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  • 1
    Online Resource
    Online Resource
    Fostering innovation at Academic Medical Centers: The Case of University of Colorado Anschutz Medical Campus
    Cambridge University Press (CUP) ; 2021
    In:  Journal of Clinical and Translational Science Vol. 5, No. 1 ( 2021)
    Details
    In: Journal of Clinical and Translational Science, Cambridge University Press (CUP), Vol. 5, No. 1 ( 2021)
    Abstract: Commercializing biomedical discoveries is a challenging process for many reasons. However, Academic Medical Centers (AMC) that have teaching, patient care, research, and service engrained in their mission are well poised to host these discoveries. These academic discoveries can lead to improvement in patient health and economic development if supported to cross the “valley of death” through institutional assistance, by providing guidance, gap funding and product development expertise. Colorado has a vibrant local startup ecosystem, state support for commercialization and entrepreneurship as well as critical mass of product development expertise. University of Colorado Anschutz Medical Campus, as a major AMC, is an engine for growth for the region. This article discusses innovation efforts at the University of Colorado Anschutz Medical Campus as a case study, which is built around two major efforts: the CCTSI and CU Innovations. I-Corps at CCTSI and the SPARK|REACH program of CU Innovations have been instrumental in fostering innovation, commercialization, and entrepreneurship on the campus.
    Type of Medium: Online Resource
    ISSN: 2059-8661
    URL: Article
    DOI: 10.1017/cts.2021.792
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2898186-8
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  • 2
    Online Resource
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    Mixed methods evaluation of the inaugural year of the Cancer Prevention and Control Research Network’s (CPCRN) scholars program
    Springer Science and Business Media LLC ; 2023
    In:  Cancer Causes & Control
    Details
    In: Cancer Causes & Control, Springer Science and Business Media LLC
    Abstract: A diverse workforce trained in dissemination & implementation (D & I) science is critical for improving cancer outcomes and reducing cancer-related health disparities. This study aims to describe and evaluate impact of the Cancer Prevention and Control Research Network (CPCRN) Scholars Program in preparing scholars for collaborative careers in cancer control and implementation research and practice, and offers evaluation-driven recommendations for program improvements. Methods The CPCRN Scholars Workgroup conducted a sequential, mixed methods evaluation. We collected baseline and follow-up surveys and invited all 20 scholars and ten mentors to participate in an exit interview. We assessed the experience with the Scholar’s program, ratings of D & I competences, progress on their project, feedback about the curriculum, and understanding of implementation science. Results Over 86% partially or fully completed their project within 9 months; 78% of scholars engaged with a CPCRN workgroup. Scholars rated the following program components as valuable: the Putting Public Health Evidence in Action (PPHEIA) training (88.9%), D & I training modules (83.3%), and webinars (kickoff webinar-88.9% and selecting theories/models-88.9%). There was an increase in D & I competencies from baseline to posttest, with the greatest in community engagement topics. About 78% reported that they were satisfied with format of the activities and increased confidence in ability to discuss D & I concepts. From the qualitative interviews, the benefit of the program was becoming more knowledgeable about D & I research and networking. Conclusion The inaugural year of the program yielded positive results, particularly related to increasing knowledge about D & I science and cancer control. This program builds the capacity of students, researchers and practitioners in D & I science.
    Type of Medium: Online Resource
    ISSN: 0957-5243 , 1573-7225
    URL: Article
    DOI: 10.1007/s10552-023-01702-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1496544-6
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  • 3
    Online Resource
    Online Resource
    Quality of Reporting on the Evaluation of Risk Minimization Programs: A Systematic Review
    Springer Science and Business Media LLC ; 2020
    In:  Drug Safety Vol. 43, No. 5 ( 2020-05), p. 427-446
    Details
    In: Drug Safety, Springer Science and Business Media LLC, Vol. 43, No. 5 ( 2020-05), p. 427-446
    Type of Medium: Online Resource
    ISSN: 0114-5916 , 1179-1942
    URL: Article
    DOI: 10.1007/s40264-020-00905-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2023894-0
    SSG: 15,3
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  • 4
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    I-Corps@NCATS trains clinical and translational science teams to accelerate translation of research innovations into practice
    Cambridge University Press (CUP) ; 2021
    In:  Journal of Clinical and Translational Science Vol. 5, No. 1 ( 2021)
    Details
    In: Journal of Clinical and Translational Science, Cambridge University Press (CUP), Vol. 5, No. 1 ( 2021)
    Abstract: A key barrier to translation of biomedical research discoveries is a lack of understanding among scientists regarding the complexity and process of implementation. To address this challenge, the National Science Foundation’s Innovation Corps™ (I-Corps™) program trains researchers in entrepreneurship. We report results from the implementation of an I-Corps™ training program aimed at biomedical scientists from institutions funded by the National Center for Advancing Translational Sciences (NCATS). Methods: National/regional instructors delivered 5-week I-Corps@NCATS short courses to 62 teams (150 individuals) across six institutions. Content included customer discovery, value proposition, and validating needs. Teams interviewed real-life customers and presented the value of innovations for specific end-users weekly, culminating in a “Finale” featuring their refined business thesis and business model canvas. Methodology was developed to evaluate the newly adapted program. National mixed-methods evaluation assessed program implementation, reach, effectiveness using observations of training delivery and surveys at Finale ( n = 55 teams), and 3–12 months post-training ( n = 34 teams). Results: Innovations related to medical devices (33%), drugs/biologics (20%), software applications (16%), and diagnostics (8%). An average of 24 interviews was conducted. Teams reported increased readiness for commercialization over time (83%, 9 months; 14%, 3 months). Thirty-nine percent met with institutional technology transfer to pursue licensing/patents and 24% pursued venture capital/investor funding following the short courses. Conclusions: I-Corps@NCATS training provided the NCATS teams a rigorous and repeatable process to aid development of a business model based on customer needs. Outcomes of this pilot program support the expansion of I-Corps™ training to biomedical scientists for accelerating research translation.
