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  • 1
    Online Resource
    Online Resource
    Long-term observations reveal the formation process of branching systems of the genus Sasa in Bambusoideae
    Oxford University Press (OUP) ; 2020
    In:  AoB PLANTS Vol. 12, No. 5 ( 2020-10-01)
    Details
    In: AoB PLANTS, Oxford University Press (OUP), Vol. 12, No. 5 ( 2020-10-01)
    Abstract: Clarifying the endogenous processes that construct gross aerial shapes such as branching architecture in plants is crucial to understanding how branching contributes to plant adaptation to environments. Architectural analysis is powerful in decomposing the branching process, by comparing observations of plant growth among closely related taxa. The genus Sasa (Gramineae: Bambusoideae) contains three major sections Crassinodi, Sasa and Macrochlamys. These sections exhibit characteristic branching architectures and are distributed separately across the Japanese archipelago, in relation to macroclimatic conditions such as snow accumulation. Our study aimed to quantitatively reveal the endogenous processes underlying branching architectures in the three sections of Sasa. Long-term observations were carried out branch architectural development on Hokkaido Island from 1979 to 2012, which corresponded to the flowering interval of the genus. The results revealed that the three characteristic branching systems of the genus arise mainly from four endogenous processes (distribution of lateral buds on a culm, internode length arrangement along a culm, determination of the fate of lateral buds, development of branching with culm fragility due to ageing) and their interactions with environmental conditions, especially snow accumulation. These processes are coordinated with each other over the life span of a single shoot in developing branching architecture.
    Type of Medium: Online Resource
    ISSN: 2041-2851
    URL: Article
    DOI: 10.1093/aobpla/plaa054
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2555823-7
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  • 2
    Online Resource
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    Comparison of clinical features between immune-related sclerosing cholangitis and hepatitis
    Springer Science and Business Media LLC ; 2021
    In:  Investigational New Drugs Vol. 39, No. 6 ( 2021-12), p. 1716-1723
    Details
    In: Investigational New Drugs, Springer Science and Business Media LLC, Vol. 39, No. 6 ( 2021-12), p. 1716-1723
    Abstract: Background Immune-related hepatotoxicity is often regarded as immune-related hepatitis (irHepatitis) despite including immune-related sclerosing cholangitis (irSC). This study examined the clinical differences between irSC and irHepatitis. Methods A single-center retrospective study of 530 consecutive patients who received immunotherapy between August 2014 and April 2020 was performed. IrSC and irHepatitis were respectively defined as the radiological presence and absence of bile duct dilation and wall thickness. Results Forty-one patients (7.7%) developed immune-related hepatotoxicity. A CT scan was performed on 12 patients, including 11 of 12 with ≥ grade 3 aminotransferase elevations. IrSC and irHepatitis were diagnosed in 4 (0.8%) and 8 (1.5%) patients, respectively. All the irSC patients had been treated with anti-PD-1. IrHepatitis was more common among patients receiving anti-CTLA-4 than among those receiving anti-PD-1/PD-L1 inhibitors (14%, 7/50 vs. 0.2%, 1/480, P   〈  0.001). A ≥ grade 2 alkaline phosphatase (ALP) elevation resulting in a cholestatic pattern was seen in all 4 irSC patients. Among the irSC patients, 3 (3/4, 75%) developed ≥ grade 3 aminotransferases elevation. The median duration from the start of immunotherapy until ≥ grade 2 liver enzymes elevation was 257 and 55.5 days in irSC and irHepatitis patients. The median times for progression from grade 2 to 3 liver enzyme elevation were 17.5 and 0 days, respectively. Conclusions IrSC and irHepatitis have different characteristics in the class of immune checkpoint inhibitor and onset pattern. Radiological examination for the diagnosis of irSC should be considered for patients with ≥ grade 2 ALP elevation resulting in a cholestatic pattern. (Registration number J2020-36, Date of registration June 3, 2020)
    Type of Medium: Online Resource
    ISSN: 0167-6997 , 1573-0646
    URL: Article
    DOI: 10.1007/s10637-021-01136-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2009846-7
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  • 3
