GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia
    Oxford University Press (OUP) ; 2022
    In:  Cerebral Cortex Vol. 33, No. 2 ( 2022-12-20), p. 403-420
    Details
    In: Cerebral Cortex, Oxford University Press (OUP), Vol. 33, No. 2 ( 2022-12-20), p. 403-420
    Abstract: Processing of linguistic negation has been associated to inhibitory brain mechanisms. However, no study has tapped this link via multimodal measures in patients with core inhibitory alterations, a critical approach to reveal direct neural correlates and potential disease markers. Methods Here we examined oscillatory, neuroanatomical, and functional connectivity signatures of a recently reported Go/No-go negation task in healthy controls and behavioral variant frontotemporal dementia (bvFTD) patients, typified by primary and generalized inhibitory disruptions. To test for specificity, we also recruited persons with Alzheimer's disease (AD), a disease involving frequent but nonprimary inhibitory deficits. Results In controls, negative sentences in the No-go condition distinctly involved frontocentral delta (2–3 Hz) suppression, a canonical inhibitory marker. In bvFTD patients, this modulation was selectively abolished and significantly correlated with the volume and functional connectivity of regions supporting inhibition (e.g. precentral gyrus, caudate nucleus, and cerebellum). Such canonical delta suppression was preserved in the AD group and associated with widespread anatomo-functional patterns across non-inhibitory regions. Discussion These findings suggest that negation hinges on the integrity and interaction of spatiotemporal inhibitory mechanisms. Moreover, our results reveal potential neurocognitive markers of bvFTD, opening a new agenda at the crossing of cognitive neuroscience and behavioral neurology.
    Type of Medium: Online Resource
    ISSN: 1047-3211 , 1460-2199
    URL: Article
    DOI: 10.1093/cercor/bhac074
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1483485-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach
    Elsevier BV ; 2020
    In:  NeuroImage Vol. 208 ( 2020-03), p. 116456-
    Details
    In: NeuroImage, Elsevier BV, Vol. 208 ( 2020-03), p. 116456-
    Type of Medium: Online Resource
    ISSN: 1053-8119
    URL: Article
    DOI: 10.1016/j.neuroimage.2019.116456
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1471418-8
    SSG: 5,2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Working Group Recommendations for the Practice of Teleneuropsychology in Latin America
    Oxford University Press (OUP) ; 2022
    In:  Archives of Clinical Neuropsychology Vol. 37, No. 3 ( 2022-02-22), p. 553-567
    Details
    In: Archives of Clinical Neuropsychology, Oxford University Press (OUP), Vol. 37, No. 3 ( 2022-02-22), p. 553-567
    Abstract: Teleneuropsychology (teleNP) could potentially expand access to services for patients who are confined, have limited personal access to healthcare, or live in remote areas. The emergence of the COVID-19 pandemic has significantly increased the use of teleNP for cognitive assessments. The main objective of these recommendations is to identify which procedures can be potentially best adapted to the practice of teleNP in Latin America, and thereby facilitate professional decision-making in the region. Method Steps taken to develop these recommendations included (1) formation of an international working group with representatives from 12 Latin American countries; (2) assessment of rationale, scope, and objectives; (3) formulation of clinical questions; (4) evidence search and selection; (5) evaluation of existing evidence and summary; and (6) formulation of recommendations. Levels of evidence were graded following the Oxford Centre for Evidence-Based Medicine system. Databases examined included PubMed, WHO-IRIS, WHO and PAHO-IRIS, Índice Bibliográfico Español en Ciencias de la Salud (IBCS), and LILACS. Results Working group members reviewed 18,400 titles and 422 abstracts and identified 19 articles meeting the criteria for level of evidence, categorization, and elaboration of recommendations. The vast majority of the literature included teleNP tests in the English language. The working group proposed a series of recommendations that can be potentially best adapted to the practice of teleNP in Latin America. Conclusions There is currently sufficient evidence to support the use of videoconferencing technology for remote neuropsychological assessments. These recommendations will likely contribute to the advancement of teleNP research and practice in the region.
