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  • 11
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    Author Correction: Dense sampling of bird diversity increases power of comparative genomics
    Springer Science and Business Media LLC ; 2021
    In:  Nature Vol. 592, No. 7856 ( 2021-04-29), p. E24-E24
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 592, No. 7856 ( 2021-04-29), p. E24-E24
    Kurzfassung: A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03473-8.
    Materialart: Online-Ressource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/s41586-021-03473-8
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2021
    ZDB Id: 120714-3
    ZDB Id: 1413423-8
    SSG: 11
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  • 12
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    Impact of COVID‐19 pandemic on mortality rate in memory clinic patients
    Wiley ; 2024
    In:  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Vol. 16, No. 1 ( 2024-01)
    Details
    In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, Vol. 16, No. 1 ( 2024-01)
    Kurzfassung: We investigated whether mortality in memory clinic patients changed due to coronavirus disease 2019 (COVID‐19) pandemic. METHODS We included patients from the Amsterdam Dementia Cohort: (1) n  = 923 pandemic patients (baseline visit: 2017–2018, follow‐up: until 2021), and (2) n  = 830 historical control patients (baseline visit: 2015–2016, follow‐up: until 2019). Groups were well‐balanced. We compared mortality during pandemic with historical control patients using Cox regression. Differences in cause of death between groups were explored using Fisher's exact test. RESULTS Pandemic patients had a higher risk of mortality than historical control patients (hazard ratio [HR] [95% confidence interval {CI}]  = 1.34 [1.05–1.70]). Stratified for syndrome diagnosis, the effect remained significant in dementia patients (HR [95% CI]  = 1.35 [1.03–1.78]). Excluding patients who died of COVID‐19‐infection, the higher mortality risk in pandemic patients attenuated (HR [95% CI]  = 1.24 [0.97–1.58]). Only the difference in cause of death between pandemic patients and historical control patients for death to COVID‐19‐infection ( p  = 0.001) was observed. CONCLUSION Memory clinic patients had increased mortality risk during COVID‐19 compared to historical control patients, attributable to dementia patients. Highlights We investigated if mortality rates in memory clinic patients changed due to COVID‐19 pandemic. We included patients along the cognitive continuum, including SCD, MCI, and dementia. We used a well‐balanced historical control group. Memory clinic patients had higher risk for mortality during COVID‐19 lockdown. Our results indicate that excess mortality is mainly caused by death to COVID‐19 infection.
    Materialart: Online-Ressource
    ISSN: 2352-8729 , 2352-8729
    URL: Issue
    URL: Article
    DOI: 10.1002/dad2.v16.1
    DOI: 10.1002/dad2.12541
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2024
    ZDB Id: 2832898-X
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  • 13
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    Safety and technical efficacy of early minimally invasive endoscopy-guided surgery for intracerebral haemorrhage: the Dutch Intracerebral haemorrhage Surgery Trial pilot study
    Springer Science and Business Media LLC ; 2023
    In:  Acta Neurochirurgica Vol. 165, No. 6 ( 2023-04-27), p. 1585-1596
    Details
    In: Acta Neurochirurgica, Springer Science and Business Media LLC, Vol. 165, No. 6 ( 2023-04-27), p. 1585-1596
    Kurzfassung: Previous randomised controlled trials could not demonstrate that surgical evacuation of intracerebral haemorrhage (ICH) improves functional outcome. Increasing evidence suggests that minimally invasive surgery may be beneficial, in particular when performed early after symptom onset. The aim of this study was to investigate safety and technical efficacy of early minimally invasive endoscopy-guided surgery in patients with spontaneous supratentorial ICH. Methods The Dutch Intracerebral Haemorrhage Surgery Trial pilot study was a prospective intervention study with blinded outcome assessment in three neurosurgical centres in the Netherlands. We included adult patients with spontaneous supratentorial ICH ≥10mL and National Institute of Health Stroke Scale (NIHSS) score ≥2 for minimally invasive endoscopy-guided surgery within 8 h after symptom onset in addition to medical management. Primary safety outcome was death or increase in NIHSS ≥4 points at 24 h. Secondary safety outcomes were procedure-related serious adverse events (SAEs) within 7 days and death within 30 days. Primary technical efficacy outcome was ICH volume reduction (%) at 24 h. Results We included 40 patients (median age 61 years; IQR 51–67; 28 men). Median baseline NIHSS was 19.5 (IQR 13.3–22.0) and median ICH volume 47.7mL (IQR 29.4–72.0). Six patients had a primary safety outcome, of whom two already deteriorated before surgery and one died within 24 h. Sixteen other SAEs were reported within 7 days in 11 patients (of whom two patients that already had a primary safety outcome), none device related. In total, four (10%) patients died within 30 days. Median ICH volume reduction at 24 h was 78% (IQR 50–89) and median postoperative ICH volume 10.5mL (IQR 5.1–23.8). Conclusions Minimally invasive endoscopy-guided surgery within 8 h after symptom onset for supratentorial ICH appears to be safe and can effectively reduce ICH volume. Randomised controlled trials are needed to determine whether this intervention also improves functional outcome. Trial registration Clinicaltrials.gov : NCT03608423, August 1st, 2018.
