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  • 1
    Online Resource
    Online Resource
    Evaluation of a Deep Neural Network for Automated Classification of Colorectal Polyps on Histopathologic Slides
    American Medical Association (AMA) ; 2020
    In:  JAMA Network Open Vol. 3, No. 4 ( 2020-04-23), p. e203398-
    Details
    In: JAMA Network Open, American Medical Association (AMA), Vol. 3, No. 4 ( 2020-04-23), p. e203398-
    Type of Medium: Online Resource
    ISSN: 2574-3805
    URL: Article
    DOI: 10.1001/jamanetworkopen.2020.3398
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2020
    detail.hit.zdb_id: 2931249-8
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  • 2
    Online Resource
    Online Resource
    Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial
    American Association for Cancer Research (AACR) ; 2022
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 31, No. 5 ( 2022-05-04), p. 1058-1067
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 31, No. 5 ( 2022-05-04), p. 1058-1067
    Abstract: Serrated polyps (SP) are important colorectal cancer precursors, yet their epidemiology is incompletely understood. We measured risk factors for incident sessile-serrated lesions (SSL) and microvesicular (MVHP) and goblet-cell rich (GCHP) hyperplastic polyp subtypes. Methods: We conducted a cohort study of patients undergoing colonoscopic surveillance nested within a chemoprevention trial. Outcomes of interest were ≥1 SPs, including SSLs, MVHPs, and GCHPs specifically. Multivariable generalized estimating equation models were used to estimate adjusted risk ratios (RR) and 95% confidence intervals (CI) for different polyp types. Results: Among 2,102 participants, a total of 1,615 SPs (including 212 SSLs) were found among 758 participants during follow-up. Prior history of SPs was strongly associated with subsequent occurrence of SPs. There was no apparent association between age, sex, or education and risk of SPs. Black participants were at lower risk of SSLs and MVHPs, but higher risk of GCHPs compared with white participants [RR, 0.40; 95% CI, 0.16–0.99); RR, 0.63 (95% CI, 0.42–0.96); and RR, 1.83 (95% CI, 1.23–2.72) respectively]. Alcohol and smoking exposure were also associated with SPs, including hyperplastic polyp subtypes in particular. Conclusions: In this prospective study, the risk of SP subtypes differed by race, alcohol, and smoking status, and prior history of SPs. Risk factor associations for SPs differ from risk factors for conventional adenomas, supporting the concept of etiologic heterogeneity of colorectal cancer. Impact: These findings allow for better risk stratification of patients undergoing colorectal cancer screening and could inform screening test selection.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1055-9965.EPI-21-1226
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2022
    detail.hit.zdb_id: 2036781-8
    detail.hit.zdb_id: 1153420-5
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  • 3
    Online Resource
    Online Resource
    In Search of Nodular Gastric Antral Vascular Ectasia: A Distinct Entity or Simply Hyperplastic Polyps Arising in Gastric Antral Vascular Ectasia?
    Archives of Pathology and Laboratory Medicine ; 2023
    In:  Archives of Pathology & Laboratory Medicine ( 2023-04-5)
    Details
    In: Archives of Pathology & Laboratory Medicine, Archives of Pathology and Laboratory Medicine, ( 2023-04-5)
    Abstract: Nodular gastric antral vascular ectasia (GAVE) is a reported phenotype of GAVE that has histologic features overlapping with gastric hyperplastic polyps (GHPs), with additional features often seen in flat mucosa of GAVE. Objective.— To determine if nodular GAVE and GHPs are distinct lesions by evaluating the prevalence of features reported in nodular GAVE in GHPs with or without associated GAVE. Design.— A review of all lesions diagnosed as GHPs between 2014 and 2017 was performed. Slides were analyzed for a number of features including established histologic features of GAVE without knowledge of clinical or endoscopic features. Results.— A total of 90 polyps were analyzed including 18 from patients with GAVE (20%). GAVE polyps were larger (average size, 1.3 cm versus 0.68 cm; P & lt; .001), with more common extensive ulceration and associated granulation tissue (61.11% [n = 11] versus 4.17% [n = 3] ; P = .004), fibrin thrombi (50% [n = 9] versus 15% [n = 11] ; P = .003), moderate to marked vascular ectasia (83% [n = 15] versus 35% [n = 11] ; P = .001), and fibrohyalinosis (72% [n = 13] versus 28% [n = 20] ; P = .001). All polyps showed foveolar hyperplasia and smooth muscle proliferation. There were no features that were exclusively found in GAVE or non-GAVE cases. Conclusions.— Nodular GAVE appears to represent GHPs arising in a background of GAVE, with superimposed features found in flat mucosa of GAVE stomachs. The presence of fibrin thrombi, marked vascular ectasia, fibrohyalinosis, and/or ulceration in a GHP is suggestive but not diagnostic of GAVE, and the absence of these features does not rule out GAVE.
