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  • 1
    Online Resource
    Online Resource
    Four‐Dimensional Deoxyribonucleic Acid–Gold Nanoparticle Assemblies
    Wiley ; 2020
    In:  Angewandte Chemie International Edition Vol. 59, No. 39 ( 2020-09-21), p. 17250-17255
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 59, No. 39 ( 2020-09-21), p. 17250-17255
    Abstract: Organization of gold nanoobjects by oligonucleotides has resulted in many three‐dimensional colloidal assemblies with diverse size, shape, and complexity; nonetheless, autonomous and temporal control during formation remains challenging. In contrast, living systems temporally and spatially self‐regulate formation of functional structures by internally orchestrating assembly and disassembly kinetics of dissipative biomacromolecular networks. We present a novel approach for fabricating four‐dimensional gold nanostructures by adding an additional dimension: time. The dissipative character of our system is achieved using exonuclease III digestion of deoxyribonucleic acid (DNA) fuel as an energy‐dissipating pathway. Temporal control over amorphous clusters composed of spherical gold nanoparticles (AuNPs) and well‐defined core–satellite structures from gold nanorods (AuNRs) and AuNPs is demonstrated. Furthermore, the high specificity of DNA hybridization allowed us to demonstrate selective activation of the evolution of multiple architectures of higher complexity in a single mixture containing small and larger spherical AuNPs and AuNRs.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v59.39
    DOI: 10.1002/anie.202007616
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 2
    Online Resource
    Online Resource
    Aktivierung der katalytischen Aktivität von Thrombin für die Bildung von Fibrin durch Ultraschall
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 26 ( 2021-06-21), p. 14829-14836
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 26 ( 2021-06-21), p. 14829-14836
    Abstract: Die Regulierung der Aktivität von Enzymen ist eine Methode zur Steuerung biologischer Funktionen. Wir berichten über zwei Systeme, die die ultraschallinduzierte Aktivierung von Thrombin ermöglichen, das für die sekundäre Hämostase wichtig ist. Erstens entwickelten wir Polyaptamere, die spezifisch an Thrombin binden können und dessen katalytische Aktivität hemmen. Mit Hilfe von Ultraschall, der Trägheitskavitation erzeugt, und therapeutisch‐medizinischem fokussiertem Ultraschall lösen sich die Wechselwirkungen zwischen Polyaptamer und Enzym, wodurch die Aktivität zur Katalyse der Umwandlung von Fibrinogen in Fibrin wiederhergestellt wird. Zweitens verwendeten wir gespaltene Aptamere, die an die Oberfläche von Gold‐Nanopartikeln (AuNPs) konjugiert sind. In Gegenwart von Thrombin assemblieren diese zu einer Aptamer‐Tertiärstruktur, induzieren die Aggregation der AuNPs und deaktivieren das Enzym. Durch Behandlung mit Ultraschall lösen sich die AuNP‐Aggregate reversibel, setzen das Enzym frei und aktivieren es. Wir glauben, dass dieser Ansatz eine Blaupause für die Steuerung der Funktion anderer Proteine durch mechanische Stimuli im Bereich der Sonogenetik sein wird.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.26
    DOI: 10.1002/ange.202105404
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 3
    Online Resource
    Online Resource
    Carbonic anhydrase IX-targeted nanovesicles potentiated ferroptosis by remodeling the intracellular environment for synergetic cancer therapy
    Royal Society of Chemistry (RSC) ; 2023
    In:  Nanoscale Horizons Vol. 8, No. 6 ( 2023), p. 783-793
    Details
    In: Nanoscale Horizons, Royal Society of Chemistry (RSC), Vol. 8, No. 6 ( 2023), p. 783-793
    Abstract: Ferroptosis is one critical kind of regulated cell death for tumor suppression, yet it still presents challenges of low efficiency due to the intracellular alkaline pH and aberrant redox status. Herein, we reported a carbonic anhydrase IX (CA IX)-targeted nanovesicle (PAHC NV) to potentiate ferroptosis by remodeling the intracellular environment. CA IX inhibitor 4-(2-aminoethyl) benzene sulfonamide (AEBS) was anchored onto nanovesicles loaded with hemoglobin (Hb) and chlorin e6 (Ce6). Upon reaching tumor regions, PAHC could be internalized by cancer cells specifically by means of CA IX targeting and intervention. Afterwards, the binding of AEBS could elicit intracellular acidification and alter redox homeostasis to boost the lipid peroxidation (LPO) level, thus aggravating the ferroptosis process. Meanwhile, Hb served as an iron reservoir that could efficiently evoke ferroptosis and release O 2 to ameliorate tumor hypoxia. With the help of self-supplied O 2 , Ce6 produced a plethora of 1 O 2 for enhanced photodynamic therapy, which in turn favored LPO accumulation to synergize ferroptosis. This study presents a promising paradigm for designing nanomedicines to heighten ferroptosis-based synergetic therapeutics through remodeling the intracellular environment.
