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  • 2020-2024  (326)
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  • 2020-2024  (326)
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  • 1
    Online Resource
    Online Resource
    Association of Bowman’s capsule rupture with prognosis in patients with lupus nephritis
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Nephrology Vol. 35, No. 4 ( 2022-05), p. 1193-1204
    Details
    In: Journal of Nephrology, Springer Science and Business Media LLC, Vol. 35, No. 4 ( 2022-05), p. 1193-1204
    Type of Medium: Online Resource
    ISSN: 1724-6059
    URL: Article
    DOI: 10.1007/s40620-022-01316-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1475007-7
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  • 2
    Online Resource
    Online Resource
    Multi-species approach strengthens the reliability of dendroclimatic reconstructions in monsoonal Northeast China
    Springer Science and Business Media LLC ; 2022
    In:  Climatic Change Vol. 171, No. 1-2 ( 2022-03)
    Details
    In: Climatic Change, Springer Science and Business Media LLC, Vol. 171, No. 1-2 ( 2022-03)
    Type of Medium: Online Resource
    ISSN: 0165-0009 , 1573-1480
    URL: Article
    DOI: 10.1007/s10584-022-03328-9
    RVK:
    RA 1000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 751086-X
    detail.hit.zdb_id: 1477652-2
    SSG: 14
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  • 3
    Online Resource
    Online Resource
    Bioinformatics algorithm for lung adenocarcinoma based on macropinocytosis-related long noncoding RNAs as a reliable indicator for predicting survival outcomes and selecting suitable anti-tumor drugs
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Medicine Vol. 101, No. 38 ( 2022-09-23), p. e30543-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 101, No. 38 ( 2022-09-23), p. e30543-
    Abstract: As a highly conserved endocytic mechanism during evolution, macropinocytosis is enhanced in several malignant tumors, which promotes tumor growth by ingesting extracellular nutrients. Recent research has emphasized the crucial role of macropinocytosis in tumor immunity. In the present study, we established a new macropinocytosis-related algorithm comprising molecular subtypes and a prognostic signature, in which patients with lung adenocarcinoma (LUAD) were classified into different clusters and risk groups based on the expression of 16 macropinocytosis-related long noncoding RNAs. According to the molecular subtypes, we discovered that patients with LUAD in cluster1 had a higher content of stromal cells and immune cells, stronger intensity of immune activities, higher expression of PD1 , PDL1 , and HAVCR2 , and a higher tumor mutational burden, while patients in cluster2 exhibited better survival advantages. Furthermore, the constructed prognostic signature revealed that low-risk patients showed better survival outcomes, earlier tumor stage, higher abundance of stromal cells and immune cells, higher immune activities, higher expression of PD1 , PDL1 , CTLA4 , and HAVCR2 , and more sensitivity to Paclitaxel and Erlotinib. By contrast, patients with high scores were more suitable for Gefitinib treatment. In conclusion, the novel algorithm that divided patients with LUAD into different groups according to their clusters and risk groups, which could provide theoretical support for predicting their survival outcomes and selecting drugs for chemotherapy, targeted therapy, and immunotherapy.
    Type of Medium: Online Resource
    ISSN: 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000030543
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2049818-4
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  • 4
    Online Resource
    Online Resource
    Skeletal Muscle Fibers Inspired Polymeric Actuator by Assembly of Triblock Polymers
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 13 ( 2022-05)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 13 ( 2022-05)
    Abstract: Inspired by the striated structure of skeletal muscle fibers, a polymeric actuator by assembling two symmetric triblock copolymers, namely, polystyrene‐ b ‐poly(acrylic acid)‐ b ‐polystyrene (SAS) and polystyrene‐ b ‐poly(ethylene oxide)‐ b ‐polystyrene (SES) is developed. Owing to the microphase separation of the triblock copolymers and hydrogen‐bonding complexation of their middle segments, the SAS/SES assembly forms a lamellar structure with alternating vitrified S and hydrogen‐bonded A/E association layers. The SAS/SES strip can be actuated and operate in response to environmental pH. The contraction ratio and working density of the SAS/SES actuator are approximately 50% and 90 kJ m −3 , respectively; these values are higher than those of skeletal muscle fibers. In addition, the SAS/SES actuator shows a “catch‐state”, that is, it can maintain force without energy consumption, which is a feature of mollusc muscle but not skeletal muscle. This study provides a biomimetic approach for the development of artificial polymeric actuators with outstanding performance.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.13
    DOI: 10.1002/advs.202105764
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 5
    Online Resource
    Online Resource
    Identification of frequent acute exacerbations phenotype in COPD patients based on imaging and clinical characteristics
    Elsevier BV ; 2023
    In:  Respiratory Medicine Vol. 209 ( 2023-04), p. 107150-
    Details
