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  • 11
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Materials Science: Materials in Electronics Vol. 34, No. 12 ( 2023-04)
    In: Journal of Materials Science: Materials in Electronics, Springer Science and Business Media LLC, Vol. 34, No. 12 ( 2023-04)
    Type of Medium: Online Resource
    ISSN: 0957-4522 , 1573-482X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2016994-2
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  • 12
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Medicine Vol. 102, No. 24 ( 2023-06-16), p. e34033-
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 102, No. 24 ( 2023-06-16), p. e34033-
    Abstract: Vertebral artery dissection is an important cause of posterior circulation ischemic stroke in young and middle-aged people. We reported a young man with cerebellar infarction caused by dissection of the right vertebral artery. Patient concerns: A 34-year-old man presented with intermittent dizziness, blurred vision, nausea, and transient tinnitus 10 days before admission. All these symptoms were gradually aggravated and followed by vomiting and unfavorable movement of the right limbs. All these symptoms gradually aggravated. Diagnosis: Neurological examination on admission showed ataxia of the right limbs. Magnetic resonance imaging of the head revealed a right cerebellar infarction. High-resolution vessel wall magnetic resonance imaging showed dissection of the right vertebral artery. Whole-brain CT digital subtraction angiography revealed occlusion of the third segment (V3) of the right vertebral artery. This supports the diagnosis of vertebral artery dissection. Interventions: The patient received anticoagulant treatment with warfarin. Outcomes: After 2 weeks of treatment, the patient showed remarkably alleviated dizziness and unfavorable movement of the right limbs. After 3 months of treatment, the modified Rankin Scale score was 0. MRI of the head revealed that the original right cerebellar focus was softened, and there were no newly formed infarct foci. Lessons: When young and middle-aged patients without atherosclerotic risk factors encounter sudden dizziness, tinnitus, and unfavorable limb movement, vertebral artery dissection may be considered. Careful inquiry into the medical history may help make a final diagnosis. Further high-resolution vessel wall magnetic resonance imaging is an effective means to find arterial dissection. Early diagnosis and treatment for vertebral artery dissection has a favorable prognosis.
    Type of Medium: Online Resource
    ISSN: 0025-7974
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2049818-4
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  • 13
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 14, No. 1 ( 2023-08-01)
    Abstract: Metal halide perovskites have shown great promise as a potential candidate for next-generation solid state lighting and display technologies. However, a generic organic ligand-free and antisolvent-free solution method to fabricate highly efficient full-color perovskite light-emitting diodes has not been realized. Herein, by utilizing porous alumina membranes with ultra-small pore size as templates, we have successfully fabricated crystalline all-inorganic perovskite quantum wire arrays with ultrahigh density and excellent uniformity, using a generic organic ligand-free and anti-solvent-free solution method. The quantum confinement effect, in conjunction with the high light out-coupling efficiency, results in high photoluminescence quantum yield for blue, sky-blue, green and pure-red perovskite quantum wires arrays. Consequently, blue, sky-blue, green and pure-red LED devices with spectrally stable electroluminescence have been successfully fabricated, demonstrating external quantum efficiencies of 12.41%, 16.49%, 26.09% and 9.97%, respectively, after introducing a dual-functional small molecule, which serves as surface passivation and hole transporting layer, and a halide vacancy healing agent.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2553671-0
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  • 14
    Online Resource
    Online Resource
    Elsevier BV ; 2023
    In:  Journal of Materials Research and Technology Vol. 24 ( 2023-05), p. 1875-1881
    In: Journal of Materials Research and Technology, Elsevier BV, Vol. 24 ( 2023-05), p. 1875-1881
    Type of Medium: Online Resource
    ISSN: 2238-7854
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2732709-7
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  • 15
    In: Immunity & Ageing, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2024-01-02)
    Abstract: Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall progression of aging. The bone marrow is the most important hematopoietic immune organ, while the spleen, as the most important extramedullary hematopoietic immune organ, maintains homeostasis of the human hematopoietic immune system (HIS) in cooperation with the bone marrow. However, the overall changes in the HIS during aging have not been described. Here, we describe a hematopoietic immune map of the spleen and bone marrow of young and old mice using single-cell sequencing and flow cytometry techniques. Results We observed extensive, complex changes in the HIS during aging. Compared with young mice, the immune cells of aged mice showed a marked tendency toward myeloid differentiation, with the neutrophil population accounting for a significant proportion of this response. In this change, hypoxia-inducible factor 1-alpha (Hif1α) was significantly overexpressed, and this enhanced the immune efficacy and inflammatory response of neutrophils. Our research revealed that during the aging process, hematopoietic stem cells undergo significant changes in function and composition, and their polymorphism and differentiation abilities are downregulated. Moreover, we found that the highly responsive CD62L + HSCs were obviously downregulated in aging, suggesting that they may play an important role in the aging process. Conclusions Overall, aging extensively alters the cellular composition and function of the HIS. These findings could potentially give high-dimensional insights and enable more accurate functional and developmental analyses as well as immune monitoring in HIS aging.
