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  • 1
    Online Resource
    Online Resource
    Baseline and interim PET‐based outcome prediction in peripheral T‐cell lymphoma: A subgroup analysis of the PETAL trial
    Wiley ; 2020
    In:  Hematological Oncology Vol. 38, No. 3 ( 2020-08), p. 244-256
    Details
    In: Hematological Oncology, Wiley, Vol. 38, No. 3 ( 2020-08), p. 244-256
    Abstract: The prospective randomized Positron Emission Tomography (PET)‐Guided Therapy of Aggressive Non‐Hodgkin Lymphomas (PETAL) trial was designed to test the ability of interim PET (iPET) to direct therapy. As reported previously, outcome remained unaffected by iPET‐based treatment changes. In this subgroup analysis, we studied the prognostic value of baseline total metabolic tumor volume (TMTV) and iPET response in 76 patients with T‐cell lymphoma. TMTV was measured using the 41% maximum standardized uptake value (SUV 41max ) and SUV 4 thresholding methods. Interim PET was performed after two treatment cycles and evaluated using the ΔSUV max approach and the Deauville scale. Because of significant differences in outcome, patients with anaplastic lymphoma kinase (ALK)‐positive lymphoma were analyzed separately from patients with ALK‐negative lymphoma. In the latter, TMTV was statistically significantly correlated with progression‐free survival, with thresholds best dichotomizing the population, of 232 cm 3 using SUV 41max and 460 cm 3 using SUV 4 . For iPET response, the respective thresholds were 46.9% SUV max reduction and Deauville score 1‐4 vs 5. The proportion of poor prognosis patients was 46% and 29% for TMTV by SUV 41max and SUV 4 , and 29% and 25% for iPET response by ΔSUV max and Deauville, respectively. At diagnosis, the hazard ratio (95% confidence interval) for poor prognosis vs good prognosis patients according to TMTV was 2.291 (1.135‐4.624) for SUV 41max and 3.206 (1.524‐6.743) for SUV 4 . At iPET, it was 3.910 (1.891‐8.087) for ΔSUV max and 4.371 (2.079‐9.187) for Deauville. On multivariable analysis, only TMTV and iPET response independently predicted survival. Patients with high baseline TMTV and poor iPET response (22% of the population) invariably progressed or died within the first year (hazard ratio, 9.031 [3.651‐22.336]). Due to small numbers and events, PET did not predict survival in ALK‐positive lymphoma. Baseline TMTV and iPET response are promising tools to select patients with ALK‐negative T‐cell lymphoma for early allogeneic transplantation or innovative therapies.
    Type of Medium: Online Resource
    ISSN: 0278-0232 , 1099-1069
    URL: Issue
    URL: Article
    DOI: 10.1002/hon.v38.3
    DOI: 10.1002/hon.2697
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2001443-0
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  • 2
    Online Resource
    Online Resource
    The other side of sea level change
    Springer Science and Business Media LLC ; 2020
    In:  Communications Earth & Environment Vol. 1, No. 1 ( 2020-12-23)
    Details
    In: Communications Earth & Environment, Springer Science and Business Media LLC, Vol. 1, No. 1 ( 2020-12-23)
    Type of Medium: Online Resource
    ISSN: 2662-4435
    URL: Article
    DOI: 10.1038/s43247-020-00075-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 3037243-4
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  • 3
    Online Resource
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    Remote VR Studies: A Framework for Running Virtual Reality Studies Remotely Via Participant-Owned HMDs
    Association for Computing Machinery (ACM) ; 2021
    In:  ACM Transactions on Computer-Human Interaction Vol. 28, No. 6 ( 2021-12-31), p. 1-36
    Details
    In: ACM Transactions on Computer-Human Interaction, Association for Computing Machinery (ACM), Vol. 28, No. 6 ( 2021-12-31), p. 1-36
    Abstract: We investigate opportunities and challenges of running virtual reality (VR) studies remotely. Today, many consumers own head-mounted displays (HMDs), allowing them to participate in scientific studies from their homes using their own equipment. Researchers can benefit from this approach by being able to recruit study populations normally out of their reach, and to conduct research at times when it is difficult to get people into the lab (cf. the COVID pandemic). In an initial online survey ( N = 227), we assessed HMD owners’ demographics, their VR setups and their attitudes toward remote participation. We then identified different approaches to running remote studies and conducted two case studies for an in-depth understanding. We synthesize our findings into a framework for remote VR studies, discuss strengths and weaknesses of the different approaches, and derive best practices. Our work is valuable for Human-Computer Interaction (HCI) researchers conducting VR studies outside labs.
