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  • 1
    Online Resource
    Online Resource
    Copernicus GmbH ; 2023
    In:  Geoscientific Model Development Vol. 16, No. 22 ( 2023-11-28), p. 6875-6897
    In: Geoscientific Model Development, Copernicus GmbH, Vol. 16, No. 22 ( 2023-11-28), p. 6875-6897
    Abstract: Abstract. We present a framework that links in situ observations from the Biogeochemical Argo (BGC-Argo) array to biogeochemical models. The framework minimizes the technical effort required to construct a Lagrangian-type 1D modelling experiment along BGC-Argo tracks. We utilize the Argo data in two ways: (1) to drive the model physics and (2) to evaluate the model biogeochemistry. BGC-Argo physics data are used to nudge the model physics closer to observations to reduce the errors in the biogeochemistry stemming from physics errors. This allows us to target the model biogeochemistry and, by using the Argo biogeochemical dataset, we identify potential sources of model errors, introduce changes to the model formulation, and validate model configurations. We present experiments for the Nordic seas and showcase how we identify potential BGC-Argo buoys to model, prepare forcing, design experiments, and approach model improvement and validation. We use the ECOSMO II(CHL) model as the biogeochemical component and focus on chlorophyll a. The experiments reveal that ECOSMO II(CHL) requires improvements during low-light conditions, as the comparison to BGC-Argo reveals that ECOSMO II(CHL) simulates a late spring bloom and does not represent the deep chlorophyll maximum layer formation in summer periods. We modified the productivity and chlorophyll a relationship and statistically documented decreased bias and error in the revised model when using BGC-Argo data. Our results reveal that nudging the model temperature and salinity closer to BGC-Argo data reduces errors in biogeochemistry, and we suggest a relaxation time period of 1–10 d. The BGC-Argo data coverage is ever-growing and the framework is a valuable asset, as it improves biogeochemical models by performing efficient 1D model configurations and evaluation and then transferring the configurations to a 3D model with a wide range of use cases at the operational, regional/global and climate scales.
    Type of Medium: Online Resource
    ISSN: 1991-9603
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2023
    detail.hit.zdb_id: 2456725-5
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  • 2
    Online Resource
    Online Resource
    Frontiers Media SA ; 2020
    In:  Frontiers in Marine Science Vol. 7 ( 2020-6-16)
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 7 ( 2020-6-16)
    Type of Medium: Online Resource
    ISSN: 2296-7745
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2757748-X
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  • 3
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 64, No. 6 ( 2020-05-21)
    Abstract: Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo-β-lactamase (MBL) families. The recent introduction of SBL carbapenemase inhibitors has provided alternative therapeutic options. Unfortunately, there are no approved inhibitors of MBL-mediated carbapenem-resistance and treatment options for infections caused by MBL-producing Gram-negatives are limited. Here, we present ZN148, a zinc-chelating MBL-inhibitor capable of restoring the bactericidal effect of meropenem and in vitro clinical susceptibility to carbapenems in 〉 98% of a large international collection of MBL-producing clinical Enterobacterales strains ( n = 234). Moreover, ZN148 was able to potentiate the effect of meropenem against NDM-1-producing Klebsiella pneumoniae in a murine neutropenic peritonitis model. ZN148 showed no inhibition of the human zinc-containing enzyme glyoxylase II at 500 μM, and no acute toxicity was observed in an in vivo mouse model with cumulative dosages up to 128 mg/kg. Biochemical analysis showed a time-dependent inhibition of MBLs by ZN148 and removal of zinc ions from the active site. Addition of exogenous zinc after ZN148 exposure only restored MBL activity by ∼30%, suggesting an irreversible mechanism of inhibition. Mass-spectrometry and molecular modeling indicated potential oxidation of the active site Cys221 residue. Overall, these results demonstrate the therapeutic potential of a ZN148-carbapenem combination against MBL-producing Gram-negative pathogens and that ZN148 is a highly promising MBL inhibitor that is capable of operating in a functional space not presently filled by any clinically approved compound.