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    Online Resource
    Acute cytotoxic effects of silica microparticles used for coating of plastic blood-collection tubes on human periosteal cells
    Springer Science and Business Media LLC ; 2020
    In:  Odontology Vol. 108, No. 4 ( 2020-10), p. 545-552
    Details
    In: Odontology, Springer Science and Business Media LLC, Vol. 108, No. 4 ( 2020-10), p. 545-552
    Abstract: Because of its simple operation, platelet-rich fibrin (PRF) is becoming more popular than the original form, platelet-rich plasma (PRP), in regenerative dentistry. PRF preparation requires plain glass blood-collection tubes, but not either anticoagulants or coagulation factors. However, such glass tubes designed for laboratory testing are no longer commercially available. Although several glass tubes specifically designed for PRF preparation are available, many clinicians prefer to obtain stably supplied substitutes, such as silica-coated plastic tubes produced by major medical device companies. The quality of PRF prepared by silica-coated tubes has not been assessed and we previously reported significant contamination of silica microparticles in the resulting PRF matrix and alerted clinicians against the use for PRF preparation. To further assess the biosafety of the silica microparticles, we presently examined their effects on human normal periosteal cells derived from alveolar bone. The periosteal cells were obtained from explant cultures of small periosteal tissues obtained from healthy donors. Silica microparticles were obtained from silica-coated tubes and added to cell cultures. Cellular responses were monitored using a tetrazolium assay, phase-contract inverted microscopy, an immunofluorescence method, and scanning electron microscopy. Silica microparticles adsorbed onto the cell surface with seemingly high affinity and induced apoptosis, resulting in significant reduction of cell proliferation and viability. These findings suggest that silica microparticles contained in plastic tubes for the purpose of blood coagulation are hazardous for various cell types around sites where silica-contaminated PRF matrices are implanted.
    Type of Medium: Online Resource
    ISSN: 1618-1247 , 1618-1255
    URL: Article
    DOI: 10.1007/s10266-020-00486-z
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2064980-0
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  • 4
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    Online Resource
    Prognostic impact of pneumonitis after durvalumab therapy in patients with locally advanced non-small cell lung cancer
    Springer Science and Business Media LLC ; 2022
    In:  Investigational New Drugs Vol. 40, No. 2 ( 2022-04), p. 403-410
    Details
    In: Investigational New Drugs, Springer Science and Business Media LLC, Vol. 40, No. 2 ( 2022-04), p. 403-410
    Abstract: Background.  Prognostic data on Japanese patients receiving durvalumab after chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (LA-NSCLC) are insufficient. Whether pneumonitis has prognostic implications in patients with LA-NSCLC who have received durvalumab also remains unclear. Methods.  We retrospectively assessed the data of 82 consecutive patients who had received durvalumab after CRT at our institution between May 2018 and August 2020. A multi-state model was used to establish the associations between co-variables and progression-free survival (PFS). Results.  The median observation period for all the censored cases was 14.5 months (5.7–28.9 months), the median PFS was 22.7 months, and the 12-month PFS rate was 62.3% (95% CI: 50.2%-72.3%). The median percentage of the lung volume receiving a radiation dose in excess of 20 Gray (V20) was 22% (4%-35%). Thirteen patients (16%) had Grade 1 pneumonitis before receiving durvalumab, and 62 patients developed pneumonitis after durvalumab (Grades 1, 2, and 3 in 25 [30%], 32 [39%] , and 4 [5%], respectively). Twenty-four patients (29%) completed the 1-year durvalumab treatment period, 16 patients (20%) were continuing to receive treatment, and 42 (51%) had discontinued treatment. In a multi-state analysis, patients with pneumonitis before durvalumab therapy had a poorer PFS than those without pneumonitis (HR: 4.29, p  = 0.002). The development of Grade 2 or higher pneumonitis after durvalumab was not a significant prognostic factor for PFS (HR: 0.71, p  = 0.852). Conclusion.  Grade 2 or higher pneumonitis after durvalumab was not a prognostic factor of PFS in LA-NSCLC patients received durvalumab.
