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  • 1
    Online Resource
    Online Resource
    SLCO1B1 Gene Polymorphisms (rs2306283 and rs4149056) and Statin-Induced Myopathy in Jordanian Diabetics
    Bentham Science Publishers Ltd. ; 2021
    In:  Current Reviews in Clinical and Experimental Pharmacology Vol. 16, No. 3 ( 2021-09-22), p. 281-288
    Details
    In: Current Reviews in Clinical and Experimental Pharmacology, Bentham Science Publishers Ltd., Vol. 16, No. 3 ( 2021-09-22), p. 281-288
    Abstract: The use of statins to lower high serum cholesterol levels may be associated with a number of adverse reactions, including severe myopathy. The solute carrier organic anion transporter 1B1 (SLCO1B1) gene, which encodes the organic anion-transporting polypeptide OATP1B1, is related to the intracellular transport of statins. The aim of this research was to study the association of rs2306283 and rs4149056 genetic polymorphism of the SLCO1B1 gene with the development of statin-induced myopathy in Jordanian diabetics receiving statins. Methods: We included 413 patients attending the Diabetes Clinics of the National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan. The study was approved by the Institutional Review Board of NCDEG. Myopathy was defined as the elevation of creatine kinase more than 3 times the upper limit of normal. Every subject signed an informed consent form and donated 3-5 mL of venous blood. Genome DNA was extracted from lymphocytes of peripheral blood. Genotypes were identified using the Tetra Amplification Refractory Mutation System of SLCO1B1. Results: The minor allele frequencies of rs2306283 [G] and rs4149056 [C] were 0.38 and 0.23, respectively. The two SNPs followed the Hardy-Weinberg equilibrium. The development of SIM was significantly associated with the homozygous and heterozygous minor allele genotype of rs4149056 (CC and CT), and the homozygous wild type allele genotype of rs2306283 (AA). There was no linkage disequilibrium between the two SNPs in the studied subgroups. Conclusions: Genetic polymorphism in the SLCO1B1 Gene is a risk factor for the development of SIM in Jordanian patients.
    Type of Medium: Online Resource
    ISSN: 2772-4328
    URL: Article
    DOI: 10.2174/1574884715666200827105612
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
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  • 2
    Online Resource
    Online Resource
    Post-COVID-19 syndrome among healthcare workers in Jordan
    World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO) ; 2023
    In:  Eastern Mediterranean Health Journal Vol. 29, No. 4 ( 2023-4-26), p. 247-253
    Details
    In: Eastern Mediterranean Health Journal, World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO), Vol. 29, No. 4 ( 2023-4-26), p. 247-253
    Abstract: Background: Post-COVID-19 syndrome covers a wide range of new, recurring or ongoing health conditions, which can occur in anyone who has recovered from COVID-19. The condition may affect multiple systems and organs. Aims: To evaluate the frequency and nature of persistent COVID-19 symptoms among healthcare providers in Jordan. Methods: Post-COVID-19 syndrome refers to symptoms extending beyond 4–12 weeks. We conducted a historical cohort study among 140 healthcare staff employed at the National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan. All of them had been infected with COVID-19 virus during March 2020 to February 2022. Data were collected through face-to-face interviews using a structured questionnaire. Results: Some 59.3% of the study population reported more than 1 persisting COVID-19 symptom, and among them 97.5%, 62.6% and 40.9% reported more than 1 COVID-19 symptom at 1–3, 3–6 and 6–12 months, respectively, after the acute phase of the infection. Post-COVID-19 syndrome was more prevalent among females than males (79.5% vs 20.5%) (P = 0.006). The most frequent reported symptom was fatigue. Females scored higher on the Fatigue Assessment Scale than males [23.26, standard deviation (SD) 8.00 vs 17.53, SD 5.40] (P 〈 0.001). No significant cognitive impairment was detected using the Mini-Mental State Examination and the Montreal Cognitive Assessment scales. Conclusion: More than half (59.3%) of the healthcare workers in our study reported post-COVID-19 syndrome. Further studies are needed to better understand the frequency and severity of the syndrome among different population groups.
