GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 2020-2024  (149)
  • 1
    Online Resource
    Online Resource
    How COVID-19 kick-started online learning in medical education—The DigiMed study
    Public Library of Science (PLoS) ; 2021
    In:  PLOS ONE Vol. 16, No. 9 ( 2021-9-21), p. e0257394-
    Details
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 9 ( 2021-9-21), p. e0257394-
    Abstract: The coronavirus disease 2019 (COVID-19) pandemic led to far-reaching restrictions of social and professional life, affecting societies all over the world. To contain the virus, medical schools had to restructure their curriculum by switching to online learning. However, only few medical schools had implemented such novel learning concepts. We aimed to evaluate students’ attitudes to online learning to provide a broad scientific basis to guide future development of medical education. Methods Overall, 3286 medical students from 12 different countries participated in this cross-sectional, web-based study investigating various aspects of online learning in medical education. On a 7-point Likert scale, participants rated the online learning situation during the pandemic at their medical schools, technical and social aspects, and the current and future role of online learning in medical education. Results The majority of medical schools managed the rapid switch to online learning (78%) and most students were satisfied with the quantity (67%) and quality (62%) of the courses. Online learning provided greater flexibility (84%) and led to unchanged or even higher attendance of courses (70%). Possible downsides included motivational problems (42%), insufficient possibilities for interaction with fellow students (67%) and thus the risk of social isolation (64%). The vast majority felt comfortable using the software solutions (80%). Most were convinced that medical education lags behind current capabilities regarding online learning (78%) and estimated the proportion of online learning before the pandemic at only 14%. In order to improve the current curriculum, they wish for a more balanced ratio with at least 40% of online teaching compared to on-site teaching. Conclusion This study demonstrates the positive attitude of medical students towards online learning. Furthermore, it reveals a considerable discrepancy between what students demand and what the curriculum offers. Thus, the COVID-19 pandemic might be the long-awaited catalyst for a new “online era” in medical education.
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1371/journal.pone.0257394
    DOI: 10.1371/journal.pone.0257394.g001
    DOI: 10.1371/journal.pone.0257394.g002
    DOI: 10.1371/journal.pone.0257394.g003
    DOI: 10.1371/journal.pone.0257394.g004
    DOI: 10.1371/journal.pone.0257394.t001
    DOI: 10.1371/journal.pone.0257394.s001
    DOI: 10.1371/journal.pone.0257394.s002
    DOI: 10.1371/journal.pone.0257394.s003
    DOI: 10.1371/journal.pone.0257394.s004
    DOI: 10.1371/journal.pone.0257394.s005
    DOI: 10.1371/journal.pone.0257394.s006
    DOI: 10.1371/journal.pone.0257394.s007
    DOI: 10.1371/journal.pone.0257394.s008
    DOI: 10.1371/journal.pone.0257394.s009
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2021
    detail.hit.zdb_id: 2267670-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Associations of myosteatosis with disc degeneration: A 3T magnetic resonance imaging study in individuals with impaired glycaemia
    Wiley ; 2023
    In:  Journal of Cachexia, Sarcopenia and Muscle Vol. 14, No. 3 ( 2023-06), p. 1249-1258
    Details
    In: Journal of Cachexia, Sarcopenia and Muscle, Wiley, Vol. 14, No. 3 ( 2023-06), p. 1249-1258
    Abstract: Intervertebral disc degeneration (IVDD) may be linked to dysregulations of skeletal muscle glucose metabolism and fatty alterations of muscle composition ( Myosteatosis ). Our aim was to evaluate the different associations of magnetic resonance imaging (MRI)‐based paravertebral myosteatosis with lumbar disc degeneration in individuals with impaired glucose metabolism and normoglycaemic controls. Methods In total, 304 individuals (mean age: 56.3 ± 9.1 years, 53.6% male sex, mean body mass index [BMI]: 27.6 ± 4.7 kg/m 2 ) from a population‐based cohort study who underwent 3‐Tesla whole‐body chemical‐shift‐encoded (six echo times) and T2‐weighted single‐shot‐fast‐spin‐echo MRI were included. Lumbar disc degeneration was assessed at motion segments L1 to L5, categorized according to the Pfirrmann score and defined as Pfirrmann grade  〉  2 and/or disc bulging/herniation on at least one segment. Fat content of the autochthonous back muscles and the quadratus lumborum muscle