    Type of Medium: Online Resource
    ISSN: 0167-6997 , 1573-0646
    URL: Article
    DOI: 10.1007/s10637-021-01191-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2009846-7
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Long-term survival data of patients with limited disease small cell lung cancer: a retrospective analysis
    Springer Science and Business Media LLC ; 2022
    In:  Investigational New Drugs Vol. 40, No. 2 ( 2022-04), p. 411-419
    Details
    In: Investigational New Drugs, Springer Science and Business Media LLC, Vol. 40, No. 2 ( 2022-04), p. 411-419
    Type of Medium: Online Resource
    ISSN: 0167-6997 , 1573-0646
    URL: Article
    DOI: 10.1007/s10637-021-01183-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2009846-7
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  • 6
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    Online Resource
    Effects of SARS‑CoV‑2 mRNA vaccines on platelet polyphosphate levels and inflammation: A pilot study
    Spandidos Publications ; 2022
    In:  Biomedical Reports Vol. 16, No. 3 ( 2022-02-03)
    Details
    In: Biomedical Reports, Spandidos Publications, Vol. 16, No. 3 ( 2022-02-03)
    Type of Medium: Online Resource
    ISSN: 2049-9434 , 2049-9442
    URL: Journal
    URL: Article
    DOI: 10.3892/br
    DOI: 10.3892/br.2022.1504
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2763624-0
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  • 7
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    Online Resource
    Non-destructive, spectrophotometric analysis of the thickness of the cell-multilayered periosteal sheet
    Springer Science and Business Media LLC ; 2022
    In:  International Journal of Implant Dentistry Vol. 8, No. 1 ( 2022-12)
    Details
    In: International Journal of Implant Dentistry, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2022-12)
    Abstract: Autologous tissue-engineered periosteal sheets, which have been clinically applied for periodontal regeneration, sinus lift, and alveolar ridge augmentation, are enriched with osteoblast precursor cells and the abundant deposition of collagen type I in the extracellular spaces. Their quality is inspected prior to clinical use; however, most criteria cannot be evaluated without sacrificing samples. To reduce such losses, we developed a non-destructive optical method that can quantitatively evaluate the thickness of the periosteal sheet. Methods Dispersed periosteal cells were inoculated into small pieces of collagen sponge (Terudermis®) and plated into 60-mm dishes for further explant culture using a conventional medium and a stem-cell culture medium. The thickness of periosteal sheets was evaluated using inverted microscopic, histological, labeling (CellVue®)-based imaging and spectrophotometric (Spectro-1®) methods. Results The three-dimensional growth of periosteal sheets did not necessarily correlate with two-dimensional growth. The periosteal sheet prepared with the stem-cell medium formed cell multilayers, a phenomenon that could be observed qualitatively by inverted microscopy. The spectrophotometric analysis enabled the quantitative evaluation of the thickness of the cell multilayer without sacrificing the samples processed for scheduled cell therapy. Conclusions The growth of periosteal sheets is influenced by several major factors, including the basic quality of the individual original periosteal tissue segments, the technical expertise of doctors and operators involved in tissue harvesting and processing, and culture conditions. This newly developed spectrophotometric analysis can quantify the thickness of cell-multilayered periosteal sheets for quality assurance in a non-destructive manner, thereby contributing to better bone augmentation prior to implant therapy.
    Type of Medium: Online Resource
    ISSN: 2198-4034
    URL: Article
    DOI: 10.1186/s40729-022-00419-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2842869-9
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  • 8
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    Online Resource
    Platelet adhesion on commercially pure titanium plates in vitro III: effects of calcium phosphate-blasting on titanium plate biocompatibility
    Springer Science and Business Media LLC ; 2020
    In:  International Journal of Implant Dentistry Vol. 6, No. 1 ( 2020-12)
    Details
    In: International Journal of Implant Dentistry, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2020-12)
    Abstract: Platelet-rich plasma (PRP) is often used to improve surface biocompatibility. We previously found that platelets rapidly adhere to plain commercially pure titanium (cp-Ti) plates in the absence, but not in the presence, of plasma proteins. To further expand on these findings, in the present study, we switched titanium plates from a plain surface to a rough surface that is blasted with calcium phosphate (CaP) powder and then examined platelet adhesion and activation. Methods Elemental distribution in CaP-blasted cp-Ti plates was analyzed using energy-dispersive X-ray spectroscopy. PRP samples prepared from anticoagulated blood samples of six healthy, non-smoking adult male donors were loaded on CaP-blasted cp-Ti plates for 1 h and fixed for examination of platelet morphology and visualization of PDGF-B and platelet surface markers (CD62P, CD63) using scanning electron microscopy and fluorescence microscopy. Plain SUS316L stainless steel plates used in injection needles were also examined for comparison. Results Significant amounts of calcium and phosphate were detected on the CaP-blasted cp-Ti surface. Platelets rapidly adhered to this surface, leading to higher activation. Platelets also adhered to the plain stainless surface; however, the levels of adhesion and activation were much lower than those observed on the CaP-blasted cp-Ti plate. Conclusions The CaP-blasted cp-Ti surface efficiently entraps and activates platelets. Biomolecules released from the activated platelets could be retained by the fibrin matrix on the surface to facilitate regeneration of the surrounding tissues. Thus, PRP immersion could not only eliminate surface air bubbles but also improve the biocompatibility of the implant surface.
