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  • 1
    Online Resource
    Online Resource
    Effects of acupuncture treatment on posttraumatic headache after traumatic brain injury in patients : A protocol for systematic review
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Medicine Vol. 101, No. 18 ( 2022-05-13), p. e29158-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 101, No. 18 ( 2022-05-13), p. e29158-
    Abstract: Posttraumatic headache (PTH) after traumatic brain injury (TBI) is a common clinical symptom, which refers to a headache that occurs after TBI. Acupuncture is often used for the treatment of such patients in China, and significant clinical effects have been achieved. However, to date, its efficacy has not been methodically evaluated. The purpose of this systematic review is to provide evidence to prove the effectiveness of acupuncture in the treatment of PTH in patients with TBI. Methods: This systematic review will be conducted in accordance with the preferred reporting items for systematic review and meta-analysis protocols. The following electronic databases will be searched from their inception to February 2022: PubMed, Web of Science, Embase, PsycINFO, the Cochrane Library, and Chinese databases such as Chinese Biomedical Literature (CBM), Chinese Medical Current Content (CMCC), Chinese Scientific Journal Database (VIP), WanFang Database, and China National Knowledge Infrastructure (CNKI). No language restrictions will be applied to the search strategy. Randomized controlled trials and cohort and case-control studies that met the inclusion and exclusion criteria will be included in this study. The meta-analysis will be performed using RevMan 5.3 software. Each session of this systematic review will be conducted independently by 2 members. Results: This review evaluates the efficacy of acupuncture in the treatment of PTH after TBI. Conclusion: This review provides substantial evidence for the clinical application of acupuncture in PTH treatment after TBI. Ethics and dissemination: Since the data in this study will be retrieved from published trials, therefore the Patient Consent Statement and Ethical Approval are not required. We will disseminate our results by publishing the research in a peer-reviewed journal. Trail registration number: The protocol was registered in INPLASY (INPLASY 202220073).
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000029158
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2049818-4
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  • 2
    Online Resource
    Online Resource
    α-Tomatine, a novel early-stage autophagy inhibitor, inhibits autophagy to enhance apoptosis via Beclin-1 in Skov3 cells
    Elsevier BV ; 2021
    In:  Fitoterapia Vol. 152 ( 2021-07), p. 104911-
    Details
    In: Fitoterapia, Elsevier BV, Vol. 152 ( 2021-07), p. 104911-
    Type of Medium: Online Resource
    ISSN: 0367-326X
    URL: Article
    DOI: 10.1016/j.fitote.2021.104911
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2027649-7
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  • 3
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    Computed tomography-based texture assessment for the differentiation of benign, borderline, and early-stage malignant ovarian neoplasms
    SAGE Publications ; 2023
    In:  Journal of International Medical Research Vol. 51, No. 1 ( 2023-01), p. 030006052211501-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 51, No. 1 ( 2023-01), p. 030006052211501-
    Abstract: This study was performed to examine the value of computed tomography-based texture assessment for characterizing different types of ovarian neoplasms. Methods This retrospective study involved 225 patients with histopathologically confirmed ovarian tumors after surgical resection. Two different data sets of thick (5-mm) slices (during regular and portal venous phases) were analyzed. Raw data analysis, principal component analysis, linear discriminant analysis, and nonlinear discriminant analysis were performed to classify ovarian tumors. The radiologist’s misclassification rate was compared with the MaZda (texture analysis software) findings. The results were validated with the neural network classifier. Receiver operating characteristic curves were analyzed to determine the performances of different parameters. Results Nonlinear discriminant analysis had a lower misclassification rate than the other analyses. Thirty texture parameters significantly differed between the two groups. In the training set, WavEnLH_s-3 and WavEnHL_s-3 were the optimal texture features during the regular phase, while WavEnHH_s-4 and Kurtosis seemed to be the most discriminative features during the portal venous phase. In the validation test, benign versus malignant tumors and benign versus borderline lesions were well-distinguished. Conclusions Computed tomography-based texture features provide a useful imaging signature that may assist in differentiating benign, borderline, and early-stage ovarian cancer.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605221150139
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2082422-1
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  • 4
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    Online Resource
    Urine-based regenerative RNA biomarkers for urinary bladder wound healing
    Future Medicine Ltd ; 2021
    In:  Regenerative Medicine Vol. 16, No. 8 ( 2021-08), p. 709-718
    Details
    In: Regenerative Medicine, Future Medicine Ltd, Vol. 16, No. 8 ( 2021-08), p. 709-718
    Abstract: Background: This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair. Materials & methods: Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), key stem cell transcription factors and cholinergic signals were detected. Results: HIF-1α, VEGF, CD44, IL-6 and prominin-1 expression in canine urine after partial cystectomy exhibited two similar peaks at ∼2 weeks. HIF-1α and VEGF expression were higher in the afternoon than the morning. The expression of key stem cell transcription factors and cholinergic signals also exhibited a rhythm along with bladder healing. Conclusions: The expression of HIF-1α, VEGF, key stem cell transcription factors and cholinergic signals exhibited a time curve distribution during canine bladder healing. The expression trend of some regenerative genes was similar during bladder healing, and a cooperative effect may exist.
    Type of Medium: Online Resource
    ISSN: 1746-0751 , 1746-076X
    URL: Article
    DOI: 10.2217/rme-2021-0057
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2021
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  • 5
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    Online Resource
    Transcription factor c-Rel regulated by E5 affects the whole process after HPV16 infection through miR-133a-modulated feedback loop aim at mir-379-369 cluster
    Springer Science and Business Media LLC ; 2022
    In:  Cancer Cell International Vol. 22, No. 1 ( 2022-12-01)
    Details
    In: Cancer Cell International, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12-01)
    Abstract: During the development of cervical cancer, HPV infection causes a series of changes in transcription factors and microRNAs. But their relationships with pathogenic processes are not clear. Methods Base on previous study, to analyse the relationship among HPV16 infection and the related transcription factors, related miRNAs, so as to further understand the molecular mechanism of HPV16 infection to cervical cancer, around the HPV16 related miRNAs we have reported, the methods of bioinformatics prediction, histology, cell model in vitro and molecular interaction were used for prediction and validation respectively Results The results showed that NF-κB family members(c-Rel, p65 and p50) were identified as main HPV16rmiR-transcription factors. They have different expressive characteristics in cervical lesions and play tumorigenesis or progression roles in different periods of HPV16 infection. c-Rel, p65 and p50 act as mediators which link the HPV16 E5 and HPV16 related miRNAs. Among them, c-Rel affects the occurrence and progression of cervical cancer during whole HPV16 infection stage through miR133a-3p–modulated mir-379-369 cluster with a positive feedback way which targeted c-Rel itself and its positive regulator AKT3. Conclusion So in the course of HPV16 infection, the E5, c-Rel, and miR-133a-3p form a positive feedback system which aim at mir-379-369 cluster for the whole process from HPV16 infection to cervical cancer.
    Type of Medium: Online Resource
    ISSN: 1475-2867
    URL: Article
    DOI: 10.1186/s12935-022-02794-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2091573-1
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