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    RVK:
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2020
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 4
    In: Remote Sensing, MDPI AG, Vol. 13, No. 8 ( 2021-04-18), p. 1570-
    Abstract: Freshwater (FW) flux between the Arctic Ocean and adjacent waterways, predominantly driven by wind and oceanic currents, influences halocline stability and annual sea ice variability which further impacts global circulation and climate. The Arctic recently experienced anomalous years of high and low sea ice extent in the summers of 2013/2014 and 2012/2016, respectively. Here we investigate the interannual variability of oceanic surface FW flux in relation to spatial and temporal variability in sea ice concentration (SIC), sea surface salinity (SSS), and sea surface temperature (SST), focusing on years with summer sea–ice extremes. Our analysis between 2010–2018 illustrate high parameter variability, especially within the Laptev, Kara, and Barents seas, as well as an overall decreasing trend of FW flux through the Fram Strait. We find that in 2012, a maximum average FW flux of 0.32 × 103 ms−1 in October passed over a large portion of the Northeast Atlantic Ocean at 53°N. This study highlights recent changes in the Arctic and Subarctic Seas and the importance of continued monitoring of key variables through remote sensing to understand the dynamics behind these ongoing changes. Observations of FW fluxes through major Arctic routes will be increasingly important as the polar regions become more susceptible to warming, with major impacts on global climate.
    Type of Medium: Online Resource
    ISSN: 2072-4292
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2513863-7
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  • 5
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Marine Science Vol. 8 ( 2021-10-28)
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 8 ( 2021-10-28)
    Abstract: Predicting the ambient environmental conditions in the coming several years to one decade is of key relevance for elucidating how deep-sea habitats, like for example sponge habitats, in the North Atlantic will evolve under near-future climate change. However, it is still not well known to what extent the deep-sea environmental properties can be predicted in advance. A regional downscaling prediction system is developed to assess the potential predictability of the North Atlantic deep-sea environmental factors. The large-scale climate variability predicted with the coupled Max Planck Institute Earth System Model with low-resolution configuration (MPI-ESM-LR) is dynamically downscaled to the North Atlantic by providing surface and lateral boundary conditions to the regional coupled physical-ecosystem model HYCOM-ECOSMO. Model results of two physical fields (temperature and salinity) and two biogeochemical fields (concentrations of silicate and oxygen) over 21 sponge habitats are taken as an example to assess the ability of the downscaling system to predict the interannual to decadal variations of the environmental properties based on ensembles of retrospective predictions over the period from 1985 to 2014. The ensemble simulations reveal skillful predictions of the environmental conditions several years in advance with distinct regional differences. In areas closely tied to large-scale climate variability and ice dynamics, both the physical and biogeochemical fields can be skillfully predicted more than 4 years ahead, while in areas under strong influence of upper oceans or open boundaries, the predictive skill for both fields is limited to a maximum of 2 years. The simulations suggest higher predictability for the biogeochemical fields than for the physical fields, which can be partly attributed to the longer persistence of the former fields. Predictability is improved by initialization in areas away from the influence of Mediterranean outflow and areas with weak coupling between the upper and deep oceans. Our study highlights the ability of the downscaling regional system to predict the environmental variations at deep-sea benthic habitats on time scales of management relevance. The downscaling system therefore will be an important part of an integrated approach towards the preservation and sustainable exploitation of the North Atlantic benthic habitats.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2757748-X
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  • 6
    In: Geoscientific Model Development, Copernicus GmbH, Vol. 14, No. 11 ( 2021-11-19), p. 7073-7116
