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  • 2020-2024  (3,330)
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  • 2020-2024  (3,330)
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  • 1
    Online Resource
    Online Resource
    ‘Eating is like experiencing a gamble’: A qualitative study exploring the dietary decision‐making process in adults with inflammatory bowel disease
    Wiley ; 2024
    In:  Health Expectations Vol. 27, No. 1 ( 2024-02)
    Details
    In: Health Expectations, Wiley, Vol. 27, No. 1 ( 2024-02)
    Abstract: For adults with inflammatory bowel disease (IBD), they experience many challenges in dietary decision‐making. Thus, this study examined the perspective and experiences of adults with IBD in dietary decision‐making. Objective This study aimed to explore the perception and consideration of people with IBD in their daily dietary decisions through monitoring, interpretation and action during the decision‐making process. Design A qualitative study of individuals affected by IBD was conducted through semistructured interviews. Results Twenty patients were recruited from four tertiary hospitals in Nanjing, China, and each participant completed a semistructured interview. The majority of participants reported on the process and experience of dietary decision‐making. Key themes were categorised into three stages: (1) assessing needs, preferences and food cues (monitor); (2) moving from experience to expertise (interpret) and (3) balancing expectations amidst limitations (act). The majority of participants reported that their decisions were shaped by assessing current disease status and food cues. Those interviewed with IBD were willing to make tradeoffs for bowel stability, but their decisions were also influenced by past dietary experiences and traditional Chinese beliefs. The lack of awareness of dietary guidelines was a significant barrier to healthy eating decisions. Positive or negative feelings accompanied dietary decisions. Conclusion Although most people with IBD change their diet after diagnosis, the changes made are often inconsistent with existing dietary recommendations. Several factors can influence the dietary decision‐making process. This study will help assess the experiences of people with IBD in dietary decision‐making to encourage the formation of targeted dietary health and well‐being interventions. Knowledge of nutrition and diet should be provided in education and training programmes for IBD management. Patient or Public Contribution The first three authors of this paper were the lead researchers in this study's design. These authors were mentored by patient researchers who also contributed to the manuscript, and the research process was co‐lead and directed by other patient participants and consultants. The results of this paper were directly obtained from patient participants.
    Type of Medium: Online Resource
    ISSN: 1369-6513 , 1369-7625
    URL: Issue
    URL: Article
    DOI: 10.1111/hex.v27.1
    DOI: 10.1111/hex.13873
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2006357-X
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  • 2
    Online Resource
    Online Resource
    A novel tissue engineered nerve graft constructed with autologous vein and nerve microtissue repairs a long-segment sciatic nerve defect
    Medknow ; 2021
    In:  Neural Regeneration Research Vol. 16, No. 1 ( 2021), p. 143-
    Details
    In: Neural Regeneration Research, Medknow, Vol. 16, No. 1 ( 2021), p. 143-
    Type of Medium: Online Resource
    ISSN: 1673-5374
    URL: Article
    DOI: 10.4103/1673-5374.286977
    Language: English
    Publisher: Medknow
    Publication Date: 2021
    detail.hit.zdb_id: 2388460-5
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  • 3
    Online Resource
    Online Resource
    Mobile Health Technology to Improve Care for Patients With Atrial Fibrillation
    Elsevier BV ; 2020
    In:  Journal of the American College of Cardiology Vol. 75, No. 13 ( 2020-04), p. 1523-1534
    Details
    In: Journal of the American College of Cardiology, Elsevier BV, Vol. 75, No. 13 ( 2020-04), p. 1523-1534
    Type of Medium: Online Resource
    ISSN: 0735-1097
    URL: Article
    DOI: 10.1016/j.jacc.2020.01.052
    RVK:
    XA 17760
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1468327-1
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  • 4
    Online Resource
    Online Resource
    CX-5461-inspired monofunctional platinum RNA polymerase I selective inhibitors with selective lethality in BRCA1-deficient cancer cells
    Royal Society of Chemistry (RSC) ; 2023
    In:  Inorganic Chemistry Frontiers Vol. 10, No. 14 ( 2023), p. 4157-4174
    Details
    In: Inorganic Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 10, No. 14 ( 2023), p. 4157-4174