    Type of Medium: Online Resource
    ISSN: 1742-4933
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2168941-6
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  • 16
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2021
    In:  Optical and Quantum Electronics Vol. 53, No. 8 ( 2021-08)
    In: Optical and Quantum Electronics, Springer Science and Business Media LLC, Vol. 53, No. 8 ( 2021-08)
    Type of Medium: Online Resource
    ISSN: 0306-8919 , 1572-817X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2000642-1
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  • 17
    In: Advanced Materials, Wiley, Vol. 35, No. 12 ( 2023-03)
    Abstract: Chelate phosphine oxide ligand (9,9‐dimethyl‐9H‐xanthene‐4,5‐diyl) bis (diphenylphosphineoxide) (XPO) is prepared as a neutral ligand to synthesize complex Nd (TTA) 3 (XPO) (TTA = 2‐thenoyltrifluoroacetone). An appropriate energy gap between the XPO and TTA ligands, which can support two additional energy transfer routines from the first excited triplet state (T 1 ) energy level of the XPO to that of the TTA, improves energy transfer in the Nd complex. Based on intramolecular energy transfer mechanism, optical gains at 1.06 and 1.31 µm are demonstrated in Nd (TTA) 3 (XPO)‐doped polymer waveguides with the excitation of low‐power light‐emitting diodes (LEDs) instead of semiconductor lasers as pump sources. Using the vertical top‐pumping mode of a 365 nm LED, relative gains of 22.5 and 8.4 dB cm −1 are obtained at 1.06 and 1.31 µm, respectively, in a 0.2 cm long embedded waveguide with a cross‐section of 8 × 5 µm 2 . The active core layer is Nd (TTA) 3 (XPO)‐doped SU‐8 polymer. Moreover, relative gains are achieved in evanescent‐field waveguide with a cross‐section of 6 × 4 µm 2 . The 21.0 and 5.6 dB cm −1 relative gains are achieved at 1.06 and 1.31 µm, respectively, with a net gain of 13.8 ± 0.3 dB cm −1 obtained at 1.06 µm in a 0.9 cm long SU‐8 waveguide with Nd (TTA) 3 (XPO)‐doped polymethylmethacrylate as upper cladding.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 18
    Online Resource
    Online Resource
    IOP Publishing ; 2021
    In:  Journal of Physics: Conference Series Vol. 1757, No. 1 ( 2021-01-01), p. 012025-
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 1757, No. 1 ( 2021-01-01), p. 012025-
    Abstract: The bi-frequency (high- and low) synthetic aperture radar (SAR) images cannot be directly compared due to their distinct statistical properties. To diminish their statistical difference, we manage to translate the bi-frequency SAR images into one another. Therefore, we propose a cycle-consistent conditional adversarial network to achieve the goal. The cycle-consistency criteria in the Cycle GAN and the conditional generation adversarial networks in the Pix2Pix are integrated to construct the cycle-consistent conditional adversarial network. Experiments on Ku-band and P-band SAR images validate that our method outperforms Cycle GAN and Pix2Pix.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 2166409-2
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  • 19
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-8-16)
    Abstract: Tetrandrine (Tet), derived from the traditional Chinese herb Fangji, is a class of natural alkaloids with the structure of bisbenzylisoquinoline, which has a wide range of physiological activities and significant pharmacfological effects. However, studies and clinical applications have revealed a series of drawbacks such as its poor water solubility, low bioavailability, and the fact that it can be toxic to humans. The results of many researchers have confirmed that chemical structural modifications and nanocarrier delivery can address the limited application of Tet and improve its efficacy. In this paper, we summarize the anti-tumor efficacy and mechanism of action, anti-inflammatory efficacy and mechanism of action, and clinical applications of Tet, and describe the progress of Tet based on chemical structure modification and nanocarrier delivery, aiming to explore more diverse structures to improve the pharmacological activity of Tet and provide ideas to meet clinical needs.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 20
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-4-12)
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-4-12)
    Abstract: Boosting Bacillus Calmette-Guérin (BCG) with subunit vaccine is expected to induce long-term protection against tuberculosis (TB). However, it is urgently needed to optimize the boosting schedule of subunit vaccines, which consists of antigens from or not from BCG, to induce long-term immune memory. To address it two subunit vaccines, Mtb10.4-HspX (MH) consisting of BCG antigens and ESAT6-CFP10 (EC) consisting of antigens from the region of difference (RD) of Mycobacterium tuberculosis ( M. tuberculosis ), were applied to immunize BCG-primed C57BL/6 mice twice or thrice with different intervals, respectively. The long-term antigen-specific immune responses and protective efficacy against M. tuberculosis H37Ra were determined. The results showed that following BCG priming, MH boosting twice at 12-24 weeks or EC immunizations thrice at 12-16-24 weeks enhanced the number and function of long-lived memory T cells with improved protection against H37Ra, while MH boosting thrice at 12-16-24 weeks or twice at 8-14 weeks and EC immunizations twice at 12-24 weeks or thrice at 8-10-14 weeks didn’t induce long-term immunity. It suggests that following BCG priming, both BCG antigens MH boosting twice and “non-BCG” antigens EC immunizations thrice at suitable intervals induce long-lived memory T cell-mediated immunity.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
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