    Type of Medium: Online Resource
    ISSN: 2198-4034
    URL: Article
    DOI: 10.1186/s40729-020-00270-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2842869-9
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  • 9
    Online Resource
    Online Resource
    Fluorometric Quantification of Human Platelet Polyphosphate Using 4′,6-Diamidine-2-phenylindole Dihydrochloride: Applications in the Japanese Population
    MDPI AG ; 2021
    In:  International Journal of Molecular Sciences Vol. 22, No. 14 ( 2021-07-06), p. 7257-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 22, No. 14 ( 2021-07-06), p. 7257-
    Abstract: Polyphosphate (polyP), a biopolymer of inorganic phosphate, is widely distributed in living organisms. In platelets, polyP is released upon activation and plays important roles in coagulation and tissue regeneration. However, the lack of a specific quantification method has delayed the in-depth study of polyP. The fluorescent dye 4′,6-diamidine-2-phenylindole dihydrochloride (DAPI) has recently received attention as a promising probe for the visualization and quantification of cellular polyP levels. In this study, we further optimized quantification conditions and applied this protocol in quantification of platelet polyP levels in a Japanese population. Blood samples were collected from non-smoking, healthy Japanese subjects (23 males, 23 females). Washed platelets were fixed and probed with DAPI for fluorometric determination. PolyP levels per platelet count were significantly higher in women than that in men. A moderate negative correlation between age and polyP levels was found in women. Responsiveness to CaCl2 stimulation was also significantly higher in women than that in men. Overall, our optimized protocol requires neither purification nor degradation steps, reducing both the time and bias for reproducible quantification. Thus, we suggest that despite its low specificity, this DAPI-based protocol would be useful in routine laboratory testing to quantify platelet polyP levels efficiently and economically.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms22147257
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 10
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    Online Resource
    Extreme Prematurity and Pulmonary Outcomes Program in Saitama: Protocol for a Prospective Multicenter Cohort Study in Japan
    JMIR Publications Inc. ; 2021
    In:  JMIR Research Protocols Vol. 10, No. 3 ( 2021-3-5), p. e22948-
    Details
    In: JMIR Research Protocols, JMIR Publications Inc., Vol. 10, No. 3 ( 2021-3-5), p. e22948-
    Abstract: Because of the improvements in survival rates for preterm infants, not only the rates of bronchopulmonary dysplasia (BPD) but also those of long-term respiratory complications of premature birth are increasing, resulting in financial and health burdens in developed countries. Thus far, the risk factors of respiratory morbidities in extremely preterm infants remain unknown. Furthermore, the definition and the predictive ability of BPD for long-term respiratory outcomes are yet to be determined. Objective The objective of our study, Extreme Prematurity and Pulmonary Outcomes Program in Saitama, is to develop the diagnostic criteria for BPD and to determine the prognostic factors contributing to the long-term pulmonary outcomes manifesting in extremely preterm infants. Methods The Extreme Prematurity and Pulmonary Outcomes Program in Saitama is an observational prospective cohort study performed by a consortium of six neonatal intensive care units (NICUs) in Saitama, Japan. The subjects included in this study are infants (from each clinical center) with gestational ages 22 to 27 weeks. The target is 400 subjects. This study aims to determine the definition of BPD and other perinatal factors that accurately predict the long-term pulmonary outcomes in survivors of extreme prematurity. Moreover, the association between BPD and postprematurity respiratory disease will be investigated using generalized linear models. Results The protocol and consent forms were evaluated and approved on September 5, 2019, by the Ethics Committee of Saitama Medical Center, Saitama Medical University. Enrollment began on April 1, 2020. It is expected to end on March 31, 2023. The follow-up for 1 year corrected age is expected to continue through the middle of 2024. Conclusions The Extreme Prematurity and Pulmonary Outcomes Program in Saitama incorporates aspects of neonatal care in secondary- and tertiary-level NICUs to develop existing research studies on the definition of BPD, objective biomarkers, and outcome measures of respiratory morbidity in extremely preterm infants beyond NICU hospitalization, thereby leading to a novel understanding of the nature and natural history of BPD and potential mechanistic and therapeutic targets in at-risk subjects. International Registered Report Identifier (IRRID) DERR1-10.2196/22948
    Type of Medium: Online Resource
    ISSN: 1929-0748
    URL: Article
    DOI: 10.2196/22948
    Language: English
    Publisher: JMIR Publications Inc.
    Publication Date: 2021
    detail.hit.zdb_id: 2719222-2
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