    Type of Medium: Online Resource
    ISSN: 1543-2165 , 0003-9985
    URL: Article
    DOI: 10.5858/arpa.2022-0230-OA
    RVK:
    XA 10000
    RVK:
    XA 29700
    Language: English
    Publisher: Archives of Pathology and Laboratory Medicine
    Publication Date: 2023
    detail.hit.zdb_id: 2028916-9
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  • 4
    Online Resource
    Online Resource
    Circulating 27-hydroxycholesterol and Risk of Colorectal Adenomas and Serrated Polyps
    American Association for Cancer Research (AACR) ; 2021
    In:  Cancer Prevention Research Vol. 14, No. 4 ( 2021-04-01), p. 479-488
    Details
    In: Cancer Prevention Research, American Association for Cancer Research (AACR), Vol. 14, No. 4 ( 2021-04-01), p. 479-488
    Abstract: The oxysterol 27-hydroxycholesterol (27-OHC) is an endogenous selective estrogen receptor modulator implicated in breast cancer etiology. It is unknown whether circulating 27-OHC is associated with colorectal neoplasia risk. Circulating 27-OHC was measured using LC/MS in fasting plasma collected at baseline from participants of the Vitamin D/Calcium Polyp Prevention Study, a completed randomized clinical trial. Participants were between 45 and 75 years old, recently diagnosed with ≥1 colorectal adenoma, and followed for new colorectal polyps during colonoscopic surveillance. Adjusted risk ratios (RR) with 95% confidence intervals (CI) of new colorectal polyps were estimated for quartiles of circulating 27-OHC using log-linear regression for repeated outcomes. Polyp phenotypes included any adenomas, advanced adenomas, hyperplastic polyps, and sessile serrated adenomas/polyps. Circulating 27-OHC was measured at baseline for 1,246 participants. Compared with participants with circulating 27-OHC below the first quartile ( & lt;138 ng/mL), those with circulating 27-OHC at or above the fourth quartile (≥201 ng/mL) had 24% higher risk of adenomas (RR, 1.24; 95% CI, 1.05–1.47) and 89% higher risk of advanced adenomas (RR, 1.89; 95% CI, 1.17–3.06). Stronger associations were observed among participants with advanced adenomas at baseline. Circulating 27-OHC was not associated with risk of hyperplastic polyps (RR, 0.90; 95% CI, 0.66–1.22) or sessile serrated adenomas/polyps (RR, 1.02; 95% CI, 0.50–2.07). Circulating 27-OHC may be a risk factor for colorectal adenomas but not serrated polyps. Prevention Relevance: This study found that plasma concentration of 27-hydroxycholesterol, a metabolite of cholesterol that regulates lipid metabolism and acts as a selective estrogen receptor modulator, is associated with the risk of developing precursor lesions for colorectal cancer.
    Type of Medium: Online Resource
    ISSN: 1940-6207 , 1940-6215
    URL: Article
    DOI: 10.1158/1940-6207.CAPR-20-0414
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2021
    detail.hit.zdb_id: 2422346-3
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  • 5
    Online Resource
    Online Resource
    Head to head: should we adopt the term ‘sessile serrated lesion’?
    Wiley ; 2022
    In:  Histopathology Vol. 80, No. 7 ( 2022-06), p. 1019-1025
    Details
    In: Histopathology, Wiley, Vol. 80, No. 7 ( 2022-06), p. 1019-1025
    Abstract: The precursor lesion for the ~30% of colon carcinomas developing along the serrated pathway was first described in detail in 1996, and was named sessile serrated adenoma in 2003. Although the entity itself was controversial initially, over time the concept of a serrated pathway initiated by this lesion has become well accepted in the medical community. The name sessile serrated adenoma, however, has been controversial since the beginning and continues to be controversial. Alternative names, including serrated polyp with abnormal proliferation, sessile serrated polyp and, most recently, sessile serrated lesion, have been proposed. Despite the fact that the term sessile serrated lesion was adopted by the World Health Organization in 2019, none of these terms has received universal acceptance. In this article, arguments for and against adopting the term sessile serrated lesion are discussed in detail.
    Type of Medium: Online Resource
    ISSN: 0309-0167 , 1365-2559
    URL: Issue
    URL: Article
    DOI: 10.1111/his.v80.7
    DOI: 10.1111/his.14618
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2006447-0
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