    Type of Medium: Online Resource
    ISSN: 1073-0516 , 1557-7325
    URL: Article
    DOI: 10.1145/3472617
    RVK:
    ST 640
    Language: English
    Publisher: Association for Computing Machinery (ACM)
    Publication Date: 2021
    detail.hit.zdb_id: 2006332-5
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  • 4
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    Dynamic boreal summer atmospheric circulation response as negative feedback to Greenland melt during the MIS-11 interglacial
    Copernicus GmbH ; 2022
    In:  Climate of the Past Vol. 18, No. 4 ( 2022-04-12), p. 775-792
    Details
    In: Climate of the Past, Copernicus GmbH, Vol. 18, No. 4 ( 2022-04-12), p. 775-792
    Abstract: Abstract. The unique alignment of orbital precession and obliquity during the Marine Isotope Stage 11 (MIS-11) interglacial produced perhaps the longest period of planetary warmth above preindustrial conditions in the past 800 kyr. Reconstructions point to a significantly reduced Greenland ice sheet volume during this period as a result, although the remaining extent and volume of the ice sheet are poorly constrained. A series of time slice simulations across MIS-11 using a coupled climate model indicates that boreal summer was particularly warm around Greenland and the high latitudes of the Atlantic sector for a period of at least 20 kyr. This state of reduced atmospheric baroclinicity, coupled with an enhanced and poleward-shifted intertropical convergence zone and North African monsoon, favored weakened high-latitude winds and the emergence of a single, unified midlatitude jet stream across the North Atlantic sector during boreal summer. Consequent reductions in the lower-tropospheric meridional eddy heat flux over the North Atlantic therefore emerge as negative feedback to additional warming over Greenland. The relationship between Greenland precipitation and the state of the North Atlantic jet is less apparent, but slight changes in summer precipitation appear to be dominated by increases during the remainder of the year. Such a dynamic state is surprising, as it bears stronger resemblance to the unified-jet state postulated as typical for glacial states than to the modern-day interglacial state.
    Type of Medium: Online Resource
    ISSN: 1814-9332
    URL: Article
    DOI: 10.5194/cp-18-775-2022
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2022
    detail.hit.zdb_id: 2217985-9
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  • 5
    Online Resource
    Online Resource
    Stability of the Atlantic overturning circulation under intermediate (MIS3) and full glacial (LGM) conditions and its relationship with Dansgaard-Oeschger climate variability
    Elsevier BV ; 2020
    In:  Quaternary Science Reviews Vol. 242 ( 2020-08), p. 106443-
    Details
    In: Quaternary Science Reviews, Elsevier BV, Vol. 242 ( 2020-08), p. 106443-
    Type of Medium: Online Resource
    ISSN: 0277-3791
    URL: Article
    DOI: 10.1016/j.quascirev.2020.106443
    RVK:
    RA 1000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 780249-3
    detail.hit.zdb_id: 1495523-4
    SSG: 14
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  • 6
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    Impact of cholesterol on proinflammatory monocyte production by the bone marrow
    Oxford University Press (OUP) ; 2021
    In:  European Heart Journal Vol. 42, No. 42 ( 2021-11-07), p. 4309-4320
    Details
    In: European Heart Journal, Oxford University Press (OUP), Vol. 42, No. 42 ( 2021-11-07), p. 4309-4320
    Abstract: Preclinical work indicates that low-density lipoprotein cholesterol (LDL-C) not only drives atherosclerosis by directing the innate immune response at plaque level but also augments proinflammatory monocyte production in the bone marrow (BM) compartment. In this study, we aim to unravel the impact of LDL-C on monocyte production in the BM compartment in human subjects. Methods and results A multivariable linear regression analysis in 12 304 individuals of the EPIC-Norfolk prospective population study showed that LDL-C is associated with monocyte percentage (β = 0.131 [95% CI: 0.036–0.225]; P = 0.007), at the expense of granulocytes (β = −0.876 [95% CI: −1.046 to −0.705] ; P & lt; 0.001). Next, we investigated whether altered haematopoiesis could explain this monocytic skewing by characterizing CD34+ BM haematopoietic stem and progenitor cells (HSPCs) of patients with familial hypercholesterolaemia (FH) and healthy normocholesterolaemic controls. The HSPC transcriptomic profile of untreated FH patients showed increased gene expression in pathways involved in HSPC migration and, in agreement with our epidemiological findings, myelomonocytic skewing. Twelve weeks of cholesterol-lowering treatment reverted the myelomonocytic skewing, but transcriptomic enrichment of monocyte-associated inflammatory and migratory pathways persisted in HSPCs post-treatment. Lastly, we link hypercholesterolaemia to perturbed lipid homeostasis in HSPCs, characterized by lipid droplet formation and transcriptomic changes compatible with increased intracellular cholesterol availability. Conclusions Collectively, these data highlight that LDL-C impacts haematopoiesis, promoting both the number and the proinflammatory activation of circulating monocytes. Furthermore, this study reveals a potential contributory role of HSPC transcriptomic reprogramming to residual inflammatory risk in FH patients despite cholesterol-lowering therapy.