    Type of Medium: Online Resource
    ISSN: 2055-6756 , 2055-6764
    URL: Article
    DOI: 10.1039/D2NH00494A
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Ultrasound meets the cell membrane: for enhanced endocytosis and drug delivery
    Royal Society of Chemistry (RSC) ; 2023
    In:  Nanoscale Vol. 15, No. 33 ( 2023), p. 13532-13545
    Details
    In: Nanoscale, Royal Society of Chemistry (RSC), Vol. 15, No. 33 ( 2023), p. 13532-13545
    Abstract: Endocytosis plays a crucial role in drug delivery for precision therapy. As a non-invasive and spatiotemporal-controllable stimulus, ultrasound (US) has been utilized for improving drug delivery efficiency due to its ability to enhance cell membrane permeability. When US meets the cell membrane, the well-known cavitation effect generated by US can cause various biophysical effects, facilitating the delivery of various cargoes, especially nanocarriers. The comprehension of recent progress in the biophysical mechanism governing the interaction between ultrasound and cell membranes holds significant implications for the broader scientific community, particularly in drug delivery and nanomedicine. This review will summarize the latest research results on the biological effects and mechanisms of US-enhanced cellular endocytosis. Moreover, the latest achievements in US-related biomedical applications will be discussed. Finally, challenges and opportunities of US-enhanced endocytosis for biomedical applications will be provided.
    Type of Medium: Online Resource
    ISSN: 2040-3364 , 2040-3372
    URL: Article
    DOI: 10.1039/D3NR02562D
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2515664-0
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  • 5
    Online Resource
    Online Resource
    Mechanochemical bond scission for the activation of drugs
    Springer Science and Business Media LLC ; 2021
    In:  Nature Chemistry Vol. 13, No. 2 ( 2021-02), p. 131-139
    Details
    In: Nature Chemistry, Springer Science and Business Media LLC, Vol. 13, No. 2 ( 2021-02), p. 131-139
    Type of Medium: Online Resource
    ISSN: 1755-4330 , 1755-4349
    URL: Article
    DOI: 10.1038/s41557-020-00624-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2464596-5
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  • 6
    Online Resource
    Online Resource
    Gold-based nanomaterials for the treatment of brain cancer
    China Anti-cancer Association ; 2021
    In:  Cancer Biology and Medicine Vol. 18, No. 2 ( 2021), p. 372-387
    Details
    In: Cancer Biology and Medicine, China Anti-cancer Association, Vol. 18, No. 2 ( 2021), p. 372-387
    Type of Medium: Online Resource
    ISSN: 2095-3941
    URL: Article
    DOI: 10.20892/j.issn.2095-3941.2020.0524
    Language: English
    Publisher: China Anti-cancer Association
    Publication Date: 2021
    detail.hit.zdb_id: 2676322-9
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  • 7
    Online Resource
    Online Resource
    Activation of the Catalytic Activity of Thrombin for Fibrin Formation by Ultrasound
    Wiley ; 2021
    In:  Angewandte Chemie International Edition Vol. 60, No. 26 ( 2021-06-21), p. 14707-14714
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 60, No. 26 ( 2021-06-21), p. 14707-14714
    Abstract: The regulation of enzyme activity is a method to control biological function. We report two systems enabling the ultrasound‐induced activation of thrombin, which is vital for secondary hemostasis. First, we designed polyaptamers, which can specifically bind to thrombin, inhibiting its catalytic activity. With ultrasound generating inertial cavitation and therapeutic medical focused ultrasound, the interactions between polyaptamer and enzyme are cleaved, restoring the activity to catalyze the conversion of fibrinogen into fibrin. Second, we used split aptamers conjugated to the surface of gold nanoparticles (AuNPs). In the presence of thrombin, these assemble into an aptamer tertiary structure, induce AuNP aggregation, and deactivate the enzyme. By ultrasonication, the AuNP aggregates reversibly disassemble releasing and activating the enzyme. We envision that this approach will be a blueprint to control the function of other proteins by mechanical stimuli in the sonogenetics field.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v60.26
    DOI: 10.1002/anie.202105404
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 8
    Online Resource
    Online Resource
    CT Imaging Features of Patients Infected with 2019 Novel Coronavirus
    Compuscript, Ltd. ; 2021
    In:  BIO Integration Vol. 2, No. 1 ( 2021-04-25), p. 5-11
    Details
    In: BIO Integration, Compuscript, Ltd., Vol. 2, No. 1 ( 2021-04-25), p. 5-11
    Abstract: Novel coronavirus pneumonia is an acute, infectious pneumonia caused by a novel coronavirus infection. Computed tomographic (CT) imaging is one of the main methods to screen and diagnose patients with this disease. Here, the importance and clinical value of chest CT examination in the diagnosis of COVID-19 is expounded, and the pulmonary CT findings of COVID-19 patients in different stages are briefly summarized, thus providing a reference document for the CT diagnosis of COVID-19 patients.