    Abstract: Unrestricted cell growth and proliferation of cancer cells correlate with accelerated hyperactivated RNA polymerase I transcription and upregulation of ribosome biogenesis. Herein, we employed 2-(4-methyl-[1,4]diazepan-1-yl)-5-oxo-5 H -7-thia-1,11 b -diaza-benzo[ c ]fluorene-6-carboxylic acid (5-methyl-pyrazin-2-ylmethyl)-amide (CX-5461), the first Pol I selective inhibitor with the multitargeting property and synthetical lethality in homologous recombination (HR) deficient cancers, to modify cisplatin, affording two monofunctional platinum Pol I selective inhibitors [PtCl(NH 3 ) 2 (LH1)]NO 3 (P1-Q1) and [PtCl(NH 3 ) 2 (LH2)]NO 3 (P1-Q2) [LH1 = N -(3-( N -methylacetimidamido)propyl)-2-(4-methylpiperazin-1-yl)-5-oxo-5 H -benzo[4,5]thiazolo[3,2- a ][1,8] naphthyridine-6-carboxamide; LH2 = 2-(4-methyl-1,4-diazepan-1-yl)- N -(3-( N -methylacetimidamido)propyl)-5-oxo-5 H -benzo[4,5]thiazolo[3,2- a ][1,8] naphthyridine-6-carboxamide]. Our data showed that P1-Q1 and P1-Q2 could preferentially target the Pol I transcription machinery, overcome platinum drug resistance, and display more potent antiproliferative activity in BRCA1-deficient A549 cells. Mechanism studies demonstrated that P1-Q1 and P1-Q2 could effectively accumulate in cancer cells and nucleoli, selectively inhibit Pol I transcription, stimulate nucleolar stress and p53 stabilization, increase intracellular ROS levels, disrupt the mitochondrial membrane potential, and inhibit migration and metastasis, which further lead to cell cycle arrest and apoptosis. Particularly, P1-Q1 could facilitate the formation and stabilization of R-loops, induce severe DNA damage, and trigger ATR/CHK1 and ATM/CHK2 kinase signaling cascades in BRCA1-deficient A549 cells, suggesting that defects in the HR pathway may exacerbate P1-Q1 induced DNA damage and cause synthetic lethality and apoptosis. Our data demonstrated that P1-Q1 and P1-Q2 are distinct from the clinical platinum anticancer drugs in their mechanism of action, and taking advantage of the selective Pol I inhibition, multitargeting property, and synthetic lethality of CX-5461 in HR-deficient cancers to modify platinum-based agents might be a brand-new approach for cancer therapy.
    Type of Medium: Online Resource
    ISSN: 2052-1553
    URL: Article
    DOI: 10.1039/D3QI00358B
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    Emergence of an ancient and pathogenic mammarenavirus
    Informa UK Limited ; 2023
    In:  Emerging Microbes & Infections Vol. 12, No. 1 ( 2023-12-31)
    Details
    In: Emerging Microbes & Infections, Informa UK Limited, Vol. 12, No. 1 ( 2023-12-31)
    Type of Medium: Online Resource
    ISSN: 2222-1751
    URL: Article
    DOI: 10.1080/22221751.2023.2192816
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2681359-2
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  • 6
    Online Resource
    Online Resource
    Neoadjuvant chemoradiotherapy induced lymphopenia in gastric cancer and associations with spleen dosimetry and survival outcomes
    Elsevier BV ; 2023
    In:  Clinical and Translational Radiation Oncology Vol. 40 ( 2023-05), p. 100617-
    Details
    In: Clinical and Translational Radiation Oncology, Elsevier BV, Vol. 40 ( 2023-05), p. 100617-
    Type of Medium: Online Resource
    ISSN: 2405-6308
    URL: Article
    DOI: 10.1016/j.ctro.2023.100617
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2885426-3
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  • 7
    Online Resource
    Online Resource
    Preoperative chemoradiation-induced hematological toxicity and related vertebral dosimetry evaluations in patients with locally advanced gastric cancer: data from a phase III clinical trial
    Springer Science and Business Media LLC ; 2023
    In:  Radiation Oncology Vol. 18, No. 1 ( 2023-06-09)
    Details
    In: Radiation Oncology, Springer Science and Business Media LLC, Vol. 18, No. 1 ( 2023-06-09)
    Abstract: To explore the hematological toxicity (HT) induced by neoadjuvant chemoradiotherapy (nCRT) compared with neoadjuvant chemotherapy (nCT) and to identify the appropriate vertebral body (VB) dosimetric parameters for predicting HT in patients with locally advanced gastric cancer (GC). Methods In the phase III study, 302 patients with GC from an ongoing multi-center randomized clinical trial (NCT 01815853) were included. Patients from two major centers were grouped into training and external validation cohorts. The nCT group received three cycles of XELOX chemotherapy, while the nCRT received the same dose-reduced chemotherapy plus 45 Gy radiotherapy. The complete blood counts at baseline, during neoadjuvant treatment, and in the preoperative period were compared between the nCT and nCRT groups. The VB was retrospectively contoured and the dose-volume parameters were extracted in the nCRT group. Patients’ clinical characteristics, VB dosimetric parameters, and HTs were statistically analyzed. Instances of HT were graded according to the Common Terminology Criteria for Adverse Events v5.0 (CTCAE v5.0). The receiver operating characteristic (ROC) curves were generated to identify the optimal cut-off points for dosimetric variables and verify the prediction efficiency of the dosimetric index in both training and external validation cohorts. Results In the training cohort, 27.4% Grade 3 + HTs were noted in the nCRT group and 16.2% in the nCT group ( P  = 0.042). A similar result was exhibited in the validation cohort, with 35.0% Grade 3 + HTs in the nCRT group and 13.2% in the nCT group ( P  = 0.025). The multivariate analysis of the training cohort revealed that V 5 was associated with Grade 3 + leukopenia ( P  = 0.000), Grade 3 + thrombocytopenia ( P  = 0.001), and Grade 3 + total HTs ( P  = 0.042). The Spearman correlation analysis identified a significant correlation of V 5 with the white blood cell nadir ( P  = 0.0001) and platelet nadir ( P  = 0.0002). The ROC curve identified the optimal cut-off points for V 5 and showed that V 5 〈 88.75% could indicate a decreased risk of Grade 3 + leukopenia, thrombocytopenia, and total HTs in the training as well as the external validation cohorts. Conclusions Compared with nCT, nCRT could increase the risk of Grade 3 + HT in patients with locally advanced GC. Dose constraints of V 5 〈 88.75% in irradiated VB could reduce the incidence of Grade 3 + HT.
