In:
Neuroendocrinology, S. Karger AG, Vol. 111, No. 8 ( 2021), p. 775-785
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Acromegaly is commonly complicated by arthropathy and skeletal fragility with high risk of vertebral fractures (VFs). 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study aimed to assess whether VFs may be associated with sagittal spine deformities, arthropathy, impaired quality of life (QoL), pain, and disability. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Thirty-eight patients with acromegaly (median age: 55 years, 20 males) and 38 matched control subjects were evaluated by a low-dose sagittal and coronal planes, X-ray imaging system (EOS®-2D/3D) for morphometric VFs, radiological signs of spine arthropathy, and spine deformities (Cobb thoracic index ≥40°, pelvic incidence minus lumbar lordosis ≥10°, pelvic tilt & #x3e;20°, and sagittal vertical axis ≥4 cm) determining sagittal spine imbalance. Acromegalic patients were also evaluated by questionnaires for QoL (Acromegaly QoL Questionnaire [AcroQoL] and Short Form-36 [SF-36] ) and pain and disability (Western Ontario and McMaster University [WOMAC]). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Acromegalic patients showed higher prevalence of thoracic hyperkyphosis (i.e., Cobb thoracic index ≥40°; 〈 i 〉 p 〈 /i 〉 = 0.04) and pelvic tilt & #x3e;20° ( 〈 i 〉 p 〈 /i 〉 = 0.02) than control subjects. VFs were found in 34.2% of acromegalic patients ( 〈 i 〉 p 〈 /i 〉 = 0.003 vs. control subjects), in relationship with higher prevalence of hyperkyphosis ( 〈 i 〉 p 〈 /i 〉 = 0.03), pelvic tilt & #x3e;20° ( 〈 i 〉 p 〈 /i 〉 = 0.04), sagittal vertical axis ≥4 cm ( 〈 i 〉 p 〈 /i 〉 = 0.03), and moderate/severe subchondral degeneration ( 〈 i 〉 p 〈 /i 〉 = 0.01). Moreover, patients with VFs had lower AcroQoL general health ( 〈 i 〉 p 〈 /i 〉 = 0.007) and SF-36 general health ( 〈 i 〉 p 〈 /i 〉 = 0.002) scores and higher WOMAC pain ( 〈 i 〉 p 〈 /i 〉 = 0.003) and global ( 〈 i 〉 p 〈 /i 〉 = 0.009) scores than patients who did not fracture. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 In acromegaly, VFs may be associated with spine deformities and sagittal imbalance, spine arthropathy, impaired QoL, and disability.
Type of Medium:
Online Resource
ISSN:
0028-3835
,
1423-0194
Language:
English
Publisher:
S. Karger AG
Publication Date:
2021
detail.hit.zdb_id:
1483028-0
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