    Type of Medium: Online Resource
    ISSN: 2712-0074
    URL: Article
    DOI: 10.15212/bioi-2020-0038
    Language: English
    Publisher: Compuscript, Ltd.
    Publication Date: 2021
    detail.hit.zdb_id: 3076462-2
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  • 9
    Online Resource
    Online Resource
    Ultrasound‐controlled drug release and drug activation for cancer therapy
    Wiley ; 2021
    In:  Exploration Vol. 1, No. 3 ( 2021-12)
    Details
    In: Exploration, Wiley, Vol. 1, No. 3 ( 2021-12)
    Abstract: Traditional chemotherapy suffers from severe toxicity and side effects that limit its maximum application in cancer therapy. To overcome this challenge, an ideal treatment strategy would be to selectively control the release or regulate the activity of drugs to minimize the undesirable toxicity. Recently, ultrasound (US)‐responsive drug delivery systems (DDSs) have attracted significant attention due to the non‐invasiveness, high tissue penetration depth, and spatiotemporal controllability of US. Moreover, the US‐induced mechanical force has been proven to be a robust method to site‐selectively rearrange or cleave bonds in mechanochemistry. This review describes the US‐activated DDSs from the fundamental basics and aims to present a comprehensive summary of the current understanding of US‐responsive DDSs for controlled drug release and drug activation. First, we summarize the typical mechanisms for US‐responsive drug release and drug activation. Second, the main factors affecting the ultrasonic responsiveness of drug carriers are outlined. Furthermore, representative examples of US‐controlled drug release and drug activation are discussed, emphasizing their novelty and design principles. Finally, the challenges and an outlook on this promising therapeutic strategy are discussed.
    Type of Medium: Online Resource
    ISSN: 2766-2098 , 2766-2098
    URL: Issue
    URL: Article
    DOI: 10.1002/exp2.v1.3
    DOI: 10.1002/EXP.20210023
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 3103468-8
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  • 10
    Online Resource
    Online Resource
    Virus-like particles nanoreactors: from catalysis towards bio-applications
    Royal Society of Chemistry (RSC) ; 2023
    In:  Journal of Materials Chemistry B Vol. 11, No. 38 ( 2023), p. 9084-9098
    Details
    In: Journal of Materials Chemistry B, Royal Society of Chemistry (RSC), Vol. 11, No. 38 ( 2023), p. 9084-9098
    Abstract: Virus-like particles (VLPs) are self-assembled supramolecular structures found in nature, often used for compartmentalization. Exploiting their inherent properties, including precise nanoscale structures, monodispersity, and high stability, these architectures have been widely used as nanocarriers to protect or enrich catalysts, facilitating catalytic reactions and avoiding interference from the bulk solutions. In this review, we summarize the current progress of virus-like particles (VLPs)-based nanoreactors. First, we briefly introduce the physicochemical properties of the most commonly used virus particles to understand their roles in catalytic reactions beyond the confined space. Next, we summarize the self-assembly of nanoreactors forming higher-order hierarchical structures, highlighting the emerging field of nanoreactors as artificial organelles and their potential biomedical applications. Finally, we discuss the current findings and future perspectives of VLPs-based nanoreactors.
    Type of Medium: Online Resource
    ISSN: 2050-750X , 2050-7518
    URL: Article
    DOI: 10.1039/D3TB01112G
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2702241-9
    detail.hit.zdb_id: 2705149-3
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