    Type of Medium: Online Resource
    ISSN: 2059-8661
    URL: Article
    DOI: 10.1017/cts.2020.561
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2898186-8
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  • 5
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    Family‐centred care in early intervention: Examining caregiver perceptions of family‐centred care and early intervention service use intensity
    Wiley ; 2020
    In:  Child: Care, Health and Development Vol. 46, No. 1 ( 2020-01), p. 1-8
    Details
    In: Child: Care, Health and Development, Wiley, Vol. 46, No. 1 ( 2020-01), p. 1-8
    Abstract: Family‐centred care (FCC) is an approach to paediatric rehabilitation service delivery endorsing shared decision making and effective communication with families. There is great need to understand how early intervention (EI) programmes implement these processes, how EI caregivers perceive them, and how they relate to EI service use. Therefore, the purpose of this study is to examine (a) parent and provider perceptions about EI FCC processes and (b) the association between FCC perceptions and EI service intensity. Methods In this cross‐sectional study, parent perceptions of EI FCC were measured using the electronically administered Measures of Processes of Care (MPOC‐56 and MPOC‐SP; using 7‐point scales). Participants included EI parents ( n = 29) and providers ( n = 9) from one urban EI programme (1/1/18–6/1/18). We linked survey responses with child characteristics and service use ascertained through EI records. We estimated parent–provider MPOC score correlations and the association between EI service intensity (hr/month) and parent MPOC scores using adjusted linear regression accounting for child characteristics. Results Parents ( M = 4.2, SD = 1.1) and providers ( M = 5.8, SD = 1.3) reported low involvement related to general information exchange. Parent and provider subscale scores were not correlated except that parent‐reported receipt of specific information was inversely associated with provider‐reported provision of general information ( r = −0.4, P 〈 .05). In adjusted models, parent perceptions related to respectful and supportive ( b = 1.57, SE = 0.56) and enabling ( b = 1.42, SE = 0.67) care were positively associated with EI intensity, whereas specific information exchange and general information exchange were not associated with intensity. Conclusion We found that EI parents and providers reported high levels of investment in the family centredness of their EI care, with the exception of information sharing. Greater EI service intensity was associated with higher perception of involvement with some metrics of family centredness.
    Type of Medium: Online Resource
    ISSN: 0305-1862 , 1365-2214
    URL: Issue
    URL: Article
    DOI: 10.1111/cch.v46.1
    DOI: 10.1111/cch.12724
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2018207-7
    SSG: 5,2
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  • 6
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    Using Innovation-Corps (I-Corps™) Methods to Adapt a Mobile Health (mHealth) Obesity Treatment for Community Mental Health Settings
    Frontiers Media SA ; 2022
    In:  Frontiers in Digital Health Vol. 4 ( 2022-5-27)
    Details
    In: Frontiers in Digital Health, Frontiers Media SA, Vol. 4 ( 2022-5-27)
    Abstract: We employed Innovation Corps (I-Corps™) methods to adaptation of a mobile health (mHealth) short-message-system (SMS) -based interactive obesity treatment approach (iOTA) for adults with severe mentall illness receiving care in community settings. Methods We hypothesized “jobs to be done” in three broad stakeholder groups: “decision makers” (DM = state and community clinic administrators), “clinician consumers” (CC = case managers, peer supports, nurses, prescribers) and “service consumers” (SC = patients, peers and family members). Semistructured interviews ( N = 29) were recorded and transcribed ver batim and coded based on pragmatic-variant grounded theory methods. Results Four themes emerged across groups: education, inertia, resources and ownership. Sub-themes in education and ownership differed between DM and CC groups on implementation ownership, intersecting with professional development, suggesting the importance of training and supervision in scalability. Sub-themes in resources and intertia differed between CC and SC groups, suggesting illness severity and access to healthy food as major barriers to engagement, whereas the SC group identified the need for enhanced emotional support, in addition to pragmatic skills like menu planning and cooking, to promote health behavior change. Although SMS was percieved as a viable education and support tool, CC and DM groups had limited familiarity with use in clinical care delivery. Conclusions Based on customer discovery, the characteristics of a minimum viable iOTA for implementation, scalability and sustainability include population- and context-specific adaptations to treatment content, interventionist training and delivery mechanism. Successful implementation of an SMS-based intervention will likely require micro-adaptations to fit specific clinical settings.