    Type of Medium: Online Resource
    ISSN: 1873-5843
    URL: Article
    DOI: 10.1093/arclin/acab080
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2003528-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    The prevalence, associated factors, and the burden on health state utilities for dementia in Chile : Epidemiology / Innovative methods in epidemiology (i.e., assessment methods, design, recruitment strategies, statistical methods, etc.)
    Wiley ; 2020
    In:  Alzheimer's & Dementia Vol. 16, No. S10 ( 2020-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 16, No. S10 ( 2020-12)
    Abstract: New procedures based on attributional methods have not been used to estimate the burden of Dementia in term of loss of Health‐State Utilities (HSU) or Quality‐Adjusted Life Years (QALY) at the populational level. Chile, in recent decades, has presented an accelerated aging process and has few studies on dementia. Method We analysed data from the Chilean National Health Survey carried out between 2016‐2017 (n=5,004). Participants older than 59 years were screened for dementia, defined by a score higher than 5 in the Pfeffer and lower than 13/19 points in a modified MMSE‐version, previously validated in Chile. HSU were measured using the health‐related quality of life instrument EQ5D plus national values for utilities for each health state. The number and fraction of total HSU lost due to dementia were calculated using attributable fraction methods. We repeated the procedure on each one of five domains of EQ5D. Factors associated with dementia were explored using a logistic regression model. Other comorbidities (depression, chronic musculoskeletal pain, hypertension, diabetes) were included in the models. Result We estimated a prevalence of 4.4% [2.9‐5.9] for dementia in people older than 59 years. Dementia, compared with other comorbidities, showed the highest loss of HSU, accounting 38.3 [26.0‐50.6] additional points of loss of HSU over the score from those without dementia (where 0 means healthy, and 100 is equivalent to death). Prevalent cases of dementia were associated with a loss of 41,046 QALYs [29,727 – 52,158], which was equivalent to a 5.0% [3.0‐7.6] of total burden among elderlies, and 1.5% [0.9‐2.4] in the population older than 14 years. ‘Self‐care’ was the domain were dementia accounted higher burden followed by ‘usual activities’ (see figure). Age was associated with dementia, while male sex, lower education, widower compared with married, and some comorbidities showed high OR but without reaching statistical significance. Conclusion Dementia at the population level showed a high impact in terms of QALY lost, as well as at the individual level in terms of loss of HUS, overpassing to other diseases. Key domains of quality of life affected higher for Dementia were self‐care and usual activities. FONDAP Program Grant 15150012.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v16.S10
    DOI: 10.1002/alz.042466
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2201940-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    The impact of culture on neuropsychological performance: A global social cognition study across 12 countries : Neuropsychology/Multicultural issues in assessment of dementia
    Wiley ; 2020
    In:  Alzheimer's & Dementia Vol. 16, No. S6 ( 2020-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 16, No. S6 ( 2020-12)
    Abstract: Decades of researches aiming to unveil truths about human neuropsychology may have instead unveil facts appropriate to only a fraction of the world’s population: those living in western educated rich democratic nations (Muthukrishna et al., 2020 Psych Sci). So far, most studies were conducted as if education and cultural assumptions on which neuropsychology is based were universals and applied everywhere in the world. The importance given to sociological or cultural factors is thus still relatively ignored. With the growth of international clinical studies on dementia, we believe that documenting the potential inter‐cultural differences at stake in a common neuropsychological assessment is an essential topic. This study thus aimed to explore these potential variations in two classical tasks used in neuropsychology that are composing the mini‐SEA (Bertoux et al., 2012 JNNP), i.e. a reduced version of the well‐known Ekman faces (FER), where