In:
Journal of Interventional Cardiology, Hindawi Limited, Vol. 2020 ( 2020-04-07), p. 1-7
Abstract:
Background . The saline-induced distal coronary pressure/aortic pressure ratio predicted fractional flow reserve (FFR). The resting full-cycle ratio (RFR) represents the maximal relative pressure difference in a cardiac cycle. Therefore, the present study aimed to compare the results of saline-induced RFR (sRFR) with FFR. Methods . Seventy consecutive lesions with only moderate stenosis were included. The FFR, RFR, and sRFR values were compared. The sRFR was assessed using an intracoronary bolus infusion of saline (2 mL/s) for five heartbeats. The FFR was obtained after an intravenous injection of papaverine. Results . Overall, the FFR, sRFR, and RFR values were 0.78 ± 0.12, 0.79 ± 0.13, and 0.83 ± 0.14, respectively. With regard to anatomical morphology were 40, 18, and 12 cases of focal, diffuse, and tandem lesion. There was a significant correlation between the sRFR and FFR ( R = 0.96, p 〈 0.01 ). There were also significant correlations between the sRFR and FFR in the left coronary and right coronary artery ( R = 0.95, p 〈 0.01 and R = 0.98, p 〈 0.01 ). Furthermore, significant correlations between sRFR and FFR were observed in not only focal but also in nonfocal lesion including tandem and diffuse lesions ( R = 0.93, p 〈 0.01 and R = 0.97, p 〈 0.01 ). A close agreement on FFR and sRFR was shown using the Bland–Altman analysis (95% CI of agreement: −0.08–0.07). In the receiver operating characteristic curve analysis, the cutoff value of sRFR to predict an FFR of 0.80 was 0.81 (area under curve, 0.97; sensitivity 90.6%; and specificity 98.2%). Conclusion . The sRFR can accurately and safely predict the FFR and might be effective for diagnosing ischemia.
Type of Medium:
Online Resource
ISSN:
0896-4327
,
1540-8183
DOI:
10.1155/2020/5787439
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2020
detail.hit.zdb_id:
2103585-4
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