In:
Dalton Transactions, Royal Society of Chemistry (RSC)
Abstract:
Reaction of (1R,2R)-(cyclohexane-1,2-diamine)dichloridoplatinum(II) with maleic acid unexpectedly resulted in the formation of an organometallic platinum(II) complex featuring a C,O-coordinating ligand. Additionally, a small series of close derivatives with increasing lipophilicity was synthesized. All complexes were fully characterized by multinuclear one- and two-dimensional (1H, 13C, 15N, 195Pt) NMR spectroscopy, high resolution mass spectrometry, and in one case by X-ray diffraction. Lipophilicity, the impact on DNA secondary structure as well as cytotoxic properties in three human cancer cell lines (A549, SW480, CH1/PA-1) were investigated. Unexpectedly, no clear-cut trend in cytotoxicity was observed when increasing the lipophilicity. Also unexpectedly, the complexes showed only little potential to inhibit cancer cell growth and no signs of interaction with DNA, in sharp contrast to the parent drug oxaliplatin, which seems to be caused by the low reactivity of the investigated compounds.
Type of Medium:
Online Resource
ISSN:
1477-9226
,
1477-9234
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2023
detail.hit.zdb_id:
1472887-4
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