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  • 1
    Online Resource
    Online Resource
    Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases
    Rockefeller University Press ; 2020
    In:  Journal of Experimental Medicine Vol. 217, No. 9 ( 2020-09-07)
    Details
    In: Journal of Experimental Medicine, Rockefeller University Press, Vol. 217, No. 9 ( 2020-09-07)
    Abstract: Chronic pain is a major comorbidity of chronic inflammatory diseases. Here, we report that the cytokine IL-1β, which is abundantly produced during multiple sclerosis (MS), arthritis (RA), and osteoarthritis (OA) both in humans and in animal models, drives pain associated with these diseases. We found that the type 1 IL-1 receptor (IL-1R1) is highly expressed in the mouse and human by a subpopulation of TRPV1+ dorsal root ganglion neurons specialized in detecting painful stimuli, termed nociceptors. Strikingly, deletion of the Il1r1 gene specifically in TRPV1+ nociceptors prevented the development of mechanical allodynia without affecting clinical signs and disease progression in mice with experimental autoimmune encephalomyelitis and K/BxN serum transfer–induced RA. Conditional restoration of IL-1R1 expression in nociceptors of IL-1R1–knockout mice induced pain behavior but did not affect joint damage in monosodium iodoacetate–induced OA. Collectively, these data reveal that neuronal IL-1R1 signaling mediates pain, uncovering the potential benefit of anti–IL-1 therapies for pain management in patients with chronic inflammatory diseases.
    Type of Medium: Online Resource
    ISSN: 0022-1007 , 1540-9538
    URL: Article
    DOI: 10.1084/jem.20191430
    RVK:
    XA 10000
    Language: English
    Publisher: Rockefeller University Press
    Publication Date: 2020
    detail.hit.zdb_id: 1477240-1
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  • 2
    Online Resource
    Online Resource
    Cézeaux-Aulnat-Opme-Puy De Dôme: a multi-site for the long-term survey of the tropospheric composition and climate change
    Copernicus GmbH ; 2020
    In:  Atmospheric Measurement Techniques Vol. 13, No. 6 ( 2020-06-26), p. 3413-3445
    Details
    In: Atmospheric Measurement Techniques, Copernicus GmbH, Vol. 13, No. 6 ( 2020-06-26), p. 3413-3445
    Abstract: Abstract. For the last 25 years, CO-PDD (Cézeaux-Aulnat-Opme-puy de Dôme) has evolved to become a full instrumented platform for atmospheric research. It has received credentials as a national observing platform in France and is internationally recognized as a global station in the GAW (Global Atmosphere Watch) network. It is a reference site of European and national research infrastructures ACTRIS (Aerosol Cloud and Trace gases Research Infrastructure) and ICOS (Integrated Carbon Observing System). The site located on top of the puy de Dôme mountain (1465 m a.s.l.) is completed by additional sites located at lower altitudes and adding the vertical dimension to the atmospheric observations: Opme (660 m a.s.l.), Cézeaux (410 m), and Aulnat (330 m). The integration of different sites offers a unique combination of in situ and remote sensing measurements capturing and documenting the variability of particulate and gaseous atmospheric composition, but also the optical, biochemical, and physical properties of aerosol particles, clouds, and precipitations. Given its location far away from any major emission sources, its altitude, and the mountain orography, the puy de Dôme station is ideally located to sample different air masses in the boundary layer or in the free troposphere depending on time of day and seasons. It is also an ideal place to study cloud properties with frequent presence of clouds at the top in fall and winter. As a result of the natural conditions prevailing at the site and of the very exhaustive instrumental deployment, scientific studies at the puy de Dôme strongly contribute to improving knowledge in atmospheric sciences, including the characterization of trends and variability, the understanding of complex and interconnected processes (microphysical, chemical, biological, chemical and dynamical), and the provision of reference information for climate/chemistry models. In this context, CO-PDD is a pilot site to conduct instrumental development inside its wind tunnel for testing liquid and ice cloud probes in natural conditions, or in situ systems to collect aerosol and cloud. This paper reviews 25 years (1995–2020) of atmospheric observation at the station and related scientific research contributing to atmospheric and climate science.