one has to recognize facial emotions, and a modified version of the Faux Pas test (mFP), where one has to detect and explain social faux. Method The data of 573 control participants were collected through the Social Cognition & FTLD Network, an international consortium investigating social cognitive changes in dementia covering 3 continents (18 research centres in 12 countries). Impact of demographic factors and the effect of countries on performance (mini‐SEA, FER, mFP) were explored through linear mixed‐effects models. Result Age, education and gender were found to significantly impact the performance of the mini‐SEA subtests. Significant and important variations across the countries were also retrieved, with England having the highest performance for all scores. When controlling for demographical factors, differences within countries explained between 14% (mFP) and 24% (FER) of the variance at the mini‐SEA. These variations were not explained by any economical or sociological metrics. Conclusion Important variations of performance were observed across the 12 countries of the consortium, showing how cultural differences may critically impact neuropsychological performance in international studies.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v16.S6
    DOI: 10.1002/alz.039675
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2201940-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Peripheral inflammatory biomarkers and risk factors of dementia in the Chilean GERO cohort : Developing topics
    Wiley ; 2020
    In:  Alzheimer's & Dementia Vol. 16, No. S5 ( 2020-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 16, No. S5 ( 2020-12)
    Abstract: Dementia is one of the mean causes of disability in elderly. Peripheral inflammatory biomarkers and ApoE‐ε4 allele have been described as important biological risk factors of dementia in Caucasian population. Currently, there is scarce information about the specific age‐related and predisposition factors to develop dementia in Latino populations. The aim of this study is to investigate these biological risks factors in Chilean elderly with healthy and pathological brain ageing. Method We evaluated and quantified plasma samples obtained from the GERO cohort (114 elderly subjects, 〉 70 years, classified in 51 subjects with subjective cognitive complaint (SCC) and 63 with mild cognitive impairment (MCI)), in addition to 36 healthy brain controls (HBC) and 31 subjects with Alzheimer’s disease dementia (ADD). Genotyping of ApoE gene was analyzed by qPCR. We analyzed inflammatory biomarkers using Luminex technique including IL‐2, IL‐6, IL‐10, TNF‐α, CRP and SAP proteins. All subjects receive a clinical and neuropsychological assessment. Result CRP protein was found significant decrease expression in SCC and ADD groups compared to MCI and HBC (p=0.048). In SAP protein was found a significant decrease in expression in the SSC (p=0.04) and MCI (p=0.0178) groups compared to HBC. It was observed a positive correlation in the SCC, MCI and ADD groups with the IL‐6 and TNFα, and, SAP and CRP. A negative correlation between IL‐2, IL‐6 and IL‐10 cytokines was found with Direct Span Digit test, which assess attentional capacity. Also was identified a negative correlation between SAP protein and the Free and Cued Selective Reminding Test (FCSRT), which assess verbal episodic memory, and IL‐10 cytokine and Montreal Cognitive Assessment (MoCA), which assess global cognition. Finally, a positive correlation was found in CRP protein with Pfeffer Functional Activity Questionnaire. Frequency of the ApoE‐ε4 allele, was significantly higher in ADD (52%) and SCC (27%) patients than controls and MCI (p=1x10 ‐4 ). Conclusion The results shown correlations between the different inflammatory proteins and performance in neuropsychological test suggesting that inflammatory biomarkers are associated with pathological brain ageing. The correlations in SCC and MCI are not being reported previously. Additionally, the frequency of ApoE‐ε4 allele in ADD group is higher than worldwide populations.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v16.S5
    DOI: 10.1002/alz.047489
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2201940-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Diverse representation in Frontotemporal Dementia research studies: implications for clinical trials.