    Type of Medium: Online Resource
    ISSN: 1020-3397 , 1687-1634
    URL: Article
    DOI: 10.26719/emhj.23.029
    Language: Unknown
    Publisher: World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO)
    Publication Date: 2023
    detail.hit.zdb_id: 2097065-1
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  • 3
    Online Resource
    Online Resource
    Prevalence of Hyperuricemia and Associated Factors Among Type 2 Diabetic Patients in Jordan
    Informa UK Limited ; 2022
    In:  International Journal of General Medicine Vol. Volume 15 ( 2022-08), p. 6611-6619
    Details
    In: International Journal of General Medicine, Informa UK Limited, Vol. Volume 15 ( 2022-08), p. 6611-6619
    Type of Medium: Online Resource
    ISSN: 1178-7074
    URL: Article
    DOI: 10.2147/IJGM.S376857
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2452220-X
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  • 4
    Online Resource
    Online Resource
    Statin Induced Myopathy Among Patients Attending the National Center for Diabetes, endocrinology, & genetics
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Annals of Medicine & Surgery Vol. 74 ( 2022-02)
    Details
    In: Annals of Medicine & Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 74 ( 2022-02)
    Type of Medium: Online Resource
    ISSN: 2049-0801
    URL: Article
    DOI: 10.1016/j.amsu.2022.103304
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2745440-X
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  • 5
    Online Resource
    Online Resource
    The National Jordanian Experts Consensus on Diagnosis and Treatment of Prediabetes
    Science Publishing Group ; 2021
    In:  International Journal of Diabetes and Endocrinology Vol. 6, No. 1 ( 2021), p. 46-
    Details
    In: International Journal of Diabetes and Endocrinology, Science Publishing Group, Vol. 6, No. 1 ( 2021), p. 46-
    Type of Medium: Online Resource
    ISSN: 2640-1363
    URL: Article
    DOI: 10.11648/j.ijde.20210601.18
    Language: English
    Publisher: Science Publishing Group
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    Effect of Insulin Injection Techniques on Glycemic Control Among Patients with Diabetes
    Informa UK Limited ; 2022
    In:  International Journal of General Medicine Vol. Volume 15 ( 2022-12), p. 8593-8602
    Details
    In: International Journal of General Medicine, Informa UK Limited, Vol. Volume 15 ( 2022-12), p. 8593-8602
    Type of Medium: Online Resource
    ISSN: 1178-7074
    URL: Article
    DOI: 10.2147/IJGM.S393597
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2452220-X
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  • 7
    Online Resource
    Online Resource
    A Novel Syndrome With Short Stature, Mandibular Hypoplasia, and Osteoporosis May Be Associated With a PRRT3 Variant
    The Endocrine Society ; 2020
    In:  Journal of the Endocrine Society Vol. 4, No. 8 ( 2020-08-01)
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 4, No. 8 ( 2020-08-01)
    Abstract: Despite considerable progress in elucidating the molecular basis of various progeroid syndromes, some rare patients remain unexplained. Objective To elucidate molecular genetic basis of a novel autosomal recessive progeroid syndrome. Participants A 24-year-old male and his 18-year-old sister with short stature, mandibular hypoplasia, pointed nose, shrill voice, severe osteoporosis, and short eyebrows and their unaffected siblings and parents belonging to a consanguineous Arab family. Results Using exome and Sanger sequencing, we report a novel homozygous p.Glu394Lys disease-causing variant in proline-rich transmembrane protein 3 (PRRT3). PRRT3 belongs to the family of proline-rich proteins containing several repeats of a short proline-rich sequence, but its function remains to be determined. Preliminary observations showing colocalization of Prrt3 and synaptophysin support its role in vesicle exocytosis. Consistent with the highest messenger ribonucleic acid expression of PRRT3 in the pituitary, both the patients had mild growth hormone deficiency but had near normal reproductive development. Conclusions We conclude that the homozygous p.Glu394Lys variant in PRRT3 may be associated with a novel autosomal recessive, progeroid syndrome with short stature, mandibular hypoplasia, osteoporosis, short eyebrows, and mild growth hormone (GH) deficiency. Our findings extend the spectrum of progeroid syndromes and elucidate important functions of PRRT3 in human biology, including secretion of GH from the pituitary.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvaa088
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2020