    Type of Medium: Online Resource
    ISSN: 1748-717X
    URL: Article
    DOI: 10.1186/s13014-023-02269-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2224965-5
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  • 8
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    Online Resource
    Immunological and inflammatory profiles in mild and severe cases of COVID-19
    Springer Science and Business Media LLC ; 2020
    In:  Nature Communications Vol. 11, No. 1 ( 2020-07-08)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2020-07-08)
    Abstract: COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/s41467-020-17240-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2553671-0
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  • 9
    Online Resource
    Online Resource
    Systematic Discovery and Pathway Analyses of Metabolic Disturbance in COVID-19
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Infectious Diseases & Immunity Vol. 1, No. 2 ( 2021-07), p. 74-85
    Details
    In: Infectious Diseases & Immunity, Ovid Technologies (Wolters Kluwer Health), Vol. 1, No. 2 ( 2021-07), p. 74-85
    Abstract: The ongoing global coronavirus disease 2019 (COVID-19) pandemic is posing a serious public health threat to nations worldwide. Understanding the pathogenesis of the disease and host immune responses will facilitate the discovery of therapeutic targets and better management of infected patients. Metabolomics technology can provide an unbiased tool to explore metabolic perturbation. Methods: Twenty-six healthy controls and 50 COVID-19 patients with mild, moderate, and severe symptoms in the Fifth Medical Center of PLA General Hospital from January 22 to February 16, 2020 were recruited into the study. Fasting blood samples were collected and subject to metabolomics analysis by liquid chromatography–mass spectrometry. Metabolite abundance was measured by peak area and was log-transformed before statistical analysis. The principal component analysis, different expression analysis, and metabolic pathway analysis were performed using R package. Co-regulated metabolites and their associations with clinical indices were identified by the weighted correlation network analysis and Spearman correlation coefficients. The potential metabolite biomarkers were analyzed using a random forest model. Results: We uncovered over 100 metabolites that were associated with COVID-19 disease and many of them correlated with disease severity. Sets of highly correlated metabolites were identified and their correlations with clinical indices were presented. Further analyses linked the differential metabolites with biochemical reactions, metabolic pathways, and biomedical MeSH terms, offering contextual insights into disease pathogenesis and host responses. Finally, a panel of metabolites was discovered to be able to discriminate COVID-19 patients from healthy controls, and also another list for mild against more severe cases. Our findings showed that in COVID-19 patients, citrate cycle, sphingosine 1-phosphate in sphingolipid metabolism, and steroid hormone biosynthesis were downregulated, while purine metabolism and tryptophan metabolism were disturbed. Conclusion: This study discovered key metabolites as well as their related biological and medical concepts pertaining to COVID-19 pathogenesis and host immune response, which will facilitate the selection of potential biomarkers for prognosis and discovery of therapeutic targets.
    Type of Medium: Online Resource
    ISSN: 2693-8839
    URL: Article
    DOI: 10.1097/ID9.0000000000000010
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 3123817-8
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  • 10
    Online Resource
    Online Resource
    Mandarin fish (Sinipercidae) genomes provide insights into innate predatory feeding
    Springer Science and Business Media LLC ; 2020
    In:  Communications Biology Vol. 3, No. 1 ( 2020-07-09)
    Details
    In: Communications Biology, Springer Science and Business Media LLC, Vol. 3, No. 1 ( 2020-07-09)
    Abstract: Mandarin fishes (Sinipercidae) are piscivores that feed solely on live fry. Unlike higher vertebrates, teleosts exhibit feeding behavior driven mainly by genetic responses, with no modification by learning from parents. Mandarin fishes could serve as excellent model organisms for studying feeding behavior. We report a long-read, chromosomal-scale genome assembly for Siniperca chuatsi and genome assemblies for Siniperca kneri , Siniperca scherzeri and Coreoperca whiteheadi . Positive selection analysis revealed rapid adaptive evolution of genes related to predatory feeding/aggression, growth, pyloric caeca and euryhalinity. Very few gill rakers are observed in mandarin fishes; analogously, we found that zebrafish deficient in edar had a gill raker loss phenotype and a more predatory habit, with reduced intake of zooplankton but increased intake of prey fish. Higher expression of bmp4 , which could inhibit edar expression and gill raker development through binding of a Xvent-1 site upstream of edar , may cause predatory feeding in Siniperca .
    Type of Medium: Online Resource
    ISSN: 2399-3642
    URL: Article
    DOI: 10.1038/s42003-020-1094-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2919698-X
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