    Materialart: Online-Ressource
    ISSN: 0942-0940
    URL: Article
    DOI: 10.1007/s00701-023-05599-2
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2023
    ZDB Id: 1464215-3
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  • 14
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    Molecular Analysis of Renal Allograft Biopsies: Where Do We Stand and Where Are We Going?
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Transplantation Vol. 104, No. 12 ( 2020-12), p. 2478-2486
    Details
    In: Transplantation, Ovid Technologies (Wolters Kluwer Health), Vol. 104, No. 12 ( 2020-12), p. 2478-2486
    Kurzfassung: A renal core biopsy for histological evaluation is the gold standard for diagnosing renal transplant pathology. However, renal biopsy interpretation is subjective and can render insufficient precision, making it difficult to apply a targeted therapeutic regimen for the individual patient. This warrants a need for additional methods assessing disease state in the renal transplant. Significant research activity has been focused on the role of molecular analysis in the diagnosis of renal allograft rejection. The identification of specific molecular expression patterns in allograft biopsies related to different types of allograft injury could provide valuable information about the processes underlying renal transplant dysfunction and can be used for the development of molecular classifier scores, which could improve our diagnostic and prognostic ability and could guide treatment. Molecular profiling has the potential to be more precise and objective than histological evaluation and may identify injury even before it becomes visible on histology, making it possible to start treatment at the earliest time possible. Combining conventional diagnostics (histology, serology, and clinical data) and molecular evaluation will most likely offer the best diagnostic approach. We believe that the use of state-of-the-art molecular analysis will have a significant impact in diagnostics after renal transplantation. In this review, we elaborate on the molecular phenotype of both acute and chronic T cell-mediated rejection and antibody-mediated rejection and discuss the additive value of molecular profiling in the setting of diagnosing renal allograft rejection and how this will improve transplant patient care.
    Materialart: Online-Ressource
    ISSN: 0041-1337
    URL: Article
    DOI: 10.1097/TP.0000000000003220
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2020
    ZDB Id: 2035395-9
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  • 15
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    Dynamics of Antibody and T Cell Immunity against SARS-CoV-2 Variants of Concern and the Impact of Booster Vaccinations in Previously Infected and Infection-Naïve Individuals
    MDPI AG ; 2022
    In:  Vaccines Vol. 10, No. 12 ( 2022-12-13), p. 2132-
    Details
    In: Vaccines, MDPI AG, Vol. 10, No. 12 ( 2022-12-13), p. 2132-
    Kurzfassung: Despite previous coronavirus disease 2019 (COVID-19) vaccinations and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, SARS-CoV-2 still causes a substantial number of infections due to the waning of immunity and the emergence of new variants. Here, we assessed the SARS-CoV-2 spike subunit 1 (S1)-specific T cell responses, anti-SARS-CoV-2 receptor-binding domain (RBD) IgG serum concentrations, and the neutralizing activity of serum antibodies before and one, four, and seven months after the BNT162b2 or mRNA-1273 booster vaccination in a cohort of previously infected and infection-naïve healthcare workers (HCWs). Additionally, we assessed T cell responses against the spike protein of the SARS-CoV-2 Delta, Omicron BA.1 and BA.2 variants of concern (VOC). We found that S1-specific T cell responses, anti-RBD IgG concentrations, and neutralizing activity significantly increased one month after booster vaccination. Four months after booster vaccination, T cell and antibody responses significantly decreased but levels remained steady thereafter until seven months after booster vaccination. After a similar number of vaccinations, previously infected individuals had significantly higher S1-specific T cell, anti-RBD IgG, and neutralizing IgG responses than infection-naïve HCWs. Strikingly, we observed overall cross-reactive T cell responses against different SARS-CoV-2 VOC in both previously infected and infection-naïve HCWs. In summary, COVID-19 booster vaccinations induce strong T cell and neutralizing antibody responses and the presence of T cell responses against SARS-CoV-2 VOC suggest that vaccine-induced T cell immunity offers cross-reactive protection against different VOC.
