUME -- SUMMARY -- BIBLIOGRAPHIE -- Chapter 10. CHROMOSOMAL STUDIES ON HUMAN LEUCOCYTES FOLLOWING TREATMENT WITH RADIOACTIVE IODINE IN VIVO AND IN VITRO -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 11. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS -- INTRODUCTION -- MATERIALS AND METHODS -- EXPERIMENTAL RESULTS -- DISCUSSION -- SUMMARY -- REFERENCES -- Chapter 12. REGULATION OF DNA REPLICATION AND VARIEGATION-TYPE POSITION EFFECTS -- PATTERNS OF ASYNCHRONOUS REPLICATION -- LATE REPLICATION, HETEROPYCNOSIS, AND GENETIC INACTIVATION -- TESTS OF THE INACTIVATION HYPOTHESIS -- INDUCTION OF THE REPRESSED STATE -- HYPOTHESIS FOR A GENERAL REPRESSOR SYSTEM -- SUMMARY AND PREDICTIONS -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 13. IDENTIFICATION AND CHARACTERIZATION OF HUMAN CHROMOSOMES BY DNA REPLICATION SEQUENCE -- INTRODUCTION. , CHROMOSOMAL CHARACTERISTICS -- COMMENTS -- SUMMARY -- REFERENCES -- Chapter 14. MUTAGENIC RESPONSE OF HUMAN SOMATIC CELL LINES -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- CONCLUSIONS AND SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 15. DNA SYNTHESIS AND CHROMOSOMAL MORPHOLOGY OF CHINESE HAMSTER CELLS CULTURED IN MEDIA CONTAINING N-DEACETYL-N-METHYLCOLCHICINE (COLCEMID) -- INTRODUCTION -- PROCEDURES -- EXPERIMENTAL DATA -- DISCUSSION -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 16. HETEROCHROMATIN IN THE HUMAN MALE -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- SUMMARY -- REFERENCES -- Chapter 17. CHROMOSOME BREAKAGE ASSOCIATED WITH VIRUSES AND DNA INHIBITORS -- INTRODUCTION -- ROUS SARCOMA -- MEASLES -- DEOXYADENOSINE AND CYTOSINE ARABINOSIDE -- ROUS VIRUS AND HUMAN LEUCOCYTE CULTURES -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 18. QUANTITATION AND AUTOMATION OF CHROMOSOMAL DATA WITH SPECIAL REFERENCE TO THE CHROMOSOMES OF THE HAMSHIRE PIG -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- SUMMARY -- REFERENCES -- AUTHOR INDEX.