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  • 2020-2024  (19,169)
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  • 1
    Online Resource
    Online Resource
    Flux pinning evolution in multilayer Pb/Ge/Pb/Ge/Pb superconducting systems
    IOP Publishing ; 2023
    In:  Chinese Physics B Vol. 32, No. 3 ( 2023-03-01), p. 037402-
    Details
    In: Chinese Physics B, IOP Publishing, Vol. 32, No. 3 ( 2023-03-01), p. 037402-
    Abstract: Multicomponent superconductors exhibit nontrivial vortex behaviors due to the various vortex–vortex interactions, including the competing one in the recently proposed type-1.5 superconductor. However, potential candidate that can be used to study the multicomponent superconductivity is rare. Here, we prepared an artificial superconducting multilayer to act as an alternative approach to study multicomponent superconductivity. The additional repulsive length and the coupling strength among superconducting films were regulated by changing the thickness of the insulting layer. The magnetization measurements were performed to clarify the effect of the competition between the repulsive vortex interactions on the macroscopic superconductivity. The vortex phase diagram and the optimum critical current density have been determined. Furthermore, a second magnetization effect is observed, and is attributed to the upper layer, which provides the weak pinning sites to localize the flux lines. The pinning behaviors switches to the mixed type with the increase of the insulting layer thicknesses. Our results open a new perspective to the study and related applications of the multilayer superconducting systems.
    Type of Medium: Online Resource
    ISSN: 1674-1056
    URL: Article
    DOI: 10.1088/1674-1056/ac89e1
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2412147-2
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  • 2
    Online Resource
    Online Resource
    m 6 A promotes planarian regeneration
    Wiley ; 2023
    In:  Cell Proliferation Vol. 56, No. 5 ( 2023-05)
    Details
    In: Cell Proliferation, Wiley, Vol. 56, No. 5 ( 2023-05)
    Abstract: Regeneration is the regrowth of damaged tissues or organs, a vital process in response to damages from primitive organisms to higher mammals. Planarian possesses active whole‐body regenerative capability owing to its vast reservoir of adult stem cells, neoblasts, providing an ideal model to delineate the underlying mechanisms for regeneration. RNA N 6 ‐methyladenosine (m 6 A) modification participates in many biological processes, including stem cell self‐renewal and differentiation, in particular the regeneration of haematopoietic stem cells and axons. However, how m 6 A controls regeneration at the whole‐organism level remains largely unknown. Here, we demonstrate that the depletion of m 6 A methyltransferase regulatory subunit wtap abolishes planarian regeneration, potentially through regulating genes related to cell–cell communication and cell cycle. Single‐cell RNA‐seq (scRNA‐seq) analysis unveils that the wtap knockdown induces a unique type of neural progenitor‐like cells (NP‐like cells), characterized by specific expression of the cell–cell communication ligand grn . Intriguingly, the depletion of m 6 A‐modified transcripts grn , cdk9 or cdk7 partially rescues the defective regeneration of planarian caused by wtap knockdown. Overall, our study reveals an indispensable role of m 6 A modification in regulating whole‐organism regeneration.