    Materialart: Online-Ressource
    ISSN: 2076-393X
    URL: Article
    DOI: 10.3390/vaccines10122132
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2703319-3
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  • 16
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    Amyloid pathology is associated with semantic loss in patients with subjective cognitive decline
    Wiley ; 2023
    In:  Alzheimer's & Dementia Vol. 19, No. S2 ( 2023-06)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 19, No. S2 ( 2023-06)
    Kurzfassung: Evidence is emerging that subtle language decline is an early indicator of Alzheimer’s disease (AD). This study assessed change in semantic and letter fluency in individuals with subjective cognitive decline (SCD), and examined whether trajectories differed between individuals with and without amyloid‐beta (Aβ)‐pathology. Method Longitudinal data from 437 individuals of the memory clinic‐based Amsterdam Dementia Cohort were included (Age 61±8 years, 184(42%) Female, follow‐up time 5.3±3.7 years; Table 1). Participants were classified as SCD at baseline, had available baseline Aβ‐information and had at least 1 follow‐up on semantic or letter fluency. Baseline Aβ‐status was dichotomized as positive/negative based on local cut‐offs for Aβ 1‐42 concentrations in cerebrospinal fluid, or visual inspection of amyloid positron emission tomography‐imaging (Florbetapir or PiB). Two linear mixed models (LMM) were used to investigate change on semantic and letter fluency. Models included time and time*Aβ‐status as predictors of interest, a random intercept for participant, and age, sex, education were adjusted for. LMMs were subsequently stratified for Aβ‐status. Result At baseline, the groups did not differ in semantic (p = 0.313) or letter fluency (p = 0.294). Over time Aβ‐positive individuals changed more rapidly on semantic fluency compared to Aβ‐negative individuals (β = ‐0.32,CI = ‐0.49 – ‐0.14;p 〈 .001). The Aβ‐positive group declined with 0.35 words per year (CI = ‐0.49 – ‐0.20;p 〈 .001), while Aβ‐negative individuals did not show change (β = 0.03;CI = ‐0.12 – 0.06;p = 0.496) (Figure 1). On letter fluency Aβ‐positive individuals changed differently compared to Aβ‐negative individuals (β = ‐0.38;CI = ‐0.72 – ‐0.04;p = 0.028), to the extent that the Aβ‐positive group did not progress (β = 0.10;CI = ‐0.21 – 0.41;p = 0.533), while Aβ‐negative individuals improved with 0.47 words per year (CI = 0.29 – 0.65;p 〈 .001) (Figure 2). Conclusion Our results indicate that Aβ‐positive individuals decreased on semantic fluency, but remained stable on letter fluency. In contrast, Aβ‐negative individuals remained stable on semantic fluency, while they improved on letter fluency over time, which might suggest a learning effect. These findings suggest that the presence of Aβ‐pathology is characterized by semantic loss, highlighting the potential of language based performance as a biomarker for Aβ‐pathology in SCD.
