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  • 1
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    Online Resource
    Functional recovery after ischemic stroke: Impact of different sleep health parameters
    Wiley ; 2023
    In:  Journal of Sleep Research
    Details
    In: Journal of Sleep Research, Wiley
    Abstract: Sleep disturbances after ischaemic stroke include alterations of sleep architecture, obstructive sleep apnea, restless legs syndrome, daytime sleepiness and insomnia. Our aim was to explore their impacts on functional outcomes at month 3 after stroke, and to assess the benefit of continuous positive airway pressure in patients with severe obstructive sleep apnea. Ninety patients with supra‐tentorial ischaemic stroke underwent clinical screening for sleep disorders and polysomnography at day 15 ± 4 after stroke in a multisite study. Patients with severe obstructive apnea (apnea–hypopnea index ≥ 30 per hr) were randomized into two groups: continuous positive airway pressure‐treated and sham (1:1 ratio). Functional independence was assessed with the Barthel Index at month 3 after stroke in function of apnea–hypopnea index severity and treatment group. Secondary objectives were disability (modified Rankin score) and National Institute of Health Stroke Scale according to apnea–hypopnea index. Sixty‐one patients (71.8 years, 42.6% men) completed the study: 51 (83.6%) had obstructive apnea (21.3% severe apnea), 10 (16.7%) daytime sleepiness, 13 (24.1%) insomnia, 3 (5.7%) depression, and 20 (34.5%) restless legs syndrome. Barthel Index, modified Rankin score and Stroke Scale were similar at baseline and 3 months post‐stroke in the different obstructive sleep apnea groups. Changes at 3 months in those three scores were similar in continuous positive airway pressure versus sham‐continuous positive airway pressure patients. In patients with worse clinical outcomes at month 3, mean nocturnal oxygen saturation was lower whereas there was no association with apnea–hypopnea index. Poorer outcomes at 3 months were also associated with insomnia, restless legs syndrome, depressive symptoms, and decreased total sleep time and rapid eye movement sleep.
    Type of Medium: Online Resource
    ISSN: 0962-1105 , 1365-2869
    URL: Article
    DOI: 10.1111/jsr.13964
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2007459-1
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  • 2
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    Trajectories of daytime sleepiness and sleep duration before diagnosis of dementia: A 14‐year follow‐up study
    Wiley ; 2021
    In:  Alzheimer's & Dementia Vol. 17, No. S10 ( 2021-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 17, No. S10 ( 2021-12)
    Abstract: Sleep problems have been associated with an increased risk of dementia. However, the period in which sleep begins to deteriorate in the natural history of dementia remains unknown. The aim was to model and compare trajectories of several sleep measurements in the 14 years prior to diagnosis of dementia in subjects with dementia and matched controls. Method Data were collected from a large community‐dwelling elderly cohort (3‐City‐Montpellier) at baseline and at each follow‐up. Incident cases of dementia were systematically diagnosed and validated. Repeated measures of total sleep time (TST), time in bed (TIB), wake‐up time, bedtime and, daytime sleepiness (DS) were assessed via self‐questionnaire. Based on a nested case‐control study, sleep trajectories between cases and controls were performed using latent‐process mixed models and a backward timescale. Result Analyses were conducted on 205 cases and 813 matched controls. TST and TIB were higher among cases during all the follow‐up with a significant faster increase in cases. For TST, mean predicted values were ‐14 years before diagnosis and at year 0 (matching visit): 6.9 [95%CI= 6.6‐7.1] and 7.2 [95%CI= 6.9‐7.4] for controls and 7.0 [95%CI= 6.6‐7.3] and 7.9 [95%CI= 7.5‐8.2] for cases. Trajectories between both groups differed from 0 to ‐8.5 years before diagnosis. Bedtime trajectories decrease significantly over time in the two groups, more strongly in cases (mean predicted values at ‐14 years before diagnosis and at year 0 were 22.8 [95%CI= 22.7‐22.9] and 22.6 [95%CI= 22.5‐22.7] for controls and 22.7 [95%CI= 22.6‐22.9] and 22.2 [95%CI= 22.0‐22.4] for cases). A significant case‐control difference from 0 to ‐8.2 years prior to diagnosis was reported. In contrast, trajectories of wake‐up time and DS remained stable over time in both groups. Still, wake‐up time trajectories crossed at about ‐5 years before diagnosis. There were no significant case‐control differences in trajectories for DS. Conclusion In prodromal dementia, TST and TIB increased, whereas bedtime was getting earlier and, wake‐up time and DS remained stable. Results suggest that optimal period for the management of sleep health to prevent dementia begins at least 8 years before the diagnosis of dementia.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v17.S10
    DOI: 10.1002/alz.053444
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2201940-6
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  • 3
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    Trajectoires de la durée et des horaires de sommeil avant la démence : une étude longitudinale sur 14 ans de suivi en population générale
    Elsevier BV ; 2022