was quantified as proton density fat fraction (PDFF muscle ). Logistic regression models adjusted for age, sex, BMI and regular physical activity were calculated to evaluate the association between PDFF muscle and outcome IVDD. Results The overall prevalence of IVDD was 79.6%. There was no significant difference in the prevalence or severity distribution of IVDD between participants with or without impaired glucose metabolism (77.7% vs. 80.7%, P  = 0.63 and P  = 0.71, respectively). PDFF muscle was significantly and positively associated with an increased risk for the presence of IVDD in participants with impaired glycaemia when adjusted for age, sex and BMI (PDFF autochthonous back muscles : odds ratio [OR] 2.16, 95% confidence interval [CI] [1.09, 4.3], P  = 0.03; PDFF quadratus lumborum : OR 2.01, 95% CI [1.04, 3.85], P  = 0.04). After further adjustment for regular physical activity, the results attenuated, albeit approaching statistical significance (PDFF autochthonous back muscles : OR 1.97, 95% CI [0.97, 3.99], P  = 0.06; PDFF quadratus lumborum : OR 1.86, 95% CI [0.92, 3.76], P  = 0.09). No significant associations were shown in healthy controls (PDFF autochthonous back muscles : OR 0.62, 95% CI [0.34, 1.14], P  = 0.13; PDFF quadratus lumborum : OR 1.06, 95% CI [0.6, 1.89], P  = 0.83). Conclusions Paravertebral myosteatosis is positively associated with intervertebral disc disease in individuals with impaired glucose metabolism, independent of age, sex and BMI. Regular physical activity may confound these associations. Longitudinal studies will help to better understand the pathophysiological role of skeletal muscle in those with concomitant disturbed glucose haemostasis and intervertebral disc disease, as well as possible underlying causal relationships.
    Type of Medium: Online Resource
    ISSN: 2190-5991 , 2190-6009
    URL: Issue
    URL: Article
    DOI: 10.1002/jcsm.v14.3
    DOI: 10.1002/jcsm.13192
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2586864-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Population‐based cohort imaging: skeletal muscle mass by magnetic resonance imaging in correlation to bioelectrical‐impedance analysis
    Wiley ; 2022
    In:  Journal of Cachexia, Sarcopenia and Muscle Vol. 13, No. 2 ( 2022-04), p. 976-986
    Details
    In: Journal of Cachexia, Sarcopenia and Muscle, Wiley, Vol. 13, No. 2 ( 2022-04), p. 976-986
    Abstract: Skeletal muscle mass is subjected to constant changes and is considered a good predictor for outcome in various diseases. Bioelectrical‐impedance analysis (BIA) and magnetic resonance imaging (MRI) are approved methodologies for its assessment. However, muscle mass estimations by BIA may be influenced by excess intramuscular lipids and adipose tissue in obesity. The objective of this study was to evaluate the feasibility of quantitative assessment of skeletal muscle mass by MRI as compared with BIA. Methods Subjects from a population‐based cohort underwent BIA (50 kHz, 0.8 mA) and whole‐body MRI including chemical‐shift encoded MRI (six echo times). Abdominal muscle mass by MRI was quantified as total and fat‐free cross‐sectional area by a standardized manual segmentation‐algorithm and normalized to subjects' body height 2 (abdominal muscle mass indices: AMMI MRI ). Results Among 335 included subjects (56.3 ± 9.1 years, 56.1% male), 95 (28.4%) were obese (BMI ≥ 30 kg/m 2 ). MRI‐based and BIA‐based measures of muscle mass were strongly correlated, particularly in non‐obese subjects [ r   〈  0.74 in non‐obese ( P   〈  0.001) vs. r   〈  0.56 in obese ( P   〈  0.001)]. Median AMMI Total(MRI) was significantly higher in obese as compared with non‐obese subjects (3246.7 ± 606.1 mm 2 /m 2 vs. 2839.0 ± 535.8 mm 2 /m 2 , P   〈  0.001, respectively), whereas the ratio AMMI Fat‐free /AMMI Total (by MRI) was significantly higher in non‐obese individuals (59.3 ± 10.1% vs. 53.5 ± 10.6%, P   〈  0.001, respectively). No significant difference was found regarding AMMI Fat‐free(MRI) ( P  = 0.424). In analyses adjusted for age and sex, impaired glucose tolerance and measures of obesity were significantly and positively associated with AMMI Total(MRI) and significantly and inversely with the ratio AMMI Fat‐free(MRI) /AMMI Total(MRI) ( P   〈  0.001). Conclusions MRI‐based assessment of muscle mass is feasible in population‐based imaging and strongly correlated with BIA. However, the observed weaker correlation in obese subjects may explain the known limitation of BIA in obesity and promote MRI‐based assessments. Thus, skeletal muscle mass parameters by MRI may serve as practical imaging biomarkers independent of subjects' body weight.