    Materialart: Online-Ressource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v19.S2
    DOI: 10.1002/alz.063833
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2201940-6
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  • 17
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    Data_Sheet_2.PDF
    Frontiers Media SA ; 2020
    In:  Frontiers in Immunology Vol. 11 ( 2020-7-3)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 11 ( 2020-7-3)
    Materialart: Online-Ressource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2020.01332
    DOI: 10.3389/fimmu.2020.01332.s001
    DOI: 10.3389/fimmu.2020.01332.s002
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2020
    ZDB Id: 2606827-8
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  • 18
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    Psychosocial Effects of COVID-19 Measures on (Pre-)Dementia Patients During Second Lockdown
    IOS Press ; 2022
    In:  Journal of Alzheimer's Disease Vol. 86, No. 2 ( 2022-03-22), p. 931-939
    Details
    In: Journal of Alzheimer's Disease, IOS Press, Vol. 86, No. 2 ( 2022-03-22), p. 931-939
    Kurzfassung: Background: The COVID-19 pandemic poses enormous social challenges, especially during lockdown. People with cognitive decline and their caregivers are particularly at risk of lockdown consequences. Objective: To investigate psychosocial effects in (pre-)dementia patients and caregivers during second lockdown and compare effects between first and second lockdown. Methods: We included n = 511 (pre-)dementia patients and n = 826 caregivers from the Amsterdam Dementia Cohort and via Alzheimer Nederland. All respondents completed a self-designed survey on psychosocial effects of COVID-19. We examined relations between experienced support and psychosocial and behavioral symptoms using logistic regression. In a subset of patients and caregivers we compared responses between first and second lockdown using generalized estimating equation (GEE). Results: The majority of patients (≥58%) and caregivers (≥60%) reported that family and friends, hobbies, and music helped them cope. Support from family and friends was strongly related to less negative feelings in patients (loneliness: OR = 0.3[0.1–0.6]) and caregivers (loneliness: OR = 0.2[0.1–0.3] ; depression: OR = 0.4[0.2–0.5]; anxiety: OR = 0.4[0.3–0.6] ; uncertainty: OR = 0.3[0.2–0.5]; fatigue: OR = 0.3[0.2–0.4] ; stress: OR = 0.3[0.2–0.5]). In second lockdown, less psychosocial and behavio ral symptoms were reported compared to first lockdown (patients; e.g., anxiety: 22% versus 13%, p = 0.007; apathy: 27% versus 8%, p  〈  0.001, caregivers; e.g., anxiety: 23% versus 16%, p = 0.033; patient’s behavioral problems: 50% versus 35%, p  〈  0.001). Patients experienced more support (e.g., family and friends: 52% versus 93%, p  〈  0.001; neighbors: 28% versus 66%, p  〈  0.001). Conclusion: During second lockdown, patients and caregivers adapted to challenges posed by lockdown, as psychosocial and behavioral effects decreased, while patients experienced more social support compared to first lockdown. Support from family and friends is a major protective factor for negative outcomes in patients and caregivers.
    Materialart: Online-Ressource
    ISSN: 1387-2877 , 1875-8908
    URL: Article
    DOI: 10.3233/JAD-215342
    Sprache: Unbekannt
    Verlag: IOS Press
    Publikationsdatum: 2022
    ZDB Id: 2070772-1
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  • 19
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    Psychosocial effects of Corona virus measures on (pre‐)dementia patients during 2 nd lockdown
    Wiley ; 2021
    In:  Alzheimer's & Dementia Vol. 17, No. S7 ( 2021-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 17, No. S7 ( 2021-12)
    Kurzfassung: The COVID‐19 pandemic poses enormous social challenges, especially during lockdown. Recently, the second lockdown started in the Netherlands. We aimed to investigate and compare the psychosocial effects of corona measures during lockdown in memory clinic (pre‐)dementia patients and their caregivers. Method During second lockdown, n=137 symptomatic patients (age=67.7±6.54, 36.5%F, MMSE = 24.4±4.7; n=82 dementia, n=55 MCI), n=244 cognitively normal (age=63.6±7.56, 38.9%F, MMSE = 28.8±1.18; SCD) and n=198 caregivers of Alzheimer Center Amsterdam completed a survey on psychosocial effects of corona. Questions related to loneliness, worries for faster cognitive decline, psychological and behavioral problems. In a subset of patients (n=169) and caregivers (n=38) we were able to compare their answers to answers on a similar survey completed during first lockdown (May 2020). Result In total, n=17 (4.5%) patients [n=3 (2.2%) symptomatic, n=14 (5.7%) cognitively normal] and n=8 (4%) caregivers reported a positive test result for COVID‐19. Over one‐third of caregivers reported worries for faster cognitive decline [n=76 (38%)] and behavioral problems [n=70 (35%)] in patients. Feelings of loneliness were experienced by n=23 (17%) symptomatic patients, n=44 (18%) cognitively normal and n=50 (25%) caregivers. One quarter of patients [n=78 (25%)] reported more depressive feelings during lockdown [n=27 (20%) symptomatic, n=51 (21%) cognitively normal]. More feelings of fatigue were reported by n=23 (17%) symptomatic patients, n=46 (19%) cognitively normal, and n=67 (34%) caregivers. Comparing results to those obtained during the first lockdown, feelings of loneliness [Χ 2 =26.4, p 〈 .001 in patients, Χ 2 =10.3, p 〈 .001 in caregivers] and anxiety [Χ 2 =25.9, p 〈 .001 in patients, Χ 2 =6.69, p=.010 in caregivers] increased. During second lockdown, less feelings of apathy [Χ 2 =13.0, p 〈 .001], but more depressive feelings [Χ 2 =27.6, p 〈 .001] were reported in patients compared to first lockdown. Caregivers were more worried for memory decline in patients during second lockdown [Χ 2 =4.09, p=.043]. Conclusion Compared to first lockdown, feelings of loneliness, anxiety, worries for faster cognitive decline and depressive feelings increased in second lockdown. A noticeable part of (pre‐)dementia patients and caregivers report feelings of loneliness, worries for faster cognitive decline, psychological and behavioral problems in second lockdown. These psychosocial effects are more frequently reported by caregivers than patients.
