In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 6 ( 2021-6-16), p. e0009494-
Kurzfassung:
We report the identification of two orthobunyaviruses, Melao virus (MELV) and Oropouche virus (OROV), in plasma specimens from Haitian children with acute febrile illness who presented during outbreaks caused by alpha- and flaviviruses in 2014. Heretofore not described as a human pathogen, MELV was isolated in cell culture from the plasma of five case patients. OROV RNA was detected in the plasma of an additional child, using an unbiased sequencing approach, with phylogenetic inference suggesting a close relationship with strains from Brazil. Abdominal pain was reported by four case patients with MELV infections, with lymphadenopathy noted in two cases. Our findings document the occurrence of these orthobunyaviruses within the Caribbean region and highlight the critical importance of surveillance with viral genome sequence analyses to identify outbreaks caused by these and other emerging viruses.
Materialart:
Online-Ressource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009494
DOI:
10.1371/journal.pntd.0009494.g001
DOI:
10.1371/journal.pntd.0009494.g002
DOI:
10.1371/journal.pntd.0009494.g003
DOI:
10.1371/journal.pntd.0009494.g004
DOI:
10.1371/journal.pntd.0009494.g005
DOI:
10.1371/journal.pntd.0009494.g006
DOI:
10.1371/journal.pntd.0009494.g007
DOI:
10.1371/journal.pntd.0009494.g008
DOI:
10.1371/journal.pntd.0009494.g009
DOI:
10.1371/journal.pntd.0009494.t001
DOI:
10.1371/journal.pntd.0009494.t002
DOI:
10.1371/journal.pntd.0009494.t003
DOI:
10.1371/journal.pntd.0009494.t004
DOI:
10.1371/journal.pntd.0009494.s001
DOI:
10.1371/journal.pntd.0009494.s002
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2021
ZDB Id:
2429704-5
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