    In:  Médecine du Sommeil Vol. 19, No. 1 ( 2022-03), p. 62-63
    Details
    In: Médecine du Sommeil, Elsevier BV, Vol. 19, No. 1 ( 2022-03), p. 62-63
    Type of Medium: Online Resource
    ISSN: 1769-4493
    URL: Article
    DOI: 10.1016/j.msom.2022.01.031
    Language: French
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 4
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    Increased Blood Pressure Dipping in Restless Legs Syndrome With Rotigotine: A Randomized Trial
    Wiley ; 2020
    In:  Movement Disorders Vol. 35, No. 12 ( 2020-12), p. 2164-2173
    Details
    In: Movement Disorders, Wiley, Vol. 35, No. 12 ( 2020-12), p. 2164-2173
    Abstract: The objective of this study was to assess the rotigotine effect on the nocturnal blood pressure (BP) dip by 24‐hour ambulatory BP monitoring and on endothelial function in patients with restless legs syndrome (RLS) compared with placebo. Methods In this double‐blind, placebo‐controlled trial, 76 adult patients with moderate to severe RLS and periodic legs movements in sleep index ≥10/hour were randomized to rotigotine at optimal dose of 3 mg per day or placebo for 6 weeks. A total of 6 patients had a major protocol deviation. Polysomnography, ambulatory BP monitoring, and endothelial function were assessed at baseline and end point. The primary outcome was the between‐group difference in the percentage of BP nondipper profiles at end point. The main secondary outcomes were the mean BP dip, periodic legs movements in sleep index, and endothelial function. Results Of the 70 patients (age, 59.4 ± 11.40; 43 women) randomized to rotigotine (n = 34) and placebo (n = 36), 66 (33 rotigotine, 33 placebo) completed the study. The percentage of BP nondippers at end point was higher in the placebo than in the rotigotine group (systolic BP, 72.22% vs 47.06%; diastolic BP, 47.22% vs 20.59%; P   〈  0.05). Mean BP dip at end point was higher in the rotigotine than in the placebo group (systolic BP, 11.24 ± 6.15 vs 6.12 ± 7.98; diastolic BP, 15.12 ± 7.09 vs 9.36 ± 10.23; P   〈  0.05). Endothelial function was comparable between the groups. No significant safety concerns were reported with similar incidences of adverse events between groups. Conclusion Rotigotine increased the percentage of BP dipper profiles and the BP dip in patients with RLS. Future studies should assess whether this change is associated with a reduction in the long‐term cardiovascular risk in RLS. © 2020 International Parkinson and Movement Disorder Society
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v35.12
    DOI: 10.1002/mds.28224
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2041249-6
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  • 5
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    Online Resource
    Sommeil de nuit perturbé dans la narcolepsie, de la plainte clinique aux marqueurs objectifs
    Elsevier BV ; 2022
    In:  Médecine du Sommeil Vol. 19, No. 1 ( 2022-03), p. 64-
    Details
    In: Médecine du Sommeil, Elsevier BV, Vol. 19, No. 1 ( 2022-03), p. 64-
    Type of Medium: Online Resource
    ISSN: 1769-4493
    URL: Article
    DOI: 10.1016/j.msom.2022.01.036
    Language: French
    Publisher: Elsevier BV
    Publication Date: 2022
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  • 6
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    Depression and suicidal thoughts in untreated and treated narcolepsy : Systematic analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Neurology Vol. 95, No. 20 ( 2020-11-17), p. e2755-e2768
    Details
    In: Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 95, No. 20 ( 2020-11-17), p. e2755-e2768
    Abstract: To assess the frequency and determinants of depressive symptoms and suicidal thoughts in adults with narcolepsy type 1 (NT1) and controls, as well as the changes after NT1 management and the risk factors of major depressive episode (MDE) and suicide risk (SR) in NT1. Methods Two hundred ninety-seven patients with NT1 (age 39 ± 17 years, 172 drug-free) and 346 controls (age 38 ± 16 years) underwent a comprehensive clinical evaluation including the Beck Depression Inventory-II (BDI-II) self-questionnaire, with 1 item on suicidal thoughts. One hundred one drug-free patients with NT1 completed the BDI-II a second time during treatment. In 162 patients with NT1, the face-to-face Mini International Neuropsychiatric Interview was performed to formally diagnose current MDE and SR. Results BDI-II total scores were higher in patients with NT1 than controls and in untreated than treated patients. Patients with moderate to severe BDI-II scores (24.9%) were less educated, were more frequently obese, and had more severe narcolepsy symptoms, more autonomic dysfunctions, and poorer quality of life. Results were unchanged in models adjusted for NT1 medication intake. Suicidal thoughts were more frequent in untreated patients than controls (22.7% vs 12.4%). Patients with suicidal thoughts were more likely to be men and to have more severe narcolepsy symptoms. After narcolepsy management, BDI-II total score and suicidal thoughts decreased. MDE was diagnosed in 29 (18.1%) and SR in 27 (16.9%) patients. Conclusions Depression, depressive symptoms, suicidal thoughts, and SR were frequent in patients with NT1, especially those without treatment, and were associated with NT1 severity. Depressive symptoms and suicidal thoughts improved after NT1 management.