    In: Respiratory Medicine, Elsevier BV, Vol. 209 ( 2023-04), p. 107150-
    Type of Medium: Online Resource
    ISSN: 0954-6111
    URL: Article
    DOI: 10.1016/j.rmed.2023.107150
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2002557-9
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  • 6
    Online Resource
    Online Resource
    Simulating the Impacts of Drought and Warming in Summer and Autumn on the Productivity of Subtropical Coniferous Forests
    MDPI AG ; 2022
    In:  Forests Vol. 13, No. 12 ( 2022-12-15), p. 2147-
    Details
    In: Forests, MDPI AG, Vol. 13, No. 12 ( 2022-12-15), p. 2147-
    Abstract: The impacts of drought and/or warming on forests have received great attention in recent decades. Although the extreme drought and/or warming events significantly changed the forest demography and regional carbon cycle, the seasonality quantifying the impacts of these climate extremes with different severities on the productivity of subtropical coniferous forests remains poorly understood. This study evaluated the effects of seasonal drought and/or warming on the net primary productivity (NPP) of subtropical coniferous forests (i.e., Cunninghamia lanceolata and Pinus massoniana forests) from Hengyang–Shaoyang Basin in southern China using the Ecosystem Demography model, Version 2.2 (ED-2.2) and based on the datasets from forest inventory, meteorological reanalysis, and remotely sensed products. The results showed that the goodness of fit of the DBH-height allometric equations was better than that of the default in ED-2.2 after model calibration; the ED-2.2 model qualitatively captured the seasonality of NPP in the subtropical coniferous forests; and the mismatch between simulated annual NPP and MODIS-NPP (MOD17A3HGF) became smaller over time. The effect of seasonal drought on NPP was greater than that of warming; the decline rate of NPP gradually increased and decreased with time (from July to October) under the seasonal drought and warming scenarios, respectively; NPP decreased more seriously under the combined drought-warming scenario in October, with an average decrease of 31.72%, than the drought-only and warming-only scenarios; seasonal drought had an obvious legacy impact on productivity recovery of subtropical coniferous forests, but it was not the case for warming. With the increase in drought severity, the average values of soil available water and NPP together showed a downward trend. With the increase in warming severity, the average values of canopy air space temperature increased, but NPP decreased. Seasonal drought and/or warming limit forest production through decreasing soil moisture and/or increasing canopy air space temperature, which impact on plant photosynthesis and productivity, respectively. Our results highlight the significance of taking into account the impacts of seasonal warming and drought when evaluating the productivity of subtropical coniferous forests, as well as the significance of enhancing the resistance and resilience of forests to future, more severe global climate change.
    Type of Medium: Online Resource
    ISSN: 1999-4907
    URL: Article
    DOI: 10.3390/f13122147
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527081-3
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  • 7
    Online Resource
    Online Resource
    Therapeutic delivery of microRNA-125a-5p oligonucleotides improves recovery from myocardial ischemia/reperfusion injury in mice and swine
    Ivyspring International Publisher ; 2023
    In:  Theranostics Vol. 13, No. 2 ( 2023), p. 685-703
    Details
    In: Theranostics, Ivyspring International Publisher, Vol. 13, No. 2 ( 2023), p. 685-703
    Type of Medium: Online Resource
    ISSN: 1838-7640
    URL: Article
    DOI: 10.7150/thno.73568
    Language: English
    Publisher: Ivyspring International Publisher
    Publication Date: 2023
    detail.hit.zdb_id: 2592097-2
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  • 8
    Online Resource
    Online Resource
    Hippo (YAP)–autophagy axis protects against hepatic ischemia-reperfusion injury through JNK signaling
    Ovid Technologies (Wolters Kluwer Health) ; 2024
    In:  Chinese Medical Journal Vol. 137, No. 6 ( 2024-03-20), p. 657-668
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 137, No. 6 ( 2024-03-20), p. 657-668
    Abstract: Hepatic ischemia-reperfusion injury (HIRI) remains a common complication during liver transplantation (LT) in patients. As a key downstream effector of the Hippo pathway, Yes-associated protein (YAP) has been reported to be involved in various physiological and pathological processes. However, it remains elusive whether and how YAP may control autophagy activation during ischemia-reperfusion. Methods: Human liver tissues from patients who had undergone LT were obtained to evaluate the correlation between YAP and autophagy activation. Both an in vitro hepatocyte cell line and in vivo liver-specific YAP knockdown mice were used to establish the hepatic ischemia-reperfusion models to determine the role of YAP in the activation of autophagy and the mechanism of regulation. Results: Autophagy was activated in the post-perfusion liver grafts during LT in patients, and the expression of YAP positively correlated with the autophagic level of hepatocytes. Liver-specific knockdown of YAP inhibited hepatocytes autophagy upon hypoxia-reoxygenation and HIRI ( P 〈 0.05). YAP deficiency aggravated HIRI by promoting the apoptosis of hepatocytes both in the in vitro and in vivo models ( P 〈 0.05). Attenuated HIRI by overexpression of YAP was diminished after the inhibition of autophagy with 3-methyladenine. In addition, inhibiting autophagy activation by YAP knockdown exacerbated mitochondrial damage through increasing reactive oxygen species ( P 〈 0.05). Moreover, the regulation of autophagy by YAP during HIRI was mediated by AP1 (c-Jun) N-terminal kinase (JNK) signaling through binding to the transcriptional enhanced associate domain (TEAD). Conclusions: YAP protects against HIRI by inducing autophagy via JNK signaling that suppresses the apoptosis of hepatocytes. Targeting Hippo (YAP)–JNK–autophagy axis may provide a novel strategy for the prevention and treatment of HIRI.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000002727
