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  • 1
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, No. 23 ( 2021-12-07), p. 1845-1855
    Abstract: Despite advances in surgery and pharmacotherapy, there remains significant residual ischemic risk after coronary artery bypass grafting surgery. Methods: In REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl–Intervention Trial), a multicenter, placebo-controlled, double-blind trial, statin-treated patients with controlled low-density lipoprotein cholesterol and mild to moderate hypertriglyceridemia were randomized to 4 g daily of icosapent ethyl or placebo. They experienced a 25% reduction in risk of a primary efficacy end point (composite of cardiovascular death, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina) and a 26% reduction in risk of a key secondary efficacy end point (composite of cardiovascular death, myocardial infarction, or stroke) when compared with placebo. The current analysis reports on the subgroup of patients from the trial with a history of coronary artery bypass grafting. Results: Of the 8179 patients randomized in REDUCE-IT, a total of 1837 (22.5%) had a history of coronary artery bypass grafting, with 897 patients randomized to icosapent ethyl and 940 to placebo. Baseline characteristics were similar between treatment groups. Randomization to icosapent ethyl was associated with a significant reduction in the primary end point (hazard ratio [HR], 0.76 [95% CI, 0.63–0.92] ; P =0.004), in the key secondary end point (HR, 0.69 [95% CI, 0.56–0.87]; P =0.001), and in total (first plus subsequent or recurrent) ischemic events (rate ratio, 0.64 [95% CI, 0.50–0.81]; P =0.0002) compared with placebo. This yielded an absolute risk reduction of 6.2% (95% CI, 2.3%–10.2%) in first events, with a number needed to treat of 16 (95% CI, 10–44) during a median follow-up time of 4.8 years. Safety findings were similar to the overall study: beyond an increased rate of atrial fibrillation/flutter requiring hospitalization for at least 24 hours (5.0% vs 3.1%; P =0.03) and a nonsignificant increase in bleeding, occurrences of adverse events were comparable between groups. Conclusions: In REDUCE-IT patients with a history of coronary artery bypass grafting, treatment with icosapent ethyl was associated with significant reductions in first and recurrent ischemic events. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01492361.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 1466401-X
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  • 2
    Online Resource
    Online Resource
    Emerald ; 2021
    In:  COMPEL - The international journal for computation and mathematics in electrical and electronic engineering Vol. 40, No. 3 ( 2021-08-20), p. 309-324
    In: COMPEL - The international journal for computation and mathematics in electrical and electronic engineering, Emerald, Vol. 40, No. 3 ( 2021-08-20), p. 309-324
    Abstract: The main purpose of this paper is to evaluate the two energy saving position control strategies for AC drives valid for a wide range of boundary conditions including an analysis of their energy expenses. Design/methodology/approach For energy demands analysis, the optimal energy control based on mechanical and electrical losses minimization is compared with the near-optimal one based on symmetrical trapezoidal speed profile. Both control strategies respect prescribed maneuver time and define acceleration profile for preplanned rest-to-rest maneuver. Findings Presented simulations confirm lower total energy expenditures of energy optimal control if compared with near-optimal one, but the differences are only small due to the fact that two energy saving strategies are compared. Research limitations/implications Developed overall control system consisting of energy saving profile generator, pre-compensator and position control system respecting principles of field-oriented control is capable to track precomputed state variables precisely. Practical implications Energy demands of both control strategies are verified and compared to simulations and preliminary experiments. The possibilities of energy savings were confirmed for both control strategies. Originality/value Experimental verification of designed control structure is sufficiently promising and confirmed assumed energy savings.
    Type of Medium: Online Resource
    ISSN: 0332-1649 , 0332-1649
    Language: English
    Publisher: Emerald
    Publication Date: 2021
    detail.hit.zdb_id: 1501321-2
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