    Abstract: Abstract. The Norwegian Climate Prediction Model version 1 (NorCPM1) is a new research tool for performing climate reanalyses and seasonal-to-decadal climate predictions. It combines the Norwegian Earth System Model version 1 (NorESM1) – which features interactive aerosol–cloud schemes and an isopycnic-coordinate ocean component with biogeochemistry – with anomaly assimilation of sea surface temperature (SST) and T/S-profile observations using the ensemble Kalman filter (EnKF). We describe the Earth system component and the data assimilation (DA) scheme, highlighting implementation of new forcings, bug fixes, retuning and DA innovations. Notably, NorCPM1 uses two anomaly assimilation variants to assess the impact of sea ice initialization and climatological reference period: the first (i1) uses a 1980–2010 reference climatology for computing anomalies and the DA only updates the physical ocean state; the second (i2) uses a 1950–2010 reference climatology and additionally updates the sea ice state via strongly coupled DA of ocean observations. We assess the baseline, reanalysis and prediction performance with output contributed to the Decadal Climate Prediction Project (DCPP) as part of the sixth Coupled Model Intercomparison Project (CMIP6). The NorESM1 simulations exhibit a moderate historical global surface temperature evolution and tropical climate variability characteristics that compare favourably with observations. The climate biases of NorESM1 using CMIP6 external forcings are comparable to, or slightly larger than those of, the original NorESM1 CMIP5 model, with positive biases in Atlantic meridional overturning circulation (AMOC) strength and Arctic sea ice thickness, too-cold subtropical oceans and northern continents, and a too-warm North Atlantic and Southern Ocean. The biases in the assimilation experiments are mostly unchanged, except for a reduced sea ice thickness bias in i2 caused by the assimilation update of sea ice, generally confirming that the anomaly assimilation synchronizes variability without changing the climatology. The i1 and i2 reanalysis/hindcast products overall show comparable performance. The benefits of DA-assisted initialization are seen globally in the first year of the prediction over a range of variables, also in the atmosphere and over land. External forcings are the primary source of multiyear skills, while added benefit from initialization is demonstrated for the subpolar North Atlantic (SPNA) and its extension to the Arctic, and also for temperature over land if the forced signal is removed. Both products show limited success in constraining and predicting unforced surface ocean biogeochemistry variability. However, observational uncertainties and short temporal coverage make biogeochemistry evaluation uncertain, and potential predictability is found to be high. For physical climate prediction, i2 performs marginally better than i1 for a range of variables, especially in the SPNA and in the vicinity of sea ice, with notably improved sea level variability of the Southern Ocean. Despite similar skills, i1 and i2 feature very different drift behaviours, mainly due to their use of different climatologies in DA; i2 exhibits an anomalously strong AMOC that leads to forecast drift with unrealistic warming in the SPNA, whereas i1 exhibits a weaker AMOC that leads to unrealistic cooling. In polar regions, the reduction in climatological ice thickness in i2 causes additional forecast drift as the ice grows back. Posteriori lead-dependent drift correction removes most hindcast differences; applications should therefore benefit from combining the two products. The results confirm that the large-scale ocean circulation exerts strong control on North Atlantic temperature variability, implying predictive potential from better synchronization of circulation variability. Future development will therefore focus on improving the representation of mean state and variability of AMOC and its initialization, in addition to upgrades of the atmospheric component. Other efforts will be directed to refining the anomaly assimilation scheme – to better separate internal and forced signals, to include land and atmosphere initialization and new observational types – and improving biogeochemistry prediction capability. Combined with other systems, NorCPM1 may already contribute to skilful multiyear climate prediction that benefits society.
    Type of Medium: Online Resource
    ISSN: 1991-9603
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2021
    detail.hit.zdb_id: 2456725-5
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  • 7
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  Communications Earth & Environment Vol. 4, No. 1 ( 2023-04-24)
    In: Communications Earth & Environment, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2023-04-24)
    Abstract: The Barents Sea is a highly biologically productive Arctic shelf sea with several commercially important fish stocks. Interannual-to-decadal predictions of its ecosystem would therefore be valuable for marine resource management. Here, we demonstrate that the abundance of phytoplankton, the base of the marine food web, can be predicted up to five years in advance in the Barents Sea with the Norwegian Climate Prediction Model. We identify two different mechanisms giving rise to this predictability; 1) in the southern ice-free Atlantic Domain, skillful prediction is a result of the advection of waters with anomalous nitrate concentrations from the Subpolar North Atlantic; 2) in the northern Polar Domain, phytoplankton predictability is a result of the skillful prediction of the summer ice concentration, which influences the light availability. The skillful prediction of the phytoplankton abundance is an important step forward in the development of numerical ecosystem predictions of the Barents Sea.
