In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2022-1-28), p. e0263165-
Abstract:
This study aimed to investigate the association between changes in brain natriuretic peptide (BNP) from discharge to 6-month visit and subsequent clinical outcomes in patients with acute heart failure (AHF). Methods Among 1246 patients enrolled in the prospective longitudinal follow-up study nested from the Kyoto Congestive Heart Failure registry, this study population included 446 patients with available paired BNP data at discharge and 6-month index visit. This study population was classified into 3 groups by percent change in BNP from discharge to 6-month visit; the low tertile (≤-44%, N = 149), the middle tertile ( 〉 -44% and ≤22%, N = 149) and the high tertile ( 〉 22%, N = 148). Findings The cumulative 180-day incidence after the index visit of the primary outcome measure (a composite endpoint of all-cause death or hospitalization for HF) was significantly higher in the high and middle tertiles than in the low tertile (26.8% and 14.4% versus 6.9%, log-rank P 〈 0.0001). The adjusted excess risk of the high tertile relative to the low tertile remained significant for the primary outcome measure (hazard ratio: 3.43, 95% confidence interval: 1.51–8.46, P = 0.003). Conclusions Percent change in BNP was associated with a subsequent risk for a composite of all-cause death and hospitalization for HF after adjustment of the absolute BNP values, suggesting that observing the change in BNP levels, in addition to absolute BNP levels themselves, helps us to manage patient with HF.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0263165
DOI:
10.1371/journal.pone.0263165.g001
DOI:
10.1371/journal.pone.0263165.g002
DOI:
10.1371/journal.pone.0263165.g003
DOI:
10.1371/journal.pone.0263165.g004
DOI:
10.1371/journal.pone.0263165.t001
DOI:
10.1371/journal.pone.0263165.t002
DOI:
10.1371/journal.pone.0263165.t003
DOI:
10.1371/journal.pone.0263165.s001
DOI:
10.1371/journal.pone.0263165.s002
DOI:
10.1371/journal.pone.0263165.s003
DOI:
10.1371/journal.pone.0263165.s004
DOI:
10.1371/journal.pone.0263165.s005
DOI:
10.1371/journal.pone.0263165.s006
DOI:
10.1371/journal.pone.0263165.s007
DOI:
10.1371/journal.pone.0263165.s008
DOI:
10.1371/journal.pone.0263165.r001
DOI:
10.1371/journal.pone.0263165.r002
DOI:
10.1371/journal.pone.0263165.r003
DOI:
10.1371/journal.pone.0263165.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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