    detail.hit.zdb_id: 2881023-5
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  • 8
    Online Resource
    Online Resource
    Dyslipidemia among patients with type 2 diabetes in Jordan: Prevalence, pattern, and associated factors
    Frontiers Media SA ; 2022
    In:  Frontiers in Public Health Vol. 10 ( 2022-11-8)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 10 ( 2022-11-8)
    Abstract: To determine the prevalence and patterns of dyslipidemia and its associated risk factors among patients with type 2 diabetes attending the National Center for Diabetes, Endocrinology, and Genetics (NCDEG). Methods A cross-sectional study was conducted at the NCDEG in Amman, Jordan. A total of 971 patients with type 2 diabetes were included during the period September- December 2021. The socio-demographic data were collected through face-to-face interview questionnaire and anthropometric and clinical data were abstracted from medical records. The last three readings of lipid profile and HbA1C were abstracted from the medical records. Results The overall prevalence of dyslipidemia among type 2 diabetic patients was 95.4%. The most common type of dyslipidemia was combined dyslipidemia (37.1%), with high triglycerides and low HDL-c (19.0%) being the most frequent type. Factors associated with hypercholesterolemia were diabetes duration ≤ 10 years, poor compliance to a statin, and HbA1c level (7–8%) ( P -values: 0.008, 0.001, 0.021, respectively). Moreover, smoking and poor compliance with statin therapy were associated with high LDL-c level ( P -values: 0.046 and 0.001, respectively). The presence of hypertension, high waist circumference, HbA1c level & gt;8%, and diabetes duration ≤ 10 years were all associated with high triglyceride level ( P -values: 0.008, 0.016, 0.011, and 0.018, respectively). Hypertension and HbA1c level & gt;8% were associated with low HDL-c level ( P -values: 0.010 and 0.011, respectively). Conclusion The combination of high triglyceride and low HDL-c is the commonest lipid abnormality detected in patients with type 2 diabetes. An educational program that emphasizes the importance of adherence to a healthy lifestyle is strongly recommended. Further studies are needed to capture a wide range of factors that might influence dyslipidemia and glycemic control.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    DOI: 10.3389/fpubh.2022.1002466
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711781-9
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  • 9
    Online Resource
    Online Resource
    Prevalence and Associated Factors of Toenail Onychomycosis among Patients with Diabetes in Jordan
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Diabetes Reviews Vol. 19 ( 2023-04-03)
    Details
    In: Current Diabetes Reviews, Bentham Science Publishers Ltd., Vol. 19 ( 2023-04-03)
    Abstract: Toenail onychomycosis is common in patients with diabetes and it can increase the risk of secondary infections and foot complications. Despite several studies investigating the prevalence and associated factors of toenail onychomycosis from different parts of the world, there are no data from Jordan. Objective: Todetermine the prevalence and the associated factors of toenail onychomycosis among patients with diabetes in Jordan. Methods: A cross-sectional study was conducted on 375 patients with diabetes at the National Centre for Diabetes, Endocrinology, and Genetics in Amman, Jordan. Several socio-demographic and health-independent variables including foot self-care practices were collected. Toenail onychomycosis was assessed by a specimen culture and microscopic examinations. Descriptive and inferential statistics were used for data analysis. Results: The prevalence of toenail onychomycosis was 57.6% (n=216). Multiple logistic regression revealed four significant associated factors; the presence of neuropathy (β=1.87, p=0.02), being an ex-smoker (β=2.69, p=0.01), being treated by both insulin and oral hypoglycemics drugs (β=1.32, p=0.03), and using antibiotics in the last year (β=1.78, p=0.02). Conclusion: The prevalence of toenail onychomycosis among patients with diabetes in Jordan is high. Regular foot screening and podiatric care are recommended especially among patients with diabetic neuropathy, current treatment by insulin and oral hypoglycemics drugs, previous history of smoking, and previous use of antibiotics.
    Type of Medium: Online Resource
    ISSN: 1573-3998
    URL: Article
    DOI: 10.2174/1573399819666230403132241
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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