    Type of Medium: Online Resource
    ISSN: 2190-5991 , 2190-6009
    URL: Issue
    URL: Article
    DOI: 10.1002/jcsm.v13.2
    DOI: 10.1002/jcsm.12913
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2586864-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Distribution patterns of intramyocellular and extramyocellular fat by magnetic resonance imaging in subjects with diabetes, prediabetes and normoglycaemic controls
    Wiley ; 2021
    In:  Diabetes, Obesity and Metabolism Vol. 23, No. 8 ( 2021-08), p. 1868-1878
    Details
    In: Diabetes, Obesity and Metabolism, Wiley, Vol. 23, No. 8 ( 2021-08), p. 1868-1878
    Abstract: To evaluate the distribution of intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs) as well as total fat content in abdominal skeletal muscle by magnetic resonance imaging (MRI) using a dedicated segmentation algorithm in subjects with type 2 diabetes (T2D), prediabetes and normoglycaemic controls. Materials and Methods Subjects from a population‐based cohort were classified with T2D, prediabetes or as normoglycaemic controls. Total myosteatosis, IMCLs and EMCLs were quantified by multiecho Dixon MRI as proton‐density fat‐fraction (in %) in abdominal skeletal muscle. Results Among 337 included subjects (median age 56.0 [IQR: 49.0‐64.0] years, 56.4% males, median body mass index [BMI] : 27.2 kg/m 2 ), 129 (38.3%) were classified with an impaired glucose metabolism (T2D: 49 [14.5%]; prediabetes: 80 [23.7%] ). IMCLs were significantly higher than EMCLs in subjects without obesity (5.7% [IQR: 4.8%‐7.0%] vs. 4.1% [IQR: 2.7%‐5.8%] , P   〈  .001), whereas the amounts of IMCLs and EMCLs were shown to be equal and significantly higher in subjects with obesity (both 6.7%, P   〈  .001). Subjects with prediabetes and T2D had significantly higher amounts of IMCLs and EMCLs compared with normoglycaemic controls ( P   〈  .001). In univariable analysis, prediabetes and T2D were significantly associated with both IMCLs (prediabetes: β: 0.76, 95% CI: 0.28‐1.24, P  = .002; T2D: β: 1.56, 95% CI: 0.66‐2.47, P   〈  .001) and EMCLs (prediabetes: β: 1.54, 95% CI: 0.56‐2.51, P  = .002; T2D: β: 2.15, 95% CI: 1.33‐2.96, P   〈  .001). After adjustment for age and gender, the association of IMCLs with prediabetes attenuated ( P  = 0.06), whereas for T2D, both IMCLs and EMCLs remained significantly and positively associated ( P   〈  .02). Conclusion There are significant differences in the amount and distribution ratio of IMCLs and EMCLs between subjects with T2D, prediabetes and normoglycaemic controls. Therefore, these patterns of intramuscular fat distribution by MRI might serve as imaging biomarkers in both normal and impaired glucose metabolism.