    Type of Medium: Online Resource
    ISSN: 0028-3878 , 1526-632X
    URL: Article
    DOI: 10.1212/WNL.0000000000010737
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
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  • 7
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    Association of CSF orexin-A levels and nocturnal sleep stability in patients with hypersomnolence
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Neurology Vol. 95, No. 21 ( 2020-11-24), p. e2900-e2911
    Details
    In: Neurology, Ovid Technologies (Wolters Kluwer Health), Vol. 95, No. 21 ( 2020-11-24), p. e2900-e2911
    Abstract: To evaluate the associations between CSF orexin-A (ORX) levels and markers of nocturnal sleep stability, assessed by polysomnography. Methods Nocturnal polysomnography data and ORX levels of 300 drug-free participants (55% men, 29.9±15.5 years, ORX level 155.1±153.7 pg/mL) with hypersomnolence were collected. Several markers of nocturnal sleep stability were analyzed: sleep and wake bouts and sleep/wake transitions. Groups were categorized according to ORX levels, in 2 categories (deficient ≤110; 〉 110), in tertiles (≤26, 26–254, 〉 254), and compared using logistic regression models. Results were adjusted for age, sex, and body mass index. Results We found higher number of wake bouts (43 vs 25, p 〈 0.0001), sleep bouts (43 vs 25.5, p 〈 0.0001), and index of sleep bouts/hour of sleep time, but lower index of wake bouts/hour of wake time (41.4 vs 50.6, p 〈 0.0001), in patients with ORX deficiency. The percentage of wake bouts 〈 30 seconds was lower (51.3% vs 60.8%, p 〈 0.001) and of wake bouts ≥1 minutes 30 seconds higher (7.7% vs 6.7%, p = 0.02) when ORX deficient. The percentage of sleep bouts ≤14 minutes was higher (2–5 minutes: 23.7% vs 16.1%, p 〈 0.0001), and of long sleep bouts lower ( 〉 32 minutes 30 seconds: 7.3% vs 18.3%, p 〈 0.0001), when ORX deficient. These findings were confirmed when groups were categorized according to ORX tertiles, with a dose–response effect of ORX levels in post hoc comparisons, and in adjusted models. Interpretation This study shows an association between ORX levels and nocturnal sleep stabilization in patients with hypersomnolence. Sleep and wake bouts are reliable markers of nighttime sleep stability that correlate with CSF ORX levels in a dose-dependent manner.
    Type of Medium: Online Resource
    ISSN: 0028-3878 , 1526-632X
    URL: Article
    DOI: 10.1212/WNL.0000000000010743
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
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  • 8
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    CSF and serum ferritin levels in narcolepsy type 1 comorbid with restless legs syndrome
    Wiley ; 2020
    In:  Annals of Clinical and Translational Neurology Vol. 7, No. 6 ( 2020-06), p. 924-931
    Details
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 7, No. 6 ( 2020-06), p. 924-931
    Abstract: To investigate whether cerebrospinal fluid (CSF) and serum ferritin levels differ between patients with narcolepsy type 1 (NT1) comorbid with restless legs syndrome (RLS) or periodic leg movements during sleep (PLMS), and patients with NT1 or controls without comorbid RLS or PLMS. Methods Sixty‐six drug‐free patients with NT1 (44 males, age 38.5 years [14–81]) were enrolled, including 20 with RLS, 18 with PLMS index ≥15/h (six with both RLS and PLMS). Thirty‐eight drug‐free patients (12 males, age 22.5 years [12–61] ) referred for sleepiness complaint, but without central hypersomnia, RLS, PLMS were included as controls. Clinical, electrophysiological and biological (CSF/serum ferritin, orexin [ORX]) data were quantified. Results NT1 patients with and without RLS did not differ for age, gender, and body mass index (BMI). No between‐group differences were found for CSF ferritin, ORX, and serum ferritin levels. No CSF ferritin, ORX, and serum ferritin level differences were found between NT1 patients with and without PLMS, or with RLS or PLMS versus not. CSF‐ferritin levels were not different between NT1 and controls in adjusted analyses. CSF‐ferritin levels in the whole population correlated positively with age, serum‐ferritin, BMI, negatively with ORX, but not with PLMS index. In NT1, CSF‐ferritin levels correlated with age and serum‐ferritin but not with PLMS. Conclusion The absence of CSF ferritin deficiency in NT1 with comorbid RLS or PLMS indicates normal brain iron levels in that condition. This result suggests that the frequent association between RLS, PLMS, and NT1 is not based on alterations in brain iron metabolism, a pathophysiological mechanism involved in primary RLS.