    Type of Medium: Online Resource
    ISSN: 1867-8548
    URL: Article
    DOI: 10.5194/amt-13-3413-2020
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2020
    detail.hit.zdb_id: 2505596-3
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  • 3
    Online Resource
    Online Resource
    Comparison of two vitamin D supplementation strategies in children with sickle cell disease: a randomized controlled trial
    Wiley ; 2021
    In:  British Journal of Haematology Vol. 192, No. 2 ( 2021-01), p. 385-394
    Details
    In: British Journal of Haematology, Wiley, Vol. 192, No. 2 ( 2021-01), p. 385-394
    Abstract: Previously, we showed that nearly 70% of children followed in our sickle cell disease (SCD) clinic were vitamin D‐ deficient and had low vitamin intake with poor use of supplements. We compared the change in serum 25‐hydroxyvitamin D [25(OH)D], safety and clinical impact of two vitamin D supplementation regimens in children with SCD. Children (5–17 years, all genotypes) were randomized to a single bolus of vitamin D 3 (300 000 IU; n  = 18) or placebo ( n  = 20). All children received a prescription for daily 1 000 IU vitamin D 3 . Serum 25(OH)D and calcium, urinary calcium/creatinine ratio, musculoskeletal pain, quality of life, haematology and bone markers were assessed at baseline and three months post intervention. Bolus administration led to a greater rise in 25(OH)D levels from baseline compared to placebo (20 ± 16 nmol/l vs. 2 ± 19 nmol/l; P  = 0·003) and correction of vitamin D deficiency. No hypercalcaemia nor hypercalciuria occurred during the study, but more children in the bolus group experienced gastrointestinal symptoms within the first month ( P  = 0·04). There were no differences between groups for other outcomes. The use of a high‐dose vitamin D bolus combined with daily 1 000 IU vitamin D 3 was more efficient in raising 25(OH)D levels than daily supplementation alone in children with SCD.
    Type of Medium: Online Resource
    ISSN: 0007-1048 , 1365-2141
    URL: Issue
    URL: Article
    DOI: 10.1111/bjh.v192.2
    DOI: 10.1111/bjh.17119
    RVK:
    XA 34100
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1475751-5
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  • 4
    Online Resource
    Online Resource
    Strategies to engage family physicians in primary care research: A systematic review
    Wiley ; 2023
    In:  Journal of Evaluation in Clinical Practice Vol. 29, No. 1 ( 2023-02), p. 233-249
    Details
    In: Journal of Evaluation in Clinical Practice, Wiley, Vol. 29, No. 1 ( 2023-02), p. 233-249
    Abstract: Moving towards high quality primary health care, involving family physicians in primary care research becomes an essential prerequisite to ensures a better adoption and routinization of patient‐centred, evidence‐based practices. Aim To assess the effectiveness of strategies to engage family physicians in primary care research. Methods We systematically reviewed evidence for strategies used to engage family physicians in primary care research. We included any study design that reported at least one quantitative outcome. Searches were carried out on MEDLINE, Embase, PsycINFO and Web of Science. Pairs of reviewers independently screened for publications in two stages using standardized forms. We performed data analysis through a narrative synthesis approach, using the Reasoned‐action approach as framework. Results A total of 4859 deduped records were identified of which 41 studies met the eligibility criteria and were included for analysis. The majority of studies ( n  = 35) investigated family physician's participation in a research project. They aimed to influence family physicians' intention ( n  = 7) or their ability ( n  = 3) to participate in a research project. Three types of strategies (compensation/incentive, recruitment by a peer and support from a research network or an academic institution) demonstrated a significant increase in participation rate. Methodological quality of the studies evaluating these strategies was relatively low. Few studies ( n  = 6) targeted research capacity‐building programmes with no significant impact noted. Conclusion Numerous strategies have been used to engage family physicians in primary care research, but few studies evaluated their effectiveness in a rigorous way. Registration The protocol of this review was registered with the SPOR Evidence Alliance and on the PROSPERO platform (registration number: CRD42020189322).
    Type of Medium: Online Resource
    ISSN: 1356-1294 , 1365-2753
    URL: Issue
    URL: Article
    DOI: 10.1111/jep.v29.1
    DOI: 10.1111/jep.13733
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2006772-0
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