    Type of Medium: Online Resource
    ISSN: 1462-8902 , 1463-1326
    URL: Issue
    URL: Article
    DOI: 10.1111/dom.v23.8
    DOI: 10.1111/dom.14413
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2004918-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    CoRad-19 – Modular Digital Teaching during the SARS-CoV-2 Pandemic
    Georg Thieme Verlag KG ; 2022
    In:  RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren Vol. 194, No. 06 ( 2022-06), p. 644-651
    Details
    In: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, Georg Thieme Verlag KG, Vol. 194, No. 06 ( 2022-06), p. 644-651
    Abstract: Ziel Während der SARS-CoV-2-Pandemie musste die Hochschullehre weltweit auf digitale Formate umstellen. In dieser Studie sollte CoRad-19, ein im Rahmen der COVID-19-Pandemie erstelltes digitales Lehrangebot der Deutschen Röntgengesellschaft (DRG) für Medizinstudierende, evaluiert werden. Material und Methoden Insgesamt 13 deutschsprachige Hochschulstandorte haben CoRad-19 in ihr Curriculum implementiert sowie ihre Lehrangebote teilweise oder sogar vollständig durch die Online-Kurse ersetzt. Mithilfe eines eigens entworfenen Fragebogens wurden Vorerfahrungen in und bisherige Kontakte zur Radiologie erfragt sowie die Meinung der Teilnehmenden gegenüber dem Medium E-Learning erhoben. Als Maßstab für den Lernerfolg wurde der subjektive Kenntnisstand bezüglich der einzelnen Module jeweils vor und nach der Teilnahme erhoben. Die Angaben 994 Medizinstudierender aus den beteiligten Standorten wurden analysiert und mittels Friedman-Test intraindividuell verglichen. Ergebnisse Vom 01.04.2020–01.10.2020 wurden aus insgesamt 994 Erhebungen 451 vollständige Datensätze inkludiert. E-Learning wurde sowohl vor als auch nach der Teilnahme an den Kursen als „sehr sinnvoll“ eingeschätzt (4 [IQR 3–4], p = 0,527, r = 0,16). Auch E-Learning als Methode wurde sowohl vor als auch nach der Teilnahme als „sehr gutes“ Medium bewertet (4 [IQR 3–4] , p = 0,414, r = 0,17). Nach Teilnahme an den Kursen schätzten die Teilnehmenden die Radiologie als besonders geeignet für digitale Lehre ein (vorher: 3 [IQR 3–4] vs. nachher 4 [IQR 3–4] , p = 0,005, r = 0,6). In allen Kursmodulen waren signifikante Lernerfolge messbar (p ≤ 0,009). Eine Post-hoc-Analyse zeigte, dass das Interesse an der Radiologie nach Teilnahme an den Kursen signifikant zunahm (p = 0,02). Schlussfolgerungen In der repräsentativen Umfrage wurden signifikante Lerneffekte in allen Kursmodulen beobachtet. Zudem ist besonders hervorzuheben, dass das Interesse der Studierenden an der Radiologie durch die Kursteilnahme gesteigert werden konnte. Die DRG konnte den deutschsprachigen medizinischen Fakultäten durch CoRad-19 also wichtige Unterstützung bei der Aufrechterhaltung exzellenter Lehre bieten. Kernaussage: Zitierweise
    Type of Medium: Online Resource
    ISSN: 1438-9029 , 1438-9010
    URL: Article
    DOI: 10.1055/a-1752-0624
    RVK:
    XA 10000
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
    detail.hit.zdb_id: 2031079-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Is There Still a Role for Two-Phase Contrast-Enhanced CT and Virtual Monoenergetic Images in the Era of Photon-Counting Detector CT?