    Type of Medium: Online Resource
    ISSN: 2662-4435
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 3037243-4
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  • 8
    In: Progress in Oceanography, Elsevier BV, Vol. 217 ( 2023-09), p. 103084-
    Type of Medium: Online Resource
    ISSN: 0079-6611
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1497436-8
    detail.hit.zdb_id: 4062-9
    SSG: 21,3
    SSG: 14
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  • 9
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Marine Science Vol. 9 ( 2022-3-24)
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 9 ( 2022-3-24)
    Abstract: Deep-sea sponges inhabit multiple areas of the deep North Atlantic at depths below 250 m. Living in the deep ocean, where environmental properties below the permanent thermocline generally change slowly, they may not easily acclimatize to abrupt changes in the environment. Until now consistent monitoring timeseries of the environment at deep sea sponge habitats are missing. Therefore, long-term simulation with coupled bio-physical models can shed light on the changes in environmental conditions sponges are exposed to. To investigate the variability of North Atlantic sponge habitats for the past half century, the deep-sea conditions have been simulated with a 67-year model hindcast from 1948 to 2014. The hindcast was generated using the ocean general circulation model HYCOM, coupled to the biogeochemical model ECOSMO. The model was validated at known sponge habitats with available observations of hydrography and nutrients from the deep ocean to evaluate the biases, errors, and drift in the model. Knowing the biases and uncertainties we proceed to study the longer-term (monthly to multi-decadal) environmental variability at selected sponge habitats in the North Atlantic and Arctic Ocean. On these timescales, these deep sponge habitats generally exhibit small variability in the water-mass properties. Three of the sponge habitats, the Flemish Cap, East Greenland Shelf and North Norwegian Shelf, had fluctuations of temperature and salinity in 4–6 year periods that indicate the dominance of different water masses during these periods. The fourth sponge habitat, the Reykjanes Ridge, showed a gradual warming of about 0.4°C over the simulation period. The flux of organic matter to the sea floor had a large interannual variability, that, compared to the 67-year mean, was larger than the variability of primary production in the surface waters. Lateral circulation is therefore likely an important control mechanism for the influx of organic material to the sponge habitats. Simulated oxygen varies interannually by less than 1.5 ml/l and none of the sponge habitats studied had oxygen concentrations below hypoxic levels. The present study establishes a baseline for the recent past deep conditions that future changes in deep sea conditions from observations and climate models can be evaluated against.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2757748-X
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  • 10
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Marine Science Vol. 8 ( 2021-11-10)
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 8 ( 2021-11-10)
    Abstract: Phytoplankton blooms provide biomass to the marine trophic web, contribute to the carbon removal from the atmosphere and can be deadly when associated with harmful species. This points to the need to understand the phenology of the blooms in the Barents, Norwegian, and North seas. We use satellite chlorophyll-a from 2000 to 2020 to assess robust climatological and the interannual trends of spring and summer blooms onset, peak day, duration and intensity. Further, we also correlate the interannual variability of the blooms with mixed layer depth (MLD), sea surface temperature (SST), wind speed and suspended particulate matter (SPM) retrieved from models and remote sensing. The climatological spring blooms start on March 10th and end on June 19th. The climatological summer blooms begin on July 13th and end on September 17th. In the Barents Sea, years of shallower mixed layer (ML) driven by both calm waters and higher freshwaters input keeps the phytoplankton in the euphotic zone, causing the spring bloom to start earlier and reach higher biomass but end sooner due to the lack of nutrients upwelling from the deep. In the Norwegian Sea, a correlation between SST and the spring blooms is found. Here, warmer waters are correlated to earlier and stronger blooms in most regions but with later and weaker blooms in the eastern Norwegian Sea. In the North Sea, years of shallower ML reduces the phytoplankton sinking below the euphotic zone and limits the SPM increase from the bed shear stress, creating an ideal environment of stratified and clear waters to develop stronger spring blooms. Last, the summer blooms onset, peak day and duration have been rapidly delaying at a rate of 1.25-day year –1 , but with inconclusive causes based on the parameters assessed in this study.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2757748-X
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