    Materialart: Online-Ressource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v17.S7
    DOI: 10.1002/alz.053995
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2201940-6
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  • 20
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    Clinical applicability of quantitative atrophy measures on MRI in patients suspected of Alzheimer’s disease
    Springer Science and Business Media LLC ; 2022
    In:  European Radiology Vol. 32, No. 11 ( 2022-05-31), p. 7789-7799
    Details
    In: European Radiology, Springer Science and Business Media LLC, Vol. 32, No. 11 ( 2022-05-31), p. 7789-7799
    Kurzfassung: Neurodegeneration in suspected Alzheimer’s disease can be determined using visual rating or quantitative volumetric assessments. We examined the feasibility of volumetric measurements of gray matter (GMV) and hippocampal volume (HCV) and compared their diagnostic performance with visual rating scales in academic and non-academic memory clinics. Materials and methods We included 231 patients attending local memory clinics (LMC) in the Netherlands and 501 of the academic Amsterdam Dementia Cohort (ADC). MRI scans were acquired using local protocols, including a T1-weighted sequence. Quantification of GMV and HCV was performed using FSL and FreeSurfer. Medial temporal atrophy and global atrophy were assessed with visual rating scales. ROC curves were derived to determine which measure discriminated best between cognitively normal (CN), mild cognitive impairment (MCI), and Alzheimer’s dementia (AD). Results Patients attending LMC (age 70.9 ± 8.9 years; 47% females; 19% CN; 34% MCI; 47% AD) were older, had more cerebrovascular pathology, and had lower GMV and HCV compared to those of the ADC (age 64.9 ± 8.2 years; 42% females; 35% CN, 43% MCI, 22% AD). While visual ratings were feasible in  〉  95% of scans in both cohorts, quantification was achieved in 94–98% of ADC, but only 68–85% of LMC scans, depending on the software. Visual ratings and volumetric outcomes performed similarly in discriminating CN vs AD in both cohorts. Conclusion In clinical settings, quantification of GM and hippocampal atrophy currently fails in up to one-third of scans, probably due to lack of standardized acquisition protocols. Diagnostic accuracy is similar for volumetric measures and visual rating scales, making the latter suited for clinical practice. Summary statement In a real-life clinical setting, volumetric assessment of MRI scans in dementia patients may require acquisition protocol optimization and does not outperform visual rating scales. Key Points • In a real-life clinical setting, the diagnostic performance of visual rating scales is similar to that of automatic volumetric quantification and may be sufficient to distinguish Alzheimer’s disease groups . • Volumetric assessment of gray matter and hippocampal volumes from MRI scans of patients attending non-academic memory clinics fails in up to 32% of cases . • Clinical MR acquisition protocols should be optimized to improve the output of quantitative software for segmentation of Alzheimer’s disease–specific outcomes .
    Materialart: Online-Ressource
    ISSN: 1432-1084
    URL: Article
    DOI: 10.1007/s00330-021-08503-7
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 1472718-3
    Standort Signatur Einschränkungen Verfügbarkeit
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