    Type of Medium: Online Resource
    ISSN: 0960-7722 , 1365-2184
    URL: Issue
    URL: Article
    DOI: 10.1111/cpr.v56.5
    DOI: 10.1111/cpr.13481
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2019986-7
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Corticosteroids usage and central serous chorioretinopathy: a meta-analysis
    Springer Science and Business Media LLC ; 2020
    In:  Graefe's Archive for Clinical and Experimental Ophthalmology Vol. 258, No. 1 ( 2020-01), p. 71-77
    Details
    In: Graefe's Archive for Clinical and Experimental Ophthalmology, Springer Science and Business Media LLC, Vol. 258, No. 1 ( 2020-01), p. 71-77
    Type of Medium: Online Resource
    ISSN: 0721-832X , 1435-702X
    URL: Article
    DOI: 10.1007/s00417-019-04486-w
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 1459159-5
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  • 4
    Online Resource
    Online Resource
    A prospective comparison of four methods for preventing pacemaker pocket infections
    Wiley ; 2021
    In:  Artificial Organs Vol. 45, No. 4 ( 2021-04), p. 411-418
    Details
    In: Artificial Organs, Wiley, Vol. 45, No. 4 ( 2021-04), p. 411-418
    Abstract: This study aims to evaluate four pacemaker pocket cleaning methods for preventing implantation‐related infections. This single‐center trial prospectively randomized 910 patients undergoing first‐time pacemaker implantation or replacement into four pocket cleaning methods: hemocoagulase (group A, n  = 228), gentamicin (group B, n  = 228), hemocoagulase plus gentamicin (group C, n  = 227), and normal saline (group D, n  = 227). Before implanting the pacemaker battery, the pockets were cleaned with gauze presoaked in the respective cleaning solutions. Then, these patients were followed up to monitor the occurrence of infections for 1 month after implantation. Twelve implantation‐related infections occurred in 910 patients (1.32%): four patients from group A (1.75%), three patients from group B (1.32%), two patients from group C (0.88%), and three patients from group D (1.32%) ( P   〉  .05). Furthermore, two patients developed bloodstream infections (0.22%), and both of these patients were associated with pocket infection (one patient was from group A, while the other patient was from group C, respectively). No cases of infective endocarditis occurred. The differences in the number of infections in these study groups were not statistically significant. The application of hemocoagulase, gentamicin, hemocoagulase plus gentamicin, or normal saline on the presoaked gauze before implantation was equally effective in preventing pocket‐associated infections.
    Type of Medium: Online Resource
    ISSN: 0160-564X , 1525-1594
    URL: Issue
    URL: Article
    DOI: 10.1111/aor.v45.4
    DOI: 10.1111/aor.13832
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2003825-2
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  • 5
    Online Resource
    Online Resource
    Fundus changes of Parry-Romberg syndrome: A report of three cases and literature review
    SAGE Publications ; 2022
    In:  European Journal of Ophthalmology Vol. 32, No. 5 ( 2022-09), p. NP13-NP19
    Details
    In: European Journal of Ophthalmology, SAGE Publications, Vol. 32, No. 5 ( 2022-09), p. NP13-NP19
    Abstract: To report three cases of Parry-Romberg syndrome (PRS) with progressive hemifacial atrophy and similar fundus changes. Methods: Retrospective case series of three patients who presented to the ophthalmology department with blurred vision in one eye. All of them underwent three-dimensional reconstruction of head computed tomography (CT), related physical examinations, and also monthly ocular examinations of both eyes, including the slit-lamp microscope, fundus autofluorescence, optical coherence tomography (OCT), and fundus fluorescein angiography (FFA). We also reviewed the current literature about the fundus change in PRS from inception to March 2020 via PubMed. Results: Coats-like fundus and exudative retinal detachment were found in all three eyes of three patients during the follow-up. No systematic changes were found except for hemifacial atrophy. The final diagnoses of these three patients were PRS. Conclusion: Only a subset of PRS patients have concomitant ocular changes, but it still should be noticed that the diagnosis of PRS should be considered if adults presented with Coats-like retinopathy and hemifacial atrophy.