    Type of Medium: Online Resource
    ISSN: 0195-668X , 1522-9645
    URL: Article
    DOI: 10.1093/eurheartj/ehab465
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2001908-7
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  • 7
    Online Resource
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    Climate-driven 21st century Caspian Sea level decline estimated from CMIP6 projections
    Springer Science and Business Media LLC ; 2023
    In:  Communications Earth & Environment Vol. 4, No. 1 ( 2023-10-07)
    Details
    In: Communications Earth & Environment, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2023-10-07)
    Abstract: Future Caspian Sea level change is estimated for the 21st century using 15 Coupled Model Intercomparison Project 6 climate models and three shared socioeconomic pathways. Projected evaporation increase is significantly larger than precipitation increase integrated over the Caspian Sea catchment basin, resulting in an increasingly negative water balance over the 21st century. A best-fit model analysis that resolves important model limitations related to spatial resolution, climate sensitivity, and Caspian Sea surface area suggests climate-driven sea level reductions of about 8 (inter-model range from 2 to 15) m and 14 (inter-model range from 11 to 21) m by the end of this century for the SSP245 and SSP585 scenarios, respectively. A sea level decline of these magnitudes will result in complete desiccation of the northern Caspian basin and will have adverse effects on ecosystems, coastal infrastructure, navigation, biodiversity, and economies of the entire Caspian region.
    Type of Medium: Online Resource
    ISSN: 2662-4435
    URL: Article
    DOI: 10.1038/s43247-023-01017-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 3037243-4
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  • 8
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    A dynamic ocean driven by changes in CO2 and Antarctic ice-sheet in the middle Miocene
    Elsevier BV ; 2021
    In:  Palaeogeography, Palaeoclimatology, Palaeoecology Vol. 579 ( 2021-10), p. 110591-
    Details
    In: Palaeogeography, Palaeoclimatology, Palaeoecology, Elsevier BV, Vol. 579 ( 2021-10), p. 110591-
    Type of Medium: Online Resource
    ISSN: 0031-0182
    URL: Article
    DOI: 10.1016/j.palaeo.2021.110591
    RVK:
    TE 1000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1497393-5
    detail.hit.zdb_id: 417718-6
    SSG: 12
    SSG: 13
    SSG: 14
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  • 9
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    Influence of the Atlantic Multidecadal Oscillation on South American Atmosphere Dynamics and Precipitation
    MDPI AG ; 2022
    In:  Atmosphere Vol. 13, No. 11 ( 2022-10-28), p. 1778-
    Details
    In: Atmosphere, MDPI AG, Vol. 13, No. 11 ( 2022-10-28), p. 1778-
    Abstract: The Atlantic Multidecadal Oscillation (AMO) is coherently linked to climate variations over many parts of the globe. Despite recent achievements, the mechanism by which the AMO influences regional precipitation over South America is not well understood. In this study, we isolate the atmospheric response to the AMO using a water isotope-enabled version of the Community Earth System Model version 1.2 (iCESM1.2) and determine its influence on (sub)tropical South American regional precipitation and atmospheric circulation. The results suggest an interhemispheric seesaw in Hadley circulation strength and that the section of the Atlantic Hadley cell is marked by a stronger upward air component south of the equator during the cold AMO phase. We also find that the precipitation anomalies over (sub)tropical South America during AMO phases are mainly related to changes in the Atlantic Intertropical Convergence Zone (ITCZ) core strength, where in the cold (warm) AMO phase the core region strengthens (weakens) from February to July, while from July to November the core region weakens (strengthens). Our results stress the importance of acknowledging the dynamics of season- and regional-dependent ITCZ responses, as they are sufficient to produce observed AMO-related signals even in the absence of marked changes in the ITCZ position.
    Type of Medium: Online Resource
    ISSN: 2073-4433
    URL: Article
    DOI: 10.3390/atmos13111778
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2605928-9
    SSG: 23
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  • 10
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    Radiocarbon Evidence for the Contribution of the Southern Indian Ocean to the Evolution of Atmospheric CO 2 Over the Last 32,000 Years
    American Geophysical Union (AGU) ; 2020
    In:  Paleoceanography and Paleoclimatology Vol. 35, No. 3 ( 2020-03)
    Details
    In: Paleoceanography and Paleoclimatology, American Geophysical Union (AGU), Vol. 35, No. 3 ( 2020-03)
    Abstract: Glacia‐interglacial circulation of the Indian sector of the Southern Ocean Indian Ocean part of glacial oceanic carbon pool Southern Indian Ocean was source of CO 2 during Heinrich Stadial 1 and during the Younger Dryas
    Type of Medium: Online Resource
    ISSN: 2572-4517 , 2572-4525
    URL: Article
    DOI: 10.1029/2019PA003733
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2020
    detail.hit.zdb_id: 2916554-4
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