    Type of Medium: Online Resource
    ISSN: 2673-253X
    URL: Article
    DOI: 10.3389/fdgth.2022.835002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 3017798-4
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  • 7
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    Chronic Disease Self-Management Mobile App: Findings from Applying Customer Discovery (Preprint)
    JMIR Publications Inc. ; 2023
    In:  JMIR Formative Research
    Details
    In: JMIR Formative Research, JMIR Publications Inc.
    Type of Medium: Online Resource
    ISSN: 2561-326X
    URL: Article
    DOI: 10.2196/50334
    Language: English
    Publisher: JMIR Publications Inc.
    Publication Date: 2023
    detail.hit.zdb_id: 2941716-8
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  • 8
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    Designing for Dissemination and Sustainability to Promote Equitable Impacts on Health
    Annual Reviews ; 2022
    In:  Annual Review of Public Health Vol. 43, No. 1 ( 2022-04-05), p. 331-353
    Details
    In: Annual Review of Public Health, Annual Reviews, Vol. 43, No. 1 ( 2022-04-05), p. 331-353
    Abstract: Designing for dissemination and sustainability (D4DS) refers to principles and methods for enhancing the fit between a health program, policy, or practice and the context in which it is intended to be adopted. In this article we first summarize the historical context of D4DS and justify the need to shift traditional health research and dissemination practices. We present a diverse literature according to a D4DS organizing schema and describe a variety of dissemination products, design processes and outcomes, and approaches to messaging, packaging, and distribution. D4DS design processes include stakeholder engagement, participatory codesign, and context and situation analysis, and leverage methods and frameworks from dissemination and implementation science, marketing and business, communications and visualarts, and systems science. Finally, we present eight recommendations to adopt a D4DS paradigm, reflecting shifts in ways of thinking, skills and approaches, and infrastructure and systems for training and evaluation.
    Type of Medium: Online Resource
    ISSN: 0163-7525 , 1545-2093
    URL: Issue
    URL: Article
    DOI: 10.1146/publhealth.2022.43.issue-1
    DOI: 10.1146/annurev-publhealth-052220-112457
    RVK:
    XA 10000
    Language: English
    Publisher: Annual Reviews
    Publication Date: 2022
    detail.hit.zdb_id: 2029879-1
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  • 9
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    Pragmatic applications of implementation science frameworks to regulatory science: an assessment of FDA Risk Evaluation and Mitigation Strategies (REMS) (2014–2018)
    Springer Science and Business Media LLC ; 2021
    In:  BMC Health Services Research Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Health Services Research, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: A Risk Evaluation and Mitigation Strategy (REMS) is a drug safety program for certain medications with serious safety concerns required by the U.S. Food and Drug Administration (FDA) of manufacturers to implement to help ensure the benefits of the medication outweigh its risks. FDA is encouraging “the research community to develop novel methods for assessing REMS,” conveying the unmet need for a standardized evaluation method of these regulatory-mandated healthcare programs. The objective of this research is to evaluate FDA REMS assessment plans using established implementation science frameworks and identify opportunities for strengthening REMS evaluation. Methods A content analysis was conducted of publicly available assessment plans for all REMS programs ( N  = 23) approved 1/1/2014–12/31/2018 for new drug applications (NDAs) and biologics license applications (BLAs) requiring FDA-mandated Elements to Assure Safe Use (ETASU). Blinded reviewers critically appraised REMS assessment measures ( n  = 674) using three established implementation science frameworks: RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance); PRECEDE-PROCEED (Predisposing, Reinforcing, and Enabling Constructs in Educational/Environmental Diagnosis and Evaluation – Policy, Regulatory, and Organizational Constructs in Educational and Environmental Development); and CFIR (Consolidated Framework for Implementation Research). Framework constructs were mapped to REMS Assessment categories as defined by FDA Guidance for Industry to evaluate congruence. Results REMS assessment measures demonstrated strong congruence ( 〉  90% mapping rate) with the evaluative constructs of RE-AIM, PRECEDE-PROCEED, and CFIR. Application of the frameworks revealed that REMS assessment measures heavily emphasize implementation and operations, focus less on health outcomes, and do not evaluate program context and design assumptions. Conclusions Implementation science frameworks have utility for evaluating FDA-mandated drug safety programs including the selection of primary measures to determine whether REMS goals are being met and of secondary measures to evaluate contextual factors affecting REMS effectiveness in varying organizational settings.
    Type of Medium: Online Resource
    ISSN: 1472-6963
    URL: Article
    DOI: 10.1186/s12913-021-06808-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2050434-2
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  • 10
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    Interpreting evidence on long-acting injectable antipsychotics
    Elsevier BV ; 2021
    In:  The Lancet Psychiatry Vol. 8, No. 5 ( 2021-05), p. 349-351
    Details
    In: The Lancet Psychiatry, Elsevier BV, Vol. 8, No. 5 ( 2021-05), p. 349-351
    Type of Medium: Online Resource
    ISSN: 2215-0366
    URL: Article
    DOI: 10.1016/S2215-0366(21)00072-9
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
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