In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 8 ( 2021-8-27), p. e0256749-
Abstract:
Cerebrovascular abnormality is linked to Alzheimer’s disease and related dementias (ADRDs). ApoE-Ɛ4 (APOE4) is known to play a critical role in neurovascular dysfunction, however current medical imaging technologies are limited in quantification. This cross-sectional study tested the feasibility of a recently established imaging modality, quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI), to identify small vessel abnormality early in development of human APOE4 knock-in female rat (TGRA8960) animal model. At 8 months, 48.3% of the brain volume was found to have significant signal increase (75/173 anatomically segmented regions; q 〈 0.05 for multiple comparisons). Notably, vascular abnormality was detected in the tri-synaptic circuit, cerebellum, and amygdala, all of which are known to functionally decline throughout AD pathology and have implications in learning and memory. The detected abnormality quantified with QUTE-CE MRI is likely a result of hyper-vascularization, but may also be partly, or wholly, due to contributions from blood-brain-barrier leakage. Further exploration with histological validation is warranted to verify the pathological cause. Regardless, these results indicate that QUTE-CE MRI can detect neurovascular dysfunction with high sensitivity with APOE4 and may be helpful to provide new insights into health and disease.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0256749
DOI:
10.1371/journal.pone.0256749.g001
DOI:
10.1371/journal.pone.0256749.g002
DOI:
10.1371/journal.pone.0256749.g003
DOI:
10.1371/journal.pone.0256749.g004
DOI:
10.1371/journal.pone.0256749.g005
DOI:
10.1371/journal.pone.0256749.s001
DOI:
10.1371/journal.pone.0256749.s002
DOI:
10.1371/journal.pone.0256749.s003
DOI:
10.1371/journal.pone.0256749.s004
DOI:
10.1371/journal.pone.0256749.s005
DOI:
10.1371/journal.pone.0256749.s006
DOI:
10.1371/journal.pone.0256749.s007
DOI:
10.1371/journal.pone.0256749.s008
DOI:
10.1371/journal.pone.0256749.s009
DOI:
10.1371/journal.pone.0256749.s010
DOI:
10.1371/journal.pone.0256749.s011
DOI:
10.1371/journal.pone.0256749.s012
DOI:
10.1371/journal.pone.0256749.s013
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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