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Issue
    URL: Article
    DOI: 10.1002/acn3.v7.6
    DOI: 10.1002/acn3.51056
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2740696-9
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  • 9
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    Characteristics associated with hypersomnia and excessive daytime sleepiness identified by extended polysomnography recording
    Oxford University Press (OUP) ; 2021
    In:  Sleep Vol. 44, No. 5 ( 2021-05-14)
    Details
    In: Sleep, Oxford University Press (OUP), Vol. 44, No. 5 ( 2021-05-14)
    Abstract: Hypersomnolence, defined by excessive daytime sleepiness (EDS) or excessive quantity of sleep (EQS), has been associated with increased morbidity. The aim of this study was to determine the clinical and polysomnographic characteristics associated with EQS and EDS assessed objectively during extended polysomnography recording. Methods A total of 266 drug-free subjects (201 women; mean age: 26.5 years [16.08; 60.87]) underwent 32-h bed-rest polysomnography recording preceded by polysomnography and modified multiple sleep latency test (mMSLT). Participants were categorized according to their total sleep time (bed-rest TST ≥19 h, hypersomnia), objective EDS (mean sleep latency on MSLT ≤8 min), and self-reported EDS (Epworth sleepiness scale score & gt;10) and EQS (≥9 h/24 h per week). Results Subjects with hypersomnia were often younger, with normal sleep architecture, high nighttime sleep efficiency, and severe objective EDS. No association with sex, body mass index, Epworth sleepiness scale, EQS, and depressive symptoms was detected. Subjects with objective EDS had less EQS, higher sleep efficiency, and increased hypersomnia. Discrepancies were observed between objective and self-reported measures of sleep duration and EDS. Finally, 71 subjects were identified who had objective hypersomnia and/or EDS, no medical and psychiatric conditions and normal polysomnography parameters, and therefore met the stringent criteria of idiopathic hypersomnia, an orphan disorder. Conclusions Sleep duration and EDS should be quantified using self-reported and objective measures in a controlled procedure to differentiate long sleepers, patients with hypersomnia, and patients with idiopathic hypersomnia. This will help to better understand their biology, to identify specific biomarkers, and to assess related health outcomes.
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsaa264
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2056761-3
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  • 10
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    Cerebrospinal fluid monoamine levels in central disorders of hypersomnolence
    Oxford University Press (OUP) ; 2021
    In:  Sleep Vol. 44, No. 7 ( 2021-07-09)
    Details
    In: Sleep, Oxford University Press (OUP), Vol. 44, No. 7 ( 2021-07-09)
    Abstract: Whether the cause of daytime sleepiness in narcolepsy type 1 (NT1) is a direct consequence of the loss of orexin (ORX) neurons or whether low orexin reduces the efficacy of the monoaminergic systems to promote wakefulness is unclear. The neurobiology underlying sleepiness in other central hypersomnolence disorders, narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH), is currently unknown. Methods Eleven biogenic amines including the monoaminergic neurotransmitters and their metabolites and five trace amines were measured in the cerebrospinal fluid (CSF) of 94 drug-free subjects evaluated at the French National Reference Center for Narcolepsy: 39 NT1(orexin-deficient) patients, 31 patients with objective sleepiness non orexin-deficient (NT2 and IH), and 24 patients without objective sleepiness. Results Three trace amines were undetectable in the sample: tryptamine, octopamine, and 3-iodothyronamine. No significant differences were found among the three groups for quantified monoamines and their metabolites in crude and adjusted models; however, CSF 5-hydroxyindoleacetic acid (5-HIAA) levels tended to increase in NT1 compared to other patients after adjustment. Most of the biomarkers were not associated with ORX-A levels, clinical or neurophysiological parameters, but a few biomarkers (e.g. 3-methoxy-4-hydroxyphenylglycol and norepinephrine) correlated with daytime sleepiness and high rapid eye movement (REM) sleep propensity. Conclusions We found no striking differences among CSF monoamines, their metabolites and trace amine levels, and few associations between them and key clinical or neurophysiological parameters in NT1, NT2/IH, and patients without objective sleepiness. Although mostly negative, these findings are a significant contribution to our understanding of the neurobiology of hypersomnolence in these disorders that remain mysterious and deserve further exploration.
    Type of Medium: Online Resource
    ISSN: 0161-8105 , 1550-9109
    URL: Article
    DOI: 10.1093/sleep/zsab012
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2056761-3
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