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 9
    Online Resource
    Online Resource
    Data_Sheet_1.zip
    Frontiers Media SA ; 2022
    In:  Frontiers in Plant Science Vol. 13 ( 2022-9-23)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2022-9-23)
    Abstract: Subtropical forests provide diverse ecosystem services to human society. However, how subtropical tree species respond to climate change is still unclear. Using a dendrochronological method, we studied the radial growth patterns and species-specific responses of four main tree species in subtropical China to recent warming and drought. Results showed that the long-term drought caused by global warming and reduced precipitation since 1997 had resulted in the growth decline of Pinus massoniana , Castanea henryi and Castanopsis eyrei but not for Liquidambar formosana . Four species had similar sensitivities to the previous year and the current year, which is probably due to the carryover effect and temporal autocorrelation of climate data. Tree growth was positively correlated with growing season precipitation and relative humidity while negatively correlated with vapor pressure deficit. The negative relationship of tree radial growth with temperatures in the previous and current summer and the positive correlation with precipitation gradually strengthened after 1997. Therefore, we highlighted that drought-induced tree decline in subtropical forests is probably a common phenomenon, and it needed to verify by more tree-ring studies on a large scale. The species-specific responses of tree radial growth to climate change are not obvious, but they still should be considered in regional carbon balance and forest dynamics. Considering future climate change, species that are more drought tolerant should be considered as potential plantation species.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
    URL: Article
    DOI: 10.3389/fpls.2022.964400
    DOI: 10.3389/fpls.2022.964400.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 10
    Online Resource
    Online Resource
    Sedimentation of cohesive sediments at the subtidal flat affected by wind wave in high turbidity estuary
    Frontiers Media SA ; 2023
    In:  Frontiers in Marine Science Vol. 9 ( 2023-1-12)
    Details
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 9 ( 2023-1-12)
    Abstract: Sedimentation is an important mechanism to mitigate the shrinking of tidal flat and to restore its ecological function by means of sand or mud nourishment. To explore the sedimentation of cohesive sediments, a seabed tripod observation system was deployed at the subtidal region of the Hengsha Shoal adjacent to the turbidity maximum zone of the Yangtze Estuary for 11 days. The results showed that the fine sediment with the median grain size around 8 mm occupied the whole water column. The seabed was in relative equilibrium state with the fluctuation of bed level smaller than 16 mm during the moderate wind condition while the seabed experienced a rapid erosion of 38mm and a successive intensive accretion of 68mm during the process of wind wave and swell. The bottom hydrodynamic at 0.3mab during the bed accretion was stronger than that during the bed erosion. The deposition process of cohesive sediments can be better described by the simultaneous deposition paradigm than that by the exclusive deposition paradigm according to the direct data-model comparison of the bed level changes, especially during the impact of fluid mud. Three possible reasons for the better performance of the simultaneous deposition paradigm were proposed. The first possibility is that the fine suspended sediments do maintain a continuous contact with the sediment bed since the direct bed level changes during our observation period has been well reproduced by the simultaneous deposition paradigm. The second possibility is the SSC-induced turbulence damping which facilitates the fine sediment settling in the form of cohesive sediment flocs, indicating the settling of sediments can’t be judged by the critical shear stress for deposition just based on the single particle grain size. The last possibility is the fluid mud-induced overestimated bed shear stress by using turbulent velocity fluctuation above the fluid mud-water interface, which produces excess sediment erosion waiting to be compensated by the simultaneous deposition paradigm. For practical modeling purposes, modeling under the simultaneous deposition paradigm can give satisfactory results for the sedimentation of cohesive sediment especially during the impact of wave or swell.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    URL: Article
    DOI: 10.3389/fmars.2022.1045335
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2757748-X
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