    Type of Medium: Online Resource
    ISSN: 1120-6721 , 1724-6016
    URL: Article
    DOI: 10.1177/11206721211015560
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 1475018-1
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  • 6
    Online Resource
    Online Resource
    Oligocene–Miocene northward growth of the Tibetan Plateau: Insights from intermontane basins in the West Qinling Belt, NW China
    Geological Society of America ; 2023
    In:  Geological Society of America Bulletin ( 2023-04-28)
    Details
    In: Geological Society of America Bulletin, Geological Society of America, ( 2023-04-28)
    Abstract: Growth of the Tibetan Plateau, Earth’s broadest and highest elevation collisional system, shapes orographic barriers, reorganizes drainage networks, and influences surface erosion and sediment delivery, whose changes in space and provenance feed back to intracontinental tectonic processes. Studies of interior basins within the northern Tibetan Plateau provide new sediment accumulation, provenance, paleodrainage, and deformation timing data that enable a reconstruction of the far-field tectono-geomorphic evolution of the rising Tibetan Plateau. Along the northern plateau margin, topographic growth in the West Qinling Belt is inferred to have initiated in the Eocene, nearly coeval with the India-Asia collision, as well as in the late Miocene. However, geological knowledge about the intervening period remains at present enigmatic, and the kinematics and dynamics are uncertain. This study presents a multidisciplinary data set from the intermontane Anhua-Huicheng Basin (AHB; Gansu Province, China) to fill this gap. Magnetostratigraphic dating, regional mapping, and sedimentological analysis imply that contractional deformation and thrust-top basin systems formed within the West Qinling Belt in the Oligocene (not later than ca. 24 Ma). A combination of observations including paleocurrent changes, detrital zircon U-Pb age variations, and appearance of growth strata along the Anhua-Huicheng Basin reveal the rapid uplift of the West Qinling Belt at ca. 15 Ma. Sedimentation in the intermontane basins ended after the late Miocene (ca. 8 Ma), when the region experienced intrabasinal deformation, uplift, and erosion with the establishment of an external drainage system. Since the late Miocene, the growth of the West Qinling Belt reached a climax with the lack of substantial contractional deformation in Cenozoic sequences heralding the onset of the modern kinematic regime and attainment of high elevation. Observed transitions in the tectonostratigraphy and paleodrainage define different phases of deformation and plateau-wide shifts in stress reorganization, which led to the northward growth and later lateral expansion of the Tibetan Plateau.
    Type of Medium: Online Resource
    ISSN: 0016-7606 , 1943-2674
    URL: Article
    DOI: 10.1130/B36722.1
    Language: English
    Publisher: Geological Society of America
    Publication Date: 2023
    detail.hit.zdb_id: 2028776-8
    detail.hit.zdb_id: 2008165-0
    detail.hit.zdb_id: 449720-X
    detail.hit.zdb_id: 1351-1
    SSG: 13
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  • 7
    Online Resource
    Online Resource
    DataSheet_1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Oncology Vol. 11 ( 2021-9-7)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-9-7)
    Abstract: This study aimed to develop a radiomics nomogram based on contrast-enhanced ultrasound (CEUS) for preoperatively assessing microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients. Methods A retrospective dataset of 313 HCC patients who underwent CEUS between September 20, 2016 and March 20, 2020 was enrolled in our study. The study population was randomly grouped as a primary dataset of 192 patients and a validation dataset of 121 patients. Radiomics features were extracted from the B-mode (BM), artery phase (AP), portal venous phase (PVP), and delay phase (DP) images of preoperatively acquired CEUS of each patient. After feature selection, the BM, AP, PVP, and DP radiomics scores (Rad-score) were constructed from the primary dataset. The four radiomics scores and clinical factors were used for multivariate logistic regression analysis, and a radiomics nomogram was then developed. We also built a preoperative clinical prediction model for comparison. The performance of the radiomics nomogram was evaluated via calibration, discrimination, and clinical usefulness. Results Multivariate analysis indicated that the PVP and DP Rad-score, tumor size, and AFP (alpha-fetoprotein) level were independent risk predictors associated with MVI. The radiomics nomogram incorporating these four predictors revealed a superior discrimination to the clinical model (based on tumor size and AFP level) in the primary dataset (AUC: 0.849  vs . 0.690; p  & lt; 0.001) and validation dataset (AUC: 0.788  vs . 0.661; p = 0.008), with a good calibration. Decision curve analysis also confirmed that the radiomics nomogram was clinically useful. Furthermore, the significant improvement of net reclassification index (NRI) and integrated discriminatory improvement (IDI) implied that the PVP and DP radiomics signatures may be very useful biomarkers for MVI prediction in HCC. Conclusion The CEUS-based radiomics nomogram showed a favorable predictive value for the preoperative identification of MVI in HCC patients and could guide a more appropriate surgical planning.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2021.709339