    Wiley ; 2022
    In:  Alzheimer's & Dementia Vol. 18, No. S10 ( 2022-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 18, No. S10 ( 2022-12)
    Abstract: The Multi‐Partner Consortium to Expand Dementia Research in Latin America (RedLat) study is a niche for the implementation of clinical trials on Frontotemporal Dementia in Latin America. We identified that one of the main limitations of recruitment was a lack of clinicians with comprehensive knowledge on Frontotemporal Dementia in the region. We aimed to fill these gaps by creating an online training for physicians. Method A group of American and Latin American brain health experts trained at the Global Brain Health Institute at the University of San Francisco California is delivering an abridged online behavioral neurology training project to a pilot group of 30 neurologists, geriatricians, and psychiatrists from Latin America. The training highlights important aspects such as culturally appropriate neuropsychological assessment and functional assessment to adequately classify participants under the frontotemporal dementia umbrella. A component about the importance of research including clinical trials is also being delivered. Baseline evaluations about the quality of their medical training regarding dementia and a dementia knowledge evaluation were conducted and we are expecting to conduct an evaluation in the third and sixth months. Result On the baseline evaluation, 80% classified the information they received as “poor”, 12% classified the information as “sufficient” and 8% classified it as “good”. Regarding baseline dementia knowledge, the mean score was 5.2 (SD ± 2.5) out of a maximum score of 10 points. We expect an increase in these numbers during the upcoming evaluations. As a side outcome, participants from this project are building pipelines to increase recruitment in RedLat. Conclusion Overcoming existing educational barriers of diagnosis of Frontotemporal Dementia as well as generating awareness of the importance of clinical trials in Latin America will hopefully be a key tool to increase the representation of persons with Frontotemporal Dementia. We will discuss the importance of adequate diagnosis and classification of frontotemporal dementia by the professionals who serve these underrepresented populations and the importance that this first step has to adequate recruitment into clinical trials.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v18.S10
    DOI: 10.1002/alz.064117
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2201940-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    The Latin American Brain Health Institute, a regional initiative to reduce the scale and impact of dementia
    Wiley ; 2022
    In:  Alzheimer's & Dementia Vol. 18, No. 9 ( 2022-09), p. 1696-1698
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 18, No. 9 ( 2022-09), p. 1696-1698
    Abstract: Latin American and Caribbean countries face complex challenges to improve brain health and reduce the impact of dementia. Regional hubs devoted to research, capacity building, implementation science, and education are critically needed. The Latin American Brain Health Institute represent an important step to address many of these needs.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v18.9
    DOI: 10.1002/alz.12710
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2201940-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Population attributable fraction of modifiable risk factors for dementia in Chile
    Wiley ; 2022
    In:  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Vol. 14, No. 1 ( 2022-01)
    Details
    In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, Vol. 14, No. 1 ( 2022-01)
    Abstract: Projected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia‐prevention strategies. Methods We analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia‐free subjects ≥45‐years‐old, using the 2016‐2017 Chilean National Health Survey. Results The overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to ‐56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women. Discussion The PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention. HIGHLIGHTS The proportion of dementia associated to modifiable risk factors in Chile is 45.8%. The main modifiable risk factors are high blood pressure, obesity, and hearing loss. Women had a greater prevalence of physical inactivity and depression than men. Chile had a greater prevalence of metabolic risk factors than other world regions.
    Type of Medium: Online Resource
    ISSN: 2352-8729 , 2352-8729
    URL: Issue
    URL: Article
    DOI: 10.1002/dad2.v14.1
    DOI: 10.1002/dad2.12273
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2832898-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Multimodal neurocognitive markers of naturalistic discourse typify diverse neurodegenerative diseases
    Oxford University Press (OUP) ; 2022
    In:  Cerebral Cortex Vol. 32, No. 16 ( 2022-08-03), p. 3377-3391
    Details
    In: Cerebral Cortex, Oxford University Press (OUP), Vol. 32, No. 16 ( 2022-08-03), p. 3377-3391
    Abstract: Neurodegeneration has multiscalar impacts, including behavioral, neuroanatomical, and neurofunctional disruptions. Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial events, in Parkinson’s disease (PD) and behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer’s disease patients and healthy controls. Text-specific correlates were evaluated via voxel-based morphometry, spatial (fMRI), and temporal (hd-EEG) functional connectivity. PD patients presented action–text deficits related to the volume of action–observation regions, connectivity across motor-related and multimodal-semantic hubs, and frontal hd-EEG hypoconnectivity. BvFTD patients exhibited social–text deficits, associated with atrophy and spatial connectivity patterns along social-network hubs, alongside right frontotemporal hd-EEG hypoconnectivity. Alzheimer’s disease patients showed impairments in all stories, widespread atrophy and spatial connectivity patterns, and heightened occipitotemporal hd-EEG connectivity. Our framework revealed disease-specific signatures across behavioral, neuroanatomical, and neurofunctional dimensions, highlighting the sensitivity and specificity of a single naturalistic task. This investigation opens a translational agenda combining ecological approaches and multimodal cognitive neuroscience for the study of neurodegeneration.
    Type of Medium: Online Resource
    ISSN: 1047-3211 , 1460-2199
    URL: Article
    DOI: 10.1093/cercor/bhab421
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1483485-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...