In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2022-7-22), p. e0270716-
Abstract:
Induction of a durable viral response is difficult to achieve in patients with chronic hepatitis B (CHB), even from long-term use of a nucleos(t)ide analogue (NA). This study investigated whether switching to peginterferon (PegIFN) alfa-2a after long-term NA therapy induced a durable viral response. Methods Patients with hepatitis B e antigen (HBeAg)-positive CHB who received any NA for at least 72 weeks and had a low level of HBV DNA (≤100 IU/mL) were randomized (1:1) to receive PegIFN alfa-2a (180 μg/week) or NA for 48 weeks. The primary endpoint was change in the hepatitis B surface antigen (HBsAg) titer during antiviral therapy. Results We randomized 149 CHB patients to the two groups. Compared to baseline, the HBsAg levels in both groups were not lower at week 12, but were lower after 24, 36, and 48 weeks (all p 〈 0.001). The maximal HBsAg decline in the PegIFN alfa-2a group was at week 36 (0.50±0.88 log 10 IU/mL), and this decline was smaller in the NA group (0.08±0.46 log 10 IU/mL). The percentage of patients with HBeAg seroconversion at week 48 was also greater in the PegIFN alfa-2a group (15/75 [20.0%] vs . 5/74 [6.8%], p = 0.018). Multivariable analysis indicated the PegIFN alfa-2a group had a greater change in HBeAg seroconversion at week 48 (p = 0.027). Patients had relatively good tolerance to PegIFN alfa-2a therapy. Conclusions CHB patients who switched to PegIFN alfa-2a for 48 weeks had a significantly lower HBsAg titer and increased HBeAg seroconversion relative to those who remained on NA therapy. Trial registration (ClinicalTrials.gov; NCT01769833 ).
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0270716
DOI:
10.1371/journal.pone.0270716.g001
DOI:
10.1371/journal.pone.0270716.g002
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10.1371/journal.pone.0270716.g003
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10.1371/journal.pone.0270716.t001
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10.1371/journal.pone.0270716.t002
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10.1371/journal.pone.0270716.t003
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10.1371/journal.pone.0270716.t004
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10.1371/journal.pone.0270716.t005
DOI:
10.1371/journal.pone.0270716.s001
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10.1371/journal.pone.0270716.s002
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10.1371/journal.pone.0270716.s003
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10.1371/journal.pone.0270716.s004
DOI:
10.1371/journal.pone.0270716.s005
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10.1371/journal.pone.0270716.s006
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10.1371/journal.pone.0270716.s007
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10.1371/journal.pone.0270716.s008
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10.1371/journal.pone.0270716.s009
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10.1371/journal.pone.0270716.s010
DOI:
10.1371/journal.pone.0270716.s011
DOI:
10.1371/journal.pone.0270716.s012
DOI:
10.1371/journal.pone.0270716.s013
DOI:
10.1371/journal.pone.0270716.s014
DOI:
10.1371/journal.pone.0270716.s015
DOI:
10.1371/journal.pone.0270716.r001
DOI:
10.1371/journal.pone.0270716.r002
DOI:
10.1371/journal.pone.0270716.r003
DOI:
10.1371/journal.pone.0270716.r004
DOI:
10.1371/journal.pone.0270716.r005
DOI:
10.1371/journal.pone.0270716.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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