    DOI: 10.3389/fonc.2021.709339.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2649216-7
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  • 8
    Online Resource
    Online Resource
    Artificial intelligence - based ultrasound elastography for disease evaluation - a narrative review
    Frontiers Media SA ; 2023
    In:  Frontiers in Oncology Vol. 13 ( 2023-6-2)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 13 ( 2023-6-2)
    Abstract: Ultrasound elastography (USE) provides complementary information of tissue stiffness and elasticity to conventional ultrasound imaging. It is noninvasive and free of radiation, and has become a valuable tool to improve diagnostic performance with conventional ultrasound imaging. However, the diagnostic accuracy will be reduced due to high operator-dependence and intra- and inter-observer variability in visual observations of radiologists. Artificial intelligence (AI) has great potential to perform automatic medical image analysis tasks to provide a more objective, accurate and intelligent diagnosis. More recently, the enhanced diagnostic performance of AI applied to USE have been demonstrated for various disease evaluations. This review provides an overview of the basic concepts of USE and AI techniques for clinical radiologists and then introduces the applications of AI in USE imaging that focus on the following anatomical sites: liver, breast, thyroid and other organs for lesion detection and segmentation, machine learning (ML) - assisted classification and prognosis prediction. In addition, the existing challenges and future trends of AI in USE are also discussed.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2023.1197447
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2649216-7
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  • 9
    Online Resource
    Online Resource
    A novel clustering algorithm based on the gravity-mass-square ratio and density core with a dynamic denoising radius
    Springer Science and Business Media LLC ; 2022
    In:  Applied Intelligence Vol. 52, No. 8 ( 2022-06), p. 8924-8946
    Details
    In: Applied Intelligence, Springer Science and Business Media LLC, Vol. 52, No. 8 ( 2022-06), p. 8924-8946
    Type of Medium: Online Resource
    ISSN: 0924-669X , 1573-7497
    URL: Article
    DOI: 10.1007/s10489-021-02753-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1479519-X
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  • 10
    Online Resource
    Online Resource
    DataSheet1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Pharmacology Vol. 12 ( 2021-12-8)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2021-12-8)
    Abstract: Purpose: This network meta-analysis was conducted to obtain the relative effectiveness of different pharmacotherapy of macular edema secondary to retinal vein occlusion (RVO) by summarizing all available evidences. Methods: PubMed, Embase, and Cochrane Library databases were searched for all relevant randomized controlled trials. The outcomes were estimated through a network meta-analysis, including the mean change in best-corrected visual acuity (BCVA) from baseline, the proportion of patients who gained ≥15 letters in BCVA from baseline, the mean change in central retinal thickness (CRT). Results: We identified 15 randomized controlled trials (RCTs) involving 3,431 patients with RVO in our study. Different therapeutic regimens were compared including three anti-vascular endothelial growth factor (VEGF) agents (ranibizumab, bevacizumab, and aflibercept), ranibizumab with laser, dexamethasone intravitreal implant, and laser. For branch RVO, ranibizumab 0.5 mg monthly [weighted mean difference (WMD) = 11, 95% confidence intervals (CrI) 3.6 to 19], ranibizumab 0.5 mg 3 + pro re nata (WMD = 9.4, 95% CrI 0.43–18) is most effective in terms of changes of BCVA and 15 letters or more of BCVA improvement. For central RVO, three anti-VEGF regimens can improve visual acuity and there is no significant difference of efficacy among ranibizumab, bevacizumab and aflibercept ( p & gt; 0.05). Ranibizumab 0.5 mg monthly could achieve additional efficacy in CRT reduction in eyes with branch RVO or central RVO (WMD = -130, 95% CrI -400 to 140 or WMD = -280, 95% CrI -590 to 16)). Dexamethasone intravitreal implant (WMD = 1.7, 95% CrI -4.2 to 7.1 or WMD = 0.38, 95% CrI -9.8 to 8.8)) did not show a significant improvement in visual acuity at the end of 6 months follow-up in eyes with branch RVO or central RVO. Conclusion: In summary, this network meta-analysis demonstrated several anti-VEGF agents had equivalent effects on mean visual acuity changes and anatomical recovery in 6 months in eyes with branch or central RVO. Only one injection of dexamethasone intravitreal implant in 6 months could not maintain the visual benefit. Patients and clinicians could choose pharmacotherapies with further consideration toward personal factors.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2021.752048
    DOI: 10.3389/fphar.2021.752048.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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