    MDPI AG ; 2023
    In:  Diagnostics Vol. 13, No. 8 ( 2023-04-18), p. 1454-
    Details
    In: Diagnostics, MDPI AG, Vol. 13, No. 8 ( 2023-04-18), p. 1454-
    Abstract: Background: To compare the diagnostic characteristics between arterial phase imaging versus portal venous phase imaging, applying polychromatic T3D images and low keV virtual monochromatic images using a 1st generation photon-counting CT detector, of CT in patients with hepatocellular carcinoma (HCC). Methods: Consecutive patients with HCC, with a clinical indication for CT imaging, were prospectively enrolled. Virtual monoenergetic images (VMI) were reconstructed at 40 to 70 keV for the PCD-CT. Two independent, blinded radiologists counted all hepatic lesions and quantified their size. The lesion-to-background ratio was quantified for both phases. SNR and CNR were determined for T3D and low VMI images; non-parametric statistics were used. Results: Among 49 oncologic patients (mean age 66.9 ± 11.2 years, eight females), HCC was detected in both arterial and portal venous scans. The signal-to-noise ratio, the CNR liver-to-muscle, the CNR tumor-to-liver, and CNR tumor-to-muscle were 6.58 ± 2.86, 1.40 ± 0.42, 1.13 ± 0.49, and 1.53 ± 0.76 in the arterial phase and 5.93 ± 2.97, 1.73 ± 0.38, 0.79 ± 0.30, and 1.36 ± 0.60 in the portal venous phase with PCD-CT, respectively. There was no significant difference in SNR between the arterial and portal venous phases, including between “T3D” and low keV images (p 〉 0.05). CNRtumor-to-liver differed significantly between arterial and portal venous contrast phases (p 〈 0.005) for both “T3D” and all reconstructed keV levels. CNRliver-to-muscle and CNRtumor-to-muscle did not differ in either the arterial or portal venous contrast phases. CNRtumor-to-liver increased in the arterial contrast phase with lower keV in addition to SD. In the portal venous contrast phase, CNRtumor-to-liver decreased with lower keV; whereas, CNRtumor-to-muscle increased with lower keV in both arterial and portal venous contrast phases. CTDI and DLP mean values for the arterial upper abdomen phase were 9.03 ± 3.59 and 275 ± 133, respectively. CTDI and DLP mean values for the abdominal portal venous phase were 8.75 ± 2.99 and 448 ± 157 with PCD-CT, respectively. No statistically significant differences were found concerning the inter-reader agreement for any of the (calculated) keV levels in either the arterial or portal-venous contrast phases. Conclusions: The arterial contrast phase imaging provides higher lesion-to-background ratios of HCC lesions using a PCD-CT; especially, at 40 keV. However, the difference was not subjectively perceived as significant.
    Type of Medium: Online Resource
    ISSN: 2075-4418
    URL: Article
    DOI: 10.3390/diagnostics13081454
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662336-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    DataSheet1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Physiology Vol. 13 ( 2022-9-20)
    Details
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 13 ( 2022-9-20)
    Abstract: Obesity-related metabolic disorders such as hypertension, hyperlipidemia and chronic inflammation have been associated with aortic dilatation and resulting in aortic aneurysms in many cases. Whether weight loss may reduce the risk of aortic dilatation is not clear. In this study, the diameter of the descending thoracic aorta, infrarenal abdominal aorta and aortic bifurcation of 144 overweight or obese non-smoking adults were measured by MR-imaging, at baseline, and 12 and 50 weeks after weight loss by calorie restriction. Changes in aortic diameter, anthropometric measures and body composition and metabolic markers were evaluated using linear mixed models. The association of the aortic diameters with the aforementioned clinical parameters was analyzed using Spearman`s correlation. Weight loss was associated with a reduction in the thoracic and abdominal aortic diameters 12 weeks after weight loss (predicted relative differences for Quartile 4: 2.5% ± 0.5 and -2.2% ± 0.8, p & lt; 0.031; respectively). Furthermore, there was a nominal reduction in aortic diameters during the 50-weeks follow-up period. Aortic diameters were positively associated with weight, visceral adipose tissue, glucose, HbA1c and with both systolic and diastolic blood pressure. Weight loss induced by calorie restriction may reduce aortic diameters. Future studies are needed to investigate, whether the reduction of aortic diameters via calorie restriction may help to prevent aortic aneurysms.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    URL: Article
    URL: Article
    DOI: 10.3389/fphys.2022.976949
    DOI: 10.3389/fphys.2022.976949.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564217-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Evaluation of computed tomography settings in the context of visualization and discrimination of low dose injections of a novel liquid soft tissue fiducial marker in head and neck imaging
    Springer Science and Business Media LLC ; 2021
    In:  BMC Medical Imaging Vol. 21, No. 1 ( 2021-12)
    Details
    In: BMC Medical Imaging, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: Intraoperative incorporation of radiopaque fiducial markers at the tumor resection surface can provide useful assistance in identifying the tumor bed in postoperative imaging for RT planning and radiological follow-up. Besides titanium clips, iodine containing injectable liquid fiducial markers represent an option that has emerged more recently for this purpose. In this study, marking oral soft tissue resection surfaces, applying low dose injections of a novel Conformité Européenne (CE)-marked liquid fiducial marker based on sucrose acetoisobutyrate (SAIB) and iodinated SAIB (x-SAIB) was investigated. Methods Visibility and discriminability of low dose injections of SAIB/x-SAIB (10 µl, 20 µl, 30 µl) were systematically studied at different kV settings used in clinical routine in an ex-vivo porcine mandible model. Transferability of the preclinical results into the clinical setting and applicability of DE-CT were investigated in initial patients. Results Markers created by injection volumes as low as 10 µl were visible in CT imaging at all kV settings applied in clinical routine (70–120 kV). An injection volume of 30 µl allowed differentiation from an injection volume of 10 µl. In a total of 118 injections performed in two head and neck cancer patients, markers were clearly visible in 83% and 86% of injections. DE-CT allowed for differentiation between SAIB/x-SAIB markers and other hyperdense structures. Conclusions Injection of low doses of SAIB/x-SAIB was found to be a feasible approach to mark oral soft tissue resection surfaces, with injection volumes as low as 10 µl found to be visible at all kV settings applied in clinical routine. With the application of SAIB/x-SAIB reported for tumors of different organs already, mostly applying relatively large volumes for IGRT, this study adds information on the applicability of low dose injections to facilitate identification of the tumor bed in postoperative CT and on performance of the marker at different kV settings used in clinical routine.
    Type of Medium: Online Resource
    ISSN: 1471-2342
    URL: Article
    DOI: 10.1186/s12880-021-00689-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2061975-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Monitoring of immunotherapy : Possibilities and limitations
    Springer Science and Business Media LLC ; 2020
    In:  Der Radiologe Vol. 60, No. 8 ( 2020-08), p. 711-720
    Details
    In: Der Radiologe, Springer Science and Business Media LLC, Vol. 60, No. 8 ( 2020-08), p. 711-720
    Abstract: Cancer immunotherapies play an increasing role in the treatment of advanced cancer. In a subset of patients, atypical response patterns and unconventional adverse events make diagnostic evaluation challenging for radiologists. Objectives In this article, we provide a review of the possibilities and limitations of imaging methods in monitoring immunotherapies, discuss the phenomena of pseudoprogression and hyperprogression, and introduce iRECIST as an evaluation standard for clinical studies with immunotherapies. In addition, we describe the most notable adverse events and their imaging features. Materials and methods This article is based on reviews and studies published since 2009. We used PubMed for the literature search and included the following search terms: “immunotherapy”, “checkpoint inhibitor”, “pseudoprogression”, “iRECIST” and “immune related adverse events”. Results and conclusion With an incidence of up to 10%, pseudoprogression is a rare phenomenon. Currently, differentiation between pseudoprogression and true progressive disease is only possible by follow-up examinations. iRECIST, published in 2017, introduced immune unconfirmed progressive disease (iUPD) and immune confirmed progressive disease (iCPD) as new categories of therapeutic response. There is still no consensus on the time interval between examinations. Crucial adverse events include hypophysitis and pneumonitis, whereby the latter may present as different patterns of interstitial pneumonia making it difficult to differentiate between drug toxicity, infection, and tumor progression.
    Type of Medium: Online Resource
    ISSN: 0033-832X , 1432-2102
    URL: Article
    DOI: 10.1007/s00117-020-00726-x
    RVK:
    XA 10000
    Language: German
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 3120921-X
    detail.hit.zdb_id: 1463036-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    PSMA-PET- and MRI-Based Focal Dose Escalated Radiation Therapy of Primary Prostate Cancer: Planned Safety Analysis of a Nonrandomized 2-Armed Phase 2 Trial (ARO2020-01)
    Elsevier BV ; 2022
    In:  International Journal of Radiation Oncology*Biology*Physics Vol. 113, No. 5 ( 2022-08), p. 1025-1035
    Details
    In: International Journal of Radiation Oncology*Biology*Physics, Elsevier BV, Vol. 113, No. 5 ( 2022-08), p. 1025-1035
    Type of Medium: Online Resource
    ISSN: 0360-3016
    URL: Article
    DOI: 10.1016/j.